Areas of Research
- Radiation Therapy
- Oral Cancer
- Throat Cancer
- Cancer Care Innovation
The Fuller Laboratory aims to advance care and reduce side effects for head and neck cancer patients by improving radiotherapy using imaging and informatics tools.
Research in the Fuller Lab focuses on:
- Standardizing data, image, treatment and informatic process.
- Adaptive and personalized treatments.
- Big data and statistical innovation.
- Multi-modal quantitative integrations.
Our lab's main research focus is directed towards the precise integration of advanced bio-imaging in radiation therapy, which is essential for improving survival and oncologic outcomes for cancer patients and is currently an unmet healthcare need. Our long-term goal is to develop novel bio-imaging based platforms that allow for biologically-modulated adaptive radiation therapy for future personalized radiation therapy applications. This involves the integration of multimodality imaging methodologies, biomarkers identification and characterization, imaging-guided dose-response assessment for tumor and normal tissues, multimodality image registration, adaptive therapy planning, patterns of failure characterization and oncologic outcomes correlation.
Wahid KA, Ahmed S, He R, van Dijk LV, Teuwen J, McDonald BA, Salama V, Mohamed ASR, Salzillo T, Dede C, Taku N, Lai SY, Fuller CD, Naser MA. Evaluation of deep learning-based multiparametric MRI oropharyngeal primary tumor auto-segmentation and investigation of input channel effects: Results from a prospective imaging registry. Clin Transl Radiat Oncol. 01/2022
Van Dijk LV, Frank SJ, Yuan Y, Gunn B, Moreno AC, Mohamed ASR, Preston KE, Qing Y, Spiotto MT, Morrison WH, Lee A, Phan J, Garden AS, Rosenthal DI, Langendijk JA, Fuller CD. Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy. Clin Transl Radiat Oncol. 01/2022
Stieb S, Engeseth GM, Mohamed ASR, He R, Perez-Martinez I, Rock S, Deshpande TS, Garden AS, Rosenthal DI, Frank SJ, Gunn GB, Fuller CD. The influence of radiation dose on taste impairment in a prospective observational study cohort of oropharyngeal cancer patients. Acta Oncol. 02/2022
Floricel C, Nipu N, Biggs M, Wentzel A, Canahuate G, Van Dijk L, Mohamed A, Fuller CD, Marai GE. THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy. IEEE Trans Vis Comput Graph. 01/2022
Cardenas CE, Blinde SE, Mohamed ASR, Ng SP, Raaijmakers C, Philippens M, Kotte A, Al-Mamgani AA, Karam I, Thomson DJ, Robbins J, Newbold K, Fuller CD, Terhaard C. Comprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study. Int J Radiat Oncol Biol Phys. 06/2022
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular Osteoradionecrosis
Major goals: 1) To establish DCE-MRI as an effective clinical outcome measure to identify acute and chronic changes in mandibular bone physiology in cancer patients undergoing definitive irradiation; and 2) To evaluate the use of DCE-MRI parameters to monitor ORN response to treatment.
P50CA097007-10 (Myers, PI) (Fuller)
Head and Neck SPORE Developmental
Bayesian Phase II Trial of MR-Guided Adaptive Radiotherapy
Major goals: To execute a multi-site Phase II trial of dose-declation based on anatomic MRI responses during radiotherapy for human papilloma virus positive head and neck cancers, using an MRI-Linear accelerator for daily dose modification and toxicity reduction.
NSF 1557559 (Fuller)
National Science Foundation (NSF)
QuBBD: Collaborative Research: SMART Spatial-nonspatial Multidimensional Adaptive Radiotherapy Treatment
Major goals: To develop, validate and implement the requisite methodological and technical infrastructure to execute an image-guided adaptive treatment regime for neck/head cancer patients using a Big Data approaches.
1R01CA214825-01 (Fuller, co-PI)
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer Treatment
Major goals: To develop and deploy a validated precision model of patient-specific outcomes for head and neck cancers based on demographics, toxicity, and complex imaging data.
Andrew Sabin Family Fellows Program (Fuller)
MD Anderson Cancer Center
Novel Methodological Approaches for Integrating Imaging Informatics and Clinical "Big Data" in Head and Neck Cancers
Major goals: To develop computational methodology that will support the construction of a sophisticated precision model of patient-specific outcomes for head and neck cancer therapy.
R01CA218148 (Fuller, co-PI)
imaging Radiation-Associated Dysphagia (iRAD)
Major goals: To reduce toxicity of head and neck radiotherapy through advanced imaging
1R01CA225190-01 (Fuller, co-PI)
QUBBD: Precision E–Radiomics for Dynamic Big Head & Neck Cancer Data
Major goals: To design a novel approach for adaptive radiotherapy treatment of head and neck cancer.