Open Trainee Positions

MD Anderson offers postdoctoral training opportunities year-round. Below are the positions currently available.

Req #: 600673-00005
Job Title:  Postdoctoral Fellow       
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​Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on the mechanisms of granulopoiesis and neutrophil turnover in sepsis. Projects will involve studies on the role of C-type lectin receptors in neutrophil generation, cell death and efferocytosis under homeostatic and pneumoseptic conditions; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in cellular or molecular immunology and infectious disease pathogenesis. Experience with flow cytometry, imaging and mouse models of disease is strongly preferred. Demonstrated productivity in publication record is required.​  Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.​

Learning Objectives:
​1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia​

Eligibility Requirements:
​1. Completion of Ph.D. or M.D/Ph.D in cellular and molecular immunology and/or infectious diseases.
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English.

Mentor Matching:
This position reports to Dr. Jyotika Sharma.

Req #: 600673-00006
Job Title:  Postdoctoral Fellow       
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Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on immunometabolism in neutrophil functions. Projects will involve studies on the metabolic regulation of neutrophil extracellular traps in inflammatory disease conditions and their modulation with small molecule inhibitors; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in biochemistry, cellular immunology, metabolic disease pathogenesis. Relevant experience with rodent models of metabolic dysregulation and pharmacological studies in cells of immune system is strongly preferred. Demonstrated productivity in publication record is required. ​Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.​

Learning Objectives:
​1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia​

Eligibility Requirements:
​1. Completion of Ph.D. or M.D/Ph.D in biochemistry, cellular and molecular immunology, molecular biology
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English​.

Mentor Matching:
This position reports to Dr. Jyotika Sharma.

Req #: 600673-00007
Job Title:  Postdoctoral Fellow       
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​Postdoctoral position is available in the laboratory of Dr. Jyotika Sharma at MD Anderson, Cancer Center to participate in NIH-funded research projects focusing on epigenomic regulation of neutrophil functions in secondary pneumonia and penumosepsis. Projects will involve studies on the mechanisms of chromatin release, modifications and interaction with immune cells related to inflammatory responses; and will use in-vitro and in-vivo approaches with mouse models and human cells. The ideal candidate will have doctoral training in Genomics/Epigenomics, Molecular Biology, Molecular Immunology. Relevant experience with rodent models of disease and functional genomic studies in cells of immune system is strongly preferred. Demonstrated productivity in publication record is required. ​Interested candidates can submit a cover letter describing research experience, interests and goals, and a curriculum vita (CV) directly to Dr. Jyotika Sharma by email.​

Learning Objectives:
​1. To train under the supervision of the mentor who will provide the opportunity for collaborative and independent research
2. To disseminate the research findings in form of publications and presentations
3. Apply for peer-reviewed funding
4. Participate in all relevant activities related to an independent career in research or academia​

Eligibility Requirements:
​1. Completion of Ph.D.or M.D/Ph.D or equivalent degree in Genetics/Epigenetics, molecular biology, immunology, infectious diseases. |
2. Evidence of productivity from publications in peer-reviewed, primary research journals originating from Ph.D. or postdoctoral work.
3. Proficiency in spoken and written English​

Mentor Matching:
This position reports to Dr. Jyotika Sharma.

Req #: 600658-00008
Job Title:  Postdoctoral Fellow       
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Learning Objectives:
Learn about the role of Augmented Reality in recovery after surgery and how to design clinical trials to test the efficacy of Augmented Reality in postoperative pain.​​

Eligibility Requirements:
US or Foreign Medical Doctor with USMLE step 1 and 2 passed board.
Experience in clinical research.
Proficiency with the use of Word, Excel, and RedCap.​

Mentor Matching:
This position reports to Juan Cata, M.D. See Dr. Cata's research profile.

No positions in the Department of Behavioral Science are currently available. Check back later for new opportunities.

Req #: 600815-00001
Job Title:  Postdoctoral Fellow       
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​​​​​​​Dr. Wang’s laboratory builds an extensive research program on tumor heterogeneity and evolution, and cancer risk prediction modeling. Development of statistical methods and tools under this program aims to address clinically relevant questions in cancer biology and genetics, such as developing novel biomarkers for the risk stratification, treatment selection, and prognostication of cancer. For further information, visit the lab website.

We have been closely affiliated with the Cancer Genome Atlas (http://cancergenome.nih.gov), NIH’s flagship project, the International Canc​​er Genome Consortium (ICGC)-PanCancer Analysis Working Groups (PCAWG), the MDACC Program in Clinical Cancer Genetics, CPRIT Integrated Single Cell Genomics Core at MDACC and The Seed Networks for the Human Cell Atlas projects.

The postdoctoral fellow will be mentored directly by Dr. Wang, with possible co-mentorship from qualified faculty members at MD Anderson Cancer Center or other institutions of the Texas Medical Center, including Rice University and will join the research programs in tumor heterogeneity and evolution, human cell atlas network, or personalized risk prediction modeling. ​

​Eligibility Requirements:
A Ph.D. degree in Statistics, Biostatistics, Applied Mathematics, Bioinformatics, Computer Science or a related field. Extensive experience with R and Python, prior experience in computational biology are required. Candidates should also have a background in any of the following areas: cancer biology, graphical models, semi-parametric Bayesian models, or penalized likelihood methods.​

Dates or Training Schedule:
12-month position from start date (suggested May 1, 2021 start date)

Mentor Matching:
This position reports to Wenyi Wang, Ph.D. See Dr. Wang's research profile.

Req #: 600815-00002
Job Title:  Postdoctoral Fellow       
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Postdoctoral positions are available in Dr. Yiwen Chen's lab. By combining computational and high-throughput approaches such as single-cell multi-omics profiling (e.g., scRNA-seq and scATAC-seq), CRISPR/Cas9, RNA-seq, ChIP-seq, RNA immunoprecipitation (RIP)-seq and Ribosome Profiling (Ribo-seq), the focuses of Dr. Chen's lab are to decipher the cell signaling, epigenetic/epitranscriptomic and RNA-based regulation mechanism of cancer immunology, neural stem cell and cancer stem cell of brain tumor at the University of Texas MD Anderson Cancer Center. The postdocs will be jointly supervised by Dr. Chen and Drs. Jian Hu/Cassian Yee.

Computational Biology/Bioinformatics Postdoc:
The postdoc will be developing novel statistical/machine learning (e.g., deep learning) methods that integrate heterogeneous bulk and single-cell multi-omics datasets to study the cell signaling, epigenetic/epitranscriptomic and RNA-based regulation mechanism that is important for tumor immunity, neural stem cell and cancer stem cell of brain tumor. Another direction is to develop new computational methods for proteogenomics, an emerging field at the intersection of genomics and mass spectrometry (MS)-based proteomics. In addition to the development of statistical/machine learning methods, he/she will be collaborating with other labs for various biomedical applications.

Eligibility Requirements:
Experimental Postdocs:
Applicants should have a Ph.D. degree (or equivalent) in biomedical sciences, focusing on one of the following areas: (a) molecular biology (b) biochemistry of RNA and/or transcriptional/epigenetic regulation, (c) cell signaling, (d) virology, (e) immunology, (f) T-cell biology, (g) cancer biology. Mouse model experience, genomics/proteomics expertise is not required, but highly desirable. 

