Shortening Adjuvant Photon Irradiation to Reduce Edema(SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer
MD Anderson Study Status
Investigators are conducting a clinical trial to compare two different treatment schedules for women who need radiation therapy to their lymph nodes as part of their breast cancer treatment. Eligible patients will be randomly assigned to either a traditional radiation therapy schedule, which takes approximately 6 weeks to complete, or to an innovative, newer radiation therapy schedule, which takes approximately 4 weeks to complete. The available evidence suggests that both the traditional and the newer radiation schedules are highly effective for preventing recurrence. The main purpose of the trial is to see if the newer radiation treatment schedule will lower the risk of developing arm swelling, also known as lymphedema, after radiation treatment. We will also be studying the impact of the innovative, shorter, treatment on patient-reported arm function and quality of life.
Information and next steps
Invasive Breast Carcinoma, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
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