Publications

• Korkut A., Zaidi S., Kanchi R.S., Rao S., Gough N.R., Schultz A., Li X., Lorenzi P.L., Berger A.C., Robertson G., Kwong L.N., Datto M., Roszik J., Ling S., Ravikumar V., Manyam G., Rao A., Shelley S., Liu Y., Ju Z., Hansel D., de Velasco G., Pennathur A., Andersen J.B., O'Rourke C.J., Ohshiro K., Jogunoori W., Nguyen B., Li S., Osmanbeyoglu H.U., Ajani J.A., Mani S.A., Houseman A., Wiznerowicz M., Chen J., Gu S., Ma W., Zhang J., Tong P., Cherniack A.D., Deng C., Resar L., The Cancer Genome Atlas Research Network, Weinstein J.N., Mishra L., Akbani R. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. Cell Systems 2018.
• Soundararajan R., Aparicio A.M., Logothetis C.J., Mani S.A., Maity S.N. Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Front Oncol 8:69, 2018. e-Pub 3/2018.
• Soundararajan R., Paranjape A.N., Maity S., Aparicio A.M., Mani S.A. EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. (2018) Article in press.
• Jolly M.K., Mani S.A., Levine H. Hybrid epithelial/mesenchymal phenotype (s): The ‘fittest’for metastasis? Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1870 (2018) 151-157.
 

• Bollong M.J., Pietilä M., Pearson A.D., Sarkar T.R., Ahmad I., Soundararajan R., Lyssiotis C.A., Mani S. A.,* Schultz P.G.,* Lairson L.L.* A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30. (*Co-corresponding author)
• Taube J.H., Sphyris N., Johnson K.S., Reisenauer K.N., Nesbit T.A., Joseph R., Vijay G.V., Sarkar T.R., Bhangre N.A., Song J.J., Chang J.T., Lee M.G., Soundararajan R., Mani S. A. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017 Jul 10;8(39):65548-65565. doi: 10.18632/oncotarget.19214. eCollection 2017 Sep 12.
• Jia D., Jolly M.K., Tripathi S.C., Den Hollander P., Huang B., Lu M, Celiktas M., Ramirez-Peña E., Ben-Jacob E., Onuchic J.N., Hanash S.M., Mani S.A., Levine H. Distinguishing mechanisms underlying EMT tristability. Cancer Converg 1(1):2, 2017. e-Pub 11/2017.
• Rigoutsos I., Lee S. K., Nam S. Y., Anfossi S., Pasculli B., Pichler M., Jing Y., Rodriguez-Aguayo C., Telonis A. G., Rossi S., Ivan C., Catela Ivkovic T., Fabris L., Clark P. M., Ling H., Shimizu M., Redis R. S., Shah M. Y., Zhang X., Okugawa Y., Jung E. J., Tsirigos A., Huang L., Ferdin J., Gafà R., Spizzo R., Nicoloso M. S., Paranjape A. N., Shariati M., Tiron A., Yeh J. J., Teruel-Montoya R., Xiao L., Melo S. A., Menter D., Jiang Z. Q., Flores E. R., Negrini M., Goel A., Bar-Eli M., Mani S. A., Liu C. G., Lopez-Berestein G., Berindan-Neagoe I., Esteller M., Kopetz S., Lanza G., Calin G. A. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol 18(1):98, 5/2017. e-Pub 5/2017.
• Tian L., Goldstein A., Wang H., Ching Lo H., Sun Kim I., Welte T., Sheng K., Dobrolecki L. E., Zhang X., Putluri N., Phung T. L., Mani S. A., Stossi F., Sreekumar A., Mancini M. A., Decker W. K., Zong C., Lewis M. T., Zhang X. H. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature 544(7649):250-254, 4/2017. e-Pub 4/2017.
• Yam C., Mani S. A., Moulder S.L. Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field. Oncologist 22(9):1086-1093, 9/2017. e-Pub 5/2017.
 

