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B-Cell Lymphoma Moon Shot™
The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies.
Nucleus-translocated ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy
Xinjian Li, Willie Yu, Xu Qian, Yan Xia, Yanhua Zheng, Jong-Ho Lee, Wei Li, Jianxin Lyu, Ganesh Rao, Xiaochun Zhang, Chao-Nan Qian, Steven G. Rozen, Tao Jiang, and Zhimin Lu
The Journal of Experimental Medicine
RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis
Yan Xia, Weiwei Yang, Ming Fa, Xinjian Li, Yugang Wang, Yuhui Jiang, Yanhua Zheng, Jong-Ho Lee, Jing Li, and Zhimin Lu
Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy
Xu Qian, Xinjian Li, Qingsong Cai, Chuanbao Zhang, Qiujing Yu, Yuhui Jiang, Jong-Ho Lee, David Hawke, Yugang Wang, Yan Xia, Yanhua Zheng, Bing-hua Jiang, David X. Liu, Tao Jiang and Zhimin Lu
Nature Cell Biology
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Xinjian Li, Xu Qian, Li-Xia Peng, Yuhui Jiang, David H. Hawke, Yanhua Zheng, Yan Xia, Jong-Ho Lee, Gilber Cote, Hongxia Wang, Liwei Wang, Chao-Nan Qian and Zhimin Lu
Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis
Xinjian Li, Yuhui Jiang, Jill Meisenhelder, Weiwei Yang, David H. Hawke, Yanhua Zheng, Yan Xia, Kenneth Aldape, Jie He, Tony Hunter, Liwei Wang, and Zhimin Lu
Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation
Yanhua Zheng, Xinjian Li, Xu Qian, Yugang Wang, Jong-Ho Lee, Yan Xia, David H. Hawke, Gang Zhang, Jianxin Lyu and Zhimin Lu
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Yuhui Jiang, Xu Qian, Jianfeng, Shen, Yugang Wang, Xinjian Li, Rui Liu, Yan Xia, Qianming Chen, Guang Peng, Shiaw-Yih Lin, and Zhimin Lu
PKM2 regulates chromosome segregation and mitosis progression of tumor cells
Yuhui Jiang, Xinjian Li, Weiwei Yang, David H. Hawke, Yanhua Zheng, Yan Xia, Kenneth Aldape, Chongyang Wei, Fang Guo, Yan Chen, Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, and Zhimin Lu
EGFR-induced and PKCε Monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
Weiwei Yang, Yan Xia, Yu Cao, Yanhua Zheng, Wen Bu, Lin Zhang, M. James You, Mei Yee Koh, Gilber Cote, Kenneth Aldape, Yi Li, Inder M. Verma, Paul J. Chiao, and Zhimin Lu
PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis
Weiwei Yang, Yan Xia, David Hawke, Xinjian Li, Ji Liang, Dongming Xing, Kenneth Aldape, Tony Hunter, W.K. Alfred Yung, and Zhimin Lu
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Weiwei Yang, YanXia, Haitao Ji, Yanhua Zheng, Ji Liang, Wenhua Huang, Xiang Gao, Kenneth Aldape, and Zhimin Lu