Hui Yao, Ph.D.

Principal Statistical Analyst


  • Ph.D. in Structural and Computational Biology, Baylor College of Medicine, Houston, TX
  • M.S. in Information System and Computer Science, National University of Singapore, Singapore
  • B.S. in Genetics, Fudan University, Shanghai, China

Areas of Interest

  • Integration of high-throughput technologies (Array CGH, SNP array, expression array, lysate array, etc.) to study mechanisms of cancers
  • Identification of biomarkers for cancer diagnosis and prognosis
  • Clinical bioinformatics
  • Survival analysis and clinical trial design
  • Programming in R/S+, SAS, C/C++, and Perl


Chen Y, Yao H, Thompson EJ, Tannir MN, Weinstein JN, Su X. VirusSeq: software to identify viruses and their integration sites using next-generation sequencing of human cancer tissue. Bioinformatics 2013; 29(2):266-267.

Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF 3rd, Calvert VS, Fodale V, Wang J, Weber RS. Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. American Journal of Pathology 2011; 178(2):548-571.

Zuo Z, Jones D, Yao H, Thomas DA, O'Brien S, Ravandi F, Kantarjian HM, Abruzzo LV, Medeiros LJ, Chen SS, Luthra R. A pathway-based gene signature correlated with therapeutic response in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia. Modern Pathology 2010; 23(11):1524-1534.

Chandra P, Luthra R, Zuo Z, Yao H, Ravandi F, Reddy N, Garcia-Manero G, Kantarjian H, Jones D. Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases. American Journal of Clinical Pathology 2010; 133(5):686-693.

Earle J, Luthra R, Romans A, Abraham R, Ensor J, Yao H, Hamilton SR. Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma. Journal of Molecular Diagnostics 2010; 12(4):433-440.

Baameur F, Morgan DH, Yao H, Tran TM, Hammitt RA, Sabui S, McMurray JS, Lichtarge O, Clark RB. Role for the RH domain of GRK5 and 6 in β2-adrenergic receptor and rhodopsin phosphorylation. Molecular Pharmacology 2010; 77(3):405-415.

Jones D, Yao H, Romans A, Dando C, Pierce S, Borthakur G, Hamilton A, Bueso-Ramos C, Ravandi F, Garcia-Manero G, Kantarjian H. Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias. Genes, Chromosomes and Cancer 2010; 49(2):182-191.

Zhang W, Cortes J, Yao H, Zhang L, Reedy N, Jabbour E, Kantarjian HM, Jones D. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary imatinib resistance. Journal of Clinical Oncology 2009; 27(22):3642-3649.

Maru DM, Singh RR, Hannah C, Albarracin CT, Li YX, Abraham R, Romans AM, Yao H, Luthra MG, Anandasabapathy S, Swisher SG, Hofstetter WL, Rashid A, Luthra R. MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus. American Journal of Pathology 2009; 174(5):1940-1948.

Tian Z, Palmer N, Schmid P, Yao H, Galdzichi M, Berger B, Wu E, Kohane IS. A practical platform for global gene expression profiling analysis based on bead array and peripheral whole blood samples. PLoS ONE 2009; 4(4):e5157.

Sargent R, Jones D, Lynne VA, Yao H, Bonderover J, Cisneros M, Wierda WG, Keating MJ, Luthra R. Customized oligonucleotide array based comparative genomic hybridization as a clinical assay for genomic profiling of chronic lymphocytic leukemia. Journal of Molecular Diagnostics 2009; 11(1):25-34.

Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apsek A, Bodell A, Partlow JN, Barry B, Yao H,  Markianos K, Ferland RJ, Greenberg ME, Walsh CA. Identifying autism loci and genes by tracing recent shared ancestry. Science 2008; 321(5886):218-223.

Yao H, Mihalek I, Lichtarge O. Rank information: a structure-independent measure of evolutionary trace analysis improves identification of protein functional sites. Proteins 2006; 65(1):111-123.

Yao H, Kristensen DM, Mihalek I, Sowa ME, Shaw C, Kimmel M, Kavraki L, Lichtarge O. An accurate, sensitive, and scalable method to identify functional sites in protein structures. Journal of Molecular Biology 2003; 326:255-261.

Lichtarge O, Yao H, Kristensen DM, Madabushi S, Mihalek I. Accurate and scalable identification of functional sites by evolutionary tracing. Journal of Structural and Functional Genomics 2003; 4(2-3):159-166.

Mihalek I, Res O, Yao H, Lichtarge O. Combining inference from evolution and geometric probability in protein structure evaluation. J. Mol. Biol. 2003; 331:263-279.

Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O. Structural clusters of evolutionary trace residues are statistically significant and common in proteins. Journal of Molecular Biology 2002; 316(1):139-154.

Du G, Pan M, Zhou Y, Chen J, Yao H, Yuan J, Qiang B. Cloning of human and mouse GRY-RBP cDNA. Chinese Science Bulletin 2000; 45(4):343-350.

Pan M, Yuan J, Du G, Zhou Y, Yao H, Qiang B. Isolation and expression pattern analysis of novel ETSs from human fetal brain. Chinese Science Bulletin 1998; 43(21):1815-1819.


Updated March 8, 2013