Open Trainee Positions
Opportunities are currently available in the following areas:
Postdoctoral Fellow Definition:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity. Appointees must have recently (within three years) received a Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., and DVM) in an appropriate field.
Postdoctoral Appointment Term Limits:
MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Stipend Policy:
Stipend support will follow the NIH NRSA level for the appropriate PGY.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.
Anesthesiology & Perioperative Medicine
Req #: 600658-00004
Job Title: Postdoctoral Fellow
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The postdoctoral fellow will perform hand-on experiments to measure ion channel activity, protein and gene expression, and the structural of protein complexes involved in pain and hypertension development. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars.
Learning Objectives:
Gain mechanistic understanding of molecular mechanisms related to pain, opioid analgesia and hypertension development. Learn ion channel recording and biochemical analysis skills, animal models of pain and hypertension. Learn study design, data analysis and manuscript writing.
Eligibility Requirements:
Ph.D. degree in biochemistry, biotechnology and structural biology.
Dates or Training Schedule:
Research training will begin in August/September and will continue for 3-5 years.
Mentor Matching:
This position reports to Shao-Rui Chen, M.D.. and Jiusheng Yan, Ph.D.
Req #: 600673-00005
Job Title: Postdoctoral Fellow
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Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on the mechanisms of granulopoiesis and neutrophil turnover in sepsis. Projects will involve studies on the role of C-type lectin receptors in neutrophil generation, cell death and efferocytosis under homeostatic and pneumoseptic conditions; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in cellular or molecular immunology and infectious disease pathogenesis. Experience with flow cytometry, imaging and mouse models of disease is strongly preferred. Demonstrated productivity in publication record is required. Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.
Learning Objectives:
1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia
Eligibility Requirements:
1. Completion of Ph.D. or M.D/Ph.D in cellular and molecular immunology and/or infectious diseases.
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English.
Mentor Matching:
This position reports to Dr. Jyotika Sharma.
Req #: 600673-00006
Job Title: Postdoctoral Fellow
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Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on immunometabolism in neutrophil functions. Projects will involve studies on the metabolic regulation of neutrophil extracellular traps in inflammatory disease conditions and their modulation with small molecule inhibitors; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in biochemistry, cellular immunology, metabolic disease pathogenesis. Relevant experience with rodent models of metabolic dysregulation and pharmacological studies in cells of immune system is strongly preferred. Demonstrated productivity in publication record is required. Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.
Learning Objectives:
1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia
Eligibility Requirements:
1. Completion of Ph.D. or M.D/Ph.D in biochemistry, cellular and molecular immunology, molecular biology
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English.
Mentor Matching:
This position reports to Dr. Jyotika Sharma.
Req #: 600658-00007
Job Title: Postdoctoral Fellow
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Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on epigenomic regulation of neutrophil functions in secondary pneumonia and penumosepsis. Projects will involve studies on the mechanisms of chromatin release, modifications and interaction with immune cells related to inflammatory responses; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in Genomics/Epigenomics, Molecular Biology, Molecular Immunology. Relevant experience with rodent models of disease and functional genomic studies in cells of immune system is strongly preferred. Demonstrated productivity in publication record is required. Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.
Learning Objectives:
1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia
Eligibility Requirements:
1. Completion of Ph.D.or M.D/Ph.D or equivalent degree in Genetics/Epigenetics, molecular biology, immunology, infectious diseases. |
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English
Mentor Matching:
This position reports to Dr. Jyotika Sharma.
Behavioral Science
Req #: 172100-00001
Job Title: Postdoctoral Fellow
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The Postdoctoral Fellow will have the opportunity to participate in several NIH-funded physical activity intervention, nutrition intervention, mobile technology based intervention, as well as obesity, and cancer survivorship studies.
Research focus will be in the following three areas:
1) Trials in cancer survivors of the effect of physical activity and weight control interventions on bio-markers or prognosis and survival, as well as symptom management.
2) Dissemination and implementation research on energy balance interventions for cancer survivors and at risk populations, including interventions delivered in health care settings and technology-based interventions.
3) Basic behavioral research in weight loss and weight loss maintenance, eating behavior, and physical activity.
Learning Objectives:
By means of electronic correspondence, virtual meetings and on-line content:
1. Expand trainee's knowledge in cancer survivors' barriers to physical activity and interest in interventions;
2. To learn how to apply information about cancer survivors and physical activity in the development of interventions;
3. Provide practical experience in grant and manuscript writing and submission.
Eligibility Requirements:
Required - Ph.D. degree
Experience - 0 years
Research interest - behavioral changes (physical activity & healthy diet);energy balance theory and weight management; integrated and multi-level approaches for public health; evaluation of environment and system that affect physical and psychological health outcomes.
Dates or Training Schedule:
One year from start date.
Mentor Matching:
This position reports to Karen Basen-Engquist, Ph.D.
Biostatistics
Cancer Biology
Req #: 188100-00001
Job Title: Postdoctoral Fellow
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The Department of Cancer Biology at MD Anderson Cancer Center has postdoctoral positions available in a highly productive laboratory for research related to overcome immune suppressive tumor microenvironment, define tumor intrinsic resistance mechanisms to immunocheckpoint therapy and identify synthetic lethal targets in a number of cancer types, including brain cancer, colon cancer and prostate cancer. Interested fellows should checkout our recent publications (Zhao et al., Nature 2017; Lu et al., Nature 2017; Hu et al., Cell 2016; Liao et al., Cancer Cell 2019; Chen et al., Cancer Cell 2019; Zhao et al., Cancer Discovery 2020; Hou et al., Cancer Discovery 2020).
Learning Objectives:
The postdoctoral fellows will be working independently but also under the supervision of Dr. Y. Alan Wang. The primary research focus will be defined together with Dr. Wang in consultation of postdoctoral fellows' prior research experience and motivation in area of interest. Both cell culture work and animal studies will be conducted using many different types of models, including 2D, 3D culture systems, organoids, PDX, GEMM and rapid ES-derived GEMM, among others. In addition, it is expected that the postdoctoral fellows will gain expert level skills for various techniques required to address a scientific question, including CyTOF, imaging-CyTOF, scSeq, other omics and downstream bioinformatic analysis in consultation with in house computational scientists. As the goal of our research projects are translational, we expect that postdoctoral fellows will actively participate in collaborations with outstanding clinicians to potentially move the bench discoveries to the clinics as exemplified by several ongoing clinical trials in prostate cancer and colon cancer. Finally, the postdoctoral fellows are expected to seek fellowships and support PI's grant application as well as writing reviews and manuscripts through which the postdoctoral fellows will gain a deep understanding on the art of scientific writing and presentation.
Eligibility Requirements:
We seek highly motivated scientists with a recent Ph.D or M.D. in biological fields, and individuals with the following experiences are encouraged to apply.
- Experience with mouse tumor models.
- Experience with laboratory techniques in the field of molecular biology and immunology.
- Experience that shows independency, critical thinking and problem solving skills.
- Willingness to work together in a multi-disciplinary team environment.
- Outstanding communication and organizational skills.
Dates or Training Schedule:
The appointment is immediately available.
Mentor Matching:
This position reports to Dr. Y. Alan Wang.
Req #: 188100-00002
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Shabnam Shalapour. Research in the Shalapour Laboratory focuses on the role of chronic inflammation and adaptive immunity in control of tumor development and the response of various cancers to therapy. While the focus of the research is primarily based on tumor immunology and immunotherapy, our work also addresses fundamental questions in immunology, immunometabolism and cancer biology using cutting-edge technology tools including multicolor Flow cytometry, CyTOF, imaging, histology and large-scale omic analysis, e.g. single-cell RNA and ATAC-seq . We aim to understand how chronic inflammation induced by obesity, aging and alcohol abuse affect the immune system and thereby regulates its response to pathogens (bacteria and virus) and support tumor development. The focus then being how to use this information to not only prevent cancer development but also to develop novel therapeutic approaches to increase the response to immunotherapy and vaccination (see our recent publications; Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9), Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul 16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).
Learning Objectives:
This postdoc fellowship will focus on the role of adaptive immune cells particular B cells in tumor immunology, and how chronic-inflammation regulate their development and effector function, using bioinformatic tools, genetically engineered mouse models (GEMM) and state-of-the-art immunological and experimental approaches.
Eligibility Requirements:
Applicants must have a recent Ph.D. or M.D./Ph.D. degree in a related biomedical field with strong interests and self-motivation for research.
Dates or Training Schedule:
The appointment is immediately available.
Mentor Matching:
This position reports to Dr. Shabnam Shalapour.
Req #: 188100-00003
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Raghu Kalluri. The central mission of the Kalluri Laboratory is to perform innovative and cutting-edge research to unravel how cells and their environment communicate to maintain organ health and how such communication network in tissues is altered in cancer and other diseases. We investigate the biology of cancer with an implicit mission to develop new strategies for diagnosis and therapy.
Learning Objectives:
This postdoctoral fellowship will focus on pancreatic cancer.
Eligibility Requirements:
Applicants must have a recent Ph.D. degree with strong research interests.
Dates or Training Schedule:
The appointment is immediately available.
Mentor Matching:
This position reports to Raghu Kalluri, M.D., Ph.D..
Cancer Systems Imaging
Req #: 710509-00001
Job Title: Postdoctoral Fellow
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The department of Cancer Systems Imaging (CSI) is one of the largest new programs at The University of Texas MD Anderson Cancer Center within the Division of Diagnostic Imaging. The goal of this department and its research program is to develop new methodologies to visualize the cellular, biochemical, and genetic processes that contribute to the development and progression of cancer and to translate these discoveries into the clinic.
Dr. Charles Manning's group is working on understanding how underlying genetic events affect cancer imaging biomarkers. Dr. Manning and his team have major research interests in radiopharmaceutical development and translation and use of these reagents for imaging and therapy. A better understanding how molecular determinants affect cancer imaging biomarkers will allow an improved understanding of cancer imaging readouts. His laboratory is fully equipped for radio tracer development, validation and translation. In addition to his laboratory in Cancer Systems Imaging, Dr. Manning's group has access to state-of-the-art small animal imaging instrumentation across all relevant modalities and the full cadre of translational imaging resources housed in the Center for Advanced Biomedical Imaging (CABI).
There is an immediate opening for a postdoctoral fellow in Dr. Manning's laboratory. The fellow would work directly under Dr. Manning, Professor in Cancer Systems Imaging and would utilize work at the scientific interface of cancer biology, molecular imaging and targeted therapy to study the biological basis of cancer imaging biomarkers.
Eligibility Requirements:
The ideal candidate would have a Ph.D. in biology, chemistry, biochemistry, or biophysics from an accredited institution of higher learning. The ideal candidate would have at least some prior experience in cancer genetics, preclinical cancer models, use of immortalized cell lines and tissues, advanced imaging techniques and other biochemistry and molecular biology techniques with interest in developing specialized skills in preclinical and clinical quantitative PET imaging, radiopharmaceutical translation, and theragnostics.
Mentor Matching:
This position reports to David Piwnica-Worms, M.D., Ph.D.
Req #: 710509-00002
Job Title: Postdoctoral Fellow
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The department of Cancer Systems Imaging (CSI) is one of the largest new programs at the University of Texas MD Anderson Cancer Center within the Division of Diagnostic Imaging. The goal of this department and its research program is to develop new methodologies to visualize the cellular, biochemical, and genetic processes that contribute to the development and progression of cancer and to translate these discoveries into the clinic.
Dr. Pratip Bhattacharya's laboratory is working at the chemistry, spin-physics and biology interface to develop new hyperpolarized metabolic and molecular imaging agents to visualize the hallmarks of cancer in living systems in real time. His laboratory is using chemical biology, hyperpolarization and Magnetic Resonance (MR) based-metabolomics to design novel compounds and materials that can be directly integrated into optical and MR-based imaging platforms. Hyperpolarized 13Carbon/15Nitrogen/29Silicon MR Imaging and Spectroscopy are non-toxic, non-radioactive methods for assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for over 10,000 fold sensitivity enhancement relative to conventional MR imaging or spectroscopy. His laboratory is fully equipped for synthetic chemistry, biochemistry, molecular biology, and tissue culture.
In addition to his laboratory in Cancer Systems Imaging, Dr. Bhattacharya's group has access to state of the art small animal imaging facility and instrumentation including an IVIS Lumina Optical Scanner, Oxford HyperSense DNP polarizer, Parahydrogen based polarizer, a Bruker Albira PET/SPECT/CT, 600 MHz, 500 MHz and 300 MHz high resolution NMR spectrometers, Bruker 4.7 and 7T MRI, and a GE 3.0T Discovery clinical MR750.
Eligibility Requirements:
There is an immediate opening for a postdoctoral fellow to integrate chemistry and biology to develop new molecular imaging agents. The fellow will work directly under Dr. Bhattacharya, Associate Professor in Cancer Systems Imaging and would utilize NMR based metabolomics, analytical chemistry, biochemistry, and molecular biology to develop new tools to characterize and manipulate biological systems. Furthermore, the candidate will be involved in translating hyperpolarized imaging into clinic with the clinical hyperpolarizer, SPINLab that will be installed at MD Anderson later this year. The ideal candidate would have a Ph.D. in chemistry, biochemistry, or medical physics from an accredited institution of higher learning. The ideal candidate will have a solid background in NMR spectroscopy and pulse sequence design and implementation with some background in biochemistry and analytical chemistry. Experience in cell culture, animal models of cancer, and/or in vivo MR imaging and spectroscopy on a clinical scanner would also be a major advantage for this multidisciplinary position.
Mentor Matching:
This position reports to Pratip Bhattacharya, Ph.D.
Additional Application Information:
Please contact Heidi Bradley (HLBradley@mdanderson.org) for any additional information.
Clinical Cancer Prevention
Req #: 600709-00003
Job Title: Postdoctoral Fellow
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The Department of Clinical Cancer Prevention - Research at MD Anderson Cancer Center has one post-doc position open for studying genomic instability and immune responses in Peng Laboratory. Her laboratory research focuses on utilizing genetic, proteomic, and chemical approaches to understand the DNA damage response and repair network and develop preventive/therapeutic strategies to harness anti-tumor immunity by targeting the DNA repair network through the interconnected adaptive (neo-antigen/mutanome dependent) and innate (neo-antigen/mutanome-independent) immune responses.
The postdoc will work under the supervision of Dr. Guang Peng on and biological projects with both mechanistic and translational significance that may impact on both cancer prevention and therapy and have the opportunity to publish in high-impact research journals.
Learning Objectives:
The postdoctoral fellow will work under the supervision of Dr. Guang Peng. The primary research focus will be conducting genomic instability research using in vitro experimental methods for the mechanistic studies. The fellow will also gain extensive experience in preclinical animal models, clinical specimen validation and bioinformatic analysis using the TCGA database and chemical compounds' databases.
Eligibility Requirements:
We seek a highly motivated individual with a Ph.D. in molecular biology/cancer biology.
Dates or Training Schedule:
September 2020
Mentor Matching:
This position reports to Guang Peng, M.D., Ph.D.
Additional Application Information:
Selected recent publications related to the projects for this postdoc position from Peng Laboratory:
- Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul;5(7):752-67. PMID: 26069190; PMCID: PMC4497871 (Cancer Discovery Cover Story)
- Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Shumei Song, Jingsong Liu, Leona D. Samson, Jaffer A. Ajani, Guomin Li, Han Liang, Xuetong Shen, Gordon B. Mills, and Guang Peng. ARID1A deficiency promotes mutability and potentiates anti-tumor immunity unleashed by immune checkpoint blockade. Nature Med. 2018 May;24(5):556-562. PubMed PMID: 29736026; PMCID: PMC6076433.
- Hsieh H, Zhang W, Lin S, Yang W, Wang J, Shen J, Zhang Y, Lu Y, Wang H, Yu J, Mills G, Peng G. Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nat Commun. 2018 Sep 28;9(1):3982. PMID:30266942; PMCID: PMC6162282.
- Shen J, Zhao W, Ju Zhenlin, Wang L, Peng Y, Labrie M, Yap T, Mills G, Peng G. PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness. Cancer Research. 79 (2):311-319, 01/2019. PMID:30482774
- Wang L, Yang L, Wang C, Zhao W, Ju Z, Zhang W, Shen J, Peng Y, Clemens A, Luu Yen T, Song S, Yap T, Ajani J, Mills G, Shen X, Peng G. Inhibition of the ATM-Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. J Clin Invest. 2020 In Press
Epigenetics
Req #: 185800-00001
Job Title: Postdoctoral Fellow
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The University of Texas MD Anderson Cancer Center Science Park invites applications for postdoctoral fellowships in experimental cancer biology, CRISPR, and functional genetics/epigenetics starting immediately. Using state-of-the-art gene-editing and functional genomics/proteomics techniques, we seek to identify genetic and epigenetic biomarkers for human cancer precision medicine, synthetic lethal and resistance mechanisms underlying disease development and signal transduction at the systems level.
The postdoctoral research will be performed in a highly interdisciplinary and collaborative environment with world-class experts and advanced technologies and facilities, which provide unique and ideal career development opportunities for postdocs.
Eligibility Requirements:
Applicants should have a recent Ph.D. degree (or equivalent) in molecular biology, cancer biology, genetics/epigenetics, immunology, or relevant fields. We are interested in passionate and self-motivated candidates who ask fundamentally important questions and are bold in taking innovative approaches. Candidates should have previous expertise with tissue culture. Experience with high-throughput biology, CRISPR screens and next-generation sequencing is a plus.
Interested applicants should send a cover letter describing your past research experience, a curriculum vitae, and the contact information of three references to Dr. Nidhi Sahni (nsahni@mdanderson.org) with the subject line “Postdoc Application in Cancer Biology, CRISPR, and Epigenetics”.
Mentor Matching:
Successful candidates will be supervised by Nidhi Sahni, Ph.D., a faculty member and recognized leader in cancer genetics and systems biology at MD Anderson Cancer Center. Dr. Sahni has received numerous prestigious awards and strong funding support, including AACR NextGen Star, Sloan Scholar Award, CPRIT Scholar Award, NIH Outstanding Investigator Award (MIRA), DoD grant, Pinnacle Research Award, Rising STARs Award, among others. Recent representative publications include Cancer Cell (2020), 37: 371-86; Cell (2015), 161: 647-60; Nature Rev Genet (2017), 18: 395-410; Cancer Cell (2018), 33: 450-462; Cell (2015), 161: 661-73; Cell (2017), 168: 856-66; Nature Commun. (2018), 9: 1317.
