Applying RPPA in my Studies

RPPA analyzes cellular protein activity in signaling networks and can be applied to normal or tumor tissue, and also to cultured cells.

Cell Lines

  • Characterize cellular signaling networks under different culture conditions
  • Determine drug selectivity
  • Identify therapeutic targets
  • Define regulatory mechanisms in signaling networks, including forward and feedback loops and cross talks
  • Ability to analyze up to 1000 conditions concurrently and allows the detailed concentration and time courses required for systems biology approaches

Patient Samples

  • Classify patient tumors
  • Correlate DNA, RNA and Protein
  • Determine prognosis
  • Predict responses to targeted therapies
  • Pharmacodynamics and biologically relevant dose
  • Determine appropriate handling procedures for clinical samples (based on antigen stability analysis)

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