Selected Publications



  • Tang DG.  Understanding Cancer Stem Cell Heterogeneity and Plasticity.  Cell Research. 2012 March; 22(3):457-72.  
  • Qin J, Liu X, Laffin B, Chen X, Choy G, Jeter C, Calhoun-Davis T, Li H, Palapattu GS, Lin K, Ivanov I, Suraneni M and Tang DG.  The PSA–/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration.  Cell Stem Cell. 2012 May 4; 10(5):556-69.
  • Liu C, Kelnar K, Vlassov AV, Brown D, Wang J, and Tang DG.  Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7. Cancer Research. 2012 July 1; 72(13):3393-404.


  • Liu, Can and Tang DG.  MicroRNA Regulation of Cancer Stem Cells.  Cancer Research. 2011 Sept 15; 71(18):5950-4.
  • Jeter C, Liu B, Liu X, Chen X, Liu C, Calhoun-Davis T, Repass J, Zaehres J, Shen JJ, and Tang DG. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene. 2011 Sept 8;30(36):3833-45.
  • Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, Wiggins JF, Bader AG, Fagin R, Brown D and Tang DG. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med. 2011 Feb;17(2):211-5.


  • Laffin B and Tang DG. An Old Player on a New Playground: Bmi-1 as a Regulator of Prostate Stem Cells. Cell Stem Cell. 2010 Dec 3;7(6): 639-4.
  • Jiang M, Strand D, Fernandez S, He Y, YI YI, Birbach A, Qiu Q, JSCHMID J, Tang D and Hayward S. Functional Remodeling of Benign Human Prostatic Tissues In Vivo by Spontaneously Immortalized Progenitor and Intermediate Cells. Stem Cells. 2010 Feb;28(2):344–56.
  • Suraneni MV, Schneider-Broussard, R, Moore JR, Calhoun-Davis T, Maldonado CJ, Li H, Newman RA, Kusewitt D, Hu J, Yang P, and Tang, DG.  Transgenic expressionof 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence. Oncogene. 2010 July 29; 29(30):4261–75.


  • Chen X, Schneider-Broussard R, Hollowell D, McArthur M, Jeter C, Benavides F, DiGiovanni J, and Tang DG. Abnormal differentiation, hyperplasia and embryonic/perinatal lethality in BK5-T/t transgenic mice. Differentiation. 2009 March;77(3): 324-34.
  • Jeter C, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, Calhoun-Davis T, Zaehres H, Daley G, and Tang DG. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells. 2009 May;27(5):993-1005.
  • Li HW, Jiang M, Honorio S, Patrawala L, Jeter C, Calhoun-Davis T, Hayward SW, and Tang DG. Methodologies in assaying prostate cancer stem cells. Methods Mol. Biol. 3009;568:85-138.


  • Bhatia, B., Multani, A.S., Patrawala, L., Chen, X., Calhoun-Davis, T., Zhou, J., Schroeder, L., Schneider-Broussard, R., Shen, J., Pathak, S., Chang, S., and Tang, D.G. Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. Int. J. Cancer. 2008 April 1;122(7):1483-95.
  • Li, H.W., Chen, X., Calhoun-Davis, T., Claypool, K., and Tang, D.G. PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells. Cancer Res. 2008 March 15;68(6): 1820-5.
  • Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward S, and Tang DG. Critical and distinct roles of p16 and telomerase in regulating the proliferative lifespan of normal human prostate epithelial progenitor cells. J Biol Chem. 2008 Oct 10;283(41): 27957-72.


  • Tang, D.G., Patrawala L, Calhoun T, Bhatia B, Schneider-Broussard R, Choy, G., and Jeter, C. Prostate cancer stem/progenitor cells: Identification, characterization, and implications. Mol. Carcinog. 2007 Jan;46(1):1-14.
  • Patrawala, L., Calhoun-Davis, T., Schneider-Broussard, R., and Tang, D.G.  Hierarchical organization of prostate cancer cells in xenograft tumors: The CD44+a2b1+ cell population is enriched in tumor-initiating cells. Cancer Res. 2007 July 15;67(14):6796-05.
  • Chandra, D., Choy, G., and Tang, D.G. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release – evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem. 2007 Oct 26;282(43), 31289-301.