Experimental Radiation Oncology
Req #: 198100-0003
Job Title: Postdoctoral Fellow
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Postdoctoral research fellow to carry out studies in translational breast cancer research.The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results from basic, omic and preclinical studies into improved clinical interventions for cancer patients.
A major effort is directed towards elucidating the contribution made by heterogeneity (genomic, phenotypic, spatial and compositional) in both the tumor and its microenvironment to cancer progression and response to therapy. Technologies include
single cell RNA sequencing, ATAC-Seq, and imaging mass cytometry (IMC). Experimental models include human tumor tissue, PDX models of breast cancer and engineered mouse models.
Eligibility Requirements:
Applicants must have a recent Ph.D. (or equivalent) with experience in cancer genomics, cell biology, biochemistry, genetics or related fields. Applicants must have at least one first author publication in a high quality journal as well as a high level of written and oral communication skills in English. Experience working with mice is preferred.
Mentor Matching:
The position reports to Helen Piwnica-Worms, Ph.D.
Additional application information:
Interested applicants should submit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to Helen Piwnica-Worms, Ph.D., at hpiwnica-worms@mdanderson.org.
Req #: 198100-0004
Job Title: Postdoctoral Fellow
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The overarching goal of the Ma Lab is to understand the molecular mechanisms of tumor progression, metastasis, and cancer therapy resistance. Specifically, Dr. Ma's team is: (1) establishing new paradigms for RNA functions and mechanisms (non-coding RNAs, RNA epigenetics, and RNA-binding proteins) in tumor progression and metastasis; (2) screening for deubiquitinating enzymes that promote tumorigenesis, metastasis, and therapy resistance; (3) investigating novel regulators and regulations of tumor radioresistance and drug resistance; and (4) studying the role of specific developmental regulators in cancer, metabolism, and regeneration by using genetically engineered mouse models generated in Dr. Ma's lab.
Eligibility Requirements:
We consider highly motivated and creative candidates with a recently obtained Ph.D. degree and strong first-author publications. For those interested, please send a CV, three letters of recommendation, and a research statement (limalab2018@gmail.com). Duration of this posting: continuous until filled.
Mentor Matching:
The position reports to Li Ma, Ph.D.
Req #: 198100-0005
Job Title: Postdoctoral Fellow
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Postdoctoral positions are available immediately to work in the area of cancer biology, mouse genetics, and stem cells. The lab focuses on the roles of tumor suppressor genes and oncogenes in cell signaling pathways involved in tumor initiation, progression, tissue homeostasis, and tissue regeneration. The approaches we take range from mammalian cell culture, molecular biology, biochemistry, next-generation sequencing to mouse genetics. For more information, please visit our web site, www.JParkLab.org.
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full- time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.
Mentor Matching:
The position reports to Jae-Il Park, Ph.D.
Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.
Req #: 198100-0006
Job Title: Postdoctoral Fellow
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Postdoctoral positions are available immediately to work in the area of DNA damage repair and cancer biology. The lab focuses on the roles of tumor suppressor genes and oncogenes in DNA repair and other signaling pathways involved in tumor initiation, progression and metastasis. The approaches we take range from mammalian cell culture, molecular biology, biochemistry to mouse genetics. We also conduct large-scale proteomic studies and gRNA screens to explore various cancer related signal transduction pathways.
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.
Mentor Matching:
The position reports to Junjie Chen, Ph.D.
Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.
Req #: 198100-0007
Job Title: Postdoctoral Fellow
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Postdoctoral research fellow to carry out studies in translational breast cancer research.The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results using transgenic mouse models as well as patient derived xenograft models. Specific pathways that examine the alteration of the G1/S transition and upregulation of IL-6 will be interrogated in these mouse model systems. Technologies include transgenic mouse modeling, single cell RNA sequencing, immune profiling and in vivo drug studies.
Learning Objectives:
In addition to wet bench and mouse model experiments, the post-doc will also have the opportunity to work with clinical investigators in the breast medical oncology and breast surgical oncology departments to learn how best to translate their pre-clinical work into clinical trials.
Eligibility Requirements:
Applicants must have a recent Ph.D. (or equivalent) with experience in cancer genomics, cell biology, biochemistry, genetics or related fields. Applicants must have at least one first author publication in a high quality journal as well as a high level of written and oral communication skills in English. Experience working with mice is preferred.
Mentor Matching:
The position reports to Khandan Keyomarsi, Ph.D.
Additional Application Information:
Interested applicants should saubmit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to Dr. Keyomarsi at kkeyomar@mdanderson.org.
Experimental Therapeutics
Req #: 404400-00002
Job Title: Postdoctoral Fellow
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The laboratory of Dr. Bulent Ozpolat in the Department of Experimental Therapeutics is seeking a post-doctoral fellow to study pharmacokinetics, apoptosis and atophagy as cellular death mechanism. Our laboratory explores the mechanisms of cancer cell survival, tumorigenesis and tumor progression and is focused on identifying signaling pathways regulating proliferation, invasion, drug resistance, apoptosis and autophagy. These studies provide a rational and basis for the development of therapeutic applications using RNA-inteference (siRNA and microRNA), oligonucleotides, (antisense), chemotherapeutic agents and small molecules in cancer and a wide variety of other diseases. Nanomedicine functions as a critical bridge that will connect basic science discoveries and clinical applications by enabling the development of highly effective targeted therapies utilizing nanoparticles that capable of delivering therapeutic payloads to disease sites and targeting identified molecular pathways.Our long-term goal is to development clinically relevant, non-toxic, tumor-targeted nano-therapeutics agents that can be used translated into the clinic to improve the treatment options for the patients therapy and further enhance efficacy of current regimens.
Learning Objectives:
Under the supervision of the faculty mentor, will study pharmacokinetics, apoptosisand autophagy as cellular death mechanisms induced by novel compounds and siRNA and will have experience in laboratory techniques, including cell culture small interfered RNA (siRNA) and micro RNA-based gene silencing/regulation, pharmacokinetics, apoptosis and autophagy as cellular death mechanisms fluorescent microscopy, confocal imaging, and flow cytometry applications.
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking an appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.
Program Dates:
October 06, 2020 - October 05, 2021
Mentor Matching:
The position reports to Bulent Ozpolat, M.D., Ph.D.
Gastrointestinal Medical Oncology
Req #: 600656-0001
Job Title: Postdoctoral Fellow
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A joint postdoctoral position is immediately available in the Gastrointestinal Medical Oncology (GIMO) and Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform to conduct research in cancer biology of intestinal adenocarcinomas. This position is responsible for characterizing the preclinical biology of minimal residual disease (MRD) in colorectal cancer. Projects will include the development use and characterization of minimal residual disease mouse models that represent micrometastases, their evolution, and drug resistance. Clonal evolution and immune infiltration will be examined using CRISPR barcoding approaches, single cell RNAseq, FACS and multiplex immunofluorescence. These studies include modeling and connections to clinical efforts involving MRD identified by circulating tumor DNA (ctDNA).
Learning Objectives:
Learning objectives are to better understand colorectal cancer tumor heterogeneity and evolution in response to therapy. Plan and perform research project using molecular biology techniques, such as cloning, transfection, site-directed mutagenesis assay, allelic expression assay, CRISPR driven cell barcoding, flow cytometry single cell RNAseq and ctDNA analysis. Generate or learn to generate animal transgene expression and targeting constructs, including those using Cre/lox and CRISPR technologies Evaluate targeted drugs key molecular targets in minimal residual disease as part of a drug development program. Examine the molecular and cellular evolution in colorectal cancer development by single cell RNAseq.
Eligibility Requirements:
M.D. and/or Ph.D. degree in the following areas: Biochemistry, Cellular and/or Molecular Biology.
Mentor Matching:
This position interfaces between Scott Kopetz, M.D., Ph.D., and David Menter, Ph.D., in GIMO and Timothy Heffernan, Ph.D., in TRACTION to identify and characterize minimal residual disease biology along with subtype specific targets and agents.
Req #: 600656- 00004
Job Title: Postdoctoral Fellow
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Assists principal investigator with clinical, translational, and basic scientific aims of project 1 under SPORE grant in HCC, focusing on targeting PD1 pathway in HCC which includes clinical trials data and blood and tissues samples to be analyzed for protein and molecular profiling to assess predictors of outcome. Functions in a separate and independent manner in the design and initiation of research experiments. Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. Interfaces with the electronic medical record, and databases of tissue samples blood cytokines and protein biomarkers analysis and tumor molecular data. Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications. Additionally, a. Applicant should have experience in methods of sensitive detection of proteins and also work on developing assays that can distinguish unphosphorylated proteins versus phoso-proteins in real time --using live cells, microscopy, and different fluorescent "markers". b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.
Learning Objectives:
- Understanding of biology of colon and appendiceal cancers
- Ability to search and evaluate clinical and scientific literature
- Ability to form and then defend hypotheses based on prior clinical or experimental data
- Ability to effectively communicate findings in written and oral form
- Ability to write persuasive grant applications
- Ability to navigate scientific publication process
Eligibility Requirements:
Graduate degree in medicine, science, or chemistry fields
Program Dates:
Anticipated start date 11/1/2020, average 40 hours per week is needed to accomplish goals
Mentor Matching:
This position reports to Ahmed Kaseb, M.D.
Req #: 600656-0005
Job Title: Postdoctoral Fellow
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Assists principal investigator with clinical, translational, and basic scientific
aims of our CRC Moon Shot and Astellas project. Mouse tumor, human tumor and PDX mouse model samples are to be analyzed for protein and molecular profiling to assess the impact of target metastatic site resident immune cells, immune infiltrates and mechanisms of CRC minimal residual disease (MRD). Functions in a separate and independent manner in the design and initiation of research experiments. Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. Interfaces with the electronic medical record, and databases of tissue samples blood cytokines and protein biomarkers analysis and tumor molecular data.
Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications.
Additionally,
a. Applicant should have experience in methods of sensitive detection of proteins and also work on developing assays and CyTOF and multiplex panels that can distinguish determine the impact of resident immunity, immune infiltrates and mechanisms involved in CRC-MRD.
b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.
Learning Objectives:
- understanding of biology of CRC-MRD and microenvironment interactions and predictors of outcome
- ability to search and evaluate clinical and scientific literature
- ability to form and then defend hypotheses based on prior clinical or experimental data
- ability to effectively communicate findings in written and oral form
- ability to write persuasive grant applications and scientific publications
Eligibility Requirements:
Graduate degree in verterinary medicine, science, or chemistry fields
Program Dates:
Anticipated start date 12/14/2020, average 40 hours per week is needed to accomplish goals
Mentor Matching:
This position interfaces between David Menter, Ph.D., Assistant Professor of GI Medical Oncology; and Scott Kopetz, M.D., Ph.D.,, Professor of GI Medical Oncology; Natalie Fowlkes, DVM, Ph.D: Assistant Professor of Veterinary Medicine
Genetics
Req #: 144300-00004
Job Title: Postdoctoral Fellow
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Chronic pain is usually caused by disease or damage involving the somatosensory nervous system, adversely affecting millions of Americans. It is difficult to treat and remains a major clinical problem. Opioids, acting through opioid receptors, function as powerful analgesics. However, chronic opioid treatment causes hyperalgesia/analgesic tolerance and addiction, which have resulted in an opioid epidemic in the U.S. One position involves studying the mechanisms of chronic pain in mouse models and determining how these mechanisms could be utilized in therapeutic interventions of chronic pain.
Glioblastoma is a highly heterogeneous and lethal human brain tumor and is made up of multiple molecular subtypes, suggesting that therapy could be targeted to particular subtypes. Yet all newly diagnosed GBM patients are treated with a similar therapeutic regimen, which results in overall poor patient outcomes. The second project involves discovering mechanism-based therapeutic approaches for a molecularly-stratified glioblastoma tumor using mouse models and advanced drug-delivery systems.
Learning Objectives:
The postdoctoral fellow will engage with the Pl in understanding how REST regulates either chronic pain or glioblastoma in mouse models. This will require deep interest in pain research, cell biology and developmental biology, and depending on the project, on bioinformatic analyses. The Pl will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation, but the fellow is expected at the same time to consistently undertake an active role in researching the literature and bringing new perspectives to the laboratory. Trainings that may be needed that are outside of the expertise of the Pl will involve attending courses or engaging in collaborative ventures. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory, and, equally importantly, to promote one's research program after leaving the laboratory.
Eligibility Requirements:
We are looking for a committed Postdoctoral Fellow to join our group to work on the mechanisms by which the transcriptional repressor REST regulates chronic pain and glioblastoma regulation.
Excellent experience in epigenomic research is required. Excellent experience in Molecular Biology techniques such as ChIP, RT-PCR, Immunofluorescence microscopy, SDS-PAGE, Analytical chromatigraphy, and bioinformatic analysis is required.
Mentor Matching:
This position reports to Sadhan Majumder, Ph.D.
Additional Application Information:
Learn more about Dr. Majumder’s lab.
Req #: 144300-00003
Job Title: Postdoctoral Fellow
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Developmental birth defects, and failed pregnancies, are often linked directly to poor oocyte quality. For example, a poor-quality oocyte with wrong number of chromosomes results in severe aneuploidy in the fetus during early development leading to embryonic birth defects or death. However, several fetal abnormalities occur despite a normal oocyte chromosomal complement, suggesting that factors in addition to chromosomal numbers regulate oocyte quality. These factors remain unknown because the cell-intrinsic molecular cues, and the cellular and physiological parameters that determine oocyte quality remain mostly uncharacterized. The growth of the oocyte to its final size and accumulation of the cytoplasmic and maternal components - critical for early fetal development - occur during meiosis I of oogenesis. Mammalian meiosis I is largely completed in the fetal ovary. Thus, deciphering the molecular cues, and physiological states within the meiosis I oocyte in vivo remains a challenge.
Caenorhabditis elegans forms an excellent model system to understand the cellular and genetic mechanisms of oocyte quality at meiosis I; meiosis I of oogenesis occurs during adulthood in C. elegans. As in vertebrates, oocyte growth and development is controlled by the ERK signaling pathway in worms. We have shown that loss of ERK activity from oocytes, results in formation of giant oocytes, and conversely, excessive ERK activity results in multiple small oocytes (. Both large and small oocytes result in embryonic death or infertility. We have also shown that insulin like receptor (DAF-2) and maternal nutrition regulate the RAS-ERK signaling pathway to control oocyte growth and quality. Thus, a major goal in the lab is to investigate the role of ERK signaling that result in accurate regulation of germ cell development and oocyte quality.
Learning Objectives:
The postdoctoral fellow will engage with the PI is determining how ERK MAPK signaling functions during germ cell development. This will require deep interest in cell and developmental biology, including an interest in mathematical modeling of imaging data. The Pl will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation. Additional training will be provided by the mentor through courses and workshops offered by Cold Spring Harbor Labs, MBL among others. These will be determined by the trainee and the PI as the need arises. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory, and, equally importantly, to promote one's research program after leaving the laboratory.
Eligibility Requirements:
Ph.D. to be awarded, minimally, in the last 12 months.
Mentor Matching:
This position reports to Swathi Arur, Ph.D.
Additional Application Information:
Learn more about Dr. Arur's lab.
Req #: 144300-00005
Job Title: Postdoctoral Fellow
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The Navin laboratory has an open position for a postdoctoral fellow in molecular biology and genomics. This individual will work on projects that use single cell DNA and RNA sequencing to study genomic evolution in breast cancer particularly in the context of metastasis and chromosome biology. The ideal candidate will have strong scientific writing skills, experience in genomics and extensive training in molecular biology and next-generation sequencing methods. Some familiarity with computational biology methods, including experience in Unix/Linux, scripting languages (Perl, Python) and statistical languages (R, Matlab) is also preferred
Learning Objectives:
The individual will learn experimental methods related to performing single cell DNA and RNA sequencing experiments and will learn computational and statistical methods related to analyzing the resulting datasets. The postdoc will work closely with the PI to learn how to write and submit manuscript, write fellowship and grant applications. Towards the end of their postdoc training they will learn how to apply for faculty positions and will present their work at national and international conferences.
Eligibility Requirements:
Ph.D. degree in molecular biology, genomics or cell biology
Mentor Matching:
This position reports to Nicholas Navin, Ph.D.
Additional Application Information:
Learn more about Dr. Navin's lab.
Req #: 144300-00006
Job Title: Postdoctoral Fellow
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The Navin laboratory has an open position for a postdoctoral fellow in computational biology in the department of Genetics at the MD Anderson Cancer Center in Houston, TX. The individual will work on the development of statistical methods to analyze large-scale single cell DNA and RNA sequencing datasets to study human cancer progression. This person will lead individual projects related to cancer evolution, invasion, metastasis or therapy resistance. Strong programming skills are required in languages such as Perl, Python and Matlab. Strong statistical skills in R are also required, including knowledge of multivariate statistical methods, such as clustering, high-dimensional data reduction and phylogenetics. Good knowledge of Unix, Linux and Clusters is also necessary.
Learning Objectives:
The individual will learn cancer genomics and computational biology, particularly in relation to skills for analyzing large-scale single cell sequencing datasets. They will learn how to analyze and interpret data related to genome evolution in breast cancer. The postdoc will work closely with the PI to learn how to write and submit manuscript, write fellowship and grant applications and apply for faculty positions.
Eligibility Requirements:
Ph.D. degree in computational biology, computer science, statistics or genomics
Mentor Matching:
This position reports to Nicholas Navin, Ph.D.
Additional Application Information:
Learn more about Dr. Navin's lab.
Req #: 144300-00007
Job Title: Postdoctoral Fellow
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The Lozano laboratory has an open position for a postdoctoral fellow to study p53 genetic pathways in tumor progression.
Learning Objectives:
The individual will learn experimental methods related to the study of p53 genetic pathways in tumor progression using mice as a model system. They will work closely with the PI to learn how to write and submit manuscripts, write fellowship and grant applications, and present their work at national and international conferences. Towards the end of their postdoc training they will learn how to apply for faculty positions.
Eligibility Requirements:
Ph.D. or M.D./Ph.D. with a strong background in genetics, molecular biology or related fields
Mentor Matching:
This position reports to Guillermina Lozano, Ph.D.
