SNP Profiling Microarrays

The SMF performs SNP genotyping microarray services using Affymetrix and Illumina platforms.

Affymetrix offers their Genome-Wide Human SNP Array 6.0 with more than 1.8 million markers of genetic variation. Approximately half of the markers include single nucleotide polymorphism (SNPs) detection probes while the other half detects copy number variation (CNV). The SNP Array 6.0 allows researchers to perform association studies with large sample sizes.

Illumina's Genotyping Infinium BeadChips offer researchers the flexibility to genotype samples with hundreds of thousands to millions of markers that deliver genome-wide coverage with the most up-to-date content. Markers on the BeadChips are strategically selected by Illumina scientists to provide maximum coverage of the genome for both association testing and copy number detection.

The Illumina Omni family of genotyping microarrays is able to detect up to 5 million markers per sample and offers customizability of array content. These arrays are designed from next-generation sequencing data from international projects such as the 1000 Genomes Project.

Illumina also has modified protocols for handling partially degraded samples from archival tissues including FFPE tissues.