Computational Biology/Bioinformatics Postdocs
Applicants should have a Ph.D. degree (or equivalent) in related quantitative fields including, but not limited to computational biology, bioinformatics, biophysics, biostatistics, computer science, statistics, bioengineering and physics. Applicants with i) strong quantitative background (computer science/statistics/physical modeling) or ii) computational genomics/proteomics experiences and large-scale biological data analysis capability are preferred. Strong programming skills in scripting language (Python or Perl), statistical and computing language (R or MATLAB), and/or programing language (C/C++ /Java) are highly desirable.

Dates or Training Schedule:
January 2021 – January 2022, renewed annually. 

Mentor Matching:
This position reports to Yiwen Chen, Ph.D., and Cassian Yee, M.D.

Req #: 600815-00003
Job Title:  Postdoctoral Fellow       
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​One postdoctoral position in systems biology is available in the Hart Lab (hart-lab.org) at The University of Texas MD Anderson Cancer Center in Houston, TX. CRISPR has revolutionized human functional genomics by rendering our genome tractable, and the Hart Lab is pushing the state of the art in the design, assay, and integrated analysis of CRISPR tools for complex genetics. We are developing multiplex perturbation technologies with a wide variety of applications from basic functional genomics to finding novel chemotherapeutic targets and understanding how tumor cells adapt to targeted therapies. Because of this breadth, we maintain strong collaborations throughout MD Anderson, the Texas Medical Center, nationally, and internationally.

We are seeking a self-motivated candidate from looking to take the next step in his or her career at a world-class research institution. If you have a background or strong interest in quantitative systems biology, a compulsion to understand complex data, a desire to work in a hybrid wet/dry environment, and a drive to make your mark in one of the most exciting frontiers in biomedical research today, apply today! The Hart Lab offers a supportive and diverse team environment, and the chance to live and work in the fourth largest city in the nation. Interested candidates are encouraged to send a CV, a statement of research interests, contact information for three references, and any relevant publications to Traver Hart at ghart1@mdanderson.org, with the subject line "Hart Lab Postdoc Application."

Eligibility Requirements:
Ph.D. in biomedical sciences or related field. Deep knowlege and experience in cloning and CRISPR library screening. Computational skills preferred.

Mentor Matching:
This position reports to Traver Hart, Ph.D. See Dr. Hart's research profile.

Req #: 600567- 00008
Job Title:  Postdoctoral Fellow       
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​The Department of Biostatistics at MD Anderson has one postdoc position open for biostatistics methodology research and clinical trial application. The main focus is research and publication. The primary focus will be develop novel methods for adaptive Bayesian clinical trial designs, derive related statistical theory, produce software for implementation, incorporate biomarkers in clinical trial design and analysis, and build statistical learning tools for large data sets. The post-doc will work under the supervision of Dr. Ying Yuan and Dr. Peter Thall on challenging and important clinical and biological projects that involve complex statistical modeling, data analysis and computation. ​

​Learning Objectives:
Learn statistical theory and application in cancer clinical trials; Obtain expertise in Bayesian adaptive designs, hierarchical models, and biomarker-based clinical trial design and analysis for precision medicine; Develop strong programming and computational skills; Gain interest in statistical methodology research; Acquire extensive experience in R and R-Shiny. ​

Eligibility Requirements:​
Applicants must have a recent PhD in biostatistics or statistics from a reputed University/Institute or within 0-1 years of graduation. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. A solid background in statistical theory, clinical trial applications, and Bayesian methods and computation are required. Some experience with machine learning is desirable.

Please send CV and information on three referees directly to slgarcia@mdanderson.org.

Dates or Training Schedule:
Tentative start date: June 2021

Mentor Matching:
This position reports to Ying Yuan, Ph.D. and Peter Thall, Ph.D. 

Req #: 600567- 00009
Job Title:  Postdoctoral Fellow       
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​The postdoctoral fellow will work under the supervision of Drs Kim-Anh Do and Ziyi Li and may collaborate with other faculty in biostatistics, computer science, bioinformatics, basic science, or clinical research. The primary research focus can encompass: (i) developing and applying novel statistical and computational methods for the analysis of omics data from various sources such as high-throughput proteomic, genomic, sequencing, transcriptomic, and imaging data, with particular emphasis on developing integrative and flexible models that incorporate both biological knowledge and empirical structures; (ii) developing novel statistical and machine learning methods for the analysis of single cell omics data with focus on cancer research. Specific research areas include the integration of single cell and bulk data, the incorporation of cell interaction and spatial information in single cell data analysis, and the analysis of single cell multi-omics data. The fellow will gain experience in cutting-edge analysis of “big data” and have the opportunity to publish in high-impact biostatistics, bioinformatics and health research journals.​

Learning Objectives:
Learn statistical theory and application in data science studies; Obtain expertise in high-dimensional variable selection, feature extraction from spatial-temporal varying data, hierarchical models, develop novel analytical methods for precision medicine; Develop strong programming and computational skills; Adapt and develop novel machine learning algorithms; Acquire extensive experience in R, R-Shiny, Python, and other programming languages/environments. ​​

Eligibility Requirements:
​​We seek a highly motivated individual with a Ph.D. in statistics/biostatistics/bioinformatics or a related quantitative field such as computer science, engineering, or quantitative computational biology. Interest or background in computer-intensive methodology, bioinformatics, genomics, and proteomics is preferred. Applicants must have strong training in statistics and excellent programming skills, in particular R/Python/Matlab and preferably one lower level computer language such as C or Fortran, and interest in the application of state-of-the-art statistical methods to complex data. Experience with high-performance computing and linux system is a plus. Expertise or skills in any of the following areas are desirable: analysis of high-dimensional data, data mining, and machine learning.

Interested applicants should send a cover letter and CV (including three references) to: kimdo@mdanderson.org and zli16@mdanderson.org.

MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment. ​

Dates or Training Schedule:
Tentative start date: July 1, 2021

Mentor Matching:
Dr. Kim-Anh Do is a full professor and Dr. Ziyi Li is a new faculty in the Department of Biostatistics with prior mentoring experience.  

Additional Application Information:
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

Req #: 600143-00001
Job Title:  Postdoctoral Fellow       
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​​​​​Dr. Arun's lab focuses on biomarker identification and prevention studies among patients who are at high risk for the development of breast cancer.

Applicants should provide highly responsible administrative related services to support clinical research and family outreach studies which are part of Breast Genetics and High-Risk Breast Cancer Registry, under the leadership of Dr. Banu Arun.  Duties include data collection from patient medical records and sample processing included, but not limited to, RNA extraction and immunoassay analysis from those who participated in the Dasatinib prevention trial. 

Eligibility Requirements:
​​Requires the ability to establish priorities, manage multiple tasks, and complete work assignments accurately and on time. The candidate needs to be self-motivated, conscientious and a team player with a strong work ethic, have critical thinking abilities, good communication, organizational, and writing skills.​

An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.​ ​​​

Mentor Matching:
This position reports to Banu Arun, M.D.  View Dr. Arun's research profile.

Additional Application Information:
The fellow will need to provide their own stipend support from their home institution. Under no circumstances should a postdoctoral fellow's or other individual's personal funds be used to supplement an internally or externally supported stipend to the MD Anderson minimum level.

