From Left: Andrew Lopez, Kenneth Trimmer, Swathi Arur, Hyoe-Jin Joo, Shin Yu Chen
Our long-term goal is to understand the exquisite control mediated by a complex signaling pathway in regulating normal development. An ability to understand the mechanisms and principles governing organization of cells and tissues into stereotypical patterns is fundamental to answering the question: What leads to the onset of disease pathology?
2012 Lab Team
From Left: Andrew Lopez, Hyoe-Jin Joo, Miri Shidate, Swathi Arur, Cedric Ksieb and Audrey Christiansen
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.
Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE.
Nat Struct Mol Biol. 2013 May;20(5):620-7. doi: 10.1038/nsmb.2557. Epub 2013 Apr 14.