A Phase 1b Study of ABT-199 (GDC-0199) in Combination with Azacitidine or Decitabine in Treatment Naive Subjects with Acute Myelogenous Leukemia Who Are >/= 60 Years of Age and Who Are Not Eligible for Standard Induction Therapy
This is a 2 part study: dose escalation and dose expansion. The goal of Part 1 (dose escalation) of this clinical research study is to find the highest tolerable dose of venetoclax (ABT-199) when given in combination with either decitabine or azacitidine in patients who have AML and are 65 years of age or older. The safety of this drug combination will also be studied. The goal of Part 2 (dose expansion) of this clinical research study is to learn if the highest tolerable dose of venetoclax and either decitabine or azacitidine found in Part 1 can help to control AML.The study doctor will discuss this in more detail with you. This consent form is for Part 1 only. MD Anderson will only be enrolling participants to receive Venetoclax and decitabine. The safety of venetoclax will be studied in both parts of this study.
Treatment Location: N/A
IRB Review and Approval Date: 10/07/2014
Recruitment Status: Closed
Projected Accrual: N/A
Information and next steps
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