Peer Reviewed Journal Articles


  1. Chakravarty T, Crane CH, Ajani JA, Mansfield PF, Briere TM, Beddar AS, Mok H, Reed VK, Krishnan S, Delclos ME, Das P. Intensity-Modulated Radiation Therapy with Concurrent Chemotherapy as Preoperative Treatment for Localized Gastric Adenocarcinoma. Int J Radiat Oncol Biol Phys. 2011 Dec 2. [Epub ahead of print] PubMed PMID: 22137021.
  2. Skinner HD, Hong TS, Krishnan S. Charged-particle therapy for hepatocellular carcinoma. Semin Radiat Oncol. 2011 Oct;21(4):278-86. PubMed PMID: 21939857; PubMed Central PMCID: PMC3230301.
  3. Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. 2011 Sep 20. doi: 10.1002/ijc.26442. [Epub ahead of print] PubMed PMID: 21935918.
  4. Kaseb AO, Morris JS, Hassan MM, Siddiqui AM, Lin E, Xiao L, Abdalla EK, Vauthey JN, Aloia TA, Krishnan S, Abbruzzese JL. Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. J Clin Oncol. 2011 Oct 10;29(29):3892-9. Epub 2011 Sep 12. PubMed PMID: 21911725; PubMed Central PMCID: PMC3189091.
  5. Ryan JL, Krishnan S, Movsas B, Coleman CN, Vikram B, Yoo SS. Decreasing the adverse effects of cancer therapy: an NCI Workshop on the preclinical development of radiation injury mitigators/protectors. Radiat Res. 2011 Nov;176(5):688-91. Epub 2011 Sep 1. PubMed PMID: 21883022.
  6. Chatterjee DK, Diagaradjane P and Krishnan S, Nanoparticle mediated hyperthermia in cancer therapy. Therapeutic Delivery Vol. 2(8) (2011), 1001–1014, Aug 2011.
  7. Skinner HD, Sharp HJ, Kaseb AO, Javle MM, Vauthey JN, Abdalla EK, Delclos ME, Das P, Crane CH, Krishnan S. Radiation treatment outcomes for unresectable hepatocellular carcinoma. Acta Oncol. 2011 Nov;50(8):1191-8. Epub 2011 Jul 27. PubMed PMID: 21793641.
  8. Crane CH, Varadhachary GR, Yordy JS, Staerkel GA, Javle MM, Safran H, Haque W, Hobbs BD, Krishnan S, Fleming JB, Das P, Lee JE, Abbruzzese JL, Wolff RA. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol. 2011 Aug 1;29(22):3037-43. Epub 2011 Jun 27. PubMed PMID: 21709185; PubMed Central PMCID: PMC3157965.
  9. Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Int J Cancer. 2011 Jun 23. doi: 10.1002/ijc.26251. [Epub ahead of print] PubMed PMID: 21702037; PubMed Central PMCID: PMC3246525.
  10. Mok H, Crane CH, Palmer MB, Briere TM, Beddar S, Delclos ME, Krishnan S, Das P. Intensity modulated radiation therapy (IMRT): differences in target volumes and improvement in clinically relevant doses to small bowel in rectal carcinoma. Radiat Oncol. 2011 Jun 8;6:63. PubMed PMID: 21651775; PubMed Central PMCID: PMC3121606.
  11. Kelly P, Das P, Varadhachary GR, Fontanilla HP, Krishnan S, Delclos ME, Jhingran A, Eifel PJ, Crane CH. Role of Definitive Radiation Therapy in Carcinoma of Unknown Primary in the Abdomen and Pelvis. Int J Radiat Oncol Biol Phys. 2011 Jun 1. [Epub ahead of print] PubMed PMID: 21640510.
  12. Xie H, Diagaradjane P, Deorukhkar AA, Goins B, Bao A, Phillips WT, Wang Z, Schwartz J, Krishnan S. Integrin αvβ3-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy. Int J Nanomedicine. 2011;6:259-69. Epub 2011 Jan 27. PubMed PMID: 21423588; PubMed Central PMCID: PMC3058535.
