MD Anderson has a very active program investigating molecular mechanisms of colon cancer metastasis to the liver. The process of metastasis is dynamic, which requires the appropriate molecular machinery to allow a tumor cell to proliferate in the colon, establish its own blood supply, invade surrounding tissues, be released into the circulation, adhere to the blood vessels of the liver, invade into the liver, proliferate and acquire its own blood supply (angiogenesis). This complex process requires that the tumor cell interact with the microenvironment of the liver such that the tumor cell can utilize the growth factors and blood vessels of the liver in order to grow.

A description of basic science research in colon cancer liver metastasis can be found in Basic Science Research.

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