Xiudong (Jennifer) Lei, Ph.D.

Research Statistician


  • Ph.D. in Biostatistics, University of California, Berkeley, CA
  • M.S. in Statistics, University of Cincinnati, Cincinnati, OH
  • B.E. in Environmental Engineering, Tsinghua University, Beijing, China

Areas of Interest

  • Survival analysis
  • Clinical trial design
  • Bayesian data analysis


Courses taught at the Graduate School of Biomedical Sciences, UTHSCH:

  • Introduction to Mathematical Probability  I & II
  • Introduction to Biomedical Statistics (co-taught)
  • Mathematical Methods for Medical Physics (co-taught)



Eapen G, Shah A, Lei X, Jimenez C, Morice R, Yarmus L, Filner J, Ray C, Michaud G, Greenhill S, Sarkiss M, Casal R, Rice, D, Ost, D.  Complications, consequences, and practice patterns of endobronchial ultrasound-guided transbronchial needle aspiration: results of the AQuIRE registry. Chest 2012 Nov 1. [Epub ahead of print]

Schier R, Marcus HE, Mansur E, Lei X, El-Zein R, Mehran R, Purugganan R, Heir JS, Riedel B, Gottumukkala V.  Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity. Journal of Atherosclerosis and Thrombosis 2012 Nov 29. [Epub ahead of print]

Ost DE, Shah AM, Lei X, Godoy MC, Jimenez CA, Eapen GA, Jani P, Larson AJ, Sarkiss MG, Morice RC. Respiratory infections increase the risk of granulation tissue formation following airway stenting in patients with malignant airway obstruction. Chest 2012; 141(6): 1473-1481.

Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer. Cancer 2012; 118(19): 4652-4659.

Yusuf SW, Daraban N, Abbasi N, Lei X, Durand JB, Daher IN. Treatment and outcomes of acute coronary syndrome in the cancer population. Clinical Cardiology 2012; 35(7): 443-450. 

Faiz SA, Bashoura L, Lei X, Sampat KR, Brown TC, Eapen GA, Morice RC, Ferrajoli A, Jimenez CA. Pleural effusions in patients with acute leukemia and myelodysplastic syndrome. Leukemia & Lymphoma 2013; 54(2): 329-335.

Lynch SP, Lei X, Chavez-MacGregor M, Hsu L, Meric-Bernstam F, Buchholz TA, Zhang H, Hortobagyi GN, Valero V, Gonzalez-Angulo AM. Multifocality and multicentricity in breast cancer and survival outcomes. Annals of Oncology; 23(12): 3063-3069.

Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of body mass index on survival outcome among women with early stage triple-negative breast cancer. Clinical Breast Cancer 2012; 12(5): 364-372.

Keus L, Bashoura L, Morice R, Blanco D, Kellner C, Lei X, Faiz S. Pulmonary function testing in patients with tracheostomies. Chest 2012; 142: 782A. (Meeting abstract).

Bayraktar S, Hernadez-Aya LF, Lei X, Meric-Bernstam F, Litton JK, Hsu L, Hortobagyi GN, Gonzalez-Angulo AM. Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer 2012; 118(5): 1202-1011.

Raghav KP, Hernandez-Aya LF, Lei X, Chavez-MacGregor M, Meric-Bernstam F, Buchholz TA, Sahin A, Do K-A, Hortobagyi, GN, Gonzalez-Angulo AM. Impact of low estrogen/progesterone receptor expression on survival outcomes in breast cancers previously classified as triple negative breast cancers. Cancer 2012; 118(6): 1498-1506.

Bayraktar S, Gonzalez-Angulo AM, Lei X, Buzdar AU, Valero V, Melhem-Bertrandt A, Kuerer HM, Hortobagyi GN, Sahin AA, Meric-Bernstam F. Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and non-anthracycline-based regimens for HER2-positive breast cancer. Cancer 2012; 118(9): 2385-2393.

Doshi SM, Shah P, Lei X, Lahoti A, Salahudeen AK. Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes. American Journal of Kidney Disease 2012; 59(2): 222-228.