Additional Application Information:
For more information please visit these websites:
Genetics Department Website
Lozano Lab Website
Genomic Medicine
Req #: 600138-00001
Job Title: Postdoctoral Fellow
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We seek a talented and highly motivated Postdoctoral Fellow to work on the cancer single cell profiling projects. The primary research focus is: to apply innovative bioinformatics approaches to dissect tumor ecosystem and better understand tumor-immune co-evolution and therapy response. In particular, to profile in-depth the cellular & functional heterogeneity, lineage plasticity and evolutionary dynamics of tumor cells, and cells of the tumor immune microenvironment (TIME).
Learning Objectives:
Gain mechanistic understanding of tumor cell heterogeneity and immune resistance. Learn skills for immunogenomics and single cell sequencing data analysis, and cancer-specific bioinformatics. Learn study design, data analysis, interpretation, presentation, and manuscript writing.
Eligibility Requirements:
Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required.
Program Dates:
The appointment is immediately available. Appointee is expected to work forty hours per week.
Mentor Matching:
This position reports to Linghua Wang, Ph.D.
Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Linghua Wang at Lwang22@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name."
Req #: 600138-00002
Job Title: Postdoctoral Fellow
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We seek a talented and highly motivated Postdoctoral Fellow to perform hands-on experiments to generate novel cell culture model systems and perform high-throughput analyses to investigate the genetic mechanisms underlying the formation and growth of gynecologic malignancies. Research will also involve scientific projects utilizing genetic mouse models of cancer with the goal of translating findings to clinically meaningful advances. The Postdoctoral Fellow will conduct experiments to measure gene expression and chromatin conformation in cultured cells and primary tissue. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars.
Learning Objectives:
The primary research focus is to gain mechanistic understanding of genetic mutations leading to formation of rare gynecologic malignancies; learn molecular biology and genomics analysis skills and train and learn study design, data analysis and manuscript writing.
Eligibility Requirements:
Individuals with a Ph.D. degree in cancer biology, molecular biology, genetics, immunology, or related fields with less than 2 years of postdoctoral experience. Experience with rodent studies is required for this role. Candidate should have strong organizational skills and the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.
Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Robert Hillman, M.D., Ph.D.
Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Robert Tyler Hillman at rthillman@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name."
Consideration of applications will begin immediately and continue until the position is filled.
Req #: 600138-00003
Job Title: Postdoctoral Fellow
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We seek a talented and highly motivated Postdoctoral Fellow to perform hands-on experiments to perform high-throughput analyses to investigate links between genomic structural variation, chromatin conformation, and mechanisms underlying the formation and growth of gynecologic malignancies. The Postdoctoral Fellow will conduct experiments to measure gene expression and chromatin conformation in cultured cells and primary tissue. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars.
Learning Objectives:
The primary research focus is to gain mechanistic understanding of how cancer genome structural variation leads to the formation and evolution of gynecologic malignancies; learn molecular biology and genomics analysis skills and train and learn study design, data analysis and manuscript writing.
Eligibility Requirements:
Individuals with a Ph.D. degree in cancer biology, molecular biology, genetics, immunology, or related fields with less than 2 years of postdoctoral experience. Candidate should have strong organizational skills and the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.
Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Robert Hillman, M.D., Ph.D.
Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Robert Tyler Hillman at rthillman@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name.”
Consideration of applications will begin immediately and continue until the position is filled.
Req #: 600138-00004
Job Title: Postdoctoral Fellow
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We seek a talented and highly motivated Postdoctoral Fellow to work on lymphoma and CAR T single cell profiling projects. Our primary research focus areas are: to apply innovative bioinformatics approaches to better understand CAR T cell biology, resistance mechanisms to CAR T therapy, and the cellular & functional heterogeneity and evolutionary dynamics of cells within the tumor immune microenviroment (TME).
Learning Objectives:
The Postdoctoral Fellow will carry out integrative analysis of the multi-platform single cell sequencing (RNA/TCR/BCR/ATAC), cfDNA sequencing, and immunogenomic datasets generated on biopsies and therapeutic CAR T products from patients and patient-derived xenograft models, to comprehensively characterize the tumor ecosystem and identify predictive/prognostic signatures/biomarkers and potential targets that could be harnessed to design rational therapeutic interventions. The Postdoctoral Fellow will have great opportunities to collaborate with diverse groups of physician scientists, laboratory scientists and computational biologists at MD Anderson Cancer Center and will be co-mentored by Drs. Linghua Wang and Michael Green.
Eligibility Requirements:
Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required.
Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Linghua Wang, Ph.D. and is co-mentored by Michael Green, Ph.D., in Department of Lymphoma and Myeloma
Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Wang (Lwang22@mdanderson.org) and Dr. Green (MGreen5@mdanderson.org) with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.
Req #: 600138-00005
Job Title: Postdoctoral Fellow
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We seek a talented and highly motivated Postdoctoral Fellow to work on bladder cancer immunogenomic profiling projects. Our primary research focus areas are: to apply innovative immunogenomics and bioinformatics approaches to better understand cell biology, tumor immune evasion and evolution, resistance mechanisms to cancer immunotherapy, by deep profiling of the cellular & functional heterogeneity of tumor cells and the diverse cell populations within the tumor immune microenviroment (TIME), the lineage plasticity and evolutionary dynamics of tumor cells and tumor-immune interactions.
Learning Objectives:
Gain mechanistic understanding of tumor cell heterogeneity and immune resistance. Learn skills for immunogenomics and single cell sequencing data analysis, and cancer-specific bioinformatics. Learn study design, data analysis, interpretation, presentation, and manuscript writing. The Postdoctoral Fellow will carry out integrative analysis of the bulk and single cell sequencing (RNA/TCR/BCR/ATAC-seq), and immunogenomic datasets generated on clinical specimens from patients and animal models, to comprehensively characterize the tumor ecosystem and identify predictive/prognostic signatures/biomarkers and potential targets that could be harnessed to design rational therapeutic interventions. The Postdoctoral Fellow will have great opportunities to collaborate with diverse groups of physician scientists, laboratory scientists and computational biologists at MD Anderson Cancer Center and will be co-mentored by Drs. Linghua Wang and Jianjun Gao.
Eligibility Requirements:
Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required.
Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Linghua Wang, Ph.D. and is co-mentored by Jianjun Gao, Ph.D., in Department of Genitourinary Medical Oncology.
Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Wang (Lwang22@mdanderson.org) and Dr. Gao (JGao1@mdanderson.org) with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.
Genitourinary Medical Oncology
Req #: 600655-00001
Job Title: Postdoctoral Fellow
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Contribute to wrap up the PSOC project on metabolic perturbation of invading cancer. Transit to bone-related project work in preparation of a resubmission of an NIH-sponsored U-01 project on bone invasion. Interact with the team of Dr. Vivek Shenoy from UPENN to link cancer biology experiments to in silico modeling of cancer invasion and progression.
Learning Objectives:
Intravital microscopy, intersection of in vivo cell biology, quantitative image analysis and mathematical modeling, RNA profiling of in vivo tissue samples.
Eligibility Requirements:
The candidate has a strong track record on cell migration and live-cell / 3D microscopy, and quantitative image analysis.
Dates or Training Schedule:
Learning objectives to be achieved within 2 years, and to be expanded towards a consolidated and diversified project line thereafter.
Mentor Matching:
This position reports to Peter Friedl, Ph.D.
Req #: 600655-00002
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Genitourinary Medical Oncology at MD Anderson Cancer Center, Houston, TX. Our research is focused on understanding the molecular basis of primary and adaptive resistance mechanisms to immune checkpoint therapies in advanced prostate cancer. The laboratory focuses on addressing this issue using a wide range of tools from next-generation sequencing (WES, WGS, RNA-seq) and in vitro and in vivo immunologic assays (flow cytometry, mass cytometry, IHC). The candidate should be familiar with basic techniques in immunology, molecular biology, cell biology, and genomic profiling of tissues.
Learning Objectives:
The postdoctoral fellow will work under the supervision of Drs. Sumit Subudhi and Theocharis Panaretakis. The successful applicant is expected to develop an in-depth understanding of cancer immunology mouse models, T cell responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.
Eligibility Requirements:
Candidates should be highly motivated individuals who have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Immunology, with preferred hand-on experience in flow/mass cytometry, molecular techniques, and mouse models of autoimmunity and/or anti-tumor immunity. Only candidates who have published work from their pre- and/or post-doctoral studies will be considered.- Experience of laboratory techniques in the fields of molecular biology and immunology.
- Develop, analyze and validate data for assays using statistical methods.
- Previous experience with SOPs and animal protocols.
- Troubleshooting daily experiments.
- Demonstrated ability for creative thinking and problem solving.
- Demonstrated ability to work in a multi-disciplinary team.
Dates or Training Schedule:
Anticipated start date is October 2020.
Mentor Matching:
This position reports to Sumit Subudhi, M.D., Ph.D.
Req #: 600655-00003
Job Title: Postdoctoral Fellow
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Work within a research laboratory with focus on mechanistic and tissue based analysis of DNA repair defects and the interaction with immune response in kidney cancer. Interact with laboratory partners, bioinformatics team members and clinicians in a collaborative manner. Develop laboratory, bioinformatics and translational knowledge pertinent to project.
Learning Objectives:
Successful candidate must be able to design novel projects, create hypothesis driven experiment, maintain excellent descriptions of experiments performed, standardize and validate new methods and be able to interpret results. The candidate will develop skills that allow them to be responsible for coordinating procedures with collaborators, including bioinformatics, tissue and clinical partners. They will learn to write and edit manuscripts and reports, as well as develop grant writing skills.
Specific technical skills that will be developed include DNA damage related procedures including fiber assays, RPA exhaustion assays, use and interpretation of multispectral imaging assays. Interest in developing an understanding of bioinformatics analyses is desirable..
Eligibility Requirements:
Candidates should be highly motivated individuals who have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in molecular biology and ideally immunology, with preferred hand-on experience in molecular techniques, and mouse cancer models . Only candidates who have published work from their pre- and/or post-doctoral studies will be considered.
- Experience of laboratory techniques in the fields of molecular biology and immunology.
- Develop, analyze and validate data for assays using statistical methods.
- Previous experience with SOPs and animal protocols.
- Troubleshooting daily experiments.
- Demonstrated ability for creative thinking and problem solving.
- Demonstrated ability to work in a multi-disciplinary team.
Dates or Training Schedule:
Anticipated start date is October 2020.
Mentor Matching:
This position reports to Eric Jonasch, M.D.
Head & Neck Surgery
Req #: 137100- 00002
Job Title: Postdoctoral Fellow
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The Amit Lab, in the Department of Head and Neck Surgery at he University of Texas M.D. Anderson Cancer Center, is seeking to recruit creative and driven postdoctoral fellows interested in working at the intersection of neuroscience and cancer biology.
A major goal of the lab is to advance the current understanding of the nervous system contribution to cancer. We established experimental models in neuroscience research to uncover novel mechanisms used by the nervous system to promote tumor initiation, progression, and metastasis.
Successful applicants will be expected to develop and/or apply these models to address basic or clinical research questions within our areas of focus, including tumor differentiation and development, the cellular composition of the tumor microenvironment, and cell lineage relationships in malignant and normal tissues. Key results are further explored experimentally, both in our lab and through collaboration, with the ultimate goal of translating promising findings into the clinic.
Learning Objectives:
Learn new skills
Learn laboratory operations and how laboratory functions
Form collaborations
Publish
Apply for funding
Transition to independence as a principal investigator
Eligibility Requirements:
Ph.D or MD and research experience in, Neuroscience, Immunology, Molecular Biology, or Cell Biology or related field.
All applicants should enjoy thinking deeply and working independently but also enjoy collaborating in a dynamic, exciting, and friendly team environment.
Qualified individuals will demonstrate the potential for research as evidenced by their training and first-author peer-reviewed publications in relevant journals and should become competitive for national research fellowships.
We are looking for candidates in two general areas to support these research goals including neuroscience and cell biology.
Wet lab candidates with a strong background in cellular and molecular techniques in cancer biology, stem cell biology, or tumor immunology are required. Familiarity with basic bioinformatics analysis is required.
Previous experience in common programming languages (i.e., R or Python) and image analysis is desired.
Dates or Training Schedule:
Postdoc Appointment Term: 3-5 years
Appointment Start Date: Immediate
Mentor Matching:
This position reports to Moran Amit, M.D., Ph.D.
Req #: 137100- 00003
Job Title: Postdoctoral Fellow
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A postdoctoral position is available within the department of Head and Neck Surgery to conduct experiments in the research area of tumor immunology and immunotherapy. Candidates must have a background in immunology, cancer research, or related fields; must work well in a team environment; and must have strong communication skills. the candidate will conduct immunologic and cancer biology experiments in animal models (including syngeneic and immune-reconstituted mouse models), primary human cells, and additional model systems as needed. Familiarity with immunology laboratory techniques, and mouse model research is required. Candidates must have Ph.D. in a relevant scientific field, or M.D. degree.
Learning Objectives:
1. Mastery of the scientific method - hypothesis generation, developing experimental design to test the hypothesis, interpretation of data, drawing conclusions from results.
2. Understanding of human and murine immunology with an emphasis on host/cancer interactions, intrisic and acquired mechanisms of resistance to immunotherapy, and understanding the tumor immune microenvironment.
3. Experience with techniques and approaches to modulate the immune microenvironment of cancers, and elicit effective anti-tumor responses.
Eligibility Requirements:
Candidates must have Ph.D. in a relevant scientific field, or M.D. degree.
Dates or Training Schedule:
40 hours per week.
Mentor Matching:
Eligible candidates will have the opportunity to work with Dr. Andrew Sikora, a nationally recognized mentor with expertise in cancer immunology.
Additional Application Information:
Responsibilities:
1. Conduct laboratory research on a semi-independent basis; design and execute laboratory experiments; prepare applications/submissions for external funding; interpret data; prepare and present findings in scholarly articles, conference presentations, etc.
2. Other responsibilities: may be responsible for operation and maintenance of specific equipment; may be assigned responsibility for certain tasks within the collaborative laboratory environment; to further the research and education missions of the institution, and comply with institutional expectations and requirements.
Health Services Research
Req #: 144300-00001
Job Title: Postdoctoral Fellow
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We are looking for candidates for postdoctoral fellowships to join the Department of Health Services Research at The University of Texas, MD Anderson Cancer Center. Under the mentorship of Dr. Maria E. Suarez-Almazor, this fellowship will provide individuals with the opportunity to work with a team of accomplished researchers in the field of medical decision-making.
As a member of the team, the fellow will gain experience in evidence-based approaches which include:
- Cochrane Collaboration methods on systematic reviews of interventions.
- Designing and implementing research protocols.
- Collecting, preparing and analyzing research data; maintaining computer database of research data; tabulating and displaying data for presentation in research conferences and for manuscript.
- Preparing manuscripts for publication at the direction of the Pl. Presenting research findings at professional meetings.
Applicants selected for this fellowship will have a one- to two-year, full-time research postdoctoral position with competitive salary and benefits.
Learning Objectives:
This fellowship focuses in: 1) developing clinical decision-analytic models based on existing literature to evaluate the benefits and risks of immunotherapy for patients with autoimmune diseases and cancer; 2) conducting interviews with target audience members to assess their knowledge and literacy levels; 3) developing decision support tools tailored to patients' individual characteristics to be used during the medical encounter in English and Spanish; and 4) pilot testing decision support tools in the clinical setting.
Eligibility Requirements:
Ideal candidates enjoy being part of a team and are self-motivated, organized, detail-oriented, and highly professional with strong interpersonal and communication skills and the ability to work effectively with a wide range of constituencies. Qualified candidates should have a doctorate in medicine, health services, public health, epidemiology, or biostatistics. Prior experience in rheumatology, health services, or decision making research is strongly preferred. Publications, statistical skills, and strong ability to deliver presentations are important. All candidates must be bilingual (English and Spanish), have evidence of strong writing skills and demonstrated experience in research study design and project implementation.
Mentor Matching:
This position reports to Maria Suarez-Almazor, M.D., Ph.D.
Imaging Physics
Req #: 600651-00002
Job Title: Postdoctoral Fellow
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We are looking for several postdoctoral researchers in the areas of medical image analysis and translational cancer research to join a newly established research lab.
Learning Objectives:
The research themes are center on 1) develop innovative quantitative imaging biomarkers to characterize cancer phenotypes; 2) integrate image with multi-omics data across multiple scales to decipher cancer mechanisms; 3) validate and translate imaging biomarkers to guide clinical practice.
Eligibility Requirements:
Candidates from a diverse background are encouraged to apply. The successful applicant must have a Ph.D. in the fields of Biomedical Engineering, Applied Mathematics,Computer Science, Electronic Engineering, Bioinformatics, or related fields.
Dates or Training Schedule:
8/15/2020-8/14/2021
Mentor Matching:
This position reports to Jia Wu, Ph.D.
Immunology
Req #: 206100 -0001
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. Our research is to understand the molecular basis of T cell mediated immune responses, and how abnormal immune regulation leads to immunodeficiency, autoimmunity and cancer. Autoimmunity and inflammation mouse models include experimental autoimmune encephalomyelitis (EAE), colitis, and lung airway inflammation; tumor immunity models include T cell-mediated immune responses against transplanted melanoma, chemical induced sarcoma, and lung cancer.
Learning Objectives:
The recruiting postdoctoral fellow will conduct research in the following projects: 1. The molecular mechanisms of T cell activation and tolerance; 2. The signaling and transcriptional mechanisms underlying T helper cell differentiation and function. Mentor’s main research goal is to understand the molecular and cellular mechanisms that control the development and progress of autoimmunity, inflammation and cancer, with particular emphasis on the signaling and transcriptional mechanisms underlying T helper cell development and T cell mediated immune responses.
Eligibility Requirements:
Candidates should have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Immunology, with preferred hand-on experience in flow cytometry, molecular techniques, and mouse models of autoimmunity and/or anti-tumor immunity.
Dates of Training Schedule:
Position is opened from January 1st 2020. Training schedule: 40 hours per week.
Mentor Matching:
This position reports to Roza Nurieva, Ph.D.
Req #: 206100-00004
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. The focus of the research project is understanding the basis of CD4+ T cell and CD8+ T cell recognition of tumor antigens in the context of a dynamic tumor microenvironment and development of improved personalized cancer treatments. This project will primarily utilize preclinical transplant and genetically engineered mouse models along with high dimensional analyses approaches such as mass cytometry by CyTOF and single-cell RNA sequencing.
