Dual targeting approach improves immunotherapy response in glioblastoma
Researchers from The University of Texas MD Anderson Cancer Center have found that simultaneously blocking two key “don’t eat me signals” found in cancer cells heightens the immune response and sensitizes tumors to immunotherapy in models of glioblastoma (GBM), highlighting a promising strategy.
The study, published in Nature Communications, was co-led by Wen Jiang, M.D., Ph.D., associate professor of Radiation Oncology, and Betty...
New biomarker predicts chemotherapy response in triple-negative breast cancer
Patients with triple-negative breast cancer have different treatment responses
Computational tools that predict treatment response historically...
Biomarkers predict patients with glioblastoma who will survive longer after treatment with cancer-targeting virus
Glioblastoma is a deadly brain cancer that suppresses the immune system and doesn’t respond well to available therapies
Researchers engineered...
Blood biomarker points to increased risk of brain metastasis in patients with inflammatory breast cancer
Brain metastases are a common complication of inflammatory breast cancer
High levels of soluble E-cadherin in the blood are associated with increased brain metastasis in these patients
A CXCR2 inhibitor reduced metastasis and improved survival in preclinical models, suggesting that targeting this pathway could prevent or treat brain metastasis
Researchers at The University of Texas MD Anderson Cancer Center have identified a targetable...
Researchers identify novel therapeutic target to improve recovery after nerve injury
Peripheral nerve injury reduces the ability of macrophages to clear dead or dying cells – a process known as efferocytosis – leading to chronic...
High levels of protein drive tumor immune suppression in head and neck cancer
BATF2 is a new type of tumor suppressor that can be epigenetically silenced by high levels of glutamine in the tumor microenvironment
Glutamine...
Circadian rhythms may affect risk of bacterial infection
Researchers identified an inflammation biomarker in laboratory model that predicts which individuals are at an increased risk of bacterial infection...