Chavez-MacGregor M, Brown E, Lei X, Litton JK, Meric-Bernstam F, Mittendorf EA, Hernandez LF, Valero V, Gonzalez-Angulo AM.  Bisphosphonates and pathologic complete response to taxane- and anthracycline-based neoadjuvant chemotherapy in patients with breast cancer. Cancer 2012; 118(2): 326-332.

Ahmed A, Chambers MS, Goldschmidt MC, Habib A, Lei X, Jacob RF. Association between microbial flora and tissue abnormality around dental implants penetrating skin in reconstructed oral cancer patients. The International Journal of Oral and Maxillofacial Implants 2012; 27(3): 684-694.


Adkins FC, Gonzalez-Angulo AM, Lei X, Hernandez-Aya LF, Litton JK Mittendorf EA, Wagner J, Hunt KK, Woodward WA, Meric-Bernstam F. Triple-negative breast cancer is not a contraindication for breast conservation. Annals of Surgical Oncology 2011; 18(11): 3164-3173.

Naing A, Kurzrock R, Burger A, Gupta S, Lei X, Busaidy NL, Hong DS, Chen HX, Doyle L, Heilbrun LK, Rohren E, Ng C, Chandhasin C, Lorusso PM. Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. Clinical Cancer Research 2011; 17(18): 6052-6060.

Ost D, Ernst A, Lei X, Fellow-Kopman D, Eapen GA, Kovitz K, Herth F, Simoff M. Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration: Results of the AQuIRE Bronchoscopy Registry. Chest 2011; 140(6): 1557-1566.

Berry DA, Ueno NT, Johnson MM, Lei X, Caputo J, Smith DA, Yancey LJ, Crump M, Stadtmauer EA, Biron P, Crown JP, Schmid P, Lotz JP, Bregni M, Demirer T. High-dose chemotherapy with autologous stem-cell support versus standard-dose chemotherapy for high-risk adjuvant breast cancer: overview of individual patient data from 15 randomized trials. Journal of Clinical Oncology 2011; 29(24): 3214-3223.

Berry DA, Ueno NT, Johnson MM, Lei X, Caputo J, Rodenhuis S, Peters WP, Leonard RC, Barlow WE, Tallman M, Bergh J, Nitz UA, Gianni AM, Basser RL, Zander AR, Coombes RC, Roché H, Tokuda Y, Hortobagyi GN, Bregni M, Demirer T. BMT primary high-dose chemotherapy with autologous hematopoietic stem-cell transplantation versus standard-dose chemotherapy: overview of individual patient data from six randomized metastatic breast cancer trials. Journal of Clinical Oncology 2011; 29(24): 3224-3231.

Tsung AI, Prabhu SS, Lei X, Chern JJ, Bekele BN, Shonka NA. Cerebellar glioblastoma: A retrospective review of 21 patients at a single institution. Journal of Neuro-oncology 2011; 105(3): 555-562.

Melhem-Bertrandt A, Chavez-MacGregor M, Lei X, Brown EN , Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo AM. Beta-blocker use is associated with improved relapse-free and overall survival in patients with triple-negative breast cancer. Journal of Clinical Oncology 2011; 29(19): 2645-2652.

Hernandez-Aya LF, Chavez-MacGregor M, Lei X,  Meric-Bernstam F, Buchholz TA, Sahin A, Do K-A, Valero V, Hortobagyi GN, Gonzalez-Angulo AM.  Nodal status and clinical outcomes in a large cohort of patients with triple negative breast cancer.  Journal of Clinical Oncology 2011; 29(19): 2628-2634.

Naqvi K, Garcia-Manero G, Sardesai S, Oh J, Pierce S, Lei X, Shan J, Kantargian H, Suarez-Almazor ME. Association of comorbidities with overall survival in patients with myelodysplastic syndrome. Journal of Clinical Oncology 2011; 29(16): 2240-2246.

Naing A, Stephen SK, Frenkel M, Chandhasin C, Hong DS, Lei X, Falchhok G, Wheler JJ, Fu S, Kurzrock R. Prevalence of complementary medicine use in a phase 1 clinical trials program:  The MD Anderson Cancer Center experience. Cancer 2011; 117(22): 5142-5150.