Learning Objectives:
The successful applicant is expected to develop an in-depth understanding of cancer immunology mouse models, cancer vaccines, T cell responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.
Eligibility Requirements:
Candidates should have a recent Ph.D. degree or be in the process of completing Ph.D. training and a solid background in Immunology, preferably with hands-on experience in mouse cancer models, flow cytometry and molecular immunology.
Dates of Training Schedule:
The position is available immediately.
Mentor Matching:
This position reports to Matthew Gubin, Ph.D.
Additional Application Information:
Successful candidates will join a collegial, dedicated group of researchers. The Department of Immunology, led by Nobel Laureate James Allison, conducts cutting-edge and diverse research using state-of-the-art tools in a highly interactive environment. Send curriculum vitae and names of three references to: Dr. Matthew Gubin, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston 77054. E-mail: mgubin@mdanderson.org.
Infectious Diseases
Institute for Applied Cancer Science
Req #: 600140-0001
Job Title: Postdoctoral Fellow
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The postdoctoral fellow will be embedded within the Structural Chemistry group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform and analyze calculations, and attend and present results at project team meetings.
Learning Objectives:
The postdoctoral fellow will learn how to a) provide computational chemistry support to drug discovery project teams, b) design novel molecules using structure and ligand-based techniques, c) interface with structural biologists and medicinal chemists, d) communicate insights from molecular modeling to a diverse team of scientists, and e) perform independent computational research aimed at improving design of novel molecules.
Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, or a related discipline.
Dates of Training Schedule:
1 year, with extension to 3 years possible
Mentor Matching:
This position reports to Jason Cross, Ph.D.
Req #: 600140-0002
Job Title: Postdoctoral Fellow
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The postdoctoral fellow will be embedded within the Structural Biology group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform biophysical experiments (X-ray crystallography, cryo-EM), and attend and present results at project team meetings.
Learning Objectives:
The postdoctoral fellow will learn how to a) express and purify high quality protein for use in biophysical and structural biology experiments, b) collect crystallographic datasets at a national lab and fully analyze to produce structural models, c) generate grids, collect data, and solve structures using cryo-EM, d) interface with computational and medicinal chemists, and e) communicate structural biology insights to a diverse team of scientists.
Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Biology, or a related discipline.
Dates or Training Schedule:
1 year, with extension to 3 years possible
Mentor Matching:
The position reports to Dr. Paul Leonard.
Req #: 600140-0003
Job Title: Postdoctoral Fellow
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The post-doctoral fellow will be embedded within the Structural Chemistry group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will develop computational tools and models, perform and analyze calculations, and attend and present results at project team meetings.
Learning Objectives:
The post-doctoral fellow will learn how to a) provide cheminformatics support to drug discovery project teams, b) develop ligand and structure based models, and publish them for team use, c) interface with computational and medicinal chemists, d) communicate insights from cheminformatics analyses to a diverse team of scientists, and e) perform independent computational research aimed at improvinq desiqn of novel molecules.
Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, Statistics, or a related discipline
Dates of Training Schedule:
1 year, with extension to 3 years possible
Mentor Matching:
This position reports to Jason Cross, Ph.D.
Interventional Radiology
Req #: 600801-00001
Job Title: Postdoctoral Fellow
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A postdoctoral research fellowship is available immediately in the Department of Interventional Radiology at The University of Texas MD Anderson Cancer Center in Houston, Texas. The fellow will participate in a highly productive multi-disciplinary research program exploring applications and effects of cell stress via thermochemistry in cancer cells and the extracellular matrix (ECM). This will include the development of native-ECM hydrogels comparable to the tumor microenvironment, and the characterization of stress responses to novel thermochemical techniques. Global and margin effects of treatment will be quantified by various methods including 3D confocal imaging of spatial distribution of the impact of the thermal and osmotic stressors. The lab is particularly interested in studying various categories of exothermic reactions performed in situ under image guidance and methods to monitor such reactions. The fellow will have an opportunity to contribute to ongoing basic and translational research and will be encouraged to explore and develop new areas of research interest.
Eligibility Requirements:
Qualified candidates should have strong background in the following areas: cancer biology, 3D cell culture, microfluidics/organ-on-a-chip, confocal imaging, and using mechanical testing methods to test and tune in vitro 3D microenvironments. The successful candidate should have a Ph.D. or M.D./Ph.D. in chemistry, molecular biology, radiation biology, or biomedical engineering with a working knowledge of animal models of cancer, particularly rodent. Experience with cell culture, heat shock proteins, stress response pathways, tumor ablation, embolization, hyperthermia, thermodynamics, heat transfer, nanoparticles and immunohistochemistry are a plus. However, applications from outstanding candidates in other spheres of expertise may be considered. Preference will be given to individuals who are about to graduate, or have graduated within the last 12 months. Strong preference will be given to individuals who are already in the United States, either as citizens or permanent residents, or have relevant work permits. Numerous opportunities for collaboration, presentation at meetings, grant writing and manuscript writing will be available, and these are expected to be leveraged by the successful applicant. Qualified candidates are expected to work independently and as part of a team, be self-motivated, have critical thinking abilities and good written and oral communication skills.
Dates or Training Schedule:
This is a two-year position but has the potential of being extended for an additional year.
Mentor Matching:
The position reports to Erik Cressman, M.D., Ph.D.
Req #: 600801-00002
Job Title: Postdoctoral Fellow
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A postdoctoral position is available in the Departments of Interventional Radiology to perform research on the use of machine-learning to predict outcomes of hepatic loco-regional therapies for the treatment of liver cancers. In particular, the postdoctoral fellow will be responsible for building predictive models for local recurrence and disease progression after loco-regional therapies.
Learning Objectives:
The postdoctoral fellow will work under the supervision of Dr. Bruno C. Odisio. The primary research focus will be conducting research using a large retrospective database of various loco-regional therapies for patients with liver cancer. The recruiting postdoctoral fellow will conduct research in the following projects: predictors of tumor recurrence following loco-regional hepatic therapies. Mentor’s main research goal is to understand predictors of success to loco-regional therapies accordingly to radiomics, molecular, advanced imaging guidance, and tumor characteristics.
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity. Strong preference will be given for candidates with training in Computer Science and Biomedical Engineering.
Dates or Training Schedule:
February 2021 - June 2022. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Mentor Matching:
The position reports to Bruno C. Odision, M.D.
lnvestigational Cancer Therapeutics
Leukemia
Req #: 600411-0002
Job Title: Postdoctoral Fellow
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The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells.
Learning Objectives:
1.) Develop skills in experimental design and conduct of biologic and molecular studies to characterize genomic alterations, epigenomic, transcriptional and protein expression studies (ATAC-Seq, ChIP-Seq, RNA-Seq, Confocal Microscopy, Flow Cytometry, Mass Cytometry and Western analysis) in bulk cell populations as well as at a single cell level.
2.) Cloning and transfer of genes into cancer cells.
3.) CRISPR-Cas9 techniques for gene-editing.
4.) Mouse xenograft models to determine biology of leukemia and lymphoma as well as to evaluate therapeutic efficacy of novel targeted agents.
Eligibility Requirements:
The qualified candidate must possess a Ph.D. in Biology, Biological Sciences, Life Sciences or related field; a keen interest and experience in cancer research; excellent English skills (both written and verbal); and current U.S. work authorization. The candidate should preferably have completed a 3 year Post-doctoral fellowship in an area relevant to the focus of research noted above. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection, analysis of gene expression through QPCR, microarrays, immunoblots and flow cytometry, as well as experience in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is preferred. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is preferred. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also preferred.
Dates of Training Schedule:
Monday - Friday, 8:00 - 6:00; Weekends when needed. Beginning April
Mentor Matching:
This position reports to Kapil Bhalla, M.D.
Req #: 600411-0003
Job Title: Postdoctoral Fellow
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The task: studying the novel immune checkpoint molecules expressed on leukemia stem cells and characterizing anti-leukemia efficacy of their targeting in immune-competent or immune-deficient humanized models of leukemia. The postdoctoral fellow will collaborate with related investigators in an interdisciplinary research project that involves immunological assays, basic cell culture, flow cytometry/sorting, metabolic assays, mass cytometry, DNA/RNA sequencing/analysis, and the use of mouse models. The postdoctoral fellow will present relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.
Learning Objectives:
Perfect and expand immunology skills; CyTOF mass cytometry; leukemia stem cell assays; in vivo work with leukemia xenograft models and novel agents that affect immune interactions
Eligibility Requirements:
The applicant should be an innovative and motivated individual with technical expertise in immunology, cancer, biochemistry, and metabolism to conduct a highly ambitious project targeting immune defects of leukemia stem cells. The ideal candidate will possess a PhD degree in a life science, like immunology, cellular or molecular biology, with research experience and an excellent knowledge-base in immunology, biochemical, and signaling process as they relate to cancer. Experience in immunology, leukemia, molecular cloning, the quantitative measurement of RNA expression, flow cytometry, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills.
Dates of Training Schedule:
May 2020
Mentor Matching:
This position reports to Marina Konopleva, M.D. Dr. Konopleva is a Professor in a Department of Leukemia, physician-scientist with over 20 years laboratory experience in hematology. She has sustained NIH funding and her research interests include leukemia stem cells, apoptosis, metabolism. She has mentored a number of post-doctoral fellows in clinical fellows over her career, many of whom have gone to assume academic positions.
Req #: 600411-0004
Job Title: Postdoctoral Fellow
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Dr. Michael Andreeff and Dr. Bing Carter, Section of Molecular Hematology & Therapy, Department of Leukemia at the University of Texas MD Anderson Cancer Center invite applications for a postdoctoral position. We are looking for a highly motivated and innovative individual with technical expertise in cell, molecular, or cancer biology to conduct a project for mechanism-based combinatorial targeting of drug-resistant leukemia stem cells.
Learning Objectives:
Applicant will conduct research into cell death and cell survival pathways, and mechanisms of drug resistance in myeloid leukemia stem cells through a combinatorial study of gene mutations, gene expression, protein expression, and responses to drug treatments in leukemia cells. The ultimate goal is to understand the functions of apoptotic regulators, cell signaling pathways, leukemia microenvironmental regulators, and their roles in drug resistance, and develop mechanism-based approach to overcome drug resistance. Researcher will collaborate with established and committed investigators in an interdisciplinary research project that involves cell culture, flow cytometry, mass cytometry, western blot analysis, immunohistochemistry, RT-PCR, DNA/RNA sequencing, and NSGS/NSG mouse models. Researcher will present scientific results in project meetings, national and international conferences, and in high impact scientific publications.
Eligibility Requirements:
The ideal candidate is a recently graduated cell, molecular or cancer biologist PhD with practical experience and excellent knowledge-base in cell death pathways and cell signaling, and with experience in at least one of the following areas of discipline: cell culture, drug treatment, and cell death assay, molecular cloning, flow cytometry, and/or mouse work. Data analysis skill is highly desirable. The applicant enjoys providing practical and theoretical training for students and promotes scientific collaboration within the research group, and will have excellent written and spoken (English) communication skills. The candidate should have one or more publication as first author.
Mentor Matching:
This position reports to Michael Andreeff, M.D., Ph.D., and Bing Carter, Ph.D.
Req #: 600411-0005
Job Title: Postdoctoral Fellow
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The task: Studying the novel immune checkpoint molecules expressed on leukemia stem cells and characterizing anti-leukemia efficacy of their targeting in immune-competent or immune-deficient humanized models of leukemia. The postdoctoral fellow will collaborate with related investigators in an interdisciplinary research project that involves immunological assays, basic cell culture, flow cytometry/sorting, metabolic assays, mass cytometry, DNA/RNA sequencing/analysis, and the use of mouse models. The postdoctoral fellow will present relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.
Learning Objectives:
Perfect and expand immunology skills; CyTOF mass cytometry; leukemia stem cell assays; in vivo work with leukemia xenograft models and novel agents that affect immune interactions
Eligibility Requirements:
The applicant should be an innovative and motivated individual with technical expertise in immunology, cancer, biochemistry, and metabolism to conduct a highly ambitious project targeting immune defects of leukemia stem cells. The ideal candidate will possess a PhD degree in a life science, like immunology, cellular or molecular biology, with research experience and an excellent knowledge-base in immunology, biochemical, and signaling process as they relate to cancer. Experience in immunology, leukemia, molecular cloning, the quantitative measurement of RNA expression, flow cytometry, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills.
Mentor Matching:
This position reports to Marina Konopleva, M.D, Ph.D. Dr. Konopleva is a Professor in a Department of Leukemia, physician-scientist with over 20 years laboratory experience in hematology.
Additional Application Information:
Dr. Konopleva has sustained NIH funding and her research interests include leukemia stem cells, apoptosis, metabolism. She has mentored a number of postdoctoral fellows in clinical fellows over her career.
Lymphoma-Myeloma
Req #: 600664-00001
Job Title: Postdoctoral Fellow
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A new postdoctoral position is available to model aberrant RNA splicing in human diseases, in the laboratory of David Symer, MD, PhD, at the world-renowned, #1 ranked MD Anderson Cancer Center in Houston, Texas, United States.
Learning Objectives:
This postdoctoral fellowship will focus on developing and studying models of aberrant RNA splicing, caused by mutations in small nuclear RNA (snRNA) transcripts which result in several human developmental diseases. Somatic mutations in snRNA genes also have been identified recently in multiple human cancers. To identify and characterize the causes and consequences of these RNA splicing-mediated diseases, we will develop and use innovative new research methods involving in vivo disease models, functional genomics/CRISPR-Cas9 technology, molecular biology, human genetics and genomics methods, single-cell sequencing, and bioinformatics analysis. This fellowship is funded by an R01 grant awarded by the National Institutes of Health.
Eligibility Requirements:
Applicants must have a recent Ph.D. and/or M.D. degree with strong research abilities and interests. The successful candidate will have a track record of productivity in research, and have the talent, energy, passion, commitment and potential to take advantage of the impressive, deep resources available at the #1 ranked University of Texas MD Anderson Cancer Center. Excellent verbal and written communication skills, molecular genetics laboratory-based technical skills and strong reference letters are required, and strong interest in developing disease models is preferred.
Dates of Training Schedule:
The appointment is immediately available. Appointee is expected to work forty hours per week.
Mentor Matching:
This position reports to David Symer, M.D, Ph.D.
Req #: 600664- 00002
Job Title: Postdoctoral Fellow
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Bioinformatics postdoctoral position in the Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Learning Objectives:
The laboratory of Dr. Michael Green is focused on understanding the molecular etiology of B-cell lymphoma, and aims to use this knowledge to identify novel therapeutic strategies. Our laboratory employs high-throughput genomics to interrogate primary tumor specimens and transgenic mouse models; including whole-genome/exome sequencing, RNA-seq, ChIP-seq, CUT&RUN and ATAC-seq, as well as cutting-edge single cell approaches. This position will focus on the integration and analysis of multi-omic datasets from patient cohorts and controlled experiments to provide biological insight.
Eligibility Requirements:
Requirements: Individuals with a PhD degree in computational biology, bioinformatics, genomics, genome science or a related field are encouraged to apply. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of biostatistics are required. Experience working in high computing cluster environment, experience working with ChIP-seq, ATAC-seq, Hi-C, or other large-scale epigenomics data analysis is highly preferred. A good understanding of cancer biology, cell signaling pathways, or drug response mechanisms is also preferred.
The University of Texas MD Anderson Cancer Center is the nation’s #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. The postdoctoral fellow will work closely with a team of wet lab researchers in the Green Laboratory, and will have great opportunities to collaborate with diverse groups of physicians, scientists and computational biologists at MDACC and the Texas Medical Center. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.
Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Michael Green, Ph.D.
Req #: 600664-00003
Job Title: Postdoctoral Fellow
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The Hun Ju Lee, M.D. at the University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated candidate for an open postdoctoral fellow position.
Dr. Lee lab is part of the Department of Lymphoma & Myeloma, which offers a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms.
Learning Objectives:
This postdoctoral fellowship will focus on exploring the role imaging analysis in patients with lymphoma.
1) To analyze our PET / CT scans using semi-automatic segmentation algorithms to measure characteristics of different subtypes of lymphoid malignancies
2) To analyze baseline PET / CT /MR data for texture and metabolic data to predict response to treatments.
3) Develop PET / CT / MRI models to monitor decrease in the volume of lymphoid malignancies
Eligibility Requirements:
Applicants should have graduated with their MD and/or PhD no earlier than 2014 and must have experience with CT/MRI/PET imagining modalities. Tumor volume and texture analysis using imaging programs such as Slicer 3D, Mango, Freesurfer or Celleste software. Anatomical understanding will be critical. Familiarity with Linux and windows is a must and coding with python, tensorflow and C++ would be highly desirable.
Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Hun Ju Lee, M.D.
Req #: 600664-00004
Job Title: Postdoctoral Fellow
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The Green Laboratory at the University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated candidate for an open postdoctoral fellow position. The project is focused on exploring the role of unique genetic drivers of B-cell lymphoma and myeloma, and circulating cell-free DNA analysis. The project will employ advanced next generation sequencing technology and patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance.
The Green lab is part of the Department of Lymphoma & Myeloma and the Department of Genomic Medicine, which offer a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Green received his training at the Dana-Farber Cancer Institute/Harvard Medical School and Stanford Medical School, and places an emphasis on career development and trainee mentorship.
Learning Objectives:
The laboratory of Dr. Michael Green is focused on understanding the molecular etiology of B-Cell lymphoma and aims to use this knowledge to identify novel therapeutics strategies. Our laboratory employs high-throughput genomics to interrogate primary tumor specimens and transgenic mouse models; including whole-genome/exome sequencing, RNA-seq, ChIP-seq, CUTRUN and ATAC-seq, as well as cutting-edge single cell approaches. This program will focus on the integration and analysis of multi-omic datasets from patient cohorts and controlled experiments to provide biological insight.
Eligibility Requirements:
The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.
Applicants should have graduated with their PhD no earlier than 2019 and must have experience with molecular biology. Experience with animal models and/or next generation sequencing and/or bioinformatics is desirable. Interested applicants are invited to submit a C.V. and cover letter.
Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Michael Green, Ph.D.
Req #: 600664-00005
Job Title: Postdoctoral Fellow
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The University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated postdoctoral fellow candidate in Dr. Michael Wang's lab. This is a full-time, hands on laboratory postdoctoral research position. We are seeking highly motivated colleagues, interested in applying his/her knowledge to in vivo tumor models, functional genomics/CRISPR-Cas9 technology, cancer biology, cell signaling, molecular biology, and pharmacology to ultimately solve therapeutic challenges in lymphoma. This position focuses on the integration and analysis of patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance.
