Victor Krasnykh, Ph.D.
Cancer Systems Imaging
The mission of our laboratory is to improve cancer care through innovative research focused on tumor detection and molecular profiling and on the development of safe and efficient anti-cancer therapies.
Our goals are to develop:
- Novel non-invasive imaging procedures that will allow reliable and accurate detection of tumors in laboratory animals and humans, and quantitative measurement of tumor biomarkers;
- Advanced imaging tracers that will be used intraoperatively to enable accurate localization of tumors and their margins;
- Novel virus-based vaccination platform for cancer immunotherapy;
- Versatile technology to alter the in vivo tropism of adenovirus-based vectors to enable efficient and safe targeting of tumors in humans.
Historically, the primary focus of our research has been on developing targeting strategies to achieve high-efficiency tumor-specific delivery of genes of interest with adenovirus vectors. To this end, we have developed and patented several methods of making adenovirus vectors tumor-specific. This work has yielded vectors that use the biomarkers predominantly expressed by tumor cell as surrogate receptors for cell entry. The strategies that we have develop are also useful in overcoming the pre-existing anti-adenovirus immunity found in most humans.
In recent years, our studies expanded to include the development of adenovirus-based epitope vaccines for cancer immunotherapy.
In addition, we began working on the development of advanced companion diagnostics for tumor detection and molecular profiling by imaging.
- New generation of radiotracers for PET imaging of molecular signatures of tumors. The major goal of this project is to develop radiotracers for measuring the levels of tumor biomarkers by PET.
- Novel probes for near-infrared fluorescence imaging-guided oncologic surgery. The major goal is to develop NIRF probes that target human epidermal growth factor receptor 2 and demonstrate the feasibility of intraoperative visualization of disseminated tumors with these probes.
- Engineered molecular shields for tumor-targeted gene theranostics. The major goal of this project is to develop a versatile strategy of tumor targeting by vascularly delivered adenovirus vectors.
- Image-guided development of novel dendritic cell-targeted platform for cancer immunotherapy. The major goal of this project is to develop a novel adenovirus-based vaccination platform for cancer immunotherapy.
Principal Investigator, New generation of radiotracers for PET imaging of molecular signatures of tumors, 1 R21 CA185714-01, NIH/NCI, 8/7/2014-7/31/2017
Principal Investigator, Novel probes for near-infrared fluorescence imaging-guided oncologic surgery, R03 EB020090, NIH/NIBIB, 4/1/2015-9/31/2017
Principal Investigator, Novel epitope vaccine for cancer immunotherapy, MDACC IRG Program, 8/1/17-7/31/18
The University of Texas MD Anderson Cancer Center
Cancer Systems Imaging
1881 East Road
Unit Number: 1907
Houston, TX 77054-1901
Room Number: 3SCR4.3628