DNA shape and rigidity regulate key players of gene expression
Researchers found how the INO80 protein moves nucleosomes to specific positions that are important for gene regulation and DNA replication
INO80 uses a unique mechanism for moving nucleosomes that depends on DNA shape and flexibility
INO80 bends DNA, causing large stretches to be displaced and create loops around the nucleosome
Inflexible, or rigid, DNA interferes with bending and displacement, which causes INO80 to stop and uniquely position...
Study uncovers hidden class of BRCA1 mutations and a potential way to target them
HSP90 buffers certain BRCA1 mutations, allowing them to persist in humans and promote resistance to PARP inhibitor treatments
Low-dose HSP90...
Inflammation may be responsible for driving earliest stages of lung cancer
Spatial maps of lung precancer and cancer cells at different points in development advance understanding of the earliest stages of lung cancer...