Cancer-related Symptom Severity and Its Impact: A Multicenter Study Proposal for Russian Hospitals

Principal Investigator: Xin Shelley Wang, M.D., M.P.H.

The goal of this study is to establish the validation of two symptom assessment instruments and look at symptoms related to cancer and its treatment in Russia.

Specific Objectives

  • To establish the validity and reliability of the Russian version of the Brief Pain Inventory (BPI), Brief Fatigue Inventory (BFI), MD Anderson Symptom Inventory (MDASI) among Russian cancer patients (Complete)
  • To evaluate the prevalence of cancer related symptoms in Russia cancer patients with advanced disease, and its impact on patient's functional status
  • To identify the adequacy of pain management in Russia, which is measured by standard WHO analgesic protocol and patients' self reported pain severity
  • To identify the barriers of adequate pain management from patient's self-report


There are two phases to the protocol. Phase 1 is the validation study of the Russian language version of the BPI, BFI and MDASI. This validation study will require a sample of patients with active disease, and a sample of age-matched normal community dwellers. Patients will be recruited from the National Cancer Research and Treatment Center in St. Petersburg. Community dwellers will be recruited through local community organizations. All participants will complete a survey packet including the BPI, BFI, MDASI, SF-36 and a demographic information sheet.

Phase 2, the symptom epidemiology study, will include cancer patients with active disease. These patients will be recruited from the National Cancer Research and Treatment Center in St. Petersburg, or one of several collaborating sites. Participants will complete the BPI, BFI, MDASI and SF-36.


Instruments included the Brief Fatigue Inventory (BFI), the Brief Pain Inventory (BPI), the MD Anderson Symptom Inventory (MDASI) and the SF-36.

For more information

Contact Xin Shelley Wang, M.D., M.P.H., at