The LeBleu laboratory studies the functional impact of the tumor microenvironment in cancer progression and metastasis. The central goal of our laboratory is to elucidate the interphase between tumor stroma, tumor immunity and tumor metabolism. Specific interests include the study of the tumor angiogenesis and associated regulation of tumor immune infiltration (Cooke VG & LeBleu VS et al. Cancer Cell 2012; Ozdemir et al. Cancer Cell 2014; Keskin D et al. Cell Reports 2015; Kim J JCI Insight 2016, Carstens JL et al. Nature Communication 2017), and the dynamic metabolic adaptation of cancer cells in response to their microenvironment (LeBleu, VS et al. Nature Cell Biology 2014). The laboratory utilizes genetically engineered mouse models, cell biology and molecular biology tools to systematically decipher nodes of regulation in the tumor microenvironment network (O’Connell JT et al. PNAS 2011; Zheng X et al. Nature 2015). Several mouse models of tissue fibrosis and injury are employed to study the fibrotic reaction associated with epithelial damage and plasticity (Sugimoto H. et al Nature Medicine 2012; LeBleu VS et al. Nature Medicine 2013A, LeBleu VS et al. Nature Medicine 2013B; Lovisa S et al. Nature Medicine 2015).
The laboratory is also exploring novel research avenues that include the regulation of mitochondria function in the cell cycle (LeBleu VS et al. Cytotechnology 2006; Tzur A et al. Science 2009) and exosomes biology (Melo SA et al Nature 2015; Kamerkar S et al. Nature 2017).
For more information about our research projects, view our full listing of publications.
JCI Insight paper: immunostaining (Drs. Jiha Kim and Pedro Correra de Sampaio)
Breast PDX, Pimonidazole adduct