Publications

2012

Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SY. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012;21(2):394-405. PMCID: PMC3276287

2011

Atanassov BS, Dent SY. USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1. EMBO Rep. 2011;12(9):924-30. PMID: 21779003.

Atanassov BS, Koutelou E, Dent SY. The role of deubiquitinating enzymes in chromatin regulation. FEBS Lett. 2011;585(13):2016-23. PMCID: PMC3036772.

Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem. 2011;286(14):12234-44. PMCID: PMC3069427.

Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011;30(2):249-62. PMCID: PMC3025463.

Kim E, Napierala M, Dent SY. Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia. Nucleic Acids Res. 2011. PMID: 21745819.

Latham JA, Chosed RJ, Wang S, Dent SY. Chromatin Signaling to Kinetochores: Transregulation of Dam1 Methylation by Histone H2B Ubiquitination. Cell. 2011;146(5):709-19. PMCID: PMC3168986.

Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY. Ubp8 and SAGA Regulate Snf1 AMP Kinase Activity. Mol Cell Biol. 2011;31(15):3126-35. PMID: 21628526.

Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011;332(6032):963-6. PMCID: PMC3128430.

2010

Koutelou E, Hirsch CL, Dent SY. Multiple faces of the SAGA complex. Curr Opin Cell Biol. 2010;22(3):374-82. PMCID: PMC2900470.

Lin Y, Dent SY, Wilson JH, Wells RD, Napierala M. R loops stimulate genetic instability of CTG.CAG repeats. Proc Natl Acad Sci U S A. 2010;107(2):692-7. PMCID: PMC2818888.

Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J. 2010;29(1):68-79. PMCID: PMC2780536.

2009

Latham JA, Dent SYR. The H2BK123Rgument. JCB. 2009, 186(3): 313-315. PMID: 19667125

Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent, SYR. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol. Cell. 2009 Aug 14 35(3):352-64. PMID: 19683498

Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP, Imhof A, Nakatani Y, Dent SYR, Almouzni G. The HP1α-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Reports. 2009 Jun:10(7):769-75. PMID: 19498464

2008

Lin W, Zhang Z, Chen C-H, Behringer RR, Dent SYR. Proper Gcn5 histone acetyltransferase expression is required for proper anteroposterior patterning of the mouse skeleton. Dev Growth and Diff. 2008 Jun;50(5):321-30 PMID: 18430026

Lin W, Zhang Z, Srajer G, Chen YC, Huang M, Phan HM, Dent SYR. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008 Mar 10;237(4)928-40. PMID: 18330926

Riefler GM, Dent SYR, Schumacher JM. Tousled-mediated activation of the Aurora B kinase does not require touseled kinase activity in vivo. J Biol Chem. 2008 May 10;383(19):12763-8. PMID: 18334486

Soragni E, Herman D, Dent SY, Gottesfeld JM, Wells RD, Napierala M. Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia. Nuc. Acid. Res. 2008 Nov;36(19) 6056-65. PMID: 18820300

2007

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhatter R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell 2007;131:633-6. PMID: 18022353

Bu P, Evrard YA, Lozano G, Dent SYR. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May;27(9):3405-16. PMID: 17325035

Chosed R, Dent SYR. A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila. Mol Cell. 2007 Apr 27;26(2):160-2. Review. PMID: 17466618

Latham JA, Dent SYR. Cross-regulation of histone modifications. Nat Struct Mol Biol. 2007 Nov 5;14(11):1017-1024. PMID: 17984964

Lin W, Srajer G, Evrard YA, Phan HM, Furuta Y, Dent SYR. Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro. Dev Dyn. 2007 Jun;236(6):1547-57. PMID: 17440986

Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang X-J, Dent SYR, Yao T-P, Lane WS, Seto E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007;26:197-213. PMID: 17643370

2006

Davie JK, Dent SYR. No Spt6, no nucleosomes, no activator required. Mol Cell 2006 Feb 17;21(4)452-3. PMID: 16483927

Lin W, Dent SYR. Functions of histone-modifying enzymes in development. Curr Opin Genet Dev 2006 Apr;16(2):137-42. PMID: 16503130

Malavé TM, Dent SYR. Transcriptional repression by Tup1-Ssn6. Biochem Cell Biol. 2006 Aug;84(4):437-43. Review. PMID: 16936817

Tripic T, Edmondson DG, Davie JK, Strahl BD, Dent SYR. The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Biochem Biophys Res Commun. 2006 Jan 20;339(3):905-14. PMID: 16329992

2005

Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SYR. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug;233(4):1337-47. PMID: 15937931

Zhang K, Dent SYR. Histone modifying enzymes and cancer: going beyond histones. J Cell Biochem. 2005 Dec 15;96(6):1137-48. Review. PMID: 16173079

Zhang K, Lin W, Latham JA, Riefler GM, Schumacher JM, Chan C, Tatchell K, Hawke DH, Kobayashi R, Dent SYR. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell. 2005 Sep 9;122(5):723-34. PMID: 16143104

2003-2004

Davie JK, Dent SYR. Histone modifications in corepressor functions. Curr Top Dev Biol 2004 59;145-63. Review. PMID: 14975250

Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SYR. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene 2003 Dec 4;22(55):8902-11. PMID: 14654786

Fujii S, Luo RZ, Yuan J, Kadota M, Oshimura M, Dent SYR, Kondo Y, Issa J-P J, Bast RC, Yu Y. Reactivation of the silenced and imprinted alleles of ARH1 is associated with increased H3 acetylation and decreased H3 lysine 9 methylation. Hum Mol Gene 2003;12:1791-1800. PMID: 12874100

Davie JK, Edmondson DG, Coco CB, Dent SY. Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 2003 Dec 12;278(50):50158-62. PMID: 14525981
Oligo information for this publication (pdf)

Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem 2003 May 30;278(22):20405-12. PMID: 12660246

Mukai Y, Davie JK, Dent SY. Physical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase. J Biol Chem 2003 May 23;278(21):18895-901. PMID: 12637515