FIP1L1-PDGFRA Fusion Transcript Detection



For determining the presence or absence of the FIP1L1-PDGFRA fusion transcript produced by an interstitial deletion at chromosome 4q12 that is seen in some cases of hypereosinophilic syndrome and systemic mast cell disease. This test can be used for diagnosis or for minimal residual disease detection following therapy.


RNA is analyzed for FIP1L1-PDGFRA fusions by reverse transcription nested PCR.

Test Parameters

A control RNA sequence is amplified in parallel as a control for sample quality.

Turnaround Time

Five to 10 working days

Sample Requirements

  • 10 ml peripheral blood in purple top tube (EDTA Vacutainer), sent by overnight express mail on wet ice

  • 2-5 ml of bone marrow aspirate in purple top tube (EDTA Vacutainer), sent by overnight express mail, sent on wet ice

  • 10 µg of purified RNA or cDNA, sent by overnight express mail on dry ice

CPT Codes


The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.