Cancer Frontline - January 2013 | MD Anderson Cancer Center Skip to Content
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BY Sharon Dent, Ph.D., David Johnson, Ph.D., and Sarah Adai

Chromatin, the intertwined histone proteins and DNA that are packaged into chromosomes, has long been recognized as a gatekeeper to the underlying DNA template.

While chromatin is typically on the receiving end of the cell's intricate signaling pathways - culminating in the regulation of gene expression - evidence is emerging to give chromatin a previously unrecognized role: as a dynamic...

BY Scott Merville

When a crucial enzyme is dotted with targets that summon an attack by a cell's protein-destroying complex, another molecule comes to the rescue...

BY MD Anderson Faculty

By Naoto Ueno M.D., Ph.D.

Each year, on the basis of new basic research discoveries and clinical observations, my research group generates...

BY Scott Merville

Cancer begins when a single cell goes haywire. Now the keys to understanding that cell's transition to lethal tumor may be found in the unprecedented analysis of single tumor cells.

By isolating, capturing and then analyzing the genome of individual cells, Nicholas Navin, Ph.D., assistant professor in MD Anderson's Department of Genetics, proposes to identify the mutations that allow a primary tumor cell to escape into the bloodstream...