  13. Park J, Estrada A, Schwartz JA, Diagaradjane P, Krishnan S, Dunn AK, Tunnell JW. Intra-organ Biodistribution of Gold Nanoparticles Using Intrinsic Two-photon Induced Photoluminescence. Lasers Surg Med. 2010 Sep;42(7):630-639. PubMed PMID: 21399728; PubMed Central PMCID: PMC3052865.
  14. Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin M, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J.HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance. Mol Cancer Res. 2011 Mar;9(3):259-70. Epub 2011 Mar 1. PubMed PMID: 21364021; PubMed Central PMCID: PMC3077053.
  15. Tsai CJ, Crane CH, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Feig BW, Eng C, Krishnan S, Maru DM, Das P. Number of lymph nodes examined and prognosis among pathologically lymph node-negative patients after preoperative chemoradiation therapy for rectal adenocarcinoma. Cancer. 2011 Aug 15;117(16):3713-22. doi: 10.1002/cncr.25973. Epub 2011 Feb 15. PubMed PMID: 21328329.


  1. Taddei PJ, Howell RM, Krishnan S, Scarboro SB, Mirkovic D, Newhauser WD. Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma. Phys Med Biol. 2010 Dec 7;55(23):7055-65. Epub 2010 Nov 12. PubMed PMID: 21076199; PubMed Central PMCID: PMC3001302.
  2. Howell RM, Scarboro SB, Taddei PJ, Krishnan S, Kry SF, Newhauser WD. Methodology for determining doses to in-field, out-of-field and partially in-field organs for late effects studies in photon radiotherapy. Phys Med Biol. 2010 Dec 7;55(23):7009-23. Epub 2010 Nov 12. PubMed PMID: 21076193; PubMed Central PMCID: PMC3001332.
  3. Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med. 2010 Oct 27;2(55):55ra79. PubMed PMID: 20980696.
  4. Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 2010 Nov 1;70(21):8695-705. Epub 2010 Sep 23. PubMed PMID: 20864511; PubMed Central PMCID: PMC2970705.
  5. Krishnan S, Diagaradjane P, Cho SH. Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy. Int J Hyperthermia. 2010;26(8):775-89. Epub 2010 Sep 21. Review. PubMed PMID: 20858069; PubMed Central PMCID: PMC3071560.
  6. Jones BL, Krishnan S, Cho SH. Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations. Med Phys. 2010 Jul;37(7):3809-16. PubMed PMID: 20831089. 
  7. Sharma D, Sandur SK, Rashmi R, Maurya DK, Suryavanshi S, Checker R, Krishnan S, Sainis KB. Differential activation of NF-κB and nitric oxide in lymphocytes regulates in vitro and in vivo radiosensitivity. Mutat Res. 2010 Dec 21;703(2):149-57. Epub 2010 Aug 21. PubMed PMID: 20732448; PubMed Central PMCID: PMC3071568.
  8. Deorukhkar A, Krishnan S. Targeting inflammatory pathways for tumor radiosensitization. Biochem Pharmacol. 2010 Dec 15;80(12):1904-14. Epub 2010 Jun 30. Review. PubMed PMID: 20599771; PubMed Central PMCID: PMC3090731.
  9. Schwarz RE, Abou-Alfa GK, Geschwind JF, Krishnan S, Salem R, Venook AP; American Hepato-Pancreato-Biliary Association; Society of Surgical Oncology; Society for Surgery of the Alimentary Tract. Nonoperative therapies for combined modality treatment of hepatocellular cancer: expert consensus statement. HPB (Oxford). 2010 Jun;12(5):313-20. PubMed PMID: 20590905; PubMed Central PMCID: PMC2951818.
  10. Diagaradjane P, Deorukhkar A, Gelovani JG, Maru DM, Krishnan S. Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in vivo. ACS Nano. 2010 Jul 27;4(7):4131-41. PubMed PMID: 20586481; PubMed Central PMCID: PMC3090730.
