Shawn Bratton, Ph.D.
B.S., Molecular Biology, The University of Texas, Austin, TX
B.S., Medical Technology, University of Texas Medical Branch, Galveston, TX
Ph.D., Pharmacology and Toxicology, The University of Texas, Austin, TX
Postdoctoral Fellow, Medical Research Council-Toxicology Unit, Leicester, England
Miao-Der (Sophie) Chen
Graduate Student, Pharmacology & Toxicology
My project is focused on determining if cytosolic acidification and cathepsin release, following heat shock-induced ELMP, is important for caspase activation and cell death following heat shock.
Nick Mastrandrea, PhD
Postdoctoral Fellow, Epigenetics and Molecular Carcinogenesis
My project is focused on elucidating the specific mechanisms through which kinases, such as ERK2 and c-Abl, regulate the activity of the Apaf-1•caspase-9 apoptosome.
My project is related to autophagy and the molecular mechanism(s) that regulate the formation and maturation of autophagosomes, with a particular emphasis on the role that p38 MAPKs play in this process.
Chu-Chiao (Chrystal) Wu
Graduate Student, Cell and Molecular Biology
My project is focused on the stoichiometry and dimerization/conformational status of caspase-9 within the Apaf-1 apoptosome complex and its activation mechanism in vivo using a novel caspase-9 knock-in mouse model.
- Epigenetics and Molecular Carcinogenesis Ph.D. Program