Brain metastases recruit suppressive immune cells via novel pathway to facilitate their growth
MD Anderson researchers have discovered that metastatic cancer cells in the brain upregulate expression of the EZH2 gene to activate a previously unknown pathway and recruit immune-suppressive neutrophils to the brain, allowing metastatic cells to thrive. The study, published in Science Translational Medicine, suggests that targeting this neutrophil recruitment may be a useful strategy for treating brain metastases.
“To gain...
Genomic study of brain metastases sheds light on unique features relative to primary tumors
A deep sequencing study of brain metastases from MD Anderson revealed many similarities but also distinct differences relative to the primary...