• Dhawan A., Tonekaboni S. A. M., Taube J.H., Stephen Hu S., Sphyris N., Mani S. A.*, & Kohandel M.*, Mathematical modeling of phenotypic plasticity and conversion to a stem-cell state under hypoxia, Scientific Reports 2016 (*co-corresponding authors)
• Zhao W., Prijic S., Urban B.C., Tisza M.J., Zuo Y., Li L., Tan Z., Chen X., Mani S. A., Chang J.T., Candidate anti-metastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity, Can Res 2016
• Paranjape A., Soundararajan R., Werden S.J., Joseph R., Taube J.H., Liu H., Rodriguez-Canales J., Sphyris N., Wistuba, I.I., Dhillon J., Mahajan N., Mahajan K., Chang J., Ittmann M., Maity S., Logothetis, C., Miura, N., Tang, D., Mani S. A., Inhibition of FOXC2 restores epithelial phenotype and drug-sensitivity in prostate cancer cells with stem-like properties, Oncogene 2016
• Jolly M.K., Tripathi S.C., Jia D., Mooney S.M., Celiktas M., Hanash S.M., Mani S. A., Pienta K.J., Ben-Jacob E., Levine H., Stability of the hybrid epithelial/mesenchymal phenotype, Oncotarget (2016)
• Pietilä M., Vijay G.V., Soundararajan R., Yu X., Symmans W.F., Sphyris N., Mani S. A., FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition, Sci. Rep (2016)
• Boareto M., Jolly M.K., Goldman A., Pietilä M., Mani S. A., Sengupta S., Ben-Jacob E., Levine H., Onuchic J.N., Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. Journal of the Royal Society, Interface / the Royal Society. 2016; 13(118).
• Ashokkumar M., Cristian Chipara A., Tharangattu Narayanan N., Anumary A., Sruthi R., Thanikaivelan P., Vajtai R., Mani S. A., Ajayan P.M., Three-Dimensional Porous Sponges from Collagen Biowastes. ACS applied materials & interfaces. 2016; 8(23):14836-44.
• Toneff M.J., Sreekumar A., Tinnirello A., Hollander P.D., Habib S., Li S., Ellis M.J., Xin L., Mani S. A., Rosen J.M., The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC biology. 2016; 14(1):47.
• Kwon O.J., Zhang L., Wang J., Su Q., Feng Q., Zhang X.H., Mani S. A., Paulter R., Creighton C.J., Ittmann M.M., Xin L., Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. The Journal of clinical investigation. 2016; 126(7):2626-41.
• Svanidze E., Besara T., Ozaydin M., Tiwary C., Wang J.K., Radhakrishnan S., Mani S. A., Xin Y., Han K., Liang H., Siegrist T., Ajayan P.M., and Morosan E., High hardness in the biocompatible intermetallic compound β-Ti3Au, Science Advances 20 Jul 2016:2 (7), e1600319.
• Werden S.J., Sphyris N., Sarkar T.R., Paranjape A.N., LaBaff A.M., Taube J.H., Hollier B.G., Ramirez-Peña E.Q., Soundararajan R., den Hollander P., Powell E., Echeverria G.V., Miura N., Chang J.T., Piwnica-Worms H., Rosen J.M., and Mani S. A., Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth, Oncogene (2016).
• Chakravarty D., Tiwary C. S., Woellner C. F., Radhakrishnan S., Vinod S., Ozden S., da Silva Autreto P. A., Bhowmick S., Asif S., Mani S. A., Galvao D. S., Ajayan P. M. 3D Porous Graphene by Low-Temperature Plasma Welding for Bone Implants. Adv Mater 28(40):8959-8967, 10/2016. e-Pub 8/2016.
• Pietila M., Ivaska J., Mani S. A., Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? Cancer Letters 2016.
 

• Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani S. A., Clise-Dwyer K, Sun X. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. Blood. e-Pub 2/2015.
• Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani S. A., A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Scientific Reports 5:11766, 2015. e-Pub 6/2015.
• Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani S. A., EMT-Induced Metabolite Signature Identifies Poor Clinical Outcome. Oncotarget. e-Pub 7/2015.
• Jolly MK, Jia D., Boareto M, Mani S. A., Pienta K.J., Ben-Jacob E., Levine H, Coupling the modules of EMT and stemness: A tunable 'stemness window' model. Oncotarget 2015.
• Cohen E.N., Gao H., Anfossi S., Mego M., Reddy N.G., Debeb B., Giordano A., Tin S., Wu Q., Garza R.J., Cristofanilli M., Mani S.A., Croix D.A., Ueno N.T., Woodward W.A., Luthra R., Krishnamurthy S., Reuben J.M. Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells. PLoS One 10(7):e0132710, 2015. e-Pub 7/2015.
• Sphyris N., Sarkar T.R., Battula V.L., Andreeff M., Mani S. A., GD2 and GD3 synthase: novel drug targets for cancer therapy. Molecular & Cellular Oncology, 2-3, (2015).
 