  • Chandra, D., Bratton, S.B., Person, M.D., Tian, Y., Martin, A., Ayers, M., Fearnhead, H.O., Gandhi, V., and Tang, D.G. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting formation of Apaf-1 apoptosome. Cell. 2006 Jun 30;125(7):1333-46.
  • Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, Coghlan L, and Tang DG. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene. 2006 March 16;25(12):1696-08.


  • Liu, J-W., Chandra, D., Rudd, M.D., Butler, A.P., Pallotta, V., Brown, D., Coffer, P.J., and Tang, D.G. Induction of pro-survival molecules by apoptotic stimuli: Involvement of FOXO3a and ROS. Oncogene. 2005 Mar 17;24(12):2020-31.
  • Bhatia, B., Tang, S., Yang, P., Doll, A., Aumüeller, G., Newman, R.A., and Tang, D.G. Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells. Oncogene. 2005 May 19;24(22):3583-95.
  • Chandra, D., Choy, G,. Daniel, P.T., and Tang, D.G. Bax-dependent regulation of Bak by VDAC-2. J. Biol. Chem. 2005 May 13;280(19):19051-61.
  • Patrawala, L., Calhoun, T., Schneider-Broussard, R., Zhou, J., Claypool, K., and Tang, D.G. Side population (SP) is enriched in tumorigenic, stem-like cancer cells whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res. 2005 Jul 15;65(14):6207-19.


  • Chandra, D., Choy, G., Deng, X., Bhatia, B., and Tang, D.G. Active caspase-8 on the outer mitochondrial membrane cleaves BAP31 and caspase-3 and mediates mitochondria – ER crosstalk in etoposide-induced apoptosis. Mol. Cell. Biol. 2004 Aug;24(15):6592-07.
  • Tang, S-H., Bhatia, B., Zhou, J-J., Maldonado, C.J., Chandra, D., Kim, E., Fischer, S., Butler, A.F., Friedman, S.L., and Tang, D.G. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate the functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal prostate epithelial cells. Oncogene. 2004 Sept 9 23(41):6942-53.


  • Liu, J-W., Shen J-J., Tanzillo-Swarts, A, Bhatia, B., Maldonado, C., Person, M.D., Lau, S., and Tang, D.G. Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. Oncogene. 2003 March 13;22(10):1475-85.
  • Chandra, D., and Tang, D.G. Mitochondrially-localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated caspase-9 activation in the mitochondria. J. Biol. Chem. 278: 17408-17420, 2003.
  • Bhatia, B., Maldonado, C., Tang, S-H., Chandra, D., Klein, R.D., Chopra, D., Shappell, S., Yang, P., Newman, R.A., and Tang, D.G. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. J. Biol. Chem. 2003 Jul 4;278(27):25091-100.


  • Tang, S., Bhatia, B., Maldonado, C., Yang, P., Newman, R.A., Liu, J., Chandra, D., Traag, J., Klein, R.D., Fischer, S.M., Chopra, D., Shen, J., Zhau, H., Chung, L.W.K., and Tang, D.G. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell-cycle regulator in normal prostate epithelial cells. J. Biol. Chem. 2002 May 3;277(18):16189-201.
  • Liu, J-W., Chandra, D., Tang, S-H., Chopra, D., and Tang, D.G. Identification and characterization of Bimg, a novel proapoptotic BH3-only splice variant of Bim. Cancer Res. 2002 May 15;62(10): 2976-81.
  • Chandra, D., Liu, J-W., and Tang, D.G. Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J. Biol. Chem. 2002 Dec 27;277(52):50842-54.


  • Tang, D.G., Tokumoto, Y.M., Apperly, Lloyd, A.C., and Raff, M.C. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science. 2001 Feb 2;291(5505):868-71.
  • Tokumoto YM, Tang D.G., Raff MC. Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein. EMBO J. 2001 Sept 17;20(18):5261-68.


  • Tang D.G., Tokumoto YM, Raff MC. Long-term culture of purified postnatal oligodendrocyte precursor cells: Evidence for an intrinsic maturation programme that plays out over months. J. Cell Biol. 2000 March 6;148(5):971-84.
  • Fernandez P-A, Tang D.G., Cheng L, Mudge AW, Prochiantz A, Raff MC. Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron. 2000 Oct;28(1):81-90.