The MD Anderson Symptom Inventory Chronic Graft-versus-Host Disease Module (MDASI-cGVHD)



MD Anderson Symptom Inventory (MDASI) modules augment the 19 core MDASI symptom and interference items with additional items identified as unique to a particular patient population. MDASI modules may be disease-specific, disease-site-specific, or treatment-specific.

The MDASI chronic graft-versus-host disease module (MDASI-cGVHD) is a treatment-specific module. Along with the core MDASI’s 13 symptom items and 6 interference items, the MDASI-cGVHD also assesses 5 symptoms specific to chronic graft-versus-host disease

  • muscle weakness
  • skin problems
  • eye problems
  • joint stiffness or soreness
  • changes in sexual function

MDASI-cGVHD Features

  • Purpose: To assess the severity of multiple symptoms related to the development of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and the impact of these symptoms on daily functioning
  • Population: Patients with symptoms caused by chronic graft-versus-host disease and its treatment
  • Assessment areas: Severity of multiple symptoms and the impact of symptoms on daily functioning during the last 24 hours
  • Method: Self-report; paper-and-pencil form or tablet PC (self-administered or via interview), or telephone-based interactive voice response (IVR) system
  • Time required: Five minutes
  • Scoring: Please see the MDASI User's Guide
  • Reliability: Cronbach alpha reliability ranges from 0.75 to 0.91

MDASI-cGVHD Language Versions

The MDASI-cGVHD is available in the languages shown below. Click on a linked language to view a sample in PDF format.

Psychometrically and Linguistically ValidatedLinguistically Validated

Future Validation Studies: We would like to collaborate with other investigators to develop and validate new language versions of the MDASI-cGVHD.  Contact us for more information. NOTE: The MDASI-cGVHD may not be modified or translated into another language without express written consent (see Notice of Copyright below).

To Order the MDASI-cGVHD

To use the MDASI-cGHVD in a publication or clinical or research trial, you must obtain permission by filling out our order form and you must comply with the copyright. Fees may apply:

Type of UseFirst Language Version (Per Project)Additional Language Versions (Per Project)
Non-funded academic researchNo chargeNo charge
Individual clinical practiceNo chargeNo charge
Funded academic research$300$150
Commercial research$2,000$1,200

The MDASI-cGVHD will be e-mailed to you as a PDF file within 7 to 10 business days. If your request is urgent or the language version you seek is not shown, contact us to make special arrangements:

Department of Symptom Research
Attn: Assessment Tools
The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard, Unit 1450
Houston, Texas 77030  

If applicable, an invoice will be e-mailed to you. Reference the invoice number on your payment and include on the memo line, "MD Anderson Assessment Tool Distribution."

Notice of Copyright

The M. D. Anderson Symptom Inventory (MDASI) copyright is held by The University of Texas MD Anderson Cancer Center and administered by the MDASI's developer, Charles S. Cleeland, PhD. The copyright applies to the MDASI, its modules, and all its derivatives in any language.

The MDASI-cGVHD may not be used or reproduced without permission from Charles S. Cleeland, PhD, or his designee. Fees for use may apply (see above).

The MDASI and its modules may not be modified or translated into another language without the express written consent of the copyright holder. Failure to comply may result in legal action. Contact us via e-mail at or at the address shown above to obtain permission to alter or translate the instrument.

Selected References


Williams LA, Couriel DR, Mendoza TR, McCarthy PL, Neumann JL, White MH, Mobley GM, Kapoor S, Hernandez L, Alousi AM, Cleeland CS. A new measure of symptom burden in chronic graft-versus-host disease [abstract]. American Society for Blood and Marrow Transplantation 2010 BMT Tandem Meetings, Orlando FL, Feb 24-28, 2010. Biol Blood Marrow Transplant 16(2 Suppl 2): S177, 2010; 60.

Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle M, Morrissey M, & Engstrom MC. Assessing Symptom Distress in Cancer: The M. D. Anderson Symptom Inventory. Cancer 89: 1634-1646, 2000.

Clinical Application

Lee SJ, Williams LA. Patient-reported outcomes for acute graft-versus-host disease prevention and treatment trials. Biol Blood Marrow Transplant 16(3): 295-300, 2010.

Wang XS, Giralt SA, Williams LA, Shi Q, Mobley GM, Reuben JM, Lee BN, Cleeland CS. Measuring acute GVHD-related symptom burden and inflammatory cytokines during the first 100 days after allogeneic hematopoietic stem cell transplantation [abstract]. Psychoneuroimmunology Research Society 17th Annual Meeting, Dublin, Ireland, Jun 2-5, 2010. Brain Behav Immun 24(Suppl 1): S5, 2010; 206.

Williams LA, Anderson KO, Wang XS, Cleeland CS, Mendoza TR, Mobley GM, Brown JO, Giralt S. Patterns of symptom burden in autologous and allogeneic hematopoietic stem cell transplantation [abstract]. American Society of Hematology 51st Annual Meeting and Exposition, New Orleans LA, Dec 5-8, 2009. Blood 114(22), 2009; 1396.

Williams LA, Neumann JL, Couriel DR, Mendoza TR, White MH, Zhang Y, Cleeland CS. Measuring the symptom burden of chronic graft-versus-host disease [abstract]. American Society for Blood and Marrow Transplantation 2008 BMT Tandem Meeting, San Diego CA, Feb 13-17, 2008. Biol Blood Marrow Transplant 14(2 Suppl 1): 56, 2008; 147.

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