ASH 2025: New data highlights promise of pivekimab sunirine in two aggressive blood cancers
Two clinical studies demonstrate high response rates by patients with two hard-to-treat and aggressive blood cancers
Pivekimab sunirine (PVEK) targets the CD123 antigen, which is overexpressed in both diseases
Frontline triplet regimen including PVEK shows promise for hard-to-treat AML in patients who are not eligible for intensive chemotherapy
PVEK monotherapy demonstrates strong responses, enables...
ASH 2025: Researchers identify CD40 as potential biomarker for a type of nodal T cell lymphoma
Researchers characterized the microenvironment of a nodal T cell lymphoma that is difficult to diagnose and treat
The study...
ASH 2025: Shorter azacitidine regimen safely improves outcomes in lower-risk MDS patients
Azacitidine is a type of targeted therapy known as a hypomethylating agent, commonly used in treating myelodysplastic syndromes (MDS)...
ASH 2025: Results show long-lasting benefits of CAR T cell therapy for hard-to-treat lymphoma
Lisocabtagene maraleucel (liso-cel), a CAR T cell therapy, achieved an overall response rate of 97% in the TRANSCEND FL study
Durable benefits persisted at three years and showed a favorable long-term safety profile with low rates of neurotoxicity and severe cytokine release syndrome
FDA granted accelerated approval in May 2024 for liso-cel in adults with relapsed or refractory follicular lymphoma
ORLANDO...
ASH 2025: New MD Anderson-developed antibody boosts immune response against blood cancers and solid cancers
New investigational therapy 77A is an antibody that converts a cancer survival protein (HSP70) into an immune system trigger
Targeting...
ASH 2025: CAR T cell therapy shows promising Phase II trial results in multiple myeloma
Anito-cel is an experimental CAR T cell therapy for relapsed/refractory multiple myeloma patients
In updated Phase II trial results...
Spatial analysis finds immune-rich pockets in diffuse large B-cell lymphoma tumors with clear treatment potential
Study identified seven distinct and unique microenvironments within diffuse large B-cell lymphoma (DLBCL)
Immune-privileged DLBCLs...
Researchers identify genetic markers that affect treatment outcomes in patients with large B-cell lymphoma
Multiple genetic markers play a key role in the treatment outcomes of patients with large B-cell lymphoma (LBCL) who received chimeric antigen...
Stem cell transplant achieves positive outcomes in second remission for adolescents and young adults with ALL
A new study from The University of Texas MD Anderson Cancer Center and Dana-Farber Cancer Institute, published in American Journal of Hematology...
Patients receiving anti-cancer treatment near end of life experience higher rates of hospitalization, ED and ICU use, and less utilization of hospice
Patients who receive systemic anti-cancer treatment near end of life are more likely to be hospitalized, go to the intensive care unit or...