  11. Checker R, Sharma D, Sandur SK, Subrahmanyam G, Krishnan S, Poduval TB, Sainis KB. Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols. J Cell Biochem. 2010 Aug 1;110(5):1082-93. PubMed PMID: 20564204; PubMed Central PMCID: PMC3065107.
  12. Silberfein EJ, Kattepogu KM, Hu CY, Skibber JM, Rodriguez-Bigas MA, Feig B, Das P, Krishnan S, Crane C, Kopetz S, Eng C, Chang GJ. Long-term survival and recurrence outcomes following surgery for distal rectal cancer. Ann Surg Oncol. 2010 Nov;17(11):2863-9. Epub 2010 Jun 15. PubMed PMID: 20552409; PubMed Central PMCID: PMC3071558.
  13. Deorukhkar A, Shentu S, Park HC, Diagaradjane P, Puduvalli V, Aggarwal B, Guha S, Krishnan S. Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells. Pancreas. 2010 Nov;39(8):1277-83. PubMed PMID: 20531243; PubMed Central PMCID: PMC2955787.
  14. Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB. Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol Cancer Res. 2010 May;8(5):751-61. Epub 2010 May 11. PubMed PMID: 20460401; PubMed Central PMCID: PMC2895997.
  15. Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2010 May;9(5):1136-46. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh]. PubMed PMID: 20442301; PubMed Central PMCID: PMC2905628.
  16. Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010 May;77(5):818-27. Epub 2010 Jan 26. PubMed PMID: 20103608; PubMed Central PMCID: PMC2872971.
  17. Das P, Cantor SB, Parker CL, Zampieri JB, Baschnagel A, Eng C, Delclos ME, Krishnan S, Janjan NA, Crane CH. Long-term quality of life after radiotherapy for the treatment of anal cancer. Cancer. 2010 Feb 15;116(4):822-9. PubMed PMID: 20041481.


  1. Cheong SK, Krishnan S, Cho SH. Modeling of plasmonic heating from individual gold nanoshells for near-infrared laser-induced thermal therapy. Med Phys. 2009 Oct;36(10):4664-71. PubMed PMID: 19928098.
  2. Haque W, Crane CH, Krishnan S, Delclos ME, Javle M, Garrett CR, Wolff RA, Das P. Reirradiation to the abdomen for gastrointestinal malignancies. Radiat Oncol. 2009 Nov 18;4:55. PubMed PMID: 19922641; PubMed Central PMCID: PMC2787526.
  3. Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB. Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int J Cancer. 2010 Jul 15;127(2):257-68. PubMed PMID: 19908231; PubMed Central PMCID: PMC3090706.
  4. Callender GG, Das P, Rodriguez-Bigas MA, Skibber JM, Crane CH, Krishnan S, Delclos ME, Feig BW. Local excision after preoperative chemoradiation results in an equivalent outcome to total mesorectal excision in selected patients with T3 rectal cancer. Ann Surg Oncol. 2010 Feb;17(2):441-7. Epub 2009 Oct 22. PubMed PMID: 19847569; PubMed Central PMCID: PMC3076509.
  5. Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42. PubMed PMID: 19735878; PubMed Central PMCID: PMC3090721.
  6. Das P, Delclos ME, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Bedi M, Krishnan S, Crane CH. Hyperfractionated accelerated radiotherapy for rectal cancer in patients with prior pelvic irradiation. Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):60-5. Epub 2009 Aug 19. PubMed PMID: 19695792.
  7. Cho SH, Jones BL, Krishnan S. The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources. Phys Med Biol. 2009 Aug 21;54(16):4889-905. Epub 2009 Jul 27. PubMed PMID: 19636084; PubMed Central PMCID: PMC3064075.
  8. Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer. 2009 Nov 1;125(9):2187-97. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Kuzhuvelil, Harikumar B [corrected to Harikumar, Kuzhuvelil B]. PubMed PMID: 19623659.