Req #: 600143-00002
Job Title:  Postdoctoral Fellow       
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​​​​The Department of Breast Medical Oncology at the University of Texas MD Anderson Cancer Center is seeking a one-year research fellow beginning August 2, 2021.The primary research focus will be conducting a retrospective clinical study using a large Breast Cancer Registry in Breast Medical Oncology and Morgan Welch Inflammatory Breast Cancer Research and Clinic. Through the study, the post-doc will learn the protocol development, study method, ethics, data handling, and statistical analysis of the clinical study. There will be many opportunities to participate in various ongoing studies based on their academic background. Also, the post-doc will have a chance of writing an original manuscript as a first/co-author and presenting their study in the lab meeting or major national oncology conferences. The fellow will be invited to participate in departmental conferences and other educational activities. ​

Eligibility Requirements:
​Applicants should provide highly responsible administrative and research support.  Requires the ability to establish priorities, manage multiple tasks and complete work assignments accurately and on time. The candidate needs to be self-motivated, conscientious and a team player with a strong work ethic, have critical thinking abilities, good communication, organizational and writing skills. An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor in preparation for an academic or research career as an independent investigator. ​​

Program Dates:
August 2, 2021 - August 1, 2022

Mentor Matching:
This position reports to Vicente Valero, M.D.  View Dr. Valero's research profile.

Additional Application Information:
The fellow will need to provide their own stipend support from their home institution. Under no circumstances should a postdoctoral fellow's or other individual's personal funds be used to supplement an internally or externally supported stipend to the MD Anderson minimum level.

Req #: 188100-00001 
Job Title:  Postdoctoral Fellow       
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​The Department of Cancer Biology at MD Anderson Cancer Center has postdoctoral positions available in a highly productive laboratory for research related to overcome immune suppressive tumor microenvironment, define tumor intrinsic resistance mechanisms to immunocheckpoint therapy and identify synthetic lethal targets in a number of cancer types, including brain cancer, colon cancer and prostate cancer. Interested fellows should checkout our recent publications (Zhao et al., Nature 2017; Lu et al., Nature 2017; Hu et al., Cell 2016; Liao et al., Cancer Cell 2019; Chen et al., Cancer Cell 2019; Zhao et al., Cancer Discovery 2020; Hou et al., Cancer Discovery 2020). ​

Learning Objectives:
​The postdoctoral fellows will be working independently but also under the supervision of Dr. Y. Alan Wang. The primary research focus will be defined together with Dr. Wang in consultation of postdoctoral fellows' prior research experience and motivation in area of interest. Both cell culture work and animal studies will be conducted using many different types of models, including 2D, 3D culture systems, organoids, PDX, GEMM and rapid ES-derived GEMM, among others.  In addition, it is expected that the postdoctoral fellows will gain expert level skills for various techniques required to address a scientific question, including CyTOF, imaging-CyTOF, scSeq, other omics and downstream bioinformatic analysis in consultation with in house computational scientists. As the goal of our research projects are translational, we expect that postdoctoral fellows will actively participate in collaborations with outstanding clinicians to potentially move the bench discoveries to the clinics as exemplified by several ongoing clinical trials in prostate cancer and colon cancer. Finally, the postdoctoral fellows are expected to seek fellowships and support PI's grant application as well as writing reviews and manuscripts through which the postdoctoral fellows will gain a deep understanding on the art of scientific writing and presentation.  ​

Eligibility Requirements:​
We seek highly motivated scientists with a recent Ph.D or M.D. in biological fields, and individuals with the following experiences are encouraged to apply.
- Experience with mouse tumor models.
- Experience with laboratory techniques in the field of molecular biology and immunology.
- Experience that shows independency, critical thinking and problem solving skills.
- Willingness to work together in a multi-disciplinary team environment.
- Outstanding communication and organizational skills.

Dates or Training Schedule:
The appointment is immediately available. 

Mentor Matching:
This position reports to Dr. Y. Alan Wang.

Req #: 188100-00002
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Shabnam Shalapour. Research in the Shalapour Laboratory focuses on the role of chronic inflammation and adaptive immunity in control of tumor development and the response of various cancers to therapy. While the focus of the research is primarily based on tumor immunology and immunotherapy, our work also addresses fundamental questions in immunology, immunometabolism and cancer biology using cutting-edge technology tools  including multicolor Flow cytometry, CyTOF, imaging, histology and large-scale omic analysis, e.g. single-cell RNA and ATAC-seq . We aim to understand how chronic inflammation induced by obesity, aging and alcohol abuse affect the immune system and thereby regulates its response to pathogens (bacteria and virus) and support tumor development. The focus then being how to use this information to not only prevent cancer development but also to develop novel therapeutic approaches to increase the response to immunotherapy and vaccination (see our recent publications; Nature. 2015 May 7;521(7550):94-8, J Clin Invest. 2015 Sep;125(9), Nature. 2017 Nov 16;551(7680):340-345.; Immunity. 2019 Jul 16;51(1):15-26, Annu Rev Immunol. 2020 Apr 26;38:649-671).​

Learning Objectives:
​This postdoc fellowship will focus on the role of adaptive immune cells particular B cells in tumor immunology, and how chronic-inflammation regulate their development and effector function, using bioinformatic tools, genetically engineered mouse models (GEMM) and state-of-the-art immunological and experimental approaches. ​

Eligibility Requirements:​
​Applicants must have a recent Ph.D. or M.D./Ph.D. degree in a related biomedical field with strong interests and self-motivation for research.​

Dates or Training Schedule:
The appointment is immediately available. 

Mentor Matching:
This position reports to Dr. Shabnam Shalapour.

Req #: 188100-00003
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. Raghu Kalluri. The central mission of the Kalluri Laboratory is to perform innovative and cutting-edge research to unravel how cells and their environment communicate to maintain organ health and how such communication network in tissues is altered in cancer and other diseases. We investigate the biology of cancer with an implicit mission to develop new strategies for diagnosis and therapy.​

Learning Objectives:
​This postdoctoral fellowship will focus on pancreatic cancer. ​

Eligibility Requirements:​
​Applicants must have a recent Ph.D. degree with strong research interests. ​

Dates or Training Schedule:
The appointment is immediately available. 

Mentor Matching:
This position reports to Raghu Kalluri, M.D., Ph.D..

Req #: 188100-00004
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellow position is available in the Department of Cancer Biology under the direct supervision of Dr. DePinho. Our research focus on studying the molecular and biological processes governing the development of cancer, the basis for aging and degenerative diseases and the maintenance of normal and cancer stem cells. We have produced an array of discoveries leading to better methods of early cancer detection, improved cancer patient care and new cancer drug development. The range of our research includes cancer drug and biomarker development, cancer gene discovery, stem cell biology and development of genetically engineered mouse models to study human cancers.  

All trainees are provided with consistent mentorship and access to a number of resources to ensure success. Trainees will have opportunities to present their work at national meetings and attend educational seminars. In addition, collaboration and contribution on other projects in the lab are encouraged.

Learning Objectives:
​​Qualified individuals will demonstrate the potential for research as evidenced by their peer-reviewed publications and funding. He/she will have background in cancer biology and expertise in the design experiments and execution of in vitro and in vivo experiments. Have expertise in molecular biology, cell culture, animal work etc.​

Eligibility Requirements:​
​​Applicants must have a recent Ph.D. degree with strong research interests. ​

Dates or Training Schedule:
The appointment will begin in March 2021.

Mentor Matching:
This position reports to Ronald DePinho, M.D.