• Yang, J*., Mani S. A*., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A., and Weinberg, R.A. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis. Cell 117:927–939, (2004). (*Denotes equal first authors). (Cited 3495 times as of 2/2019 based on Google Scholar)
• Samudre, K.R., Mani S. A., Vathsala, P.G., Rangarajan, P.N., Padmanaban, G. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. BBRC, 292:312-7, (2002).
• Harish S., Khanam, T., Mani S. A., and Rangarajan, P.N. Transcriptional activation by hepatocyte nuclear factor-4 in a cell-free system derived from rat liver nuclei. Nucleic Acids Res 29:1047-53, (2001).
• Mani S. A., Harish, S., Vathsala, P.G., Rangarajan, P.N., and Padmanaban, G. Receptor-mediated gene delivery demonstrates the role of 5' proximal DNA region in conferring phenobarbitone responsiveness to CYP2B1/B2 gene in rat liver in vivo. Biochem Biophys Res Commun 268:734-739, (2000).
• Fernandez, M.A., Mani S. A., Rangarajan, P.N., and Seshagiri, P.B. Sperm-mediated gene transfer into oocytes of golden hamster: Assessment of sperm function. Indian Journal of Experimental Biology 37:1085-1092, (1999).
• Prabhu, L., Upadhya, P., Ram, N., Nirodi, C. S., Sultana, S., Vatsala, P. G., Mani S. A., Rangarajan, P. N., Surolia, A., Padmanaban, G. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver. Proc Natl Acad Sci USA 92:9628-963, (1995).

