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BY Scott Merville

Surveying the landscape of T cell presence and activity across the lungs of patients treated for localized non-small cell lung cancer, researchers have found that what matters most are T cells found in normal tissue.

When the tumor and uninvolved normal tissue elsewhere in the lung share high proportions of T cells, the immune response is less focused on the tumor and more distracted by the pursuit of viruses and other inflammatory...

Jianjun Zhang, M.D., Ph.D.

BY Scott Merville

President Donald Trump today announced his intent to appoint Hussein Tawbi, M.D., Ph.D., associate professor and deputy chairman of Melanoma...

BY Scott Merville


An immunotherapy used against advanced non-small cell lung cancer is being tested at MD Anderson for a different...

BY Scott Merville

Combining two types of immune checkpoint inhibitor fires up responses in T cells that are separate from those initiated by the two drugs individually, a research team led by Nobel Laureate Jim Allison, Ph.D., reports in the Proceedings of the National Academy of Sciences.

Administering two immunotherapy antibodies that unleash an immune attack on cancer by separately blocking the CTLA-4 and PD-1 checkpoints on T cells doesn’t have...

These t-distributed stochastic neighbor embedding (tSNE) plots reflect the grouping of similar T cells gathered from the blood of patients treated with immune checkpoint blockade. The overlaid colors show expression of important proteins – CD4, CD8 and TBET – as heat maps, with red representing high expression ranging to blue at low expression.

BY Scott Merville

Small precancerous growths in the lungs are capable of progressing to invasive lung cancer, but so little has been known about them that understanding...

BY Scott Merville

Using an antibody to plug a protein secreted by fibrous tissues in tumors stifles ovarian and pancreatic cancer in mouse models by reducing...

BY Scott Merville

A slice of RNA that doesn’t code for a protein manages to stifle tumor-suppressing genes and wreck the cellular mechanism that flags cancer...

BY Scott Merville

Combining two types of drugs that, separately, have extended the lives of people with metastatic melanoma has yielded higher response rates...

BY Scott Merville

V. Craig Jordan, Ph.D., professor of Breast Medical Oncology, has been recognized for his “services to women’s health” with his appointment...

BY Scott Merville

Improvements in breast cancer treatment over the past five decades have reduced the mortality rate of women with the disease by 40 percent...