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Biomedical Optics & NanoDiagnostics (BOND)

Highlights

  • VERSATILE PLATFORM FOR CAPTURE AND ANALYSES OF RARE CELLS

    Versatile Platform for Capture & Analyses of Rare Cells

    We have developed  a versatile assay for highly efficient capture of circulating cancer cells. Read More.

  • Imaging and Tracking of Single Biomolecules

    Imaging and Tracking of Single Biomolecules

    Figure: Polarization microscopy with stellated gold nanoparticles for in-situ monitoring of biomolecules. Read More.

  • “Stealth” Nanoparticles – The Concept of a Hydrophobic Shield

    “Stealth” Nanoparticles – The Concept of a Hydrophobic Shield

    Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. Read More.

  • Dynamic Imaging of Molecular Assemblies

    Dynamic Imaging of Molecular Assemblies

    We have pioneered a new method for imaging of dynamic behavior of molecular assemblies in-situ. Read More.

  • Nanotheranostics

    Nanotheranostics

    Our lab has been developing multi-modal magneto-plasmonic nanoparticles that can be used with multiple imaging modalities. Read More.

  • Nanotherapeutics

    Nanotherapeutics

    We have shown that multivalent presentation of therapeutic antibodies (Abs) can influence their biological function. Read More.

Goals

The overall goal of our lab is to improve early detection, diagnosis/prognosis and treatment of cancer and cardiovascular diseases through development of:

  • Methodology and devices for in vivo imaging and spectroscopy with optical contrast.
  • Smart biophotonic probes for molecular imaging.
  • Diagnostic assays for efficient capture, detection and analysis of rare cells in the body.
  • Engineered cells for theranostic applications.

Achieving these objectives requires synergy between fundamental, exploratory and translational research.

Therefore, our lab’s approach to solving challenging biomedical problems is through fundamental studies leading to future clinical applications.

Selected Publications

  1. Wu CH, Huang YY, Chen P, Hoshino K, Liu H, Frenkel EP, Zhang JXJ, Sokolov KV. Versatile Immunomagnetic Nanocarrier Platform for Capturing Cancer Cells. ACS Nano v. 7(10): 8816-8823, 2013.
  2. Kumar S, Aaron J, Sokolov KV. Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties. Nature Protocols v. 3 (2): 314-320, 2008. PMID: 18274533.
  3. Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, and Richards-Kortum R, Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles – Cancer Research, 2003, v. 63, pp. 1999-2004. PMID: 12727808.

View full list of publications

Funded Research Support

Principal Investigator, Biodegradable Plasmonic Nanoparticles for Cancer Imaging and Therapy, R01 CA143663, NIH/NCI, 01/01/2010 – 12/31/2014.

Principal Investigator, Acoustic Imaging of Sentinel Node Metastasis Using Plasmonic Nanosensors, RO1 EB008101, NIH/NIBIB, MPI – Emelianov/Sokolov, 4/1/2012-2/29/2016.

Mentor, Comprehensive Training Program in Imaging Science and Informatics, T32 NIH/NIBIB, PI - Rylander G, and Markey M, 08/01/09 – 07/31/14

Co-Investigator, Molecular Photothermal Therapy of Cancer Using Targeted Metal Nanoparticles, R01 CA 149740, NIH/NCI, PI – Emelianov, 04/01/2010 – 03/31/2015.

Co-Investigator/Principal Investigator of MDACC sub, Optical Systems for In Vivo Molecular Imaging of Cancer, R01 CA103830 BRP, NIH/NCI, PI - Richards- Kortum, 9/23/2011 - 7/31/2016.

Principal Investigator, Functional, cellular and molecular imaging using ultrasound-guided photoacoustics, R01 CA158598, NIH/NCI, MPI - Emelianov, Esteva, Homan and Sokolov, 10/01/2012 – 08/31/2017.

Co-Investigator, Electrically-connected plasmonic metamaterials for capture and detection of CTC, R21 CA173663, NIH, PI – Shvets, 06/01/2013 – 05/31/2015.

View pending and completed grants and contracts

Konstantin Sokolov, PhD

Konstantin (Kostia) Sokolov, PhD
Professor & Lab PI
ksokolov@mdanderson.org

Curriculum Vitae

Research Profile

Ongoing Research Projects

Biodegradable Plasmonic Nanoparticles for Cancer Imaging and Therapy

Figure: Concept of a Biodegradable Plasmonic Nanoparticle

Capture, Enumeration and Characterization of Circulating Tumor Cells (CTCs)

Capture, Enumeration and Characterization of Circulating Tumor Cells (CTCs)

Figure: Concept of the Versatile Immunomagnetic Nanocarrier Platform

Optical Systems for In Vivo Molecular Imaging of Cancer

Optical Systems for In Vivo Molecular Imaging of Cancer

Figure: Molecular Imaging of Epithelial Pre-Cancers

Acoustic Imaging of Sentinel Node Metastasis Using Plasmonic Nanosensors

  Acoustic Imaging of Sentinel Node Metastasis Using Plasmonic Nanosensors

Figure: Highly Sensitive in vivo Molecular Imaging of Cancer Cells

© 2014 The University of Texas MD Anderson Cancer Center