Our Publications

Sentrin 1 = SUMO 1
Sentrin 2 = SUMO 3
Sentrin 3 = SUMO 2


Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, Chang HM, Yeh ET. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. J Immunol. 1996 Nov 15;157(10):4277-81.


Kamitani T, Nguyen HP, Yeh ET. Preferential modification of nuclear proteins by a novel ubiquitin-like molecule. J Biol Chem. 1997 May 30;272(22):14001-4. 

Kamitani T, Kito K, Nguyen HP, Yeh ET. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem. 1997 Nov 7;272(45):28557-62.

Gong L, Kamitani T, Fujise K, Caskey LS, Yeh ET. Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9. J Biol Chem. 1997 Nov 7;272(45):28198-201. 


Kamitani T, Nguyen HP, Kito K, Fukuda-Kamitani T, Yeh ET. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J Biol Chem. 1998 Feb 6;273(6):3117-20.

Kamitani T, Kito K, Nguyen HP, Fukuda-Kamitani T, Yeh ET. Characterization of a second member of the sentrin family of ubiquitin-like proteins. J Biol Chem. 1998 May 1;273(18):11349-53.

Kamitani T, Kito K, Nguyen HP, Wada H, Fukuda-Kamitani T, Yeh ET. Identification of three major sentrinization sites in PML. J Biol Chem. 1998 Oct 9;273(41):26675-82.

Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T. Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochem Biophys Res Commun. 1998 Oct 29;251(3):688-92.


Gong L, Li B, Millas S, Yeh ET. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 1999 Apr 1;448(1):185-9.

Wada H, Yeh ET, Kamitani T. Identification of NEDD8-conjugation site in human cullin-2. Biochem Biophys Res Commun. 1999 Apr 2;257(1):100-5.

Gong L, Yeh ET. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42.

Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF 3rd, Maul GG. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol. 1999 Oct 18;147(2):221-34.

Wada H, Yeh ET, Kamitani T. The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2. J Biol Chem. 1999 Dec 10;274(50):36025-9.


Gong L, Millas S, Maul GG, Yeh ET. Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J Biol Chem. 2000 Feb 4;275(5):3355-9.

Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ET, Medrano EE. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res. 2000 Mar 15;255(2):135-43.

Yeh ET, Gong L, Kamitani T. Ubiquitin-like proteins: new wines in new bottles. Gene. 2000 May 2;248(1-2):1-14. Review.

Gong L, Kamitani T, Millas S, Yeh ET. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. J Biol Chem. 2000 May 12;275(19):14212-6. 

Wada H, Yeh ET, Kamitani T. A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. J Biol Chem. 2000 Jun 2;275(22):17008-15.


Kamitani T, Kito K, Fukuda-Kamitani T, Yeh ET. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. J Biol Chem. 2001 Dec 7;276(49):46655-60.

Kito K, Yeh ET, Kamitani T. Nub1, a nedd8-interacting protein, is induced by interferon and down-regulates the nedd8 expression. J Biol Chem. 2001 Jun 8;276(23):20603-9.


Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM. The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. Hum Mol Genet. 2002 Oct 15;11(22):2723-33.

Fukuda-Kamitani T, Kamitani T. Ubiquitination of Ro52 autoantigen. Biochem Biophys Res Commun. 2002 Jul 26;295(4):774-8.

Yeh ET, Ubiquitin, proteasome, and restenosis: a brave new world for cardiovascular research. Circulation. 2002 Jan 29;105(4):408-10.

Kanaya K, Tsai AL, Kamitani T. Cobalt- and nickel-binding property of cullin-2. Biochem Biophys Res Commun. 2002 Jan 11;290(1):294-9.


Akey D.T., Zhu X., Dyer M., Li A., Sorensen A., Fukada-Kamitani T., Daiger S.P., Craft C., Kamitani T., Sohocki M.M. Functional studies of AIPL1: potential role of AIPL1 in cell cycle exit and/or differentiation of photoreceptors. Advances in Experimental Medicine and Biology 533: 287-95, 2003.

Tanaka T, Kawashima H, Yeh ETH, and Kamitani T. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. Journal of Biological Chemistry 2003 Aug. 29, 278:32905-32913.