Req #: 188100-00005
Job Title:  Postdoctoral Fellow       
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The Kalluri laboratory at the MD Anderson Cancer Center wants to expand their work on the molecular underpinnings of cancer initiation, progression and metastasis, and to translate the findings into novel therapeutic approaches. The Kalluri laboratory focuses on innovation research in the area of cancer biology with a specific focus on oncogene addiction, tumor microenvironment, stromal biology, exosomes biology, tumor metabolism and tumor immunology. Recent publications on the stromal biology of cancer (Ozdermir et al. 2014, Cancer Cell), exosomes biology in cancer (Kalluri & LeBleu, 2020, Science, Melo et al., 2014 Cancer Cell; Melo et al. 2015, Nature), tumor immunology (Ozdermir et al. 2014, Cancer Cell; Carstens et al. 2017, Nature Communications), metastasis (Zheng et al. 2015, Nature; Lovisa et al. 2015, Nature Medicine), exosomes mediated oncogene targeting (Kamerkar et al. 2017, Nature) and tumor metabolism (LeBleu et al. 2014, Nature Cell Biology, Becker et al. 2020, Cell Reports), have formed the framework for the next set of projects that use innovative technologies such as CRISPR-Cas9, single cell and nuclei sequencing, exosome engineering and mouse modeling to address cutting-edge questions in cancer biology. The Kalluri laboratory strives to transform seminal basic cancer research to inform clinical translation of such findings and will employ any required technology to address important unanswered questions in cancer biology. With strong funding from the NCI, CPRIT Established Investigator Award, and other funding sources, the laboratory is well positioned to exploit the new avenues for fundamental discoveries in cancer and translate such findings into the clinic, exploiting the translational potential of MD Anderson Cancer Center. 

Learning Objectives:
We seek outstanding candidates with a strong background in neurobiology. Expertise may include a focus on neurodegenerative diseases, synapse biology, neuroimaging, brain and peripheral neuropathies, and brain tumor. We are only interested in scientists who are committed to solve important questions in neurobiology and are innovative and `out of the box' in their approach of science. The candidate must demonstrate expertise in neurobiology, and interests in exosomes biology, tumor biology, mouse modeling of disease (with a focus on neurodegenerative disorders), and in advancing therapeutic testing. The ideal candidate must demonstrate a committed enthusiasm for science, superior interpersonal and communication skills, exceptional organization skills, and is able to work in dynamic teams.  ​​

Eligibility Requirements:​
​​Applicants must have a recent Ph.D. degree with strong research interests. ​

Dates or Training Schedule:
The appointment is immediately available. 

Mentor Matching:
This position reports to Raghu Kalluri, M.D., Ph.D..

Additional Application Information:
To apply, a cover letter is required, and should indicate areas of research interest, highlight publication record, and list future professional aspirations. Candidates must also submit a complete CV, key publications if any, and a minimum of 3 reference letters via E-mail to:

Jennifer Yang
Department of Cancer Biology
1881 East Road, Box 1906
UT MD Anderson Cancer Center
jsyang@MDAnderson.org

Req #: 710509-0005
Job Title:  Postdoctoral Fellow       
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​​The Department of Cancer Systems Imaging (CSI) is one of the largest new programs within the Division of Diagnostic Imaging at The University of Texas MD Anderson Cancer Center. The goal of this department and its research program is to develop new methodologies to visualize the cellular, biochemical, and genetic processes that contribute to the development and progression of cancer and to translate these discoveries into the clinic.

Dr. Marty Pagel, Professor and Deputy Chair, leads a research program that is developing new molecular imaging methods that improve cancer diagnoses and evaluate cancer therpaies, and translating molecular imaging to the radiology clinic. Dr. Pagel and his team have developed methods that measure tumor acidosis and hypoxia, detect tumor enzyme activities, and evaluate vascular permeabilities using Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), PET/MRI, and MultiSpectral Optoacoustic Tomography (MSOT; also known as photoacoustic imaging). In addition to his chemistry and molecular biology laboratories in Cancer Systems Imaging, Dr. Pagel's research group has access to state-of-the-art small animal imaging instrumentation, clinical imaging instrumentation, and other core facilities.

Dr. Pagel's research program is currently recruiting a Post-doctoral Fellow to lead research that focuses on advanced image analysis of a variety of molecular imaging methods for small animal imaging and clinical imaging. This research primarily focuses on the use of Matlab, Python, VivoQuant, and other image analysis software for analyzing MRI, PET/MRI and MSOT images. As a secondary focus, this research will also involve participation in all other aspects of biomedical imaging including the development of tumor models; in vivo imaging acquisitions; and validation studies that support in vivo imaging results. A strong emphasis is placed on the development of a long-term research career in molecular imaging or a related discipline. The Fellow will work directly with Dr. Pagel and other members of the research group, who provide extensive support for each of these research activities.​​

Eligibility Requirements:
​​​The ideal candidate will have a Ph.D. degree in biomedical engineering or a related discipline in engineering or the sciences from an accredited institution of higher learning. The ideal candidate will have experience in biomedical image analysis, and a strong technical acumen with interest in further developing multidisciplinary research skills. Experience with cancer imaging studies, multiple imaging modalities, and collaborating with research colleagues with a range of experience and expertise will also be a major advantage for this research position.

The University of Texas MD Anderson Cancer Center values diversity in its broadest sense. Diversity works at MD Anderson. EEO/AA Smoke-free environment.​

Mentor Matching:
This position reports to Mark D Pagel, Ph.D. 

Additional Application Information:
Please direct any questions related to this position to CSIEducation@mdanderson.org and/or Heidi Bradley (HLBradley@mdanderson.org).

Req #: 710509-0006
Job Title:  Postdoctoral Fellow       
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​The department of Cancer Systems Imaging (CSI) is one of the largest new programs at The University of Texas MD Anderson Cancer Center within the Division of Diagnostic Imaging.  The goal of this department and its research program is to develop new methodologies to visualize the cellular, biochemical, and genetic processes that contribute to the development and progression of cancer and to translate these discoveries into the clinic.   

Dr. Loukia Karacosta's lab focuses on poorly characterized processes such as senescence and epithelial-mesenchymal transition (EMT) and aims to dissect how phenotypic plasticity drives the dynamics of drug resistance, therapy response and subsequent disease progression in the tumor microenvironment as a whole. By leveraging cancer systems biology approaches and single-cell technologies like mass cytometry (CyTOF), multiplexed imaging, live imaging and computational tools, we aim to interrogate the complex biology and spatiotemporal dynamics of therapy resistance in various cancer systems such as: cell lines, patient-derived organoids and tissue explants and longitudinal clinical specimens. The overall goal is to utilize innovative approaches of cancer systems biology to develop tools at the translational forefront of cancer systems research, towards predicting and counteracting mechanisms of drug resistance and evaluating – at a personalized level – disease status and response to treatment in cancer patients.​

Eligibility Requirements:
​Prospective candidates with a variety of backgrounds are welcome to apply with a Ph.D. in fields such as cancer biology, molecular and cellular biology, biomedical engineering, biochemistry, and computational biology/bioinformatics from an accredited institution of higher learning.  The ideal candidate would have at least some prior experience in areas like cancer cell biology, cancer systems biology, preclinical cancer models, use of immortalized cell lines, organoids and tissues, analysis of advanced imaging techniques and single-cell data, computational biology or bioinformatics with interest in developing specialized skills in generating high-dimensional data and downstream analysis with translational applications. Although not required, expertise in single-cell analysis (e.g. CyTOF and RNAseq), multiplexed imaging and cancer systems biology is highly desirable.​

Mentor Matching:
This position reports to Loukia Karacosta, Ph.D. 

