Jichao Chen Laboratory

The human lung is a complex three-dimensional tubular network consisting of more than 20 generations of conducting airways and 300 million alveoli for gas exchange. The entire lung arises from a group of embryonic progenitor cells via exquisitely orchestrated processes that include branching morphogenesis to build a tree-like structure and cellular differentiation to generate diverse cell types. 

Although much is known about each process individually, a key knowledge gap and hence the focus of the Chen laboratory is how different processes are coordinated and deployed at the correct time and location.