BY Joe Munch

Chemotherapy is a proven and effective method for treating many types of cancer, but up to 90% of patients who receive the treatment develop chemotherapy-induced peripheral neuropathy, also known as CIPN. The condition occurs when the same toxic ingredients in chemotherapy drugs that kill cancer cells also damage the nerves in the hands and feet.

Survivors are left with numbness, tingling or loss of feeling in their extremities...

Photomicrographs of biopsy specimens from the paws of mice with cisplatin-induced neuropathy treated with control vehicle (left) or the HDAC6 inhibitor ACY-1083 (right) show that ACY-1083 reversed intraepidermal nerve fiber (IENF) loss, an early indicator of axonal pathology.