Cancer treatment decisions must be made with consideration of multiple patient and disease characteristics. To help physicians make evidence-based treatment recommendations, experts at The University of Texas MD Anderson Cancer Center have developed a series of online clinical calculators. The clinical calculators, or nomograms, are designed to predict survival or treatment outcomes for patients with various cancer types.
The clinical calculators make these predictions on the basis of patient data entered by the physician. For example, the calculator for predicting response to neoadjuvant chemotherapy for breast cancer prompts physicians to enter the patient’s age; the neoadjuvant chemotherapy regimen; the tumor’s T category, diameter, histologic type and grade, and estrogen receptor status; and whether the tumor is multicentric. From this information, the calculator predicts the patient’s probability of achieving a pathological complete response to neoadjuvant chemotherapy, of having a residual invasive tumor less than 3 cm in diameter after neoadjuvant chemotherapy, and of being a candidate for breast-conserving surgery.
Other clinical calculators for breast cancer treatment predict disease-free survival after breast surgery; residual cancer burden; lymph node status with or without neoadjuvant chemotherapy; and—for women 66–79 years old—the likelihood of benefiting from radiation therapy after breast-conserving surgery. Clinical calculators are also available to predict lymph node involvement in patients with esophageal cancer and survival outcomes for patients with cancers of the colon, rectum, or pancreas.
The clinical calculators were developed using data from peer-reviewed journal articles to be used in conjunction with medical opinions by qualified physicians.
The clinical calculators are available at www.mdanderson.org/education-and-research/resources-for-professionals/clinical-tools-and-resources/clinical-calculators/index.html.