  9. Crane CH, Eng C, Feig BW, Das P, Skibber JM, Chang GJ, Wolff RA, Krishnan S, Hamilton S, Janjan NA, Maru DM, Ellis LM, Rodriguez-Bigas MA. Phase II trial of neoadjuvant bevacizumab, capecitabine, and radiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):824-30. Epub 2009 May 21. PubMed PMID: 19464823.
  10. Sharma D, Kumar SS, Checker R, Raghu R, Khanam S, Krishnan S, Sainis KB. Spatial distribution, kinetics, signaling and cytokine production during homeostasis driven proliferation of CD4+ T cells. Mol Immunol. 2009 Jul;46(11-12):2403-12. Epub 2009 May 17. PubMed PMID: 19447493; PubMed Central PMCID: PMC3090723.
  11. Briere TM, Beddar S, Balter P, Murthy R, Gupta S, Nelson C, Starkschall G, Gillin MT, Krishnan S. Respiratory gating with EPID-based verification: the MDACC experience. Phys Med Biol. 2009 Jun 7;54(11):3379-91. Epub 2009 May 13. PubMed PMID: 19436104.
  12. Puvanakrishnan P, Park J, Diagaradjane P, Schwartz JA, Coleman CL, Gill-Sharp KL, Sang KL, Payne JD, Krishnan S, Tunnell JW. Near-infrared narrow-band imaging of gold/silica nanoshells in tumors. J Biomed Opt. 2009 Mar-Apr;14(2):024044. PubMed PMID: 19405772; PubMed Central PMCID: PMC2810638.
  13. Krishnan S. The role of adjuvant radiation therapy in nonmetastatic gastric cancer: an evolving paradigm. Gastrointest Cancer Res. 2009 Jan;3(1):33-5. PubMed PMID: 19343136; PubMed Central PMCID: PMC2661118.
  14. Taddei PJ, Krishnan S, Mirkovic D, Yepes P, Newhauser WD. Effective Dose from Stray Radiation for a Patient Receiving Proton Therapy for Liver Cancer. AIP Conf Proc. 2009 Mar 10;1099:445-449. PubMed PMID: 20865142; PubMed Central PMCID: PMC2943390.
  15. Hodges JC, Das P, Eng C, Reish AG, Beddar AS, Delclos ME, Krishnan S, Crane CH. Intensity-modulated radiation therapy for the treatment of squamous cell anal cancer with para-aortic nodal involvement. Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):791-4. Epub 2009 Feb 21. PubMed PMID: 19231109.
  16. Park HC, Janjan NA, Mendoza TR, Lin EH, Vadhan-Raj S, Hundal M, Zhang Y, Delclos ME, Crane CH, Das P, Wang XS, Cleeland CS, Krishnan S. Temporal patterns of fatigue predict pathologic response in patients treated with preoperative chemoradiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):775-81. Epub 2009 Feb 21. PubMed PMID: 19231100; PubMed Central PMCID: PMC3090722.
  17. Katz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol. 2009 Apr;16(4):836-47. Epub 2009 Feb 5. PubMed PMID: 19194760; PubMed Central PMCID: PMC3066077.
  18. Maru DM, Luthra R, Correa AM, White-Cross J, Anandasabapathy S, Krishnan S, Guha S, Komaki R, Swisher SG, Ajani JA, Hofstetter WL, Rashid A. Frequent loss of heterozygosity of chromosome 1q in esophageal adenocarcinoma: loss of chromosome 1q21.3 is associated with shorter overall survival. Cancer. 2009 Apr 1;115(7):1576-85. PubMed PMID: 19156915.
  19. Herman MP, Kopetz S, Bhosale PR, Eng C, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Delclos ME, Krishnan S, Crane CH, Das P. Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors, and clinical course. Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):818-23. Epub 2009 Jan 13. PubMed PMID: 19147305; PubMed Central PMCID: PMC3071557.
