Yan Heather Lin, Ph.D.

Principal Statistical Analyst


  • Ph.D. in Biostatistics, Medical University of South Carolina, Charleston, SC
  • M.S. in Biostatistics, Medical University of South Carolina, Charleston, SC
  • M.S. in Epidemiology, Shanghai Medical University, Shanghai, China
  • M.D., Shanghai Medical University, Shanghai, China

Areas of Interest

  • Clinical trial design
  • Survival analysis
  • Epidemiology



Carter RE, Lin Y, Lipsitz SR, Newcombe RG, Hermayer KL. Relative risk estimated from the ratio of two median unbiased estimates. Journal of the Royal Statistical Society: Series C, Applied Statistics 2010; 59(4): 657-671.

Lee JJ, Lin HY, Liu DD, Kong M. Emax model and interaction index for assessing drug interaction in combination studies. Frontiers in Bioscience (Elite Edition) 2010; 2: 582-601.

Lin Y, Lipsitz S, Sinha D, Gawande AA, Regenbogen SE, Greenberg CC. Using Bayesian p-values in a 2 x 2 table of matched pairs with incompletely classified data. Journal of the Royal Statistical Society, Series C 2009; 58(2): 237-246.

Lin Y, Newcombe R, Lipsitz S, Carter R. Fully-specified bootstrap confidence intervals for the difference of two independent binomial proportions based on the median unbiased estimator. Statistics in Medicine 2009; 28(23): 2876-2890.

Collaborative Biomedical Research

Zheng Y, Yang J, Qian J, Zhang L, Lu Y, Li H, Lin H, Lan Y, Liu Z, He J, Hong S, Thomas S, Shah J, Baladandayuthapani V, Kwak LW, Yi Q. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. Journal of Molecular Medicine (Berlin) 2012; 90(6): 695-706.

Nunez MI, Behrens C, Woods DM, Lin H, Suraokar M, Kadara H, Hofstetter W, Kalhor N, Lee JJ, Franklin W, Stewart DJ, Wistuba II. High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation. Journal of Thoracic Oncology 2012; 7(5): 833-840.

Solis LM, Behrens C, Raso MG, Lin HY, Kadara H, Yuan P, Galindo H, Tang X, Lee JJ, Kalhor N, Wistuba II, Moran CA. Histologic patterns and molecular characteristics of lung adenocarcinoma associated with clinical outcome. Cancer 2012; 118(11): 2889-2899.

Crosby MA, Garvey PB, Selber JC, Adelman DM, Sacks JM, Villa MT, Lin HY, Park SJ,  Baumann DP. Reconstructive outcomes in patients undergoing contralateral prophylactic mastectomy. Plastic and Reconstructive Surgery 2011; 128(5): 1025-1033.

Selber JC, Sanders E, Lin H, Yu P. Venous drainage of the radial forearm flap: technique for selecting the deep or superficial system. Annals of Plastic Surgery 2011; 66(4): 347-350.

Cascone T, Herynk MH, Xu L, Du Z, Kadara H, Nilsson MB, Oborn CJ, Park YY, Erez B, Jacoby JJ, Lee JS, Lin HY, Ciardiello F, Herbst RS, Langley RR, Heymach JV. Upregulated stromal EGFR and vascular remodeling in murine NSCLC xenograft models of VEGF inhibitor resistance. The Journal of Clinical Investigation 2011; 121(4): 1313–1328.

Baumann DP, Lin HY, Chevray PM. Perforator number predicts fat necrosis in a prospective analysis of breast reconstruction with free TRAM, DIEP, and SIEA flaps. Plastic and Reconstructive Surgery 2010; 125(5): 1335-1341.

Hanrahan EO, Lin HY, Kim ES, Yan S, Du DZ, McKee KS, Tran HT, Lee JJ, Ryan AJ, Langmuir P, Johnson BE, Heymach JV. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. Journal of Clinical Oncology 2010; 28(2): 193-201.

Kies MS, Holsinger FC, Lee JJ, William WN, Jr., Glisson BS, Lin HY, Lewin JS, Ginsberg LE, Gillaspy KA, Massarelli E, Byers L, Lippman SM, Hong WK, El-Naggar AK, Garden AS, Papadimitrakopoulou V. Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. Journal of Clinical Oncology 2010; 28(1): 8-14.

Yilmaz T, Jiffar T, de la Garza G, Lin H, Milas Z, Takahashi Y, Hanna E, MacIntyre T, Brown JL, Myers JN, Kupferman ME. Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC. Cancer Biology Therapeutics 2010; 10(6): 644-653.

William WN Jr, Lin HY, Lee JJ, Lippman SM, Roth JA, Kim ES. Revisiting stage IIIB and IV non-small cell lung cancer: analysis of the surveillance, epidemiology and end results data. CHEST 2009; 136(3): 701-709.

Holsinger FC, Kies MS, Diaz EM Jr, Gillenwater AM, Lewin JS, Ginsberg LE, Glisson BS, Garden AS, Ark N, Lin HY, Lee JJ, El-Naggar AK, Hong WK, Shin DM, Khuri FR. Durable long-term remission with chemotherapy alone for stage II to IV laryngeal cancer. Journal of Clinical Oncology 2009; 27(12): 1976-1982.

Holsinger FC, Lin HY, Bassot V, Laccourreye O. Platin-based exclusive chemotherapy for selected patients with squamous cell carcinoma of the larynx and pharynx. Cancer 2009; 115(17):3909-3918.

Behrens C, Lin HY, Lee JJ, Raso MG, Hong WK, Wistuba II, Lotan R. Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer. Clinical Cancer Research 2008; 14(19): 6014-6022.  


Updated March 7, 2013