Keping Xie, M.D., Ph.D.
- Gastrointestinal Cancer Research
Keping Xie, M.D., Ph.D., has had a long-standing interest in the process of tumor progression and the molecules that contribute to it, especially as they relate to tumor invasion and progression. Our research focus is on gastrointestinal cancers, including cancers of pancreas, liver and stomach. The types of molecules that have received most of the attention include progression-related genes and their regulators, i.e., transcription factors.
The goal of the proposed research is to investigate the interactions among signaling pathways such as FOXM1, KLF4 and microRNA and their impacts on gastrointestinal carcinogenesis using genetic mouse models, state-of-art cell and molecular biology technology, and human specimens. Our long-term goal is to translate our laboratory findings to benefit patients in clinics in forms of novel and effective intervention strategies.