  20. Badgwell B, Cormier JN, Xing Y, Yao J, Bose D, Krishnan S, Pisters P, Feig B, Mansfield P. Attempted salvage resection for recurrent gastric or gastroesophageal cancer. Ann Surg Oncol. 2009 Jan;16(1):42-50. Epub 2008 Nov 5. PubMed PMID: 18985270.


  1. Wang X, Krishnan S, Zhang X, Dong L, Briere T, Crane CH, Martel M, Gillin M, Mohan R, Beddar S. Proton radiotherapy for liver tumors: dosimetric advantages over photon plans. Med Dosim. 2008 Winter;33(4):259-67. PubMed PMID: 18973852. 
  2. Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy FJ, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton RF, Rowland KM Jr, Mischel P, Yong WH, Scheithauer BW, Schiff D, Giannini C, Buckner JC; North Central Cancer Treatment Group Study N0177. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol. 2008 Dec 1;26(34):5603-9. Epub 2008 Oct 27. PubMed PMID: 18955445; PubMed Central PMCID:
  3. Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood. 2009 Feb 26;113(9):2003-13. Epub 2008 Oct 24. PubMed PMID: 18952893; PubMed Central PMCID: PMC2947354.
  4. Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN. Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone. Ann Surg Oncol. 2008 Nov;15(11):3147-56. Epub 2008 Aug 27. PubMed PMID: 18754070.
  5. Wang H, Krishnan S, Wang X, Beddar AS, Briere TM, Crane CH, Mohan R, Dong L. Improving soft-tissue contrast in four-dimensional computed tomography images of liver cancer patients using a deformable image registration method. Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):201-9. PubMed PMID: 18722271.
  6. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 2008 Aug 1;68(15):6100-8. PubMed PMID: 18676832; PubMed Central PMCID: PMC2714276.
  7. Maru DM, Khurana H, Rashid A, Correa AM, Anandasabapathy S, Krishnan S, Komaki R, Ajani JA, Swisher SG, Hofstetter WL. Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus. Am J Surg Pathol. 2008 Sep;32(9):1404-11. PubMed PMID: 18670347.
  8. Badgwell B, Cormier JN, Krishnan S, Yao J, Staerkel GA, Lupo PJ, Pisters PW, Feig B, Mansfield P. Does neoadjuvant treatment for gastric cancer patients with positive peritoneal cytology at staging laparoscopy improve survival? Ann Surg Oncol. 2008 Oct;15(10):2684-91. Epub 2008 Jul 23. PubMed PMID: 18649106.
  9. Varadhachary GR, Wolff RA, Crane CH, Sun CC, Lee JE, Pisters PW, Vauthey JN, Abdalla E, Wang H, Staerkel GA, Lee JH, Ross WA, Tamm EP, Bhosale PR, Krishnan S, Das P, Ho L, Xiong H, Abbruzzese JL, Evans DB. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol. 2008 Jul 20;26(21):3487-95. PubMed PMID: 18640929.
  10. Wagener M, Zhang X, Villarreal HG, Levy L, Allen P, Shentu S, Fang B, Krishnan S, Chang JY, Cheung MR. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncol Rep. 2008 May;19(5):1071-7. PubMed PMID: 18425360. 
  11. Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB, Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. Clin Cancer Res. 2008 Apr 15;14(8):2476-83. PubMed PMID: 18413840.
  12. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Lett. 2008 May;8(5):1492-500. Epub 2008 Apr 16. PubMed PMID: 18412402.
  13. Kim MM, Mansfield PF, Das P, Janjan NA, Badgwell BD, Phan AT, Delclos ME, Maru D, Ajani JA, Crane CH, Krishnan S. Chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgery. Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):167-72. PubMed PMID: 18406886.
  14. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PubMed PMID: 18381954.
  15. Diagaradjane P, Orenstein-Cardona JM, Colón-Casasnovas NE, Deorukhkar A, Shentu S, Kuno N, Schwartz DL, Gelovani JG, Krishnan S. Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin Cancer Res. 2008 Feb 1;14(3):731-41. PubMed PMID: 18245533.