Additional Application Information:
Please contact Heidi Bradley (HLBradley@mdanderson.org) or CSIEducation@mdanderson.org for additional information or any questions.

Req #: 710509-0007
Job Title:  Postdoctoral Fellow       
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​A postdoctoral position is open at the University of Texas MD Anderson Cancer Center within the Department of Cancer Systems Imaging under the direction of Dr. Daniel E. Frigo.

The position is focused on understanding the roles nuclear receptor signaling, signal transduction and/or metabolism in prostate cancer. The successful candidate will research various aspects of endocrinology, pharmacology, signal transduction, metabolism and cancer biology within the context of developing novel treatments for prostate cancer. In addition, candidates will work with physicians within the Department of Genitourinary Medical Oncology to coordinate their laboratory work with current clinical questions.​

Eligibility Requirements:
Preferred candidates will have experience in genetic mouse models of cancer. Backgrounds in xenograft and syngeneic models of cancer, molecular and cellular biology, immunology and/or cancer metabolism are also encouraged.

The candidate should have a Ph.D. in biology, biochemistry, bioengineering or equivalent by the time of hire from an accredited institution of higher learning with a solid publication record. Preference will be given to candidates that are within one year of receiving their Ph.D.​​

Mentor Matching:
This position reports to Daniel Frigo, Ph.D., Associate Professor in the Departments of Cancer Systems Imaging and Genitourinary Medical Oncology.  View Dr. Frigo's research profile.

Additional Application Information:
Please contact Heidi Bradley (HLBradley@mdanderson.org) with any questions.

Req #: 600709-00004 
Job Title:  Postdoctoral Fellow       
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​The Department of Clinical Cancer Prevention (CCP), The Department of Genitourinary Medical Oncology (GMO) and The Department of Investigational Cancer Therapeutics (ICT)- Research at MD Anderson Cancer Center have multiple post-doc positions open for studying genomic instability, anti-tumor immunity and immunotherapy in a collaborative research group led by Dr. Guang Peng (CCP), Dr. Eric Jonasch (GMO) and Dr. Timothy Yap (ICT). Their laboratory and clinical research studies focus on utilizing genetic, proteomic, and chemical approaches to understand the DNA damage response and repair network and develop preventive/therapeutic strategies to harness anti-tumor immunity by targeting the DNA repair network through the interconnected adaptive (neo-antigen/mutanome dependent) and innate (neo-antigen/mutanome-independent) immune responses. A variety of cell models, animal models and disease models will be used including kidney, ovarian and breast cancers.

The post-doc will work in an extremely collaborative and supportive environment with mentoring and supervision from both a basic research scientist (Dr. Peng) and physician-scientists (Dr. Jonasch and Dr. Yap). Our recently funded biological projects (R01, DODs and private foundations) with both mechanistic and translational significance may impact both cancer prevention and therapy and the candidate will have the opportunity to publish in high-impact journals.

Learning Objectives:
The primary research focus will be conducting genomic instability research using in vitro experimental methods for the mechanistic studies. The fellow will also gain extensive experience in preclinical animal models, clinical specimen validation and bioinformatic analysis using the TCGA database and chemical compounds' databases. ​

Eligibility Requirements:
​We seek a highly motivated individual with a Ph.D. in molecular biology/cancer biology.

Mentor Matching:
This position reports to Guang Peng, M.D., Ph.D.  View Dr. Peng's research profile. 

Additional Application Information:
Selected recent publications related to the projects for this postdoc position from our research group:
Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul;5(7):752-67. PMID: 26069190; PMCID: PMC4497871 (Cancer Discovery Cover Story)

Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Shumei Song, Jingsong Liu, Leona D. Samson, Jaffer A. Ajani, Guomin Li, Han Liang, Xuetong Shen, Gordon B. Mills, and Guang Peng. ARID1A deficiency promotes mutability and potentiates anti-tumor immunity unleashed by immune checkpoint blockade. Nature Med. 2018 May;24(5):556-562. PubMed PMID: 29736026; PMCID: PMC6076433.

Hsieh H, Zhang W, Lin S, Yang W, Wang J, Shen J, Zhang Y, Lu Y, Wang H, Yu J, Mills G, Peng G. Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nat Commun. 2018 Sep 28;9(1):3982. PMID:30266942; PMCID: PMC6162282.

Shen J, Zhao W, Ju Zhenlin, Wang L, Peng Y, Labrie M, Yap T, Mills G, Peng G. PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness. Cancer Research. 79 (2):311-319, 01/2019. PMID:30482774

Wang L, Yang L, Wang C, Zhao W, Ju Z, Zhang W, Shen J, Peng Y, Clemens A, Luu Yen T, Song S, Yap T, Ajani J, Mills G, Shen X, Peng G. Inhibition of the ATM-Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. J Clin Invest. 2020 130(11):5951-5966. PMID: 33016929

Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, Lam T, Pilie PG, Zhu H, Beckermann KE, Haake SM, Isgandrova S, Martinez-Moczygemba M, Sahni N, Tannir NM, Lin SY, Rathmell, WK, Jonasch E. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020 May 1;11(1):2135 PMID: 32358509

Yap TA, O'Carrigan B, Penney MS, Lim JS, Brown JS, de Miguel Luken MJ, Tunariu N, Perez-Lopez R, Rodrigues DN, Riisnaes R, Figueiredo I, Carreira S, Hare B, McDermott K, Khalique S, Williamson CT, Natrajan R, Pettitt SJ, Lord CJ, Banerji U, Pollard J, Lopez J, de Bono JS. Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors. Journal of Clinical Oncology, 6/2020. PMID: 32568634.

Yap TA, Tan DSP, Terbuch A, Caldwell R, Guo C, Goh BC, Heong V, Haris N, Bashir S, Drew Y, Hong DS, Meric-Bernstam F, Wilkinson G, Hreiki J, Wengner AM, Bladt F, Schlicker A, Ludwig M, Zhou Y, Liu L, Bordia S, Plummer R, Lagkadinou E, de Bono JS. First-in-human trial of the oral ataxia telangiectasia and Rad3-related (ATR) inhibitor BAY 1895344 in patients with advanced solid tumors. Cancer Discovery, 9/2020. PMID: 32988960.

Yap TA, Kristeleit R, Michalarea V, Pettitt SJ Lim JSJ, Carreira S, Roda D, Miller R, Riisnaes R, Miranda S, Figueiredo I, Rodriguez DN, Ward S, Mattews R, Parmar M, Turner A, Tunariu N, Chopra N, Gevensleben H, Turner NC, Ruddle R, Raynaud FI, Decordova S, Swales KE, Finneran L, Hall E, Rugman P, Lindemann JPO, Fozley A, Lord CJ, Banerji U, Plummer R, Basu B, Lopez JS, Drew Y, de Bono JS. Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non- BRCA1/2-Mutant Cancers. Cancer Discov 10(10):1528-1543, 10/2020. PMID: 325327

Req #: 406200-00001
Job Title:  Postdoctoral Fellow       
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​The Guise Laboratory studies the molecular mechanisms of bone metastases, the role of TGFb in the tumor-bone microenvironment and cancer treatment-induced bone loss to promote tumor growth as well as to mediate systemic effects on skeletal and cardiac muscle, metabolism and cognitive function. Alterations in the unique bone microenvironment, such as with osteolysis due to cancer and cancer treatment are under investigation with respect to target organ functions at distant sites. The research projects focus on the systemic effects of bone destruction due to cancer and cancer treatment to impact other target organs: 1) pancreatic islets and glucose metabolism; 2) brain and cognitive function and 3) heart and cardiac function to increase morbidity and mortality. These clinically relevant studies will identify new targets to treat consequences of pathologic bone destruction and are funded by a CPRIT scholar award.