Learning Objectives:
Dr. Michael Wang's lab is part of the Department of Lymphoma & Myeloma, which offers a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Wang currently has two R21s and two R01s funded by NIH/NCI and one CPRIT grant.
The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.
Eligibility Requirements:
Individuals with a PhD degree in bioinformatics, genomics, molecular biology, cancer biology or a related field are encouraged to apply. Must have experience with animal models. Experience with next generation sequencing and/or ChIP-seq, ATAC-seq, Hi-C, or other large-scale epigenomics data analysis is highly desirable. A good understanding of cancer biology, cell signaling pathways, or drug response mechanisms is also preferred. Interested applicants are invited to submit a C.V. and cover letter.
Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Luhua (Michael) Wang, M.D.
Req #: 600664-00006
Job Title: Postdoctoral Fellow
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The University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated bioinformatics postdoctoral fellow candidate in Dr. Michael Wang's lab. This is a full-time, hands on laboratory postdoctoral research position. We are seeking highly motivated colleagues, interested in applying his/her knowledge to in vivo tumor models, functional genomics/CRISPR-Cas9 technology, cancer biology, cell signaling, molecular biology, and pharmacology to ultimately solve therapeutic challenges in lymphoma. This position focuses on the integration and analysis of patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance.
Learning Objectives:
Dr. Michael Wang's lab is part of the Department of Lymphoma & Myeloma, which offers a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Wang currently has two R21s and two R01s funded by NIH/NCI and one CPRIT grant.
The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.
Eligibility Requirements:
Individuals with a PhD degree in bioinformatics, genomics, molecular biology, cancer biology or a related field are encouraged to apply. Must have experience with animal models. Experience with next generation sequencing and/or ChIP-seq, ATAC-seq, Hi-C, or other large-scale epigenomics data analysis is highly desirable. A good understanding of cancer biology, cell signaling pathways, or drug response mechanisms is also preferred. Interested applicants are invited to submit a C.V. and cover letter
Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.
Mentor Matching:
This position reports to Luhua (Michael) Wang, M.D.
Melanoma Medical Oncology
Req #: 600300-00001
Job Title: Postdoctoral Fellow
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A postdoctoral fellowship position is available immediately in the Department of Melanoma Medical Oncology at the University of Texas MD Anderson Cancer Center. The focus of our lab is dissecting the role of modifiable host factors on melanoma biology and anti-tumor immunity. Candidates will work with a multidisciplinary research team involving biologists, clinicians, nutritionists, epidemiologists, and bioinformaticians and under the direct supervision of Dr. Jennifer McQuade, Assistant Professor, a Physician-Scientist in Melanoma Medical Oncology, and also have opportunities for co-mentorship.
This position will include focused studies on the role of diet on melanoma biology, immune response, metabolism, and the microbiome. These preclinical studies (both in vivo and in vitro) will be in parallel to controlled feeding studies being conducted in humans by the McQuade lab with intensive translational components and the candidate will have opportunity to work on these correlative studies as well. Unique resources include metabolic phenotyping systems (metabolic mouse cage systems and Seahorse), one of the largest repositories of annotated melanoma biospecimens in the world, and resources such as patient-derived tumor cell lines with matched autologous tumor infiltrating lymphocytes. The ideal candidate will be proficient in basic molecular biology techniques (cell culture, assessment of growth inhibition and apoptosis, western blotting, immunohistochemistry, DNA/RNA/protein isolation) and or immunology (flow cytometry), and training or interest in nutritional biochemistry, as well as have experience and comfort with mouse models. Candidates should be enthusiastic about collaborative and interdisciplinary research, be eager to learn new skills and areas, self-motivated, independent, detail-oriented and a problem solver.
Eligibility Requirements:
The ideal candidate will be proficient in flow cytometry and basic immunology and molecular biology techniques (cell culture, assessment of growth inhibition and apoptosis, western blotting, immunohistochemistry, DNA/RNA/protein isolation). Candidates should be enthusiastic about collaborative and interdisciplinary research, as well as self-motivated and independent.
Mentor Matching:
This position reports to Jennifer McQuade, M.D.
Additional Application Information:
Requesting CV, Cover letter, 3 references and contact information. Please send emails to jmcquade@mdanderson.org.
Molecular & Cellular Oncology
Req #: 127800-0002
Job Title: Postdoctoral Fellow
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Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. The laboratory is also investigating the functional importance of long noncoding RNAs in metabolic disorders and has been developed CRISPR/Cas9-mediated lncRNA editing/knockout/knockin mouse models, and transgenic mouse models. The newest projects will study lncRNAs' functional roles in the development of breast/pancreatic/lung cancer, and metabolic dis orders.
Eligibility Requirements:
1. PhD in Molecular Biology, Biochemistry or related field; 2. Outstanding publication record; 3. Strong previous experience in biochemistry; 4. Prior experience in RNA biology is preferred; 5. Prior experience in genetic mouse models is preferred; 6. Excellent communication with a focus on teamwork is required.
Mentor Matching:
The position reports to Dr. Chunru Lin.
Additional application information:
Responsibilities: Use cutting-edge methods to seek novel therapy targets for human cancers and metabolic disorders; 2. Be responsible for the design and execution of experimental work, data analysis and their written records; 3. Attend and present at internal and international meetings; 4, Be expected to publish data in top scientific journals.
Req #: 127800-0003
Job Title: Postdoctoral Fellow
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The Program will define and integrate multi-scale structures and mechanisms controlling the DNA damage response to DNA double strand breaks (DSBs). DSBs are a highly cytotoxic and genotoxic form of DNA damage that can give rise to deletions, insertions, and chromosomal rearrangements, all of which are frequently observed in the genomes of cancer cells. Our NCI Program on the Structural Biology of DNA Repair strives to define abnormalities in DSB recognition and repair in cancer cells that can be targeted to enhance the efficacy of existing cancer therapies and the development of precision medicine approaches. We will determine how the core DSB repair complexes act together and the manner in which distinct DSB repair pathways are selected for lesion removal. Non-homologous end joining (NHEJ) (Aim 1), the main pathway for the repair of radiation-induced DSBs, is efficient but error-prone. The more accurate homologous recombination repair (HRR) pathway plays a lesser role in the elimination of radiation-induced DSBs but represents the primary mechanism for repairing DNA replication-associated DSBs (Aim 2). Emerging evidence points to functional interactions of HRR with NHEJ factors that challenges canonical concepts of distinct linear pathways. Furthermore, a highly error-prone, but mechanistically ill-defined minor DSB repair pathway, known as alternate end-joining (Alt-EJ), helps ensure the survival of cancer cells that are deficient in one of the major DSB pathways (Aim 3) and, as such, represents an attractive cancer cell-specific target for therapeutic development. Our integrated Aims will define the mechanistic underpinnings of the commitment step in the three DSB pathways and their crosstalk that will integrate data from atoms to cells.
Learning Objectives:
Learn advanced methods to combine X-ray scattering with X-ray crystal and cryo-EM structures. Learn to integrate these combined methods with other biophysical measurements to enable design separation-of-function mutants, test and validate mechanisms and develop inhibitor tools for cancer biology. Learn to collect, analyze, and publish experimental structural and biochemical data and develop grant proposals for research support. One focus will on whether our newly discovered interaction between Artemis and the MRE11-RAD50-NBS1 (MRN) complex provides a functional link between NHEJ and HRR and test the hypothesis whether DNA-PK and ATM-mediated Artemis phosphorylation function as a key determining switch for this pathway crosstalk.
Eligibility Requirements:
Required: PhD in structural biology and experience in the structural biology and biochemistry of DNA repair. Preferred: Two years of experience in scientific experimental research with DNA repair proteins as well as a general knowledge of DNA repair structural biology and biochemistry.
Mentor Matching:
The position reports to Dr. John Tainer.
Pathology
Req #: 600663-00001
Job Title: Postdoctoral Fellow
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A postdoctoral position is available immediately at the M.D. Anderson Cancer Center to conduct studies for the newly funded NIH ROI projects on pancreatic cancer. We are seeking applicants who are highly motivated, self-starters with strong bench skills, and can work independently. Candidates must have PhD or MD/PhD degree in biological sciences with a strong research background including designing and performing experiments involving transgenic animal models, siRNA gene silencing, IP-western, kinase assay, mammalian cell transfection techniques etc. Experience in transgenic animal models, cell cycle, receptor endocytosis, or ubiquitin pathway is a plus.
Eligibility Requirements:
Ph.D or M.D./Ph.D with 2 years minimum experience
Dates or Training. Schedule:
April 1, 2020
Mentor Matching:
The position reports to Huamin Wang, M.D., Ph.D.
Pulmonary
Req #: 600469-00001
Job Title: Postdoctoral Fellow
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This position will study the role of the platelets in the progression of cancer and on the mechanisms of platelet extravasation into tumors.
1. To design and conducts in vitro experiments on the role of platelets in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of platelets on immune cells (neutrophils, T cells, B cells, and antigen-presenting cells)
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of platelets on the growth and metastasis of different cancers, and the therapeutic benefit of platelet inhibitors on blocking tumor growth.
4. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelet extravasation into the tumor microenvironment.
5. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelets on the immune profile of tumor microenvironment.
6. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
7. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
8. To conduct DNA, RNA, and protein extraction and purification.
9. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
10. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
11. To communicate freely and clearly, but also to be respectful to other lab members.
12. Records the experiments and results meticulously.
13. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.
Learning Objectives:
- Learning to design and conduct experiments in vitro and in mouse models of cancer
- Learning to troubleshoot and analyze the generated data
- Learning important topic in platelet biology, imaging studies, immune profiling tumor microenvironment, mouse genetics
Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as ELISA, Western-blotting, flowcytomtery, RT-PCR, PCR, RNA, and DNA extraction
Familiarity with imaging studies including immunohistochemistry and immune fluorescence microscopy
Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.
Req #: 600469-00002
Job Title: Postdoctoral Fellow
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This position will study the role of the complement system on the tumorigenesis and progression of cancer.
1. To design and conducts in vitro experiments on the role of complement proteins in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of complement proteins in proliferation, differentiation, and polarization of T cells
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of the complement system in growth and metastasis of different cancers, and the therapeutic benefit of complement inhibitors on blocking tumor growth.
4. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
5. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
6. To conduct DNA, RNA, and protein extraction and purification.
7. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
8. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
9. To communicate freely and clearly, but also to be respectful to other lab members.
10. Records the experiments and results meticulously.
11. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.
Learning Objectives:
- Learning to design and conduct experiments in vitro and in mouse models of cancer
- Learning to troubleshoot and analyze the generated data
- Learning important topic in complement biology, the immune response to the tumor, immune profiling tumor microenvironment, mouse genetics
Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as flow cytometry, ELISA, Western blotting, PCR, RT-PCR, RNA, and DNA extraction
Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.
Req #: 600469-00003
Job Title: Postdoctoral Fellow
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Lung adenocarcinoma (LUAD), is still the leading cause of cancer mortality. Unfortunately, lung cancer patients harboring activating mutations of K-ras, which are heavily associated with tobacco exposure and poor prognosis, are resistant to most forms of systemic or targeted therapies. This fact clearly indicates that there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras and/or its cooperating pathways for treatment and prevention of K-ras mutant LUAD (KM-LUAD). Accordingly, our research program is focused on airway inflammation, intrinsic (e.g. oncogene driven) and extrinsic (e.g. smoke or infection induced), and its role in airway epithelial tumorigenesis. It is known that mutant epithelial cells begin to edit the microenvironment as soon as they transform but the exact mechanisms involved in this immuno-editing process from escaping the immunosurveillance to tumor progression and contribution of pro-tumor inflammatory signals in this process still not well understood.
Our laboratory has developed and interrogated various human-relevant mouse models that closely emulate the molecular pathobiology of human airway inflammation, COPD, and lung cancer. We have previously shown that a network of immunomodulatory cytokines released during inflammation promotes lung tumorigenesis by providing a pro-tumor lung microenvironment in a genetic mouse model of lung cancer with K-ras mutation. We have further shown that targeting inflammatory pathways and modulating this cytokine network could be used as a preventive and therapeutic strategy for KM-LUAD. We are currently dissecting the cell-specific autocrine and paracrine mechanisms responsible for this phenomenon. We employ genetic and pharmacologic targeting interventions, immunophenotyping, histopathology, single-cell RNA sequencing, and other RNA- and protein-based approaches to study the effect of targeting these pathways on tumor cells and changes in immunomodulatory responses in vivo that could affect the pathogenesis of KM-LUAD.
These studies have the potential to detect and target important immunomodulatory pathways in the lung tumor cells and infiltrating immune cells, which could have major impacts on personalized prevention and treatment of lung cancer. They will also lay the groundwork to develop predictive and prognostic biomarkers to identify responders and non-responders.
Learning Objectives:
1. To prepare and conduct in vivo studies of lung inflammatory microenvironment and lung cancer using mouse models.
2. To prepare and conduct ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and immunofluorescence staining.
3. To performs microscopic and morphometric image analyses of histological specimens.
4. To perform RNA and protein-based analysis of tumor and immune cells.
5. To perform cell sorting and flow cytometry of lung infiltrating immune cells.
6. To extract and record relevant information from published literature.
7. To learn data analysis, and graph/figure preparation for presentations (poster, and oral), manuscripts, reports, and grant proposals.
8. To learn writing and submitting manuscript as well as grant proposal.
9. To present at the local, national, and international meeting.
10. To co-mentor undergrad, graduate students, and other trainees.
Eligibility Requirements:
EDUCATION: Required: PhD
EXPERIENCE: Required: Basic molecular biology and immunology techniques are required. Work experience with small rodents is a plus.
Mentor Matching:
The position reports to Seyed Moghaddam, M.D.
Req #: 600469-00004
Job Title: Postdoctoral Fellow
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Pneumonias are a leading cause of death in all populations, and exact a particularly severe toll on immunocompromised individuals, such as cancer patients receiving cytotoxic therapies or those who have received stem cell transplants. In an effort to protect vulnerable patients against lethal pneumonias, the Evans lab investigates means to manipulate the lungs’ intrinsic antimicrobial defenses to protect against the pathogens that people inhale or aspirate every day. Rather than rely on the canonical responses of leukocytes that are often deficient or dysfunctional in our cancer patient populations, the focus of our work is on manipulating microbicidal responses directly from lung epithelial cells, a long-lived cell population that is largely tolerant of cytotoxic therapies. Using this approach, the Evans lab has discovered epithelium-focused immunostimulatory therapies that are now in FDA-approved clinical trials in a variety of settings.
Our work now focuses on understanding how this manipulation can prevent both acute (lethal pneumonia) and chronic (asthma) complications of respiratory infections. Such understanding can allow development of next-generation therapies that exert even greater efficacy with even fewer off-target effects. Active projects in the laboratory include investigations into novel mechanisms to detect pathogens (and our pathogen-associated molecular pattern-based therapies), into mechanisms of intra- and inter-cellular signaling events that promote synergistic protective responses, into the inducible microbicidal effector mechanisms that reduce pathogen burdens, and into immunomodulatory effects of our epithelial treatments that exert their effects independent of pathogen burden.
Learning Objectives:
1. To prepare and conduct in vivo studies of pneumonia and pneumonia protection in wildtype and genetically-manipulated mice.
2. To prepare and maintain cultures of immortalized and primary cells to investigate mechanisms of inducible protection.
3. To prepare and conduct ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and immunofluorescence staining.
4. To perform microscopic and morphometric image analyses of histological specimens.
5. To perform RNA and protein-based analysis of epithelial cells and leukocytes.
To perform cell sorting and flow cytometry to characterize immune responses.
7. To extract and record relevant information from published literature.
8. To learn data analysis and figure preparation for presentations.
9. To learn to write and submit manuscripts and grant proposals.
10. To present data and literature reviews at local, national, and international meetings.
11. To mentor undergraduate, graduate students, and other trainees.
12. To develop organizational and leadership skills in preparation for a career in science.
Eligibility Requirements:
EDUCATION: Required: Ph.D. or M.D.
EXPERIENCE: Required: Basic molecular biology and immunology techniques are required. Work experience with small rodents is a plus.Mentor Matching:
Mentor Matching:
The position reports to Scott Evans, M.D.
Additional Application Informaiton:
SUMMARY:
Function: Carrying out studies of therapeutically-inducible lung antimicrobial responses to protect vulnerable subjects against pneumonia.
Scope: Enhance our understanding of the mechanisms of inducible antimicrobial responses from lung parenchymal cells, particularly epithelia, to protect against acute and chronic complications of lower respiratory tract infections.
ESSENTIAL JOB FUNCTIONS:
1. Prepares and conducts in vivo studies of inducible lung antimicrobial responses, including breeding mutant and wildtype mice, delivering various treatments to mice, delivering infectious challenges to mice, clinically assessing mice, harvesting mouse tissues, euthanizing some mice, and keeping excellent records of these processes.
2. Establishes and maintains in vitro/ex vivo cultures of primary and immortalized cells.
3. Prepares and conducts ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and in situ hybridization.
4. Performs microscopic and morphometric image analyses of histological specimens.
5. Constructs, assembles, and operates laboratory apparatus and equipment including thermocyclers, agarose gel electrophoresis units, nebulizers/gas compressors, and spectrophotometers.
6. Cultures and expands various microorganisms for both in vitro and in vivo infectious challenges.
7. Isolates, extracts, purifies, and analyzes mouse genomic DNA for genotyping purposes using PCR.
8. Isolates, extracts, purifies, and analyzes mouse RNA for purposes of gene expression analysis.
9. Performs cell sorting and flowcytometry.
10. Performs protein extraction and performing the protein based assays including ELISA and Western Blot
11. Reads literature relevant to lung infections, epithelial biology, immune cell functions and/or laboratory methods.
12. Communicates freely and clearly, and must confer with superiors regarding new procedures and modify them according to the needs of the project.
13. Records and evaluates data obtained in accordance with methods requested and confers with superiors regarding results obtained.