  16. Krishnan S, Dawson LA, Seong J, Akine Y, Beddar S, Briere TM, Crane CH, Mornex F. Radiotherapy for hepatocellular carcinoma: an overview. Ann Surg Oncol. 2008 Apr;15(4):1015-24. Epub 2008 Jan 31. Review. PubMed PMID: 18236114.
  17. Yu TK, Bhosale PR, Crane CH, Iyer RB, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Das P. Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1175-80. Epub 2008 Jan 22. PubMed PMID: 18207667.
  18. Krishnan S, Briere TM, Dong L, Murthy R, Ng C, Balter P, Mohan R, Gillin MT, Beddar AS. Daily targeting of liver tumors: screening patients with a mock treatment and using a combination of internal and external fiducials for image-guided respiratory-gated radiotherapy. Med Phys. 2007 Dec;34(12):4591-3. PubMed PMID: 18196785.
  19. Beddar AS, Briere TM, Balter P, Pan T, Tolani N, Ng C, Szklaruk J, Krishnan S. 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning. Radiother Oncol. 2008 Jun;87(3):445-8. Epub 2008 Jan 14. PubMed PMID: 18194819.


  1. Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):741-7. Epub 2007 Dec 31. PubMed PMID: 18164837.
  2. Murthy R, Eng C, Krishnan S, Madoff DC, Habbu A, Canet S, Hicks ME. Hepatic yttrium-90 radioembolotherapy in metastatic colorectal cancer treated with cetuximab or bevacizumab. J Vasc Interv Radiol. 2007 Dec;18(12):1588-91. PubMed PMID: 18057297.
  3. Krishnan S, Rana V, Evans DB, Varadhachary G, Das P, Bhatia S, Delclos ME, Janjan NA, Wolff RA, Crane CH, Pisters PW. Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):735-43. Epub 2007 Nov 5. PubMed PMID: 17980502.
  4. Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs. 2007 Nov;16(11):1753-73. Review. PubMed PMID: 17970636.
  5. Kim MM, Rana V, Janjan NA, Das P, Phan AT, Delclos ME, Mansfield PF, Ajani JA, Crane CH, Krishnan S. Clinical benefit of palliative radiation therapy in advanced gastric cancer. Acta Oncol. 2008;47(3):421-7. PubMed PMID: 17899453.
  6. Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem. 2007 Oct 15;102(3):580-92. Review. PubMed PMID: 17668425.
  7. Krishnan S, Rana V, Janjan NA, Varadhachary GR, Abbruzzese JL, Das P, Delclos ME, Gould MS, Evans DB, Wolff RA, Crane CH. Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy. Cancer. 2007 Jul 1;110(1):47-55. PubMed PMID: 17538975.
  8. Murthy R, Brown DB, Salem R, Meranze SG, Coldwell DM, Krishnan S, Nunez R, Habbu A, Liu D, Ross W, Cohen AM, Censullo M. Gastrointestinal complications associated with hepatic arterial Yttrium-90 microsphere therapy. J Vasc Interv Radiol. 2007 Apr;18(4):553-61; quiz 562. PubMed PMID: 17446547.
  9. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007 Apr 15;67(8):3853-61. PubMed PMID: 17440100.
  10. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Wolff RA, Eng C, Krishnan S, Janjan NA, Crane CH. Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer. 2007 May 1;109(9):1750-5. PubMed PMID: 17387743.
  11. Das P, Bhatia S, Eng C, Ajani JA, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Bhosale P, Delclos ME, Krishnan S, Janjan NA, Crane CH. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):794-800. Epub 2007 Mar 26. PubMed PMID: 17379452.
  12. Bedi M, Das P, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Eng C, Wolff RA, Janjan NA, Krishnan S, Crane CH. Capecitabine and timing of radiotherapy during preoperative chemoradiation for rectal cancer. Gastrointest Cancer Res. 2007 Mar;1(2):44-8. PubMed PMID: 19262718; PubMed Central PMCID: PMC2632878.