Kanaya K, Kamitani T. pVHL-independent ubiquitination of HIF1alpha and its stabilization by cobalt ion. Biochem Biophys Res Commun. 2003 Jul 4;306(3):750-5.

Morris KR, Lutz RD, Choi HS, Kamitani T, Chmura K, Chan ED. Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide. Infect Immun. 2003 Mar;71(3):1442-52.

Dil Kuazi A, Kito K, Abe Y, Shin RW, Kamitani T, Ueda N. NEDD8 protein is involved in ubiquitinated inclusion bodies. J Pathol. 2003 Feb;199(2):259-66.


Kanaya K., Sohocki M.M., and Kamitani T.: Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis.  Biochemical and Biophysical Research Communications 317: 768-773, 2004.

Cheng J, Wang D, Wang Z, Yeh ET. SENP1 Enhances Androgen Receptor-Dependent Transcription through Desumoylation of Histone Deacetylase 1., Mol Cell Biol. 2004 Jul;24(13):6021-8. 

Tanaka T, Yeh ET, Kamitani T. NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis. European Journal of Biochemistry 271: 972-982, 2004.


Cheng J., Perkins N.D., Yeh E.T.H. Differential regulation of c-Jun-dependent transcription By SUMO-specific proteases. Journal of Biological Chemistry 280:14492-14498, 2005.

Mori F., Nishie M., Piao Y.S., Kito K., Kamitani T., Takahashi H., and Wakabayashi K.:  Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders.  Neuropathology and Applied Neurobiology 31: 53-61, 2005.

Akiyama H., Kamitani T., Yang X., Kandyil R., Bridgewater L.C., Fellous M., Mori-Akiyama Y., and de Crombrugghe B.: The transcription factor Sox 9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.  Matrix Biology 23: 499-505, 2005.

Veltman IM, Vreede LA, Cheng J, Looijenga LH, Janssen B, Schoenmakers EF, Yeh ET, van Kessel AG. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Human Molecular Genetics, 14(14):doi:10.1093/hmg/ddi200, 2005.

Izumiya Y, Ellison TJ, Yeh ET, Jung JU, Luciw PA, and Kung HJ. Kaposi’s Sarcoma-Associated Herpesvirus K-bZIP Represses Gene Transcription via SUMO Modification, Journal of Virology, July 2005, p. 001 Vol. 79, No. 15.

Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM. A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun. 2005 Sep 22; [Epub ahead of print] PMID: 16198310 [PubMed - as supplied by publisher]

Tanji K., Tanaka T., and Kamitani T.  Interaction of NUB1 with the proteasome subunit S5a.  Biochem Biophys Res Commun.2005 Nov 11;337(1):116-20.


Wada K, Kamitani T.  Autoantigen Ro52 is an E3 ubiquitin ligase.  Biochem Biophys Res Commun. 2006 Jan 6;339(1):415-21.

Wada K, Tanji K, Kamitani T.  Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.  Biochem Biophys Res Commun. 2006 Jan 20;339(3):731-6.

Wada K, Tanji K, Kamitani T.  Function and subcellular location of Ro52-beta.  Biochem Biophys Res Commun. 2006 Feb 17; 340(3): 872-8.

Wada K, Kamitani T.  UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.  Biochem Biophys Res Commun. 2006 Mar 31;342(1):253-8.

Itahana, Y., Yeh, E.T.H., Zhang, Y. Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol. 2006 Jun;26(12):4675-89.

Gong L, Yeh ET. Characterization of a family of nucleolar sumo-specific proteases with preference for sumo-2 or sumo-3. J Biol Chem. 2006 Jun 9;281(23):15869-77.

Gao F, Cheng J, Shi T, Yeh ET. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription.
Nat Cell Biol. 2006 Oct;8(10):1171-1177.


Cheng, J., Kang, X., Zhang, S., Yeh, E.T.H. SUMO-specific protease 1 is essential for stabilization of HIF1a during hypoxia. Cell, 131:584-595, 2007.

Bawa-Khalfe, T., Cheng, J., Wang, Z., Yeh, E.T.H. Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. Journal of Biological Chemistry, 282(52):37341-37349, 2007.