Learning Objectives:
1. Develop skills to study bone metastases including development of animal models, bone and muscle histology and histomorphometry, imaging techniques, molecular and cell biology of tumor and bone cells, material properties of bone, metabolism and muscle physiology. This includes development of and writing scientific protocols.

2. Prepare scientific manuscripts of research studies as well as grant applications to local, state and national agencies to obtain independent funding for research projects.

3. Develop skills to present scientific findings of research at laboratory meetings, departmental seminars and relevant scientific meetings at the local, state and national level.

4. Develop skills in teaching trainees in laboratory and related research techniques.

Eligibility Requirements:​
​The Guise Laboratory at the University of Texas MD Anderson Cancer Center is seeking applicants for post-doctorate fellowship to perform laboratory work in cellular and molecular biology, in vivo studies of bone metastases, muscle function and metabolism to understand the role of pathologic bone destruction in the mortality of cancer patients. The fellow will work on CPRIT-funded studies and will develop a new independent project that will extend the studies into clinically relevant and fundable areas.  The applicant must have a minimum of a Ph.D degree in relevant biological or other life sciences, and have at least two years of experience in basic laboratory techniques such as tissue culture, molecular analysis of DNA, RNA, and protein and tumor models. The postdoctoral fellow will be trained in specialized relevant analysis of bone, muscle, and pancreas and expected to write and prepare research presentations, manuscripts and grant proposals.

Mentor Matching:
Successful candidates will be supervised by Theresa A. Guise, M.D.

Req #: 106100-00001
Job Title:  Postdoctoral Fellow       
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​The Nead group is based in the departments of Epidemiology (primary) and Radiation Oncology (secondary). The Nead group currently has a funded open postdoctoral fellow position to study the association of somatic (acquired) genetic changes with cancer development, cancer treatments, and cancer outcomes. Developing research has demonstrated that normal tissues commonly acquire genetic changes and that these acquired variants may have implications for health and treatment outcomes. Our group studies acquired genetic changes in normal tissues (e.g. breast tissue, blood) and how these acquired genetic changes are influenced by cancer treatments (e.g. chemotherapy and radiation therapy), how they impact cancer outcomes (e.g. survival, toxicity), and how they are modulated by cancer risk factors (e.g. age, obesity, smoking). We have ongoing projects available for a postdoctoral fellow to take the lead on as well as ample opportunity and resources for the fellow to explore new avenues of independent research. The Nead group has significant computational resources, wet laboratory space, access to a wide array of clinical samples and data, and the support of a full-time computational scientist, research analyst, and laboratory research assistant. Additionally, we support a rich learning environment with multiple active trainees from the masters to M.D. and/or Ph.D. level.

Learning Objectives:
Gain or advance skills in the analysis of genotype and sequencing data, specifically surrounding the study of acquired genetic changes using advanced sequencing techniques and bioinformatic approaches
Gain or advance skills in the analysis of clinical data as it relates to patient level genetics and genomics
Learn to develop independent lines of research
Advance skills in study design, data analysis and interpretation
Present at national and international conferences
Improve manuscript writing skills
Develop skills in fellowship application and grant writing in order to advance career to the desired next step

Eligibility Requirements:​
​PhD and/or MD or equivalent with a degree and/or significant experience in molecular/genetic epidemiology, computational biology, bioinformatics, data science, or a related field. A computational background and proficiency in at least one scripting language (e.g. R, Python) and at least basic knowledge of biostatistics are required. Experience working with genotyping and/or sequencing data, multi-dimensional datasets, and/or clinical data are desired. A proven track record of publications and proficiency in writing manuscripts is required. The ideal candidate has clear career goals, whether in academic or industry, that we can work together to achieve. Proficiency in spoken and written English is highly desired.

Program Dates:
The appointment is immediately available for a forty hours per week position. Two-year minimum commitment with additional commitment reviewed annually.

Mentor Matching:
This position reports to Kevin T. Nead, M.D., MPhil with ample opportunity for co-mentoring from other faculty collaborators.  

Req #: 185800-00001
Job Title:  Postdoctoral Fellow       
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​The University of Texas MD Anderson Cancer Center Science Park invites applications for postdoctoral fellowships in experimental cancer biology, CRISPR, and functional genetics/epigenetics starting immediately. Using state-of-the-art gene-editing and functional genomics/proteomics techniques, we seek to identify genetic and epigenetic biomarkers for human cancer precision medicine, synthetic lethal and resistance mechanisms underlying disease development and signal transduction at the systems level.

The postdoctoral research will be performed in a highly interdisciplinary and collaborative environment with world-class experts and advanced technologies and facilities, which provide unique and ideal career development opportunities for postdocs.

Eligibility Requirements:​
Applicants should have a recent Ph.D. degree (or equivalent) in molecular biology, cancer biology, genetics/epigenetics, immunology, or relevant fields. We are interested in passionate and self-motivated candidates who ask fundamentally important questions and are bold in taking innovative approaches. Candidates should have previous expertise with tissue culture. Experience with high-throughput biology, CRISPR screens and next-generation sequencing is a plus. 

Interested applicants should send a cover letter describing your past research experience, a curriculum vitae, and the contact information of three references to Dr. Nidhi Sahni (nsahni@mdanderson.org) with the subject line “Postdoc Application in Cancer Biology, CRISPR, and Epigenetics”.​

Mentor Matching:
Successful candidates will be supervised by Nidhi Sahni, Ph.D., a faculty member and recognized leader in cancer genetics and systems biology at MD Anderson Cancer Center. Dr. Sahni has received numerous prestigious awards and strong funding support, including AACR NextGen Star, Sloan Scholar Award, CPRIT Scholar Award, NIH Outstanding Investigator Award (MIRA), DoD grant, Pinnacle Research Award, Rising STARs Award, among others. Recent representative publications include Cancer Cell (2020), 37: 371-86; Cell (2015), 161: 647-60; Nature Rev Genet (2017), 18: 395-410; Cancer Cell (2018), 33: 450-462; Cell (2015), 161: 661-73; Cell (2017), 168: 856-66; Nature Commun. (2018), 9: 1317. 

Req #: 198100-0003
Job Title:  Postdoctoral Fellow 
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Postdoctoral research fellow to carry out studies in translational breast cancer research.The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results from basic, omic and preclinical studies into improved clinical interventions for cancer patients.

A major effort is directed towards elucidating the contribution made by heterogeneity (genomic, phenotypic, spatial and compositional) in both the tumor and its microenvironment to cancer progression and response to therapy. Technologies include
single cell RNA sequencing, ATAC-Seq, and imaging mass cytometry (IMC). Experimental models include human tumor tissue, PDX models of breast cancer and engineered mouse models.

Eligibility Requirements:
Applicants must have a recent Ph.D. (or equivalent) with experience in cancer genomics, cell biology, biochemistry, genetics or related fields. Applicants must have at least one first author publication in a high quality journal as well as a high level of written and oral communication skills in English. Experience working with mice is preferred.

