BOLERO-2 Trial Offers Hope to Patients With Advanced Breast Cancer
By William Fitzgerald, MD Anderson Staff Writer
Seven years ago, Suzanne Hebert was diagnosed with metastatic breast cancer that spread to her liver and bones. After four rounds of chemotherapy and decreasing response rates, she decided it was time for a change. That change came after advice from a friend, who also had advanced breast cancer, and was enrolled on a clinical trial at MD Anderson.
The trial combined two drugs, everolimus, and a hormone therapy called arimidex. A different trial named BOLERO-2, or Breast Cancer Trials of Oral Everolimus, showed that combining everolimus with a different hormone therapy, exemestane, dramatically improved progression-free survival for women with advanced breast cancer.