Gynecologic Oncology Pharmacology Research Program

Over the past four years, Director Judith Smith, Pharm.D., BCOP, has established a strong foundation for her research program focusing on new agents and new combinations of agents for the treatment of gynecologic malignancies. Dr. Smith's research also has focused on mechanisms of drug resistance and aspects of drug toxicity associated with drug metabolism and plasma protein binding drug interactions that effect therapeutic outcomes. Dr. Smith and her research team are critical component of translational research projects to implement findings into clinical practice and vice versa to enhance the clinical perspective in the direction of laboratory research projects in the gynecologic oncology arena.

Pharmacology Research Program Goal

To discover the optimal combination of chemotherapeutic agents while minimizing toxicity to improve response rates and prolong overall survival for patients with gynecologic malignancies.

Pharmacology Research Program Focus

New Drug Development

  • New molecular entities
  • New combinations of traditional chemotherapy agents for the treatment of gynecologic malignancies
  • Emphasis on defining drug interactions involving the cytochrome P450 enzyme system, plasma protein binding and mechanisms of drug resistance and how these ultimately influence pharmacokinetic parameters, pharmacodynamics and efficacy

Related Divisions and Departments

Division of Cancer Medicine

Division of Pharmacy

Gynecologic Oncology

Related Program

Pharmacy Translational Research Fellowship Program