• Yao Y., Suraokar M., Darnay B.G., Hollier B.G., Shaiken T.E., Asano T., Chen C., Chang B., Lu Y., Mills G.B., Sarbassov D., Mani S. A., Abbruzzese J.L., Reddy S.A.G. BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation. Sci Signal 6(257)2013.
• Hollier B.G., Tinnirello A.A., Werden S.J., Evans K.W., Taube J.H., Sarkar T.R., Sphyris N., Shariati M., Kumar S.V., Battula V.L., Herschkowitz J.I., Guerra R., Chang J.T., Miura N., Rosen J.M., and Mani S. A., FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Research 73(6); 1–12 (2013)
• Lu J., Ye X., Fan F., Xia L., Bhattacharya R., Bellister S., Tozzi F., Sceusi E., Zhou Y., Tachibana I., Maru D.M., Hawke D.H., Rak J., Mani S. A., Zweidler-McKay P., Ellis L.M., Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1. Cancer Cell. 23(2):171-85 (2013).
• Mathkar A., Narayanan T.N., Alemany L.B., Cox P., Nguyen P., Gao G., Chang P., Romero-Aburto R., Mani S. A., Ajayan P.M., Synthesis of Fluorinated Graphene Oxide and its Amphiphobic Properties. Particle & Particle Systems Characterization. 30 (3), 266-272 (2013)
• Zarkoob H., Taube J.H., Singh S.K., Mani S. A., and Kohandel M., Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein. PLOS ONE (2013).
• Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis R, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen J, Beverloo B, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn G, Gotley D, Bhardwaj V, Imad S, Sen S, Multani A, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau S, Marchand LL, Tiirikainen M, Mani S. A., Zhang W, Davuluri R, Mimori K, Mori M, Sieuwerts A, Martens J, Tomlinson I, Neagoe I, Negrini M, Foekens J, Hamilton S, Lanza G, Kopetz S, Fodde R, Calin G. CCAT2, a novel non-coding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. (2013) 23 (9), 1446-1461.
• Romero-Aburto R., Narayanan T.N., Nagaoka Y., Hasumura T., Mitcham T.M., Fukuda T., Cox P.J., Bouchard R.R., Maekawa T., Kumar D.S., Torti S.V., Mani S. A.,* and Ajayan P.M.,* Fluorinated Graphene Oxide; a New Multimodal Material for Biological Applications (2013) Adv Mater. 2013 Oct 18;25(39):5632-7 (*co-corresponding authors)
• Highlighted in Y. H. Hu*, "The First Magnetic-Nanoparticle-Free Carbon-based Contrast Agent of Magnetic Resonance Imaging (MRI)---Fluorinated Graphene Oxide (FGO)", Small 10, 1451(2014).
• Taube J.H., Malouf G.G., Lu E., Sphyris N., Vijay V., Ramachandran P.R., Ueno K.R., Gaur S., Nicoloso M.S., Rossi S., Herschkowitz J.I., Rosen J.M., Issa J.J., Calin G.A., Chang J.T., Mani S. A., Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Scientific Reports. 3, 2687 (2013).
• Liu, Y., Zhou, R., Baumbusch, L.O., Tsavachidis, S., Brewster, A.M., Do, K.-A., Sahin, A., Hortobagyi, G.N., Taube, J.H., Mani, S. A., Aarøe, J., Wärnberg, F., Børresen-Dale, A.-L., Mills, G.B., Thompson, P.A. , Bondy, M.L. Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer, Breast Cancer Research and Treatment 2013, Pages 1-13
• Malouf G.G., Taube J.H., Lu Y., Roysarkar T., Panjarian S., Estecio M.R., Jelinek J., Yamazaki J., Raynal N.J., Long H., Tahara T., Tinnirello A., Ramachandran P., Zhang X.Y., Liang S., Mani S. A.*, Issa J.P.*, Architecture of epigenetic reprogramming following Twist1 mediated epithelial-mesenchymal transition. Genome Biol. 2013 Dec 24;14(12): R144 (*co-corresponding authors)
• Chang J.T., Mani S. A., Sheep, Wolf, or Werewolf: Cancer Stem Cells and the Epithelial-to-Mesenchymal Transition, Cancer Letters (2013) 341(1), 16-23
• Barsan, V., Cristofanilli, M., Mani S. A., Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition, Breast Diseases, Volume 24, Issue 3, 2013, Pages 225-226
 

• Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani S. A., van Oudenaarden A, Weinberg RA. Slug and sox9 cooperatively determine the mammary stem cell state. Cell 148(5):1015-28 (2012).
• Roman-Perez E, Casbas-Hernandez P, Rein J, Carey LA, Lubet RA, Mani S. A., Amos KD, Troester MA, Pirone JR. Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Res 14(2) R51. (2012).
• Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani S. A., Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM. Hybrid 2D Nanomaterials as Dual-Mode Contrast Agents in Cellular Imaging. Adv Mater. 24(22):2992-8 (2012).
• Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani S. A.*, Andreeff M*. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest. 122(6):2066-78 (2012). (*co-corresponding authors).
• Fan F, Samuel S, Evans KW, Lu J, Xia L, Zhou Y, Sceusi E, Tozzi F, Ye X, Mani S. A., Ellis LM. Overexpression of snail induces epithelial–mesenchymal transition and a cancer stem cell–like phenotype in human colorectal cancer cells. Cancer Medicine 2012, 1(1) 5-16
• Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani S. A., Esteva FJ, Cristofanilli M, Reuben JM. Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer. Mol Cancer Ther. 11(11):2526-34 (2012).
• Smitha S., Haseena V.S., Narayanan T.N., Reena Mary A.P., Ajayan P.M., Puthumana J., Aziz A.A., Aburto R.R., Mani S. A., Joy P.A., and Anantharaman M.R. Fluorescent Superparamagnetic Iron Oxide Core–Shell Nanoprobes for Multimodal Cellular Imaging. Mater. Express, 2 (4), 2012.