Yeh E.T. SUMOylation and De-SUMOylation: Wrestling with Life's Processes. Yeh ET. J Biol Chem. 2009 Mar 27;284(13):8223-7. Epub 2008 Nov 13.


Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 2009 Sep 16;28(18):2748-62.


Kang X., Qi Y., Zuo Y., Wang Q., Zou Y., Schwartz R.J., Cheng J., Yeh E.T.H. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23;38(2):157-9.

Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J. SENP3-mediated de-conjugation of SUMO2/3 from PML is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem. 2010 Apr 23;285(17):12906-15.

Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem. 2010 Aug 13;285(33):25859-66. Epub 2010 Jun 15.

Dou H, Huang C, Singh M, Carpenter P, Yeh ETH. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.Mol Cell. 2010 Aug 13;39(3):333-45

Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ETH, Cheng J. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene. 2010 Oct 14;29(41):5568-78. Epub 2010 Jul 26.

Yan S, Sun X, Xiang B, Cang H, Kang X, Chen Y, Li H, Shi G, Yeh ET, Wang B, Wang X, Yi J. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J. 2010 Nov 17;29(22):3773-3786. Epub 2010 Oct 5.

Xu Y, Zuo Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J. Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis. J Biol Chem. 2010 Nov 19;285(47):36682-8. Epub 2010 Sep 14.

Bawa-Khalfe T, Yeh ET. SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.
Genes Cancer. 2010 Jul;1(7):748-752.

Bawa-Khalfe T, Yeh ET. The in vivo functions of desumoylating enzymes. Subcell Biochem. 2010;54:170-83.

Zhang S, Cheng J, Yeh ETH.  Ubiquitination, Sumoylation and De-sumoylation of HIF-1α, a key molecule involved in brain development and adaptation to hypoxia in adult brain.  In: Di Napoli M and Wojcik C.  The Ubiquitin Proteasome System in the Central Nervous System:  From Physiology to Pathology-2008 Update, 2010, p. 441-468, Nova Science Publishers, Inc.


Dou H, Huang C, Van Nguyen T, Lu LS, Yeh ET. SUMOylation and de-SUMOylation in response to DNA damage. FEBS Lett. 2011 Sep 16;585(18):2891-6. Epub 2011 Apr 8.Mol Cell.

Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 2011 Jul 22;43(2):180-91.

Lin, F., Yeh, E.T.H., Balancing act during development: lessons from a SUMO-less SF-1. Developmental Cell, Aug. 16;21:191-192, 2011. 

Yeh, E.T.H
., Microphthalmia-associated transcription factor, Melanoma, and Renal Carcinoma: the Small Ubiquitin-like Modifier Connection, Pigment Cell and Melanoma Research, 24:1079-1080, Nov. 21, 2011


Nguyen, T.V., Angkasekwinai, P., Dou, H., Lin, F.M., Lu, L.S., Cheng, J., Chin, E., Dong, C., and Yeh, E.T.H. SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell 45(2):210-221, 1/27/2012. PMCID: PMC3269036.

Schwartz, R., Yeh, E.T.H.  Weighing in on heart failure: The role of SERCA2a SUMOylation.  Circulation Research, 110(2):198-199, 2012

Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene, doi:10.1038/onc.2012.250. e-Pub 6/2012. PMID: 22733136.

Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET. Differential Expression of SUMO-Specific Protease 7 Variants Regulates Epithelial Mesenchymal Transition. Proc Natl Acad Sci U S A 109(43):17466, 10/23/2012. e-Pub 10/8/2012. PMID: 23045645.

Cai, R., Yu, T., Huang, C., Xia, X., Liu, X., Gu, J., Xue, S., Yeh, E.T., Cheng, J.  SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC1α.  Journal of Biological Chemistry, 2012 Dec 28;287(53):44464-70. doi: 10.1074/jbc.M112.422626. Epub 2012 Nov 14.


Heo K., Chang E., Le N., Cushman H., Yeh E.T.H., Fujiwara K., Abe J.  De-SUMOylation Enzyme of Sentrin/SUMO-Specific Protease 2 (SENP2) Regulates Disturbed Flow-induced SUMOylation of ERK5 and p53 that Leads to Endothelial Dysfunction and Atherosclerosis.  Circulation Research, 112(6):911-923, 2013.

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