  13. Beddar AS, Kainz K, Briere TM, Tsunashima Y, Pan T, Prado K, Mohan R, Gillin M, Krishnan S. Correlation between internal fiducial tumor motion and external marker motion for liver tumors imaged with 4D-CT. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):630-8. PubMed PMID: 17236980.


  1. Krishnan S, Lin EH, Gunn GB, Chandra A, Beddar AS, Briere TM, Das P, Delclos ME, Janjan NA, Crane CH. Conformal radiotherapy of the dominant liver metastasis: a viable strategy for treatment of unresectable chemotherapy refractory colorectal cancer liver metastases. Am J Clin Oncol. 2006 Dec;29(6):562-7. PubMed PMID: 17148992.
  2. Krishnan S, Rana V, Janjan NA, Abbruzzese JL, Gould MS, Das P, Delclos ME, Palla S, Guha S, Varadhachary G, Evans DB, Wolff RA, Crane CH. Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation. Cancer. 2006 Dec 1;107(11):2589-96. PubMed PMID: 17083124.
  3. Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH. Concurrent capecitabine and upper abdominal radiation therapy is well tolerated. Radiat Oncol. 2006 Oct 24;1:41. PubMed PMID: 17062148; PubMed Central PMCID: PMC1634749.
  4. Das P, Lin EH, Bhatia S, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Delclos ME, Krishnan S, Janjan NA, Crane CH. Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis. Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1378-83. Epub 2006 Oct 23. PubMed PMID: 17056196.
  5. Krishnan S, Janjan NA, Skibber JM, Rodriguez-Bigas MA, Wolff RA, Das P, Delclos ME, Chang GJ, Hoff PM, Eng C, Brown TD, Crane CH, Feig BW, Morris J, Vadhan-Raj S, Hamilton SR, Lin EH. Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):762-71. PubMed PMID: 17011451.
  6. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Levy LB, Ellis LM, Crane CH. Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol. 2006 Jun;29(3):219-24.PubMed PMID: 16755173.
  7. Beddar AS, Krishnan S, Briere TM, Wang X, Delclos ME, Ballo MT, Das P, Gould S, Horton JL, Crane CH. The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. Radiother Oncol. 2006 Feb;78(2):207-12. Epub 2006 Jan 10. PubMed PMID: 16376445.


  1. Beddar AS, Krishnan S. Intraoperative radiotherapy using a mobile electron LINAC: a retroperitoneal sarcoma case. J Appl Clin Med Phys. 2005 Summer;6(3):95-107. Epub 2005 Aug 12. PubMed PMID: 16143794.

Invited Articles

  1. Krishnan S. Commentary on: Prognostic significance of IGF-1R expression in patients treated with breast conserving surgery and radiation therapy. Breast Diseases: A Year Book Quarterly. In Press.
  2. Skinner HD, Hong TS, Krishnan S. Charged particle therapy for HCC. Seminars Radiat Oncol. In Press.
  3. Krishnan S. The integration of oxaliplatin into preoperative chemoradiation regimens for rectal cancer. Am J Hemat Oncol 6(1):28-30, 2007.
  4. Krishnan S, Crane CH. Radiation therapy in the treatment of cholangiocarinoma. Oncology (Williston Park) 20(8):893-895, 2006.


  1. Skinner HD, Krishnan S. Predicting, preventing, treating and understanding radiation nephropathy. Am J Hemat Oncol 6(1):28-30, 2010.
  2. Krishnan, S. The role of adjuvant radiation therapy in nonmetastatic gastric cancer: an evolving paradigm. Gastrointest Cancer Res 3(1):33-35, 2009.

Book Chapters

  1. Krishnan S, Foote RL. Radiation treatment of endocrine tumors. In: Endocrine Pathology – differential diagnosis and molecular advances, 1st. Ed(s) Lloyd RV, 399-408, 2004.