• Tong Z, Chakraborty S, Sung B, Koolwal P, Kaur S, Aggarwal BB, Mani S. A., Bresalier RS, Batra SK, Guha S. Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells. Cancer. 117;2408-18, (2011). http://db.tt/N9qK4d0
• Mego, M*., Mani S. A.,* Lee, B., Li, C., Evans, K.W., Cohen, E. N., Gao, H., Jackson, S. A., Giordano, A., Hortobagyi, G. N., Cristofanilli, M., Lucci, A., Reuben, J. M., Expression of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Primary Breast Cancer: The Effect of Neoadjuvant Therapy, Int. J. of Cancer. 130(4):808-16 (2011). (* denotes equal first authors)
• Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani S. A., Rao K, Premkumar L, Elble RC. Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis. Oncogene. 31(17):2237-46 (2011).
• May, C. D., Sphyris, N., Evans, K.W., Werden, S.J., Guo, W., Mani S. A., Epithelial–mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression, Breast Cancer Research. 13 (1), 202 (2011).
Kolonin MG, Evans KW, Mani S. A., Gomer RH. Alternative origins of stroma in normal organs and disease. Stem Cell Res. 8 (2) 312-323 (2011).

• Battula, V.L., Evans, K.W., Hollier, B.G., Shi, Y., Marini, F.C., Ayyanan, A., Wang, R., Brisken, C., Guerra, R., Andreeff, M., Mani S. A., Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multi-Lineage Differentiation Potential Similar to Mesenchymal Stem Cells. Stem Cells, 28(8):1435-45 (2010).
• Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani S. A., Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A. 107(35):15449-54 (2010). (Cited 777 times as of 2/2019 based on Google Scholar)
• Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani S. A, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia. 15(2):235-52 (2010).
• Mego M, Mani S. A., Cristofanilli M. Molecular mechanisms of metastasis in breast cancer -- clinical applications. Nat Rev Clin Oncol. 7 (12):693-701 (2010).
 

• Hollier, B.G., Evans K.W., Mani S. A., The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies. Journal of mammary gland biology and neoplasia, 14, (1): 29, (2009).
• Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani S. A, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. Breast Cancer Metastasis: Challenges and Opportunities. Cancer Research 69: (12)-4951. (2009).
• Sphyris N., Mani S. A., The Importance of the Epithelial–Mesenchymal Transition in Breast Cancer, Current Breast Cancer Reports (2009) 1:229–237.

• Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani S. A., Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K. Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A 105 (37):14076-81 (2008).
• Onder, T., Gupta, P.B., Mani S. A., Yang, J., Lander, E.S., Weinberg R.A., Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways. Cancer Res 68: 1-10 (2008).
• Mani S. A.,*,# Guo, W.*, Liao, M.J.,*Eaton E., Ayyanan A., Zhou A, Brooks M, Reinhard F., Zhang C., Shipitsin. M., Campbell. L. L., Polyak K., Brisken. C., Yang. J, Weinberg R.A.,# The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715. (2008) (*equal first authors & # Co-corresponding authors). (Cited 6700 times as of 2/2019 based on Google Scholar)
A 3 minute YouTube video highlight by Robert Weinberg
• Highlighted in New York Times, September 9th, 2008.
• Highlighted in Nature Reviews in Cancer 8, 483 (July 2008); Cell Stem Cell 2 (6):511-2 (June 2008); Nature Reviews in Mol. Cell Bio. 11, 466 (July 2010).

• Mani S. A., Yang, J., Brooks, M., Schwaninger, G., Zhou, A., Miura, N., Kutok, J.L., Hartwell, K., Richardson, A.L., Weinberg, R.A. FOXC2 plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci 104:10069-10074 (2007). (Cited 534 times as of 2/2019 based on Google Scholar)
• Liao, M.J., Zhang, C.C., Zhou, B., Zimonjic. D.B., Mani S. A., Lodish, H.F., Weinberg, R.A. Enrichment of a population of mammary gland cells that forms mammospheres and has in vivo repopulating activity. Cancer Research 67:8131-8138, (2007).

• Yang, J., Mani S. A., and Weinberg, R.A. Exploring a New Twist in Tumor Metastasis. Cancer Res 66:1-3, (2006).

• Gupta, P., Mani S. A., Yang, J., Hartwell, K., Weinberg, R.A. The evolving portrait of cancer metastasis. Cold Spring Harbor Symposia on Quantitative Biology 70:291-298, (2005).

