John de Groot, M.D.
John de Groot, M.D., is a professor and the chair, ad interim, of Neuro-Oncology at MD Anderson. He joined the faculty in 2004, after completing the Neuro-Oncology Fellowship Program. He is a leading expert in the field of mechanisms of glioblastoma resistance to antiangiogenic therapy. He directs both clinical and translational programs in the fields of glioma angiogenesis and molecularly targeted therapy, which have led to unique therapeutic approaches for the treatment of glioblastoma.
He has served as the principal investigator or co-investigator on multiple funded National Cancer Institute, foundation and industry-sponsored grants. He is the PI of numerous clinical trials involving novel agents being tested in patients with glioblastoma and is a co-leader of MD Anderson’s Glioblastoma Moon Shot and Brain Cancer SPORE. He also serves as director of the Neuro-Oncology Fellowship Program and is also helping develop the next generation of neuro-oncologists.
Jian-Wen (Jane) Dong, Ph.D.
Jianwen Dong received her Ph.D. in physiology from Chinese Academy of Sciences in 2003. Her research training as a postdoctoral fellow in Baylor College of Medicine focused on the role of innate immunity and ischemic preconditioning in heart failure. Her current research focuses on exploring target therapy in glioblastoma through high throughput-screening. Her research aims to identify predictive biomarkers of drug sensitivity, explore the mechanisms of sensitivity and resistance of novel single and/or combination therapy in glioblastoma, and transition the candidate drug into clinical development. She joined the de Groot lab in 2013.
Juan Emmanuel Martinez-Ledesma, Ph.D.
Juan Emmanuel Martinez-Ledesma received his Ph.D. in computer science from Tecnologico de Monterrey Mexico in 2013. During his graduate studies, he spent a semester as a visitor graduate student at MD Anderson in the lab of Roel Verhaak, Ph.D. He has developed algorithms to analyze TCGA data, including a comparison of tumor subtypes across different cancer types and network-based gene expression biomarkers for cancer clinical outcomes. Since September 2014, he has been working as a postdoctoral fellow for Verhaak and de Groot. The principal focus of his research is analyzing drug response data and finding biomarkers using genomic data from glioma-sphere models.
Soon Young Park, Ph.D.
Soonyoung Park received her Ph.D. in pharmacology and molecular cell biology from University of Konyang at South Korea in August 2010. While obtaining her Ph.D, she studied the underlying mechanisms by which biolipid lysophosphatidic acid regulate cancer invasion, metastasis and EMT. From 2010 to Oct 2013, Soonyoung worked as a senior researcher in Department of AIDS, Korea National Institute of Health, studying the role of epigenetics in HIV-1 patients. She joined MD Anderson in 2013 as a postdoctoral fellow in Neuro-Oncology. As a member of the de Groot lab, she evaluates the mechanistic role of new genes in glioma stem cell biology, both in vitro and in vivo, and its role in resistance to radiation and chemotherapy.
Yuji Piao, M.D., Ph.D.
Yuji Piao received her M.D. from Inner Mongolia Medical College in China 1997. She received her Ph.D. in biochemistry and molecular biology at Kyung Hee University in South Korea 2005. She joined MD Anderson as a postdoctoral fellow for Juan Fueyo, M.D., in Neuro-Oncology in 2005. She contributed to establishing a new oncolytic adenovirus and investigating the anticancer activity. She joined the de Groot lab in August 2007. Her projects focus on identifying mechanisms responsible for glioblastoma resistance to anti-angiogenic therapy using a xenograft model. She also evaluated biochemical compounds to validate specific targeted therapies in glioblastoma with unique subtype and molecular profiles, and investigated new combination therapy for glioblastoma in stem cell xenograft models.
Sr. Research Assistant
Ningyi Tiao received her associate of education from Wuhan First Teacher’s College in China. She joined MD Anderson in 2003 as a research assistant in the lab of W.K. Alfred Yung, M.D. in Neuro-Oncology. She joined the de Groot lab in 2008. As a member of the lab, she cultures and maintains a variety of cell lines for research projects, makes tissue slides, performs immunohistochemical staining, and collects and processes blood samples.