Mentor Matching:
The position reports to Helen Piwnica-Worms, Ph.D.

Additional application information:
Interested applicants should submit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to Helen Piwnica-Worms, Ph.D., at hpiwnica-worms@mdanderson.org.

Req #: 198100-0004
Job Title:  Postdoctoral Fellow 
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The overarching goal of the Ma Lab is to understand the molecular mechanisms of tumor progression, metastasis, and cancer therapy resistance. Specifically, Dr. Ma's team is: (1) establishing new paradigms for RNA functions and mechanisms (non-coding RNAs, RNA epigenetics, and RNA-binding proteins) in tumor progression and metastasis; (2) screening for deubiquitinating enzymes that promote tumorigenesis, metastasis, and therapy resistance; (3) investigating novel regulators and regulations of tumor radioresistance and drug resistance; and (4) studying the role of specific developmental regulators in cancer, metabolism, and regeneration by using genetically engineered mouse models generated in Dr. Ma's lab.

Eligibility Requirements:
We consider highly motivated and creative candidates with a recently obtained Ph.D. degree and strong first-author publications. For those interested, please send a CV, three letters of recommendation, and a research statement (limalab2018@gmail.com). Duration of this posting: continuous until filled.

Mentor Matching:
The position reports to Li Ma, Ph.D.

Req #: 198100-0005
Job Title:  Postdoctoral Fellow 
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Postdoctoral positions are available immediately to work in the area of cancer biology, mouse genetics, and stem cells. The lab focuses on the roles of tumor suppressor genes and oncogenes in cell signaling pathways involved in tumor initiation, progression, tissue homeostasis, and tissue regeneration. The approaches we take range from mammalian cell culture, molecular biology, biochemistry, next-generation sequencing to mouse genetics. For more information, please visit our web site, www.JParkLab.org.

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full- time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
The position reports to Jae-Il Park, Ph.D.

Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 198100-0006
Job Title:  Postdoctoral Fellow 
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​Postdoctoral positions are available immediately to work in the area of DNA damage repair and cancer biology. The lab focuses on the roles of tumor suppressor genes and oncogenes in DNA repair and other signaling pathways involved in tumor initiation, progression and metastasis. The approaches we take range from mammalian cell culture, molecular biology, biochemistry to mouse genetics. We also conduct large-scale proteomic studies and gRNA screens to explore various cancer related signal transduction pathways.​

Eligibility Requirements:
​​An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.​

Mentor Matching:
The position reports to Junjie Chen, Ph.D.

Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 198100-0007
Job Title:  Postdoctoral Fellow 
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Postdoctoral research fellow to carry out studies in translational breast cancer research.The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results using transgenic mouse models as well as patient derived xenograft models. Specific pathways that examine the alteration of the G1/S transition and upregulation of IL-6 will be interrogated in these mouse model systems. Technologies include transgenic mouse modeling, single cell RNA sequencing, immune profiling and in vivo drug studies. ​

Learning Objectives:
​In addition to wet bench and mouse model experiments, the post-doc will also have the opportunity to work with clinical investigators in the breast medical oncology and breast surgical oncology departments to learn how best to translate their pre-clinical work into clinical trials.

Eligibility Requirements:
​Applicants must have a recent Ph.D. (or equivalent) with experience in cancer genomics, cell biology, biochemistry, genetics or related fields. Applicants must have at least one first author publication in a high quality journal as well as a high level of written and oral communication skills in English. Experience working with mice is preferred.​

Mentor Matching:
The position reports to Khandan Keyomarsi, Ph.D.

Additional Application Information:
Interested applicants should saubmit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to Dr. Keyomarsi at kkeyomar@mdanderson.org.

Req #: 198100-0007
Job Title:  Postdoctoral Fellow 
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​​Postdoctoral fellow positions are available for highly motivated candidates with a background in molecular/cellular biology, epigenetics, immunology or cancer mouse modeling. Projects will focus on the biology and genetics of prostate cancer, the identification of novel therapeutic targets, and the mechanism underlying metastasis and treatment resistance. We study these areas by using genetically engineered mouse models, transcriptional profiling, single-cell based analysis as well as other traditional biochemical, genetic, molecular and cell biological approaches. ​

Eligibility Requirements:
A Ph.D. degree in Biochemistry, Molecular Biology or equivalent is required. Applicants with good publication record and relevant research experience with epigenetics, immunology, or single cell sequencing are preferred. We highly value hard work, curiosity, innovation, teamwork and professional development in combination with a healthy work/life balance. The salary will be based on the NIH postdoc salary scale. The postdoc candidates should expect to join the lab in six months. ​​​

Mentor Matching:
The position reports to Di Zhao, Ph.D. View Dr. Zhao's research profile.

Additional Application Information:
View Dr. Zhao's lab website.

Req #: 404400- 00004
Job Title:  Postdoctoral Fellow 
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​The laboratory of Dr. Gabriel Lopez in the Department of Experimental Therapeutics is seeking a post-doctoral fellow to study pharmacokinetics, apoptosis and atophagy as cellular death mechanism. Our laboratory explores the mechanisms of cancer cell survival, tumorigenesis and tumor progression and is focused on identifying signaling pathways regulating proliferation, invasion, drug resistance, apoptosis and autophagy. These studies provide a rational and basis for the development of therapeutic applications using RNA-inteference (siRNA and microRNA), oligonucleotides, (antisense), chemotherapeutic agents and small molecules in cancer and a wide variety of other diseases. Nanomedicine functions as a critical bridge that will connect basic science discoveries and clinical applications by enabling the development of highly effective targeted therapies utilizing nanoparticles that capable of delivering therapeutic payloads to disease sites and targeting identified molecular pathways.

Our long-term goal is to development clinically relevant, non-toxic, tumor-targeted nano-therapeutics agents that can be used translated into the clinic to improve the treatment options for the patients therapy and further enhance efficacy of current regimens.

Learning Objectives:
​Under the supervision of the faculty mentor, will study pharmacokinetics, apoptosisand autophagy as cellular death mechanisms induced by novel compounds and siRNA and will have experience in laboratory techniques, including cell culture small interfered RNA (siRNA) and micro RNA-based gene silencing/regulation, pharmacokinetics, apoptosis and autophagy as cellular death mechanisms fluorescent microscopy, confocal imaging, and flow cytometry applications.

Eligibility Requirements:
​An individual holding a recent PH.D. or equivalent doctorate who is seeking an appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

Program Dates:
July 1, 2021 - October 1, 2021

Mentor Matching:
The position reports to Gabriel Lopez-Berestein, M.D. View Dr. Lopez-Berestein's research profile.

Req #: 600656-0001
Job Title:  Postdoctoral Fellow       
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A joint postdoctoral position is immediately available in the Gastrointestinal Medical Oncology (GIMO) and Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform to conduct research in cancer biology of intestinal adenocarcinomas. This position is responsible for characterizing the preclinical biology of minimal residual disease (MRD) in colorectal cancer. Projects will include the development use and characterization of minimal residual disease mouse models that represent micrometastases, their evolution, and drug resistance. Clonal evolution and immune infiltration will be examined using CRISPR barcoding approaches, single cell RNAseq, FACS and multiplex immunofluorescence. These studies include modeling and connections to clinical efforts involving MRD identified by circulating tumor DNA (ctDNA).