Lei X, Yuan Y, Yin G. Bayesian phase II adaptive randomization by jointly  modeling time-to-event efficacy and binary toxicity. Lifetime Data Analysis 2011; 17(1): 156-174.

2010 and earlier

Shannon VR, Anderson BS, Lei X, Champlin RE, Kontoyiannis DPK. Utility of early versus late fiberoptic bronchoscopy in the evaluation of new pulmonary infiltrates following hematopoietic stem cell transplantation. Bone Marrow Transplantation 2010; 45(4): 647-655.

Kennedy MP, Jimenez CA, Morice RC, Sarkiss M, Lei X, Rice D, Eapen GA. Factors influencing the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration. Journal of Bronchology & Interventional Pulmonology 2010; 17: 202-208.

Yusuf SW, Gladish G, Lenihan DJ, Lei X, Durand J-B, Swafford J, Daher IN. Computerized tomographic finding of saddle pulmonary embolism is associated with high mortality in cancer patients. Internal Medicine Journal 2010; 40: 293-299.

Vemulapalli S, Lakshmi C, Tsimberidou A-M, Dhillon N, Lei X, Hong D, Kurzrock R. Clinical outcome and factors predicting development of thromboembolic complications in patients with advanced refractory cancer in a phase I clinic: the M D Anderson Cancer Center experience. American  Journal of Hematology 2009; 84(7): 408-413.

Craft BS, Kurzrock R, Lei X, Herbst R, Lippman S, Fu S, Karp DD. The changing face of phase I cancer clinical trials: new challenges in study requirements. Cancer 2009; 115(8): 1592-1597.

Wahba H, Truong MT, Lei X, Kontoyiannis DP, Marom EM. Reversed halo sign in invasive pulmonary fungal infections. Clinical Infectious Diseases 2008; 46(11): 1733-1737.

Marom EM, Martinez CH, Truong MT, Lei X, Sabloff BS, Munden RF, Gladish GW, Herbst RS, Morice RC, Stewart DJ, Jimenez CA, Blumenschein GR Jr, Onn A. Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer. Journal of Thoracic Oncology 2008; 3(4): 351-357.

Kennedy MP, Jimenez CA, Bruzzi JF, Mhatre AD, Lei X, Giles FJ, Fanning T, Morice RC, Eapen GA. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax 2008; 63(4): 360-365.

Jewell NP, Lei X, Ghani AC, Donnelly CA, Leung GM, Ho LM, Cowling BJ, Hedley AJ. Non-parametric estimation of the case fatality rate with competing risks data: an application to severe acute respiratory syndrome (SARS). Statistics in Medicine 2007; 26(9): 1982-1998.

Chen YQ, Jewell NP, Lei X, Cheng S-C. Semiparametric estimation of proportional mean residual model in presence of censoring. Biometrics 2005; 61: 170-178.

Eisenberg JN, Lei X, Hubbard AH, Brookhart MA, Colford JM Jr. The role of disease transmission and conferred immunity in outbreaks: analysis of the 1993 Cryptosporidium outbreak in Milwaukee. American Journal of Epidemiology 2005; 161(1): 62-72.

Jewell NP, van der Laan MJ, Lei X. Bivariate current status data with univariate monitoring times. Biometrika 2005; 92(4): 847-862.

Galvani AP, Lei X, Jewell NP. Temporal and geographic variation in case fatality rates and doubling times of SARS epidemics. Emerging Infectious Diseases 2003; 9(8): 991-994.

Pong A, Chen YQ, Lei X. Semiparametric rank regression methods in stability analysis. Encyclopedia of Biopharmaceutical Statistics. New York: Dekker, 2003.

Deddens J, Petersen MR, Lei X. Estimation of prevalence ratios when PROC GENMOD does not converge. Proceedings of the 28th Annual SAS Users Group International Conference. Seattle, Washington, March 30, 2001.


Updated March 8, 2013