Faculty Spotlight:Taiping Chen, Ph.D.

Epigenetic mechanisms, including DNA methylation and histone modifications, play crucial roles in chromatin structure and gene expression. The Chen lab investigates the roles of epigenetic regulators in developmental and pathological processes, focusing on epigenetic reprogramming events during early embryogenesis and gametogenesis (including genomic imprinting), tumorigenesis, and stem cell biology. Currently, Dr. Chen’s lab is: 1) defining the interplay between histone lysine and arginine methylation and DNA methylation during mammalian development; 2) defining the role of epigenetic modifiers in cancer formation and progression; and 3) defining the roles of the histone methyltransferase SetDB1 in stem cell functions, including tissue homeostasis, regeneration and repair.