14. Analyzes data, prepares graphs and figures, and helps in writing and submitting manuscripts.
PERIODIC FUNCTIONS:
1. Presents data in formal departmental Laboratory Seminars.
2. Presents papers in departmental Journal Clubs.
3. Present data in weekly meetings of the Evans laboratory personnel.
4. Present papers in weekly Evans laboratory Journal Clubs.
5. Present data in national and international meetings in form of poster or podium talk.
SUPERVISION:
Received: Scientific Mentor and Technical supervisor.
Given: Laboratory Assistants, undergrad and grad students.
Radiation Oncology
Req #: 600661-0003
Job Title: Postdoctoral Fellow
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Postdoctoral positions are available immediately to work in the area of endoplasmic reticulum stress/unfolded protein response and cancer biology. Candidates should possess mastery of basic knowledge and techniques in molecular & cell biology, biochemistry, and mouse genetics. Knowledge and hands-on experience in immunology research is desirable. The candidate should also be highly motivated in learning new techniques and independent thinking. Compensation will adhere to institutional and NIH postdoc guidelines.
Learning Objectives:
- Use cutting-edge methods to delineate cancer-promoting cellular & molecular mechanisms and seek novel cancer therapy targets
- Be responsible for the design and execution of experimental work, data analysis and their written records
- Attend and present at internal and external meetings
- Publish data in top scientific journals
Eligibility Requirements:
- PhD in Cell and Molecular Biology, Biochemistry or related field obtained within three years.
- Outstanding publication record.
- Prior experience in in vitro & in vivo pharmacological studies is preferred.
- Prior experience in in vitro & in vivo immunological assays and flow cytometry analysis is a plus.
- Prior experience in genetic mouse models is a plus.
- Basic skills in data analysis using e.g. Excel and GraphPad Prism is required.
- Excellent communication with a focus on teamwork is required.
Mentor Matching:
This position reports to Albert Koong, M.D., Ph.D.
Additional application information:
The major focus of our laboratory is to investigate tumor microenvironment-regulated signaling pathways that contribute to tumor progression and resistance to anti-cancer therapy. Our laboratory has shown that the IRE1alpha-XBP1 pathway, a key component of the unfolded protein response (UPR), was activated by stress signals in the tumor microenvironment, such as hypoxia. Since identifying IRE1alpha-XBP1 as a potential therapeutic target in cancer, our laboratory has completed a high throughput small molecule screen of >120,000 compounds for inhibitors of this pathway and identified classes of compounds that selectively inhibit the endoribonuclease activity of IRE1alpha and demonstrate potent anti-cancer activity (Papandreou et al., Blood 2010; Jiang et al., Mol Cancer Ther 2016). To further accelerate the preclinical evaluation of other compounds targeting this pathway, we also developed an XBP1-luciferase transgenic mouse in which luciferase activity is detectable only when XBP1 is activated (Spiotto et al., Cancer Res 2009). In addition, the laboratory has completed a genome wide siRNA screen to identify other genes that are required for the activation of IRE1alpha (Yang et al., Mol Cancer Res 2017). Studies investigating the mechanisms of IRE1alpha activation will lead to the development of novel cancer therapeutics targeting this pathway. More recently, our laboratory has developed several computational biology methods of analyzing the drug screening data to improve the efficiency of drug discovery (Jiang et al. Jiang et al., Mol Cancer Ther 2016; Alagappan et al. Adv Exp Med Biol 2016), as well as novel application of artificial intelligence (AI) and deep learning approaches in drug discovery (Yuan et al. J Chem Inf Model 2017).
Our ongoing research projects include:
(1) Studying the role of IRE1alpha/XBP1 in tumor progression and chemo-/radio-resistance, using in vitro cell culture and organoid systems as well as in vivo xenograft and genetically modified mouse tumor models.
(2) Investigating the role of IRE1alpha/XBP1 in regulating proliferation and DNA damage response pathway.
(3) Developing biomarkers that may be used to guide therapeutic decisions in pancreatic cancer (Danai et al., Nature 2018; Qian et al., JAMA Oncol 2018).
Req #: 600661-0004
Job Title: Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.
The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.
An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.
Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org).
Eligibility Requirements:
A recent Ph.D. or equivalent doctorate in microbiology (or similar, with experience in microbiology laboratory-based research and molecular biology) who is seeking a temporary appointment under the supervision of a faculty mentor involving full-time laboratory based research and scholarship in preparation for an academic or research career as an independent investigator.
Mentor Matching:
This position reports to Lauren Colbert, M.D.
Additional application information:
Required Background/ Skills:
- PhD in Microbiology or related field and relevant research experience
- Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development
Preferred Background/ Skills:
- Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
- Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
- Development and testing of model microbial systems in animals
- Experience with immune assays including flow cytometry and immunohistochemistry
- Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.
Req #: 600661-0005
Job Title: Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a funded project that will investigate how to exploit mitochondrial dynamics for therapy against pancreatic cancer. This project uses a combination of microscopy, metabolomics, cell biology, and mouse models and the successful candidate should have some experience in several of these core skill sets. Competency with SeaHorse is helpful, but expected.
Learning Objectives:
- Training and expertise in mitochondrial metabolism and mitochondrial biology
- Experimental approaches to model tumor-stroma interactions
- Expectations to present and publish their data in a timely fashion
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.
Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.
Dates or Training Schedule:
Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars
Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.
Req #: 600661-0006
Job Title: Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a NIH/NCI-funded project that seeks to protect the intestine from radiation injury. This science has implications for oncology treatments (pancreatic and liver cancers) and nuclear countermeasures (medical response to a terrorist attack or nuclear accident). The successful candidate will have significant experience in intestinal stem cell biology or radiation biology/physics. Experience with molecular biology, histology and tissue preparation, cell biology, and mouse modeling are very
helpful but not required.
Learning Objectives:
- Training and expertise in radiation biology, intestinal stem cell biology
- A stimulating environment with freedom to develop new research directions, includingmechanistic approaches to understanding and translating EGLN inhibition to protect thesmall intestinal tract.
- Expectations to present and publish their data in a timely fashion
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary
appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an
independent investigator.
Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.
Dates or Training Schedule:
Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars
Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.
Req #: 600661-0007
Job Title: Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.
The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.
An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.
Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org).
Mentor Matching:
This position reports to Lauren Colbert, M.D.
Additional application information:
Required Background/ Skills:
- PhD in Microbiology or related field and relevant research experience
- Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development/ optimization
Preferred Background/ Skills:
- Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
- Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
- Development and testing of model microbial systems in animals
- Experience with immune assays including flow cytometry and immunohistochemistry
- Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.
Req #: 600661-0008
Job Title: Postdoctoral Fellow
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A postdoctoral fellow position is available in the department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. The program consists of a proposed plan for Health Economics Analysis of Proton Therapy vs. IMRT for Patients with Head and Neck Cancer. The program is designed to estimate the cost-effectiveness for all patients diagnosed nationally using US cancer statistics and to estimate economic burden of treating head and neck cancer in the US, considering lifetime treatment cost as well as the growing incidence of head and neck cancer in the future.
Learning Objectives:
- Lifetime cost per patient
- National annual cost of head and neck cancer management
- If there are cost differences, then national expenditure of treating patients using Proton therapy compared to IMRT
- Incremental cost-effectiveness ratio (ICERs) to identify valuable treatment
- ICERs specific to patient characteristics to evaluate whether the cost-effective strategy shifts
- Model will be validated through cross validation with by comparing with the model of the HPV-positive oropharyngeal cancer natural history and disease burden, and independent validation with empirical data sources.
Mentor Matching:
This position reports to Steven Frank, M.D. We will match the candidate with the appropriate co-mentoring team of faculty with the relevant expertise for the proposed post-doctor.
Dates or Training Schedule:
04/01/2020- 04/01/2021
Req #: 600661-0009
Job Title: Postdoctoral Fellow
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Postdoctoral position is available immediately in the area of cancer immunology and translational research. The laboratory seeks to identify novel agents and targets to enhance immune responses with cancer therapies and translate those findings to the clinic in ongoing clinical trials. We are interested in studying immunologic mechanisms that confer response through targeting dendritic cell and lymphocyte activation using various in vitro and in vivo tumor models.
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. The candidate should have proven scholarship in publications and presentations at major meetings in immunology, preferably cancer immunology.
Mentor Matching:
This position reports to Steven H. Lin
Dates or Training Schedule:
Available immediately, 3 years at the minimum
Additional Application Information:
We seek applicants who are self-motivated and career-oriented who ultimately would want to become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in immunology, cancer biology and translational collaborations.
Req #: 600661-0010
Job Title: Postdoctoral Fellow
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The program is introducing a formal one-year educational and research program that will effectuate expertise sufficient to lead and accelerate the development of biomedical imaging application in radiation oncology. We aim to develop and effectuate a program that includes a mentored
education, training, and hands-on implementation of research activities related to biomedical imaging, clinical informatics, and clinical trial design and to enhance the recruitment of early career physician scientist from under-represented minorities or with disabilities or other social, cultural, economic, or educational disadvantages to enrich the diversity of our national workforce in biomedical imaging. Successful implementation of this program will directly augment novel research approaches towards the development of new biomedical imaging techniques and devices to fundamentally improve the detection, treatment, and prevention of disease; as well as enhancing existing imaging and clinical research and its implications.
Learning Objectives:
One of our direct objectives is to inculcate trainees with requisite research skills for integration of biomedical imaging and clinical imaging informatics in radiation oncology applications.
Eligibility Requirements:
Domestic resident post-graduate physician trainees (PGY1-4).
-Accepted to the ACGME MD Anderson Clinical Radiation Oncology Program.
-Academically gifted physician trainees desiring a focal clinical research development term, and commitment to formal K01/K08/K12/K23 award application by R25 term completion.
-Commitment to academic radiation oncology career
-Evidence of clinical and scholastic performance (USMLE, undergraduate medical GPA, recommendation letters, etc.)
-History of publication or prior research is favorable
-Commitment to 1-year post-clinical residency clinical research fellowship (i.e. 1 year of R25-supported focal research effort).
Mentor Matching:
This position reports to Clifton David Fuller, M.D., Ph.D. and Kristy K. Brock, Ph.D.
Dates or Training Schedule:
August 2020 through February 2021
Req #: 600661-0011
Job Title: Postdoctoral Fellow
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A Postdoctoral Fellow position is avaialable in the department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. Dr. Chung's lab major research focus is to utilize advanced medical imaging tools to measure and predict response and toxicity to treatment with novel systemic agents and high precision radiotherapy. In addition, the lab is working on the standardization of collection and nomenclature of images to facilitate meaningful measurements and interpretation of imaging biomarkers across departments and institutions.
Learning Objectives:
The Postdoctoral Fellow will develop quantitative imaging processing and analysis approaches in order to identify key imaging parameters that can be utilized as imaging biomarkers and to guide adaptice radiotherapy approaches. In addition, the Postdoctoral Fellow will also assist in leadership and mentoring of undergraduate and graduate students.
Eligibility Requirements:
Successful applicants must have a PhD and/or MD degree with less that 2 years of postdoctoral experience, at least one first author publication, as well as a high level of written and oral communication skills in English.
Mentor Matching:
This position reports to Caroline Chung, M.D., a practicing central nervous system radiation oncologist with a translational research career focused on imaging biomarkers to guide personalized cancer therapy.
Dates or Training Schedule:
This position is open immediately.
Req #: 600662-0010
Job Title: Postdoctoral Fellow
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Development of evaluation metrics for radiation therapy treatment plans based on patient outcomes. We will develop an evaluation methodology that quantifies the probability of a particular patient outcome based on the patient's radiation therapy treatment plan. The resulting metric will then be used to develop a scoring system for patient plans.
Learning Objectives:
1. Learn how to correlate patient outcomes to radiation therapy treatment plans.
2. Learn how to create probability density functions that converts a planned radiation therapy dose into a probability for a particular patient outcome.
3. Learn about radiation oncology and medical physics in general.
Eligibility Requirements:
The ideal candidates should have finished (or be about to finish) their Ph.D. degree in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python, R and/or C# is required. The individual is
expected to work within a large group of motivated interdisciplinary professionals.
Program Start Date:
This position will start as soon as a suitable candidate is able to start.
Mentor Matching:
The position reports to Dr. Thomas Whitaker and Dr. Laurence Court.
Radiation Physics
Req #: 600662-0003
Job Title: Postdoctoral Fellow
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A postdoctoral position is immediately available in the Departments of Experimental Radiation Oncology and Radiation Physics to perform research in radiation induced immune activation. In particular, the postdoctoral fellow will be responsible for examining the use of different types of radiation, including photons and photons, in combination with DNA repair defects and immunotherapy to induce a systemic anti-tumor immune response.
Learning Objectives:
To understand how radiation in combination with DNA repair defects, DNA repair inhibiting drugs, and immunotherapy can activate a systemic anti-tumor immune response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.
Eligibility Requirements:
Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, immunology, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with immunology, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.
Dates of Training Schedule:
Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Mentor Matching:
The postdoctoral fellow will be mentored by Simona Shaitelman, M.D., and Gabriel Sawakuchi, Ph.D. to identify combination strategies to activate anti-tumor systemic responses.
Additional application information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.
Req #: 600662-0001
Job Title: Postdoctoral Fellow
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A postdoctoral position is immediately available in the Departments of Radiation Physics and Experimental Radiation Oncology to perform research in genomic biomarkers of radiation response. In particular, the postdoctoral fellow will be responsible for developing a bioinformatics pipeline to analyze cancer cell line and patient data from treatments with photon and proton therapies.
Learning Objectives:
To understand genomic biomarkers of radiation response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.
Eligibility Requirements:
Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, bioinformatics, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with bioinformatics, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.
Dates or Training Schedule:
Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Mentor Matching:
The postdoctoral fellow will be mentored by Gabriel Sawakuchi, Ph.D. and Simona Shaitelman, M.D., to identify genomic biomarkers of radiation response.
Dates or Training Schedule:
Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Additional Application Information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.
Req #: 600662-0002
Job Title: Postdoctoral Fellow
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in application of Case-Based Reasoning to Radiation Therapy Treatment planning.
Learning Objectives:
The learning objectives are to evaluate the efficacy and application of Case Based Reasoning approach to Radiation Therapy treatment planning and to explore its limitations and strength.
Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics and/or Computer Science
Mentor Matching:
This position reports to Mohammad R. Salehpour, Ph.D.
Additional Application Information:
Desired experiences: Radiation Treatment Planning, Python and C++, Artificial Intelligence and Fuzzy Logic programming
Req #: 600662-0004
Job Title: Postdoctoral Fellow
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Learning Objectives:
The learning objectives are to develop and evaluate the performance of a novel automated treatment planning solution for a new treatment unit.
Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics or Nuclear Engineering
Mentor Matching:
The position reports to Laurence Court, Ph.D., and Carlos Cardenas, Ph.D.
Additional application information:
Desired experiences: Radiation Treatment Planning, Python, and Artificial Intelligence.
Req #: 600662-0005
Job Title: Postdoctoral Fellow
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in Radiation transport and X-ray diffraction as applied to Radiation Therapy. The successful applicant will join a team of highly accomplished scientists to assist with computer simulation code development for the design and implementation of a novel radiation therapy delivery system.
Learning Objectives:
The learning objective of this fellowship is to evaluate the efficacy of focusing x-ray radiations using metallic crystals and further study its usability in treatment of cancerous tumors.
Eligibility Requirements:
The ideal candidate should have a PhD in physics and have experience in performing radiation transport calculations using Monte Carlo techniques. In addition he/she should have proven working knowledge of multiphysics simulation software and CAD systems, and be well versed in calculational methods of X-Ray diffractions.
Mentor Matching:
The postdoctoral position reports to Mohammad Salehpour, Ph.D.
Req #: 600662-0006
Job Title: Postdoctoral Fellow
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Research into applications of deep learning and radiomics to understand patient outcomes. The fellow will help develop software tools for analyzing images and predicting outcomes. We will focus specifically on understanding how images can be used to support clinical decision making for patients with metastatic brain lesions.
Learning Objectives:
1. Learn how radiomics and deep learning can be applied to problems in radiation oncology
2. Learn how to investigate the impact of image quality on image analysis tasks
3. Learn about radiation oncology and medical physics in general, including how artificial intelligence can be applied to improve these fields and patient outcomes.
Eligibility Requirements:
The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python and/or C++/C# is required. The individual is expected to work within a large group of motivated interdisciplinary professionals.
Program Start Date:
This position will start as soon as a suitable candidate is able to start.
Mentor Matching:
The position reports to Laurence Court, Ph.D., (primary), Carlos Cardenas, Ph.D., (deep learning), and Jinzhong Yang, Ph.D., (deformable image registration and auto-contouring).
Additional application information:
More information on our research group can be found at rpa.mdanderson.org.
Req #: 600662-0007
Job Title: Postdoctoral Fellow
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The fellow will develop deep-learning-based algorithms and tools for various applications in proton radiation therapy, such as fast dose prediction, plan robustness evaluation and optimization, auto segmentation and radiomics based on dual-energy CT, etc.
Learning Objectives:
1. Learn how deep learning can be used for problems in proton radiation therapy.
2. Learn how to apply mathematical knowledge and skills to medical problems.
3. Learn about radiation oncology and medical physics in general.
Eligibility Requirements:
The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python and/or C++/C# is required.
Program Start Date:
This position will start as soon as a suitable candidate is able to start.
Mentor Matching:
The position reports to Dr. Ming Yang.
Req #: 600662-0008
Job Title: Postdoctoral Fellow
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Research into applications of FLASH RT. Fellow will develop and commission FLASH beam lines, develop detectors and dosimetry protocols, and be involved in developing shielding and irradiation setups for animal irradiations.
Learning Objectives:
1. Learn how to establish FLASH beam lines and the requirements of the dosimetry.
2. Develop detectors of FLASH RT
3. Developing irradiation setups for animal irradiations
Eligibility Requirements:
The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, physics, engineering or similar. The individual is expected to work within a large group of motivated interdisciplinary professionals.
Program Start Date:
This position will start as soon as a suitable candidate is able to start.
Mentor Matching:
The position reports to Dr. Emil Schueler.
Req #: 600662-0009
Job Title: Postdoctoral Fellow
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Assists principal investigator with clinical, translational, and basic scientific
Learning Objectives:aims of our CRC Moon Shot and Astellas project. Mouse tumor, human tumor and PDX mouse model samples are to be analyzed for protein and molecular profiling to assess the impact of target metastatic site resident immune cells, immune infiltrates and mechanisms of CRC minimal residual disease (MRD). Functions in a separate and independent manner in the design and initiation of research experiments. Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. Interfaces with the electronic medical record, and databases of tissue samples blood cytokines and protein biomarkers analysis and tumor molecular data.
Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications.
Additionally,
a. Applicant should have experience in methods of sensitive detection of proteins and also work on developing assays and CyTOF and multiplex panels that can distinguish determine the impact of resident immunity, immune infiltrates and mechanisms involved in CRC-MRD.
b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.
Learning Objectives:
- understanding of biology of CRC-MRD and microenvironment interactions and predictors of outcome
- ability to search and evaluate clinical and scientific literature
- ability to form and then defend hypotheses based on prior clinical or experimental data
- ability to effectively communicate findings in written and oral form
- ability to write persuasive grant applications and scientific publications
Eligibility Requirements:
Graduate degree in verterinary medicine, science, or chemistry fields
Program Start Date:
Anticipated start date 12/14/2020, average 40 hours per week is needed to accomplish goals
Mentor Matching:
David Menter, Ph.D., Assistant Professor of GI Medical Oncology; Scott Kopetz, MD, PhD. Professor of GI Medical Oncology; Natalie Fowlkes, DVM, Ph.D: Assistant Professor of Veterinary Medicine.
Req #: 600662-0010
Job Title: Postdoctoral Fellow
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Development of evaluation metrics for radiation therapy treatment plans based on patient outcomes. We will develop an evaluation methodology that quantifies the probability of a particular patient outcome based on the patient's radiation therapy treatment plan. The resulting metric will then be used to develop a scoring system for patient plans.
Learning Objectives:
1. Learn how to correlate patient outcomes to radiation therapy treatment plans.
2. Learn how to create probability density functions that converts a planned radiation therapy dose into a probability for a particular patient outcome.
3. Learn about radiation oncology and medical physics in general.
Eligibility Requirements:
The ideal candidates should have finished (or be about to finish) their Ph.D. degree in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python, R and/or C# is required. The individual is
expected to work within a large group of motivated interdisciplinary professionals.
Program Start Date:
This position will start as soon as a suitable candidate is able to start.
Mentor Matching:
The position reports to Dr. Thomas Whitaker and Dr. Laurence Court.
Stem Cell Transplantation
Req #: 600379- 00002
Job Title: Postdoctoral Fellow
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The Rezvani laboratory broadly focuses on the role of natural killer (NK) cells in mediating protection against hematologic malignancies and solid tumors and strategies to enhance killing function against various cancer.
Learning Objectives:
- Comprehensive analysis of NK cells and their receptors in cancer following hematopoietic stem cell transplantation using mass cytometry (CyTOF) and transcriptomic profiling.
- Engineering NK cells to express chimeric antigen receptor (CAR) and cytokine genes to enhance their effector function and persistence.
- Understanding mechanisms of NK immune evasion and using gene editing tools to target checkpoints to enhance NK effector function.
- Enhancing T cell function against viruses and cancer antigens using CARs and gene editing tools such as CRISPR.
Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research in preparation for independent research/academic career.
Dates or Training Schedule:
MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.
Mentor Matching:
This position reports to Katy Rezvani, M.D., Ph.D.
Req #: 600379-00003
Job Title: Postdoctoral Fellow
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Postdoctoral research fellowship program is primary focusing on clinical training and conducting clinical researches in the field of stem cell transplantation and cellular therapy. The position is designed to provide the experience needed to perform hematopoietic cell transplant to treat patients with benign and malignant hematologic diseases as well as conduct and publish transplant-related prospective and retrospective researches. The fellow will work under supervision of Dr. Samer A. Srour and may collaborate with other faculties in the Department of Stem Cell Transplant and Cellular Therapy.
Learning Objectives:
1. Fellow will learn the processes of hematopoietic stem cell transplantation including pre-transplant patient evaluation, donor selection, mobilization and stem cell collection/apheresis, transplant procedure planning and performing, and spectrum and management of posttranspant complications.
2. Fellow will learn the processes of conducting researches in the field of hematopoietic cell transplant including data management, statistical analysis, manuscript writing and publishing research articles.
Eligibility Requirements:
Appointee must have received a Ph.D. or M.D., completed hematology training and must have at least 1 year prior experience in clinical hematology patient cares.
Dates or Training Schedule:
October 2020 through October 2023
Mentor Matching:
This position reports to Samer A. Srour, M.B.
Surgical Oncology
Req #: 600377- 00002
Job Title: Postdoctoral Fellow
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The Postdoctoral Fellowship Program is a one to five-year research fellowship dedicated to the advanced training of fellows focusing on research related to surgical oncology diseases. The goal of the fellowship is to train, and education select fellows in advanced research of multidisciplinary treatment and surgery for challenging disorders and malignancies.The responsibilities include participating in the design, implementation and evaluation of collaborative research studies; analyzing and interpreting data; creating publication quality figures summarizing data; assisting with manuscript and grant preparation; maintaining a legible and self-explanatory scientific notebook and presenting results during lab meetings and at appropriate scientific conferences. Major duties will be to conduct bench research as deemed necessary and appropriate by PI and to assist and/or collaborate with other research staff on scientific pursuits of mutual interests.
Eligibility Requirements:
The candidate should have a Ph.D. and/or M.D./Ph.D. degree in Biology/ Molecular Biology/Genetics; excellent written and verbal communication; effective judgment and problem solving, ability to work independently and collaboratively, and a solid foundation in genetically engineered animal models, microscopy and biochemistry. Expertise in Excel, and other bioinformatics analysis software; strong attention to detail, multi-tasking; and a willingness to learn new technologies.
Mentor Matching:
This position reports to Jean Nicolas Vauthey, M.D.
Req #: 600377- 00003
Job Title: Postdoctoral Fellow
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The Postdoctoral Fellowship Program is a one to five-year research fellowship dedicated to the advanced training of fellows focusing on research related to surgical oncology diseases. The goal of the fellowship is to train, and education select fellows in advanced research of multidisciplinary treatment and surgery for challenging disorders and malignancies.
The responsibilities include participating in the design, implementation and evaluation of collaborative research studies; analyzing and interpreting data; creating publication quality figures summarizing data; assisting with manuscript and grant preparation; maintaining a legible and self-explanatory scientific notebook and presenting results during lab meetings and at appropriate scientific conferences. Major duties will be to conduct bench research as deemed necessary and appropriate by PI and to assist and/or collaborate with other research staff on scientific pursuits of mutual interests.
Eligibility Requirements:
The candidate should have a Ph.D. and/or M.D./Ph.D. degree in Biology/ Molecular Biology/Genetics; excellent written and verbal communication; effective judgment and problem solving, ability to work independently and collaboratively, and a solid foundation in genetically engineered animal models, microscopy and biochemistry. Expertise in Excel, and other bioinformatics analysis software; strong attention to detail, multi-tasking; and a willingness to learn new technologies.
Mentor Matching:
This position reports to Emily Keung, M.D.
Symptom Research
Req #: 600659-0003
Job Title: Postdoctoral Fellow
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The Laboratories of Neuroimmunology consist of the research teams of five collaborating Principal Investigators who aim at understanding chronic pain, cognitive deficits and fatigue in response to cancer treatment.
We are seeking an enthusiastic Postdoctoral Researcher to study how Fe gamma antibody receptors activate astrocytes and the consequences of this new activation pathway for neuropathic pain. Investigations will be performed using primary astrocytes in vitro and rat models of neuropathic pain. Experience in working with rodents and a background in pain or immunology is preferred. The position is funded by a Department of Defense grant and is available immediately. We highly value innovation, learning. hard work, creativity and an interactive, respectful and fun atmosphere. The post-doctoral fellow will work under direct supervision of the principal investigator on this Department of Defense-funded project.
If you are interested in helping to understand the molecular and cellular mechanisms of pain and developing novel interventions to help improve the quality of life for people suffering from chronic pain in an internationally-renowned, well-funded group of scientists using a highly integrated and interdisciplinary approach in the number one cancer center in the USA, we are the perfect environment for you!
ESSENTIAL FUNCTIONS
Research Activity
- Primary astrocyte isolations and culture
- Live cell imaging
- Luciferase assays and immunoassays
- CRISPR/Cas9 gene editing in vitro and in vivo
- Nerve injury surgery
- lntrathecal drug treatments in vivo
- Behavioral assays of pain in rats
- Collect and process ex vivo biological samples including brain and spinal cord lmmunohistochemistry and microscopy studies on cells and nervous system tissues
- Western blotting and qPCR
- Present results in departmental and national meetings
- Prepare and write manuscripts for publication.
.lnterpersonal Skills, Communication, Learning Skills
- Strong written and oral communication skills, Good problem-solving abilities
- Communication with faculty and staff within and outside the laboratory, Ability to work with others in a highly collaborative manner.
Other
- Responsible for monitoring laboratory equipment and implementing safety procedures.
- Strong interest in basic and translational research
- Supervision of 1-2 research assistants
Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in models of neuropathic pain. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.
Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular consequences of peripheral nerve injury in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.
Mentor Matching:
The position reports to Peter Grace, Ph.D.
Req #: 600659-00006
Job Title: Postdoctoral Fellow
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The Laboratory of Neuroimmunology focuses on basic and translational research on exploring the mechanisms and treatment of the neurotoxic effects of cancer treatment.
Dr. Kavelaars is one of the founding scientists of the field of psychoneuroimmunology. Her research focuses on educational, behavioral, and medical interventions for pain, fatigue and cognitive impairment. Laboratory and neuroimaging studies are exploring the neurophysiological mechanisms of pain, fatigue, cognitive impairment and treatment-induced neuropathy.
Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in murine models of cancer and treatment-related neurotoxicities. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.
Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular damage to the brain as a result of cancer treatment and the neuroregenerative effects of cell therapy in the repair of structural and functional brain damage in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.
Applicants should have strong written and oral communication skills, ability to work with others in a highly collaborative manner and good problem-solving abilities.
Mentor Matching:
The position reports to Annemieke Kavelaars, Ph.D.
Req #: 600659-00007
Job Title: Postdoctoral Fellow
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The Laboratory of Neuroimmunology focuses her basic and translational research on exploring the mechanisms and treatment of the neurotoxic effects of cancer treatment.
Dr. Heijnen is one of the founding scientists of the field of psychoneuroimmunology. Her research focuses on educational, behavioral, and medical interventions for pain, fatigue and cognitive impairment. Laboratory and neuroimaging studies are exploring the neurophysiological mechanisms of pain, fatigue, cognitive impairment and treatment-induced neuropathy.
Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in murine models of cancer and treatment-related neurotoxicities. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.
Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular damage to the brain as a result of cancer treatment and the neuroregenerative effects of cell therapy in the repair of structural and functional brain damage in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.
Applicants should have strong written and oral communication skills, ability to work with others in a highly collaborative manner and good problem-solving abilities.
Mentor Matching:
The position reports to Jacoba (Cobi) J. Heijnen, Ph.D.
Req #: 600659-0008
Job Title: Postdoctoral Fellow
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The Laboratories of Neuroimmunology consist of the research teams of five collaborating Principal Investigators who aim at understanding chronic pain, cognitive deficits and fatigue in response to cancer treatment.
We are seeking an enthusiastic Postdoctoral Researcher to study how the antioxidant transcription factor NRF2 regulates neuroinflammation and neuronal hyperexcitability in neuropathic pain (Li et al., Anesthesiology (2020) 132: 343-56). Investigations will be performed using mouse models of neuropathic pain and DRG neurons isolated from human donors. Experience in working with rodents and a background in pain or immunology is preferred. The position is funded by a National Institutes of Health grant and is available immediately. We highly value innovation, learning, hard work, creativity and an interactive, respectful and fun atmosphere. The post-doctoral fellow will work under direct supervision of the Principal Investigator on this NIH-funded project.
If you are interested in helping to understand the molecular and cellular mechanisms of pain and developing novel interventions to help improve the quality of life for people suffering from chronic pain in an internationally-renowned, well-funded group of scientists using a highly integrated and interdisciplinary approach in the number one cancer center in the USA, we are the perfect environment for you!
ESSENTIAL FUNCTIONS
- Research Activity
- Live cell imaging
- Luciferase assays and immunoassays
- CRISPR/Cas9 gene editing in vitro and in vivo
- Nerve injury surgery
- Intrathecal drug treatments in vivo
- Behavioral assays of pain in mice
- Collect and process ex vivo biological samples including brain and spinal cord
- Assay human DRG neurons
- Immunohistochemistry and microscopy studies on cells and nervous system tissues
- Western blotting and qPCR
- Present results in departmental and national meetings
- Prepare and write manuscripts for publication.
Interpersonal Skills, Communication, Learning Skills
- Strong written and oral communication skills
- Communication with faculty and staff within and outside the laboratory.
- Ability to work with others in a highly collaborative manner.
- Good problem-solving abilities.
Other
- Responsible for monitoring laboratory equipment and implementing safety procedures.
- Strong interest in basic and translational research
- Supervision of 1-2 research assistants
Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in models of neuropathic pain. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.
Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular consequences of peripheral nerve injury in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.
Mentor Matching:
The position reports to Peter Grace, Ph.D.
Req #: 600659-0009
Job Title: Postdoctoral Fellow
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A position is open for a post-doctoral researcher with a strong background in behavioral neuroscience and neuroimmunology to join the Neuroimmunology lab at MD Anderson Cancer Center. Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project will study the role of inflammation and mitochondrial dysfunction in depression and fatigue using animal models of inflammation and cancer. Experience working with mice and a background in neuroscience, behavioral pharmacology and/or neuroimmunology is preferred. The position is available December 1, 2020.
Research Activity:
- Immunohistochemistry and microscopy studies on brain and other tissues.
- Behavioral assays of fatigue and motivated behavior.
- Work with genetically modified mice.
- Live-cell imaging of neuronal/immune cell physiology.
- Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues after cell separation when needed.
- Perform pharmacological manipulations in vivo.
- Prepare and write manuscripts for publication.
Learning Objectives:
Applicants should have some experience with neurobehavioral studies in mice, but training will be provided in immunohistochemistry and microscopy studies on nervous system and other tissues, live-cell imaging of neuronal/ immune cell physiology, preparing and writing manuscripts for publication, and preparing grant applications.Applicants will become proficient with in vivo longitudinal studies of pathological processes, and advanced molecular and cellular biology techniques. They will develop skills in the organization, presentation, and analysis of data. They will learn how to navigate pluridisciplinarity.
Eligibility Requirements:
Applicants should hold (or soon receive) a Ph.D. in Behavioral Neuroscience or a related discipline. Experience with rodent behavioral testing is required. Successful applicants should be highly self-motivated, have outstanding experimental skills, and be able to think independently but also work well in a plurisciplinary team.
Mentor Matching:
The position reports to Robert Dantzer, Ph.D.
Thoracic & Cardiovascular Surgery
Req #: 600386-00001
Job Title: Postdoctoral Fellow
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A postdoctoral position is available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Cardiovascular and Thoracic Surgery at The University of Texas MD Anderson Cancer Center with joint appointment in the Department of Genomic Medicine. Our lab focuses on understanding the role of chromatin biology in cancer development, identifying genetic vulnerabilities of cancers and development of novel cancer therapeutics (Lissanu Deribe et al Nature Medicine 2018, Lissanu Deribe et al PNAS 2016).
To this end, we utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens and epigenomic technologies such as high-throughput RNA- and ChIP-Seq and ATAC-Seq.
Learning Objectives:
We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and won several grants to further develop these molecules as therapies.
This position will provide deep exposure and training in cancer genetics, chromatin biology, functional genomics and cancer therapeutic development.
We seek a highly motivated individual with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry or genetics. Candidates with training in statistics or programming expertise, in particular R/Python and interest in the application of state-of-the-art computational/statistical methods to complex data are particularly encouraged to apply. Experience with hands on mice work is a big plus but not required.
The Lissanu laboratory is situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows.
Eligibility Requirements:
• PhD or equivalent in Molecular Biology, Biochemistry, Genetics or related field
• Good publication record
• Excellent communication skills is required.
Dates or Training Schedule:
MD Anderson Cancer Center allows up to 5 years of postdoctoral training.
Mentor Matching:
This position reports to Yonathan Lissanu Deribe, M.D ,Ph.D.
Thoracic/Head and Neck Medical Oncology
Req #: 600657 - 0001
Job Title: Postdoctoral Fellow
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A postdoctoral position is available to study novel therapeutic targets and molecular mechanisms associated with therapeutic resistance in small cell lung cancer (SCLC) in the laboratory of Lauren Averett Byers, M.D. at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested using high-throughput proteomic screening to discover and validate potential drug targets and biomarkers of therapeutic resistance in SCLC. Qualified applicants are encouraged to apply and provide three professional references.
JOB KNOWLEDGE AND SKILLS:
- Enthusiastic, highly self-motivated candidate, with the ability to function independently and as part of an interactive team
- A strong background in cell signaling, molecular biology, and immunology/immunotherapy.
- Experience in flow cytometry is preferred
- Dedication to basic research, a true “drive”, is important
- Prior experience with studies involving mice is preferred
- Command of written and spoken English language
Eligibility Requirements:
Applications are invited from qualified individuals, interested in working in a translational research lab, with a Ph.D. and/or M.D.. Preferred candidate should have less than 2 years of prior postdoctoral experience with background in cancer biology, biochemistry, cell biology, or molecular biology and be highly motivated to pursue a career in biomedical research.
Mentor Matching:
This position reports to Lauren A. Byers, M.D.
Req #: 600657-0002
Job Title: Postdoctoral Fellow
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Learning Objectives:
- Planning and development of experimental studies testing novel immune-based therapies (T cell therapies and/or immune checkpoint inhibitors administered alone or in combination with other cancer therapies) in preclinical murine models of lung cancer.
- Analysis and interpretation of the results of in vivo and in vitro experimental studies using murine models of lung cancer and lung cancer cell lines, respectively.
- Integration of findings of experimental studies into multiple peer reviewed manuscripts as first and author and as co-author in collaboration with other trainees/collaborators.
Eligibility Requirements:
Qualified postdoctoral candidates should hold a doctorate degree and have strong background training in one or more of the following areas: biochemistry, molecular biology, cell biology, cancer biology, tumor immunology and cancer immunotherapy. Experience with murine models of cancer and an ability to analyze data derived from in vivo studies is strongly preferred. Expertise in performing flow cytometry on tissue-derived cell suspensions (human and murine tumor tissues), analyzing independently and interpreting data from flow cytometry studies is highly desired. Expertise in any of the following fields is advantageous: oncogenic signaling pathways, biomarkers of response and resistance to cancer therapies (targeted therapies, antiangiogenic therapies and immune-based therapies), cancer metabolism, and immuno-genomics. Highly motivated postdoctoral fellows who are self-starters and have critical thinking ability are encouraged to apply. Candidates should have good technical skills a strong work ethic and excellent organizational and communication skills.
