Molecular targeting of 15-LOX-1 for apoptosis induction in human colorectal tumors
The goal of this clinical research study is to learn how (Celebrex) celecoxib affects polyp cells of the colon and rectum.
Treatment Location: N/A
To determine whether celecoxib downregulates GATA-6 expression to upregulate 15-LOX-1 expression and induce apoptosis in human rectal tumors, we will measure GATA-6 and 15-LOX-1 expression, 13-S-HODE levels, and apoptosis rates in normal and colorectal polyp epithelial tissues before and after 6 months of celecoxib treatment of patients with familial adenomatous polyposis (FAP).
IRB Review and Approval Date: NOV 6,2002
Recruitment Status: Closed
Projected Accrual: N/A
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Clinical Cancer Prevention
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