  2. Janjan N, Krishnan S, Das P, Gould MS, Zampieri J, Crane C, Delclos M, Cleeland C, Lutz ST, Chow E. Palliative radiation therapy techniques. In: Cancer Pain Management. Ed(s) MJ Fisch, AW Burton. McGraw Hill: New York, NY, 271-293, 2007.
  3. Krishnan S, Rana V, Crane CH. Combining targeted biological agents with radiotherapy: current status and future directions. In: Targeted therapies in pancreatic cancer. Ed(s) WJ Small. Demos Medical Publishing, 163-184, 2008.
  4. Jagetia GC, Krishnan S, Aggarwal BB. Natural agents that can sensitize tumor cells to chemotherapy and radiation therapy. In: Cancer Drug Discovery and Development. Ed(s) B Bonavida. Humana Press: Totowa, NJ, 211-242, 2008.
  5. Janjan N, Mahajan A, Chang EL, McCutcheon I, Lin E, Das P, Krishnan S, Chow E. Spinal cord compression. In: Prognosis in Advanced Cancer. Ed(s) P Glare, NA Christakis. Oxford University Press: Oxford, UK, 329-344, 2008.
  6. Janjan NA, Delclos ME, Crane CH, Krishnan S, Das P. The colon and rectum. In: Radiation Oncology, 9th. Ed(s) Cox JD, Ang KK. Elsevier: Philadelphia, PA, 560-605, 2009.
  7. Krishnan S, Das P, Crane CH. The liver and biliary system. In: Radiation Oncology, 9th. Ed(s) JC Cox, KK Ang. Elsevier: Philadelphia, 534-559, 2009.
  8. Crane CH, Janjan NA, Krishnan S. The stomach and small intestine. In: Radiation Oncology, 9th. Ed(s) JC Cox, KK Ang. Elsevier: Philadelphia, 2009.
  9. Szklaruk J, Abdalla EK, Krishnan S, Kaseb AO. Gallbladder/biliary tract. In: Oncologic imaging for the practicing radiologist, oncologist and surgeon. Ed(s) Silverman PM, 2010.
  10. Bhadkamkar NA, Javle MM, Avritscher R, Krishnan S, Kaseb AO. Hepatobiliary malignancies. In: MDACC: Medical Oncology, A Comprehensive Review, 4th. McGraw-Hill: New York, NY, 2010
  11. Szklaruk J, Abdalla EK, Krishnan S, Kaseb AO. Liver. In: Oncologic imaging for the practicing radiologist, oncologist and surgeon. Ed(s) Silverman PM, 2010.
  12. Balachandran A, Krishnan S, Yao J. Neuroendocrine tumors. In: Oncologic imaging for the practicing radiologist, oncologist and surgeon. Ed(s) Silverman PM, 2010.
  13. Krishnan S, Suresh D, Foote RL. Radiation treatment of endocrine tumors. In: Endocrine Pathology - differential diagnosis and molecular advances, 2nd. Ed(s) RV Lloyd. Humana Press: Totowa, N.J., 567-580, 2010.
  14. Diagaradjane P, Mohindra P, Krishnan S. Theranostic applications of gold nanoparticles in cancer. In: Nanoplatform-Based Molecular Imaging. Ed(s) Xiaoyuan Chen. John Wiley & Sons, 639-657, 2010
  15. Janjan NA, Lin E, McCutcheon I, Perkins G, Das P, Krishnan S, Kuban D, Chang EL. Spinal cord compression. In: Palliative Medicine. Ed(s) D Walsh. Elsevier Press: Philadelphia, PA. In Press.

Books (edited and written)

  1. Aggarwal BB, Krishnan S, Guha S. Ed(s) Aggarwal BB, Krishnan S, Guha S. Inflammation, Life Style and Chronic Diseases: The Silent Link. Taylor & Francis Group: Boca Raton, FL.
  2. Cho SH and Krishnan S Ed(s). Cancer Nanotechnology: Principles and Applications in Radiation Oncology. Taylor & Francis Group: Boca Raton, FL