Dates of Training Schedule:
Expected starting date: 1/2020
Expected training time: 3 to 5 years
Mentor Matching:
This position reports to Tina Cascone, M.D., Ph.D.
Req #: 600657-0004
Job Title: Postdoctoral Fellow
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My research program is focused on developing new and more effective treatments for HPV+ cancers using a combination of radiation and immunotherapy, and associated response biomarkers. In particular, to improve the responsiveness of HPV+ cancers to immunotherapy, it is necessary to understand 1) if HPV-antigens are effective targets for CD8+ T cells, and if not; 2) if other cancer antigens may be targeted, and whether the latter are unique to or shared between patients; 3) the features of T cells that recognize HPV+ cancer-associated Ag; and 4) how to unlock superior T cell functions in HPV+ cancer patients.
To answer these questions, my lab employs a combination of multidisciplinary wet- and dry-lab based techniques. I strongly believe in team science, and I am building a lab in which scientists will be responsible for and learn from having one or several main projects, while also working together towards the lab's main goal.
Learning Objectives:
The position is designed to allow trainees to further develop their skills in immunological assays such as flow cytometry and sorting, functional T cell assays, and TCR engineering, as well as single cell sequencing (transcriptional, TCR, and cell surface stains), and bulk whole exome and RNA sequencing. The trainee will work in collaboration with other trainees and staff in the lab, as well as other labs and cores in the department and MD Anderson as a whole.
The trainee will also work on developing his/her grantsmanship skills.
Eligibility Requirements:
Individuals who have completed a Ph.D. and have training relevant to the position are eligible.
Dates of Training Schedule:
The position is immediately available.
Mentor Matching:
This position reports to Nils-Petter Rudqvist, Ph.D.
Translational Molecular Pathology
Req #: 149100-004
Job Title: Postdoctoral Fellow
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Despite recent advances in immunotherapy, lung adenocarcinoma remains the leading cause of death in smokers. A significant fraction of lung adenocarcinomas display somatic activating mutations in the KRAS oncogene. KRAS-mutant lung adenocarcinoma, compared to other solid tumors, displays very poor clinical outcomes. Despite the overwhelming public health burden of KRAS-mutant lung adenocarcinoma, there are very few, if any, strategies for early treatment of this disease -- largely due to a very poor understanding of molecular changes that drive its initiation and development. One of our laboratory's goals is to delineate early immune events in the transition of smoking-exposed normal airway to KRAS-mutant lung adenocarcinoma. Understanding these changes may pave for the development of new prevention (immune-based) strategies for KRAS-mutant lung cancer. Our laboratory is also actively investigating th role of the host microbiome in lung cancer development. We find that knockout of specific host defense and airway lineage genes perturb host microbiome homeostatis concomitant with lung tumor development. We are also eager to mechanistically understand novel cues between airway lineage factors and microbiome homeostasis as well as understand the role of the host gut (and possibly the lung) microbiome in the pathogenesis of KRAS-mutant lung cancer. Our laboratory is looking for a postdoctoral fellow to embark on different vignettes in the microbiome and mmune evolution of KRAS-mutant lung cancer including understanding the dynamic interplay between host defense (including immunomodulatory) responses, tumor-initiating inflammation and microbiome dysbiosis (local and systemic) in the development of the malignancy. There will be opportune elements for the candidate postdoctoral fellow at MD Anderson Cancer Center to collaborate with physician and physician-scientists to gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches these exciting and timely projects. The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry/cytochemistry, cell culture as well as basic molecular and cellular biology techniques. Experience in microbial (in vivo) research is a big plus. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork.
Learning Objectives:
-Learn uncharted cues and pathways in the inception and development of KRAS-mutant lung cancer (which will likely be applicable to other subtypes of lung cancer or other solid tumors).
-Learn individual roles of immune and epithelial cell subsets and functional states/phenotypes in the development of KRAS-mutant lung adenocarcinoma.
-Develop a skill for collaboration and translation of laboratory-based findings (e.g., development of markers for outcome and response).
-Acquire skills for progression in academia including but not limited to delivering presentations, writing manuscripts and applying for grants/fellowships.
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Training Scheduled:
January 2021 - December 2021, renewed annually
Mentor Matching:
This position reports to Dr. Humam Kadara.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-005
Job Title: Postdoctoral Fellow
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Looking for highly motivated and talented pathologist fellow who is interested in making a difference against breast cancer and the other tumors and improving the lives of patients. The long-term goal of our laboratory is to elucidate the molecular mechanism in the pathogenesis and progression of breast cancer and identifying molecular markers related with tumor development, progression, and metastasis in breast cancer and the other solid tumors. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of breast cancer by IHC, multiplex IF, RNAscope etc and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies in breast cancer. This lab in TMP is combined with Department of Investigation Cancer therapeutics providing biomarker assessment on longitudinal biopsy tissues for phase I clinical trials supported by strategic alliances and PI initiated studies. The broad areas of research in the Dr. Yang laboratory can be summarized as follows:
Identifying new molecular targets, validating biomarkers for targeted therapy and immunotherapy Molecular pathology research on tumor microenvironment Translational tissue biomarker study in Phase I/II clinic trials of multiple solid tumors.
Learning Objectives:
To learn aspects of breast cancer research undertaken in a hospital/research institute
To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
To understand how studies done in laboratories can have an impact on patient care in the future
The trainee will To how to perform basic statistical analysis on path data
The trainee along with the mentor will present his data in lab meetings.
The trainee will participate in departmental education activities in particular those offered by ITERT
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Mentor Matching:
This position reports to Dr. Fei Yang.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-006
Job Title: Postdoctoral Fellow
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A postdoc will learn the techniques for assessing the role of an oncogene in cancer, specifically the gene encoding S6K1. An inhibitor for S6K1 or the upstream protein MEK will be tested in vitro, with or without knockout of the gene.
Learning Objectives:
This will entail CRISPR editing of cell lines, western blotting, and drug assays in vitro. Postdoc will also be expected to learn to write up the results for weekly meetings and to contribute writing to the eventual manuscript.
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Dates or Training Schedule:
December 2020- June 2021
Mentor Matching:
This position reports to Dr. Larry Kwong.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-007
Job Title: Postdoctoral Fellow
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We are looking for a motived and passionate postdoctoral fellow to join our laboratory focused on brain tumor research. We focus on glioblastoma (GBM), one of the most recalcitrant cancers with a median survival of only 12-15 months. Unlike other cancers, targeted therapies or "personalized medicine" approaches as well as immunotherapies have failed to improve outcome in GBM and therefore novel strategies are urgently needed to combat this disease. Our laboratory takes multipronged approaches to address these areas of unmet need for brain tumors. The current position will focus on single cell genomic studies on brain tumor immune cells and spatial statistics to elucidate pro-/anti-tumoral innate immune cell states using multiplexed imaging analyses on clinical specimens.
Learning Objectives:
- To understand the biology of brain tumors at the cellular and molecular level
- To elucidate mechanisms underlying tumor progression in brain cancer with a a focus on immune biology
- To be able to apply computational and statistical approaches to understand immune landscape of brain tumors
- To be able to present findings in institutional and national meetings
- To document data and write manuscripts for publication
- To utilize educational and training opportunities within the department and the Institution to enrich career path
Eligibility Requirements:
An individual with a Ph.D. in bioinformatics and/or computational biology from a reputed University/Institute within one year of graduation is eligible. At least one first author publication in a peer reviewed journal stemming from Ph.D. studies is required. The candidate must have independent thinking and passionate about a career in academic science.
Mentor Matching:
This position reports to Dr. Krishna Bhat.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-008
Job Title: Postdoctoral Fellow
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The Computational Pathology Program (CPP) in the Department of Translational Molecular Pathology is a focused initiative aimed at research and discovery to enable the emerging concepts of precision pathology and medicine using data science and computational algorithms. A major goal of this program is to apply statistical and computational principles to develop novel biomarkers as well as performing image-based data analytics for elucidating biological and clinical variables that underlie cancer mechanisms. CPP strives to identify critical molecular markers, signatures, and mechanisms through appropriate statistical analysis and data integration schemes, including clinical and omics data.
We invite a highly motivated post-doctoral fellow to perform cutting-edge research on the Immune Topographical Atlas of Brain Tumors. The primary focus is on developing a robust spatial statistics portfolio through the application of stochastic processes and analysis of brain tumor images using R/Python, leading to good quality publication(s). The person will need to be able to work as part of a multidisciplinary team involving immunology, pathology, and neurosurgery at MD Anderson Cancer Center while working towards enhancing his/her research portfolio.
Learning Objectives:
The position will require learning and applying stochastic processes and algorithms to multiplex brain tumor images to understand and decipher the immune landscape. He/she will be offering creative solutions and are expected to develop good data science skills and solutions in elucidating mechanisms underlying tumor progression in brain cancer with a focus on immune biology.
The postdoc will also be expected to learn to write up the results for weekly meetings, contribute writing to manuscripts, and present findings in institutional and national meetings.
Eligibility Requirements:
The position will require learning and applying stochastic processes and algorithms to multiplex brain tumor images to understand and decipher the immune landscape. He/she will be offering creative solutions and are expected to develop good data science skills and solutions in elucidating mechanisms underlying tumor progression in brain cancer with a focus on immune biology.The postdoc will also be expected to learn to write up the results for weekly meetings, contribute writing to manuscripts, and present findings in institutional and national meetings.
Mentor Matching:
This position reports to Dr. Kasthuri Kannan.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-009
Job Title: Postdoctoral Fellow
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The Genomics Test Development Laboratory (GTDL) in the Department of Translational Molecular Pathology, develops new techniques for cancer genotyping in liquid biopsies, hematological malignancies and solid tumors; partners with the Molecular Diagnostic Laboratory (MDL) at MD Anderson to assess, optimize and validate novel molecular diagnostic tests to facilitate the cost-effective transfer of discovery markers and related assays into the CLIA environment.
The GTDL is interested in having a Post-doctoral fellow with a strong molecular biology background and a familiarity with Bioinformatics pipelines for Next Generation Sequencing (NGS) who will work to accomplish the goals of the laboratory. The primary purpose of the Post-doc is to design, optimize and perform new molecular assays geared for use in both the research and clinical space. This person would also help to facilitate the transition of translational research projects into the clinical lab and work closely with collaborators in different departments.
Key functions:
- Design, optimize, and validate new or existing genomic assays, including NGS, ddPCR, and gene expression by PCR, HTG, and NanoString for translational research or transfer into the CLIA environment.
- Works with internal and external collaborators (clinicians, vendors, faculty, staff, industry partners) to develop new molecular assays for the laboratory
- Assists in project planning and adheres to realistic timelines for implementation of assays in development.
- Works closely with Bioinformatics in the analysis and interpretation of NGS data and provides written reports to collaborators.
- Assists in the development of lab policies and procedures including assay Standard Operating Procedures (SOPs), assay transfer documentation and quality control procedures.
- Evaluates instruments, reagents and supplies for new and existing molecular assays
- Presents work at National conferences and for publication in peer-reviewed scientific journals
Desired skills:
- Hands on experience with NGS library preparation and sequencing platforms.
- Hands on experience in running different molecular assays including qPCR, ddPCR,
- NanoString and HTG.
- Experience with manual and automated nucleic acid extraction methodologies.
- Familiarity with Bioinformatics analysis for NGS and laboratory automation software.
Learning Objectives:
- To understand the process of diagnostic test development.
- To apply the scientific method in the design and optimization of new molecular assays.
- To analyze data, write manuscripts for publication, present data/results at National and International conferences.
- To participate in the teaching/training of Research Assistants, graduate students and visiting fellows.
- To utilize the education and training opportunities within the department and the institution for career growth.
Eligibility Requirements:
An individual with a PhD in bioinformatics and/or computational biology from a reputed University/Institute with zero to one year of experience post-graduation is eligible. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. The candidate must have independent thinking and be passionate about a career in academic science.
Program Dates:
Appointment will be for one year from date of hire.
Mentor Matching:
This position reports to Rajyalakshmi Luthra, Ph.D.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-009
Job Title: Postdoctoral Fellow
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Seeking a to incorporate to our Research Lab a highly motivated and talented pathologist fellow who is interested in making a difference against cancer and improve patient's outcomes. The long-term goal of our laboratory is to elucidate the molecular mechanism in cancer pathogenesis and progression, identifying molecular markers related with tumor development, progression, and metastasis in breast cancer and the other solid tumors. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of breast cancer by IHC, multiplex IF, RNAscope etc and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies in breast cancer. This lab in TMP is combined with Department of Investigation Cancer therapeutics providing biomarker assessment on longitudinal biopsy tissues for phase I clinical trials supported by strategic alliances and PI initiated studies. The broad areas of research in this laboratory can be summarized as follows:
Identifying new molecular targets, validating biomarkers for targeted therapy and immunotherapy Molecular pathology research on tumor microenvironment Translational tissue biomarker study in Phase I/II clinic trials of multiple solid tumors.
Learning Objectives:
- To learn aspects of breast cancer research undertaken in a hospital/research institute
- To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
- To understand how studies done in laboratories can have an impact on patient care in the future
- The trainee will learn how to perform basic statistical analysis on path data
- The trainee along with the mentor will present his/her data in lab meetings.
- The trainee will participate in departmental education activities in particular those offered by ITERT
Eligibility Requirements:
An individual holding an M.D. or equivalent doctorate (e.g., Sc.D., Ph.D., D.V.M.) in an appropriate field , with postgraduate training in surgical or anatomical pathology or equivalent and who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Program Dates:
November 2020 to November 2021
Mentor Matching:
This position reports to Gabriela Raso, M.D.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-00011
Job Title: Postdoctoral Fellow
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Looking for highly motivated and talented individual who is interested in making a difference against pancreatic cancer, and improving the lives of patients stricken with this disease. The most important criteria will be your creativity and zeal to make a difference.
The long-term goal of our laboratory is to improve the dismal survival rates for patients with pancreatic cancer, which is now the 3rd most common cause of cancer-related deaths in the United States. Our laboratory has been an integral part of the team that sequenced the genomes of pancreatic ductal adenocarcinoma (PDAC) and other variant tumors, including pancreatic cystic neoplasms and neuroendocrine tumors of the pancreas. The research performed in our laboratory is entirely translational in that we always keep a line of sight to the clinic as one of the overarching objectives. The broad areas of research in the Maitra laboratory can be summarized as follows:
· Functional annotation of epigenetic drivers in pancreatic cancer
· Mouse models of pancreatic cystic neoplasia
· Liquid Biopsies for Therapeutic Stratification and Disease Monitoring
Learning Objectives:
- To learn aspects of pancreatic cancer research undertaken in a hospital/research institute
- To learn how laboratory operations are conducted and how data is interpreted, and analyzed in research laboratory
- To understand how studies done in laboratories can have an impact on patient care in the future
- The trainee will learn cell culture techniques of pancreatic cancer.
- The trainee along with the mentor will present his data in lab meetings.
- The trainee will participate in departmental education activities in particular those offered by ITERT.
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Program Dates:
March 1, 2021 - February 28, 2022
Mentor Matching:
This position reports to Anirban Maitra, M.D.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-00012
Job Title: Postdoctoral Fellow
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Seeking to incorporate to our Translational Molecular Pathology Immnunoprofiling Research Laboratory (TMP-IL ) a highly motivated and talented pathologist fellow who is interested in making a difference against cancer and improve patient's outcomes. The Translational Molecular Pathology –Immunoprofiling lab (TMP-IL) translates immunopofiling data into research that is clinically applicable and can aid in the treatment and outcome of future cancer patients. The long-term goal of our laboratory is to elucidate the molecular mechanism in cancer pathogenesis and progression, identifying molecular markers related with tumor development, progression, and metastasis in solid tumors and hematological malignancies. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of cancer by IHC, multiplex IF, RNAscope and highplex technologies and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies.
Learning Objectives:
- To learn aspects of cancer research undertaken in a hospital/research institute
- To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
- To develop research projects using novel multiplex based techniques (CODEX, GeoMxDSP, IMC, MIBI) utilizing FFPE surgical specimens, core needle biopsies and smears from different tumor types for biomarkers analysis of complex research projects of TMP-IL.
- To understand how studies done in laboratories can have an impact on patient care in the future
- The trainee will learn how to perform basic statistical analysis on path data
- The trainee along with the mentor will present his/her data in lab meetings.
- The trainee will participate in departmental education activities in particular those offered by ITERT
Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.
Program Dates:
One year from the date of hire; may be renewed.
Mentor Matching:
This position reports to Ignacio Wistuba, M.D.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
Req #: 149100-00012
Job Title: Postdoctoral Fellow
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Our program is focused on identifying context-specific druggable vulnerabilities required for oncogenic signaling and function, with a specific interest in surface proteins. We aim to gain deep molecular insights into the complicated array of oncogene-dependent and -independent events driving tumor progression to discover novel therapeutic approaches that target mechanism essential for cancer cell survival. We are currently using proteomic, genetic, molecular biological as well as biochemical technologies to identify context-specific druggable vulnerabilities required for oncogenic function in preclinic model system, such as genetically engineered mouse model and patient derived xenograft model. We have been focusing on gaining deep molecular insights into the complicated array of oncogenic Kras-dependent (published in Nature, 2019) and –independent (published in Cell, 2014) events driving tumor progression to discover novel therapeutic approaches that target mechanism essential for cancer cell survival.
Learning Objectives:
- Learn under the supervision of the faculty mentor who will provide mentoring in topics and basic/advanced techniques and the opportunity for collaborative and independent research.
- To better understand pancreatic cancer tumor heterogeneity and evolution.
- To gain ability to search and evaluate scientific literature, to propose and verify hypotheses based on preliminary data, to plan and perform research project, to effectively disseminate research findings in form of publication and presentation, and to write persuasive grant application.
- To participate in all relevant activities related to an independent research career.
Program Dates:
April 1, 2021
Mentor Matching:
This position reports to Dr. Wantong Yao.
Additional application information:
Visit the Translational Molecular Pathology page for more information.
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