Biomedical Optics & NanoDiagnostics (BOND)
Versatile Platform for Capture & Analyses of Rare Cells
We have developed a versatile assay for highly efficient capture of circulating cancer cells. Read More.
Imaging and Tracking of Single Biomolecules
Figure: Polarization microscopy with stellated gold nanoparticles for in-situ monitoring of biomolecules. Read More.
“Stealth” Nanoparticles – The Concept of a Hydrophobic Shield
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. Read More.
Dynamic Imaging of Molecular Assemblies
We have pioneered a new method for imaging of dynamic behavior of molecular assemblies in-situ. Read More.
Our lab has been developing multi-modal magneto-plasmonic nanoparticles that can be used with multiple imaging modalities. Read More.
We have shown that multivalent presentation of therapeutic antibodies (Abs) can influence their biological function. Read More.
The overall goal of our lab is to improve early detection, diagnosis/prognosis and treatment of cancer and cardiovascular diseases through development of:
- Methodology and devices for in vivo imaging and spectroscopy with optical contrast.
- Smart biophotonic probes for molecular imaging.
- Diagnostic assays for efficient capture, detection and analysis of rare cells in the body.
- Engineered cells for theranostic applications.
Achieving these objectives requires synergy between fundamental, exploratory and translational research.
Therefore, our lab’s approach to solving challenging biomedical problems is through fundamental studies leading to future clinical applications.
- Wu CH, Huang YY, Chen P, Hoshino K, Liu H, Frenkel EP, Zhang JXJ, Sokolov KV. Versatile Immunomagnetic Nanocarrier Platform for Capturing Cancer Cells. ACS Nano v. 7(10): 8816-8823, 2013.
- Kumar S, Aaron J, Sokolov KV. Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties. Nature Protocols v. 3 (2): 314-320, 2008. PMID: 18274533.
- Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, and Richards-Kortum R, Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles – Cancer Research, 2003, v. 63, pp. 1999-2004. PMID: 12727808.
Funded Research Support
Principal Investigator, Biodegradable Plasmonic Nanoparticles for Cancer Imaging and Therapy, R01 CA143663, NIH/NCI, 01/01/2010 – 12/31/2014.
Principal Investigator, Acoustic Imaging of Sentinel Node Metastasis Using Plasmonic Nanosensors, RO1 EB008101, NIH/NIBIB, MPI – Emelianov/Sokolov, 4/1/2012-2/29/2016.
Mentor, Comprehensive Training Program in Imaging Science and Informatics, T32 NIH/NIBIB, PI - Rylander G, and Markey M, 08/01/09 – 07/31/14
Co-Investigator, Molecular Photothermal Therapy of Cancer Using Targeted Metal Nanoparticles, R01 CA 149740, NIH/NCI, PI – Emelianov, 04/01/2010 – 03/31/2015.
Co-Investigator/Principal Investigator of MDACC sub, Optical Systems for In Vivo Molecular Imaging of Cancer, R01 CA103830 BRP, NIH/NCI, PI - Richards- Kortum, 9/23/2011 - 7/31/2016.
Principal Investigator, Functional, cellular and molecular imaging using ultrasound-guided photoacoustics, R01 CA158598, NIH/NCI, MPI - Emelianov, Esteva, Homan and Sokolov, 10/01/2012 – 08/31/2017.
Co-Investigator, Electrically-connected plasmonic metamaterials for capture and detection of CTC, R21 CA173663, NIH, PI – Shvets, 06/01/2013 – 05/31/2015.