Faculty Spotlight: Blaine Bartholomew, PhD

The cellular machinery responsible for DNA replication, transcription and repair is prevented from contacting naked DNA by a higher-order DNA-protein structure known as chromatin. The basic repeating unit of chromatin is the nucleosome, which is composed of a core histone octamer, wrapped with DNA. The Bartholomew lab investigates a family of proteins that reorganize chromatin using energy derived from ATP. His lab focuses on the structure and function of these complexes and their roles in development and differentiation. The laboratory utilizes a variety of model systems and combines genetic, biochemical and biophysical techniques to interrogate physical interactions within these complexes and their nucleosomal substrates.