Selected Recent Publications

Yousefzadeh M, Wood R. DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair. 2013;12:1-9. PubMed ID:23219161

Takata K, Reh S, Tomida J, Person MD, Wood RD. Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nature Communications. 2013; in press.

Lange SS, Bedford E, Reh S, Wittschieben JP, Carbajal S, Kusewitt DF, DiGiovanni J, Wood RD. Dual role for mammalian DNA polymerase zeta in maintaining genome stability and proliferative responses. Proc Natl Acad Sci. 2013;110:E687-E96. PubMed ID:23386725

Lange SS, Wittschieben JP, Wood RD. DNA polymerase zeta is required for proliferation of normal mammalian cells. Nucleic Acids Res. 2012;40:4473-82. PubMed ID:22319213

Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-Diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases. Chemical research in toxicology. 2012;25:1652-61. PubMed ID:22721435

Lange SS, Takata K, Wood RD. DNA polymerases and cancer. Nature Reviews Cancer. 2011;11:96-110. PubMed ID:21258395

Hogg M, Seki M, Wood RD, Doublié S, Wallace SS. Lesion bypass activity of DNA polymerase  theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts. J Mol Biol. 2011;405:642-52. PubMed ID:21050863

Yamanaka K, Minko IG, Takata K-i, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS. Novel enzymatic function of DNA polymerase ν in translesion DNA synthesis past major groove DNA−peptide and DNA−DNA cross-links. Chemical Research in Toxicology. 2010; 23:689-95. PubMed ID:20102227

Wood RD. Mammalian nucleotide excision repair proteins and interstrand crosslink repair. Environ Mol Mutagen. 2010;51:520-6. PubMed ID:20658645

Wittschieben JP, Patil V, Glushets V, Robinson LJ, Kusewitt DF, Wood RD. Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res. 2010;70:2770-8. PubMed ID:20215524

Takata K, Arana ME, Seki M, Kunkel TA, Wood RD. Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity. Nucleic Acids Res. 2010;38:3233-44. PubMed ID:20144948

Lemée F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire M-J, Bieth A, Gentil C, Baker L, Martin A-L, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Jordan L, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roche H, Bourdon J-C, Wood RD, Hoffmann J-S, Cazaux C. POLQ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication and promotes genetic instability. Proc Natl Acad Sci (USA). 2010;107:13390-5. PubMed ID:20624954

Takata K, Wood RD. Bypass specialists operate together. EMBO J. 2009;28:313-4. PubMed ID:19225445

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS. Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiat Res. 2009;172:165-74. PubMed ID:19630521

Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res. 2009;69:6831-8. PubMed ID:19723666

Seki M, Wood RD. DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct. DNA Repair (Amst). 2008;7:119-27. PubMed ID:17920341

Koberle B, Roginskaya V, Zima KS, Masters JR, Wood RD. Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiation. Mol Carcinog. 2008;47:580-6. PubMed ID:18240296

Gan GN, Wittschieben JP, Wittschieben BØ, Wood RD. DNA polymerase zeta (pol ζ) in higher eukaryotes. Cell Res. 2008;18:174-83. PubMed ID:18157155

Arana ME, Seki M, Wood RD, Rogozin IB, Kunkel TA. Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res. 2008;36:3847-56. PubMed ID:18503084