• Yang, J*., Mani S. A*., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A., and Weinberg, R.A. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis. Cell 117:927–939, (2004). (*Denotes equal first authors). (Cited 3495 times as of 2/2019 based on Google Scholar)
• Samudre, K.R., Mani S. A., Vathsala, P.G., Rangarajan, P.N., Padmanaban, G. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. BBRC, 292:312-7, (2002).
• Harish S., Khanam, T., Mani S. A., and Rangarajan, P.N. Transcriptional activation by hepatocyte nuclear factor-4 in a cell-free system derived from rat liver nuclei. Nucleic Acids Res 29:1047-53, (2001).
• Mani S. A., Harish, S., Vathsala, P.G., Rangarajan, P.N., and Padmanaban, G. Receptor-mediated gene delivery demonstrates the role of 5' proximal DNA region in conferring phenobarbitone responsiveness to CYP2B1/B2 gene in rat liver in vivo. Biochem Biophys Res Commun 268:734-739, (2000).
• Fernandez, M.A., Mani S. A., Rangarajan, P.N., and Seshagiri, P.B. Sperm-mediated gene transfer into oocytes of golden hamster: Assessment of sperm function. Indian Journal of Experimental Biology 37:1085-1092, (1999).
• Prabhu, L., Upadhya, P., Ram, N., Nirodi, C. S., Sultana, S., Vatsala, P. G., Mani S. A., Rangarajan, P. N., Surolia, A., Padmanaban, G. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver. Proc Natl Acad Sci USA 92:9628-963, (1995).

• Sphyris N, Mani S. A., pIgR: Frenemy of Inflammation, EMT, and HCC Progression, J Natl Cancer Inst 103 (22) 1644-45 (2011)
• Mani S. A., Barton M. C., HDAC3 at the Fulcrum of an Epithelial-Mesenchymal Balance, Mol. Cell, 43 (5): 697-698 (2011).
• Ferracin M., Gautheret D., Hubé F., Mani S. A., Mattick J.S., Ørom U.A., Santulli Q., Slotkin R.K., Szweykowska-Kulinska Z., Taube J.H., Vazquez F., Yang J., The Non-Coding RNA Journal Club: Highlights on Recent Papers, Non-Coding RNA 2015, 1, 87-93.
• Francastel C., Hubé F., Mani S.A., Santulli G., Taube J.H., Szweykowska-Kulinska Z., The Non-Coding RNA Journal Club: Highlights on Recent Papers—2, Non-Coding RNA 2015, 1, 167-169.
• Gautheret D., Taube J. H., Mani S. A., Santulli G., Cuerda-Gil D., Slotkin R. K., Zhang B., Wang Y., Salzman D. W., Weidhaas J. B. The Non-Coding RNA Journal Club: Highlights on Recent Papers—4. Non-Coding RNA, 9/2016.
• Tian L., Zhang X. H. F., Mani S. A. Effective models for antimetastatic therapies. Oncotarget, 6/2017.
• Achour C., Bogard B., Hubé F., Mani S. A., Santulli G., Taube J. H. The Non-Coding RNA Journal Club: Highlights on Recent Papers—5. Non-Coding RNA, 6/2017.
• Xiao H., Shiu P., Shu J., Santulli G., Gheybi M., Conn S., Bogard B., Hubé F., Taube J.H., Mani S.A., Song L., Calin G., Zhang S. The Non-Coding RNA Journal Club: Highlights on Recent Papers—6. Non-Coding RNA, 9/2018.
 

• Mani S. A., Evans, K.W., Hollier, B.G., Guo, W., Weinberg, R.A., Generation of Stem-like Cells via EMT: A New Twist in Cancer Initiation and Progression. AACR education book, (1): 173. (2009).
• Taube J., Mani S. A., Epithelial-to-mesenchymal transition, stem cells, and cancer progression. NOVA publishers book on “Stem Cell, Regenerative Medicine and Cancer” (2010).
• Mego M., Reuben J., Mani S. A., Epithelial-Mesenchymal Transition and Cancer Stem Cells (CSCs): The Traveling Metastasis, Human Press Book on “Liquid Biopsies in Solid Tumor” (2017)

