Mutation predicts chemotherapy resistance and better responses to immunotherapy in advanced bladder cancer
Researchers studied the KDM6A gene, which is altered in about 26% of advanced bladder cancers
Tumors with KDM6A mutations did not respond well to chemotherapy but demonstrated enhanced sensitivity to anti-PD1 immune checkpoint therapy
KDM6A mutations could serve as a biomarker to guide treatment selection
Researchers at The University of Texas MD Anderson Cancer Center have determined that mutations in the KDM6A gene – common in advanced...
Immunotherapy combination does not improve outcomes for patients with advanced anal cancer
Phase II ETCTN trial found ipilimumab plus nivolumab did not improve outcomes over nivolumab alone in...
Targeted therapy plus immunotherapy improved outcomes in advanced metastatic colorectal cancer
Phase III COMMIT trial evaluated better first-line options for patients with dMMR/MSI-H metastatic colorectal cancer
The study...