• Herschkowitz J.I., Coarfa C., Prat A., Toneff M.J., Hoadley K.A., Dinger M.E., Mattick J.S., Mani S.A., Perou C.M., Rosen J.M. The role of long noncoding RNAs in epithelial to mesenchymal transition and cancer stem cells. Cancer Research 1(10 Suppl):A039, 10/2013.
• Zhao W., Tisza M., Sjol J., Mani S.A., Chang J.T. Plasma membrane fluidity drives metastasis in breast cancer. Cancer Research 74(19 Suppl):2080, 10/2014.
• Paranjape A.N., Soundararajan R., Werden S.J., Joseph R., Taube J.H., Bhangre N., Liu H., Rodriguez-Canales J., Wistuba I.I., Chang J.T., Tang D.G., Mahajan N., Mahajan K., Miura N., Mani S.A. Delineating the role of epithelial-mesenchymal transition in the generation and maintenance of prostate cancer stem cells. Cancer Research 75(15 Suppl):4065, 8/2015.
• Stylianou N., Lehman M., Wang C., Jovanovic L., Rockstroh A., Sadowski M., Kashyap A.S., Mani S.A., Westbrook T.F., Williams E.D., Gunter J.H., Nelson C., Hollier B.G. Investigating Epithelial‐Mesenchymal Plasticity in Prostate Cancer Invasion and Metastasis, 8/2015.
• Mitra S., Federico L., Roysarkar T., Mani S.A., Mills G.B. Transcription factor Snail mediates EMT by altering vesicular trafficking protein Rab25. Cancer Research 75(15 Suppl):4040, 8/2015.
• Jolly M.K., Huang B., Lu M., Mani S.A., Levine H., Ben-Jacob E. Coupled cellular decision-making of EMT and stemness: A bottom-up regulatory model. Cancer Research 75(22 Supplement 2): B2-49, 11/2015.
• Zhao W., Sara P., Urban B., Tisza M., Mani S.A., Chang J.T. Systems biology reveals role of cholesterol homeostasis in breast cancer metastasis. Cancer Research 75(22 Supplement 2):B2-10, 11/2015.
• Joseph R., Soundararajan R., Paranjape A., Mani S.A. Immune regulation of EMT and metastatic competence in breast tumor progression. Cancer Immunology Research 4(1 Suppl):A130, 1/2016.
• Joseph R., Soundararajan R., Paranjape A., Mani S.A. Determinants of metastatic competence in breast carcinoma: a role for immune cells. Cancer Research 76(14 Suppl):5141, 7/2016.
• Kumar M., DeVaux R.S., Shen J.J., Davis S.P., Dinger M.E., Mattick J.S., Perou C.M., Rosen J.M., Mani S.A., Herschkowitz J.I. LncRNA AK001796 as a therapeutic target in aggressive breast cancers. Cancer Research 76(14 Suppl):1598, 7/2016.
• Jolly M. K., Jia D., Tripathi S., Hanash S., Mani S. A., Ben-Jacob E., Levine H. Network motifs that stabilize the hybrid epithelial/mesenchymal phenotype. APS Meeting Abstracts, 2016.
• Arnold J. M., Rasaily U., Ramirez-Peña E., Pathak R., San Martin R., Purwaha P., Rao A., Putluri N., Rowley D., Sikora A., Mani S. A., Sreekumar A.. Uridine diphosphate glucose dehydrogenase is required for hyaluronic acid production and breast cancer invasion. Cancer Research 77(4), 2/2017.
• Vallecillo L. B., Chang J. T., Chen K., Moss T. J., Shaw K. R., Meric-Bernstam F., Eterovic A. K., Mills G. B., Mani S. A., Li X., Gilcrease M., Moulder SL. Whole exome sequencing of metaplastic breast cancer (MpBC): Effect of mutation status on survival. Journal of Clinical Oncology 35(15_Suppl):1090, 5/2017.
• Jolly M.K , Jia D., Tripathi S. C., Mooney S., Celiktas M., Hanash S. M., Mani S. A., Pienta K. J., Ben-Jacob E., Levine H. Stability and stemness of the hybrid epithelial-mesenchymal phenotype. Cancer Research, 7/2017.