Learning Objectives:
Learning objectives are to better understand colorectal cancer tumor heterogeneity and evolution in response to therapy. Plan and perform research project using molecular biology techniques, such as cloning, transfection, site-directed mutagenesis assay, allelic expression assay, CRISPR driven cell barcoding, flow cytometry single cell RNAseq and ctDNA analysis. Generate or learn to generate animal transgene expression and targeting constructs, including those using Cre/lox and CRISPR technologies Evaluate targeted drugs key molecular targets in minimal residual disease as part of a drug development program. Examine the molecular and cellular evolution in colorectal cancer development by single cell RNAseq.

Eligibility Requirements:
M.D. and/or Ph.D. degree in the following areas: Biochemistry, Cellular and/or Molecular Biology.

Mentor Matching:
This position interfaces between Scott Kopetz, M.D., Ph.D., and David Menter, Ph.D., in GIMO and Timothy Heffernan, Ph.D., in TRACTION to identify and characterize minimal residual disease biology along with subtype specific targets and agents.

Req #: 600656-0005
Job Title:  Postdoctoral Fellow       
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​Assists principal investigator with clinical, translational, and basic scientific 
aims of our CRC Moon Shot and Astellas project. Mouse tumor, human tumor and PDX mouse model samples are to be analyzed for protein and molecular profiling to assess the impact of target metastatic site resident immune cells, immune infiltrates and mechanisms of CRC minimal residual disease (MRD).  Functions in a separate and independent manner in the design and initiation of research experiments.  Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems.  Interfaces with the electronic medical record, and databases of tissue samples blood cytokines and protein biomarkers analysis and tumor molecular data.   
Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications. 
Additionally, 
a. Applicant should have experience in methods of sensitive detection of proteins and also work on developing assays and CyTOF and multiplex panels that can distinguish determine the impact of resident immunity, immune infiltrates and mechanisms involved in CRC-MRD. 
b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.

Learning Objectives:
​- understanding of biology of CRC-MRD and microenvironment interactions and predictors of outcome
- ability to search and evaluate clinical and scientific literature
- ability to form and then defend hypotheses based on prior clinical or experimental data
- ability to effectively communicate findings in written and oral form
- ability to write persuasive grant applications and scientific publications

Eligibility Requirements:
​Graduate degree in verterinary medicine, science, or chemistry fields

Program Dates:
Anticipated start date 12/14/2020, average 40 hours per week is needed to accomplish goals 

Mentor Matching:
This position interfaces between David Menter, Ph.D., Assistant Professor of GI Medical Oncology; and Scott Kopetz, M.D., Ph.D.,, Professor of GI Medical Oncology; Natalie Fowlkes, DVM, Ph.D: Assistant Professor of Veterinary Medicine

Req #: 600656-0006
Job Title:  Postdoctoral Fellow       
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A postdoctoral position is immediately available in the Gastrointestinal Medical Oncology (GIMO) to conduct research in cancer biology of intestinal adenocarcinomas. This position will focus on oncolytic virus infections to target abscopal tumors as a model for colorectal liver metastasis using transplantable syngeneic tumors. This position is also responsible for characterizing the preclinical biology of minimal residual disease (MRD) in colorectal cancer. Projects will include the development use and characterization of minimal residual disease mouse models that represent micrometastases, their evolution, and drug resistance. Clonal evolution and immune infiltration will be examined using CRISPR barcoding approaches, single cell RNAseq, FACS and multiplex immunofluorescence. These studies include modeling and connections to clinical efforts involving MRD identified by circulating tumor DNA (ctDNA).
This position will identify and characterize minimal residual disease biology, immune function and TGF-β pathway activity, along with subtype specific targets and agents in immune competent mouse models.
Core Values
• Courtesy: Is respectful and courteous to each other at all times
• Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; Is sensitive to the concerns of our patients and our co-workers
• Reliability: Communicates frequently, honestly and openly
• Accountability: Holds self and others accountable for practicing our values
• Safety: Notices a safety concern and brings it to someone's attention; Models safe behaviors (wears badge, washes hands, keeps work area clean and orderly); Mitigates risk to the institution through sound business practices
• Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas
• Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so

Key Functions
• Plan and perform research project using molecular biology techniques, such as cloning, transfection, site-directed mutagenesis assay, allelic expression assay, CRISPR driven cell barcoding, flow cytometry single cell RNAseq and ctDNA analysis.
• Evaluate targeted oncolytic virus activity in minimal residual disease using transplantable syngeneic tumor models
• Generate or learn to generate animal transgene expression and targeting constructs, including those using Cre/lox and CRISPR technologies
• Evaluate targeted drugs key molecular targets in minimal residual disease as part of a drug development program
• Examine the molecular and cellular evolution in colorectal cancer development by single cell RNAseq.
• To conduct immunohistochemistry and protein and mRNA expression analyses and single cell RNAseq in CRC samples.
• Perform laboratory testing of novel agents, combination therapies in cell lines, animal models and tissue cultures and patient-derived xenografts.
• Plan and perform independent research projects using experimental assays techniques such as DNA, RNA, protein extraction, western blotting, Q-Real Time and digital PCR, and FACS.
• Maintain accurate data storage and record filling systems to include all pertinent data and specifications on all experiments performed. Use computer programs for data analysis and presentation. Review and analyze scientific data and laboratory test results.
• Maintain a safe laboratory environment, including updating regulatory documents for animal use, chemical and laboratory safety.

Core Competencies
o IC – Team with Others:
o Encourage collaboration and input from all team members;
o Value the contributions of all team members; and
o Balance individual and team goals
o IC – Self-Motivation:
o Set high standards of performance;
o Pursue goals with energy and persistence; and
o Drive for results and achievement.
o IC-Self-Adaptability:
o Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.
o Help coworkers with tasks as necessary.
o Smoothly handle multiple demands, shifting priorities, and rapid change.
o Persist despite obstacles

Eligibility Requirements:
Education Required: Doctor of Philosophy (Ph.D) degree in the following areas: Biochemistry, Cellular and/or Molecular Biology.

Experience Required: A proven track record of publications.

This position requires:
• Exposure to human/animal blood, body fluids, or tissues
• Exposure to harmful chemicals
• Exposure to animals

Mentor Matching:
This position interfaces between David Menter, Ph.D., Assistant Professor of GI Medical Oncology; and Scott Kopetz, M.D., Ph.D., Professor of GI Medical Oncology

Req #: 600656-00007
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellowship position is immediately available in the Kopetz Laboratory in the Department of Gastrointestinal Medical Oncology at The University of Texas M. D. Anderson Cancer Center. The position will involve basic and translational research in the area of metastatic colorectal cancers. Successful candidate will be a key member of a team working on multiple experimental therapeutics projects sponsored by leading pharmaceutical companies and NIH.

Essential qualifications for this position include a PhD in cancer biology or related discipline and a demonstrated ability to communicate research through publications and presentations. A strong background in biochemistry, molecular biology, and cell biology is required. Preferred qualifications include demonstrated experience in in vitro/in vivo pharmacology and basic bioinformatics skills.

Please provide a curriculum vitae, names of three recent referees (including at least one in a direct supervisory role) and a brief statement of prior research experience to: skopetz@mdanderson.org.

Learning Objectives:

• Perform laboratory testing of novel agents, combination therapies in vivo and in vitro (cell lines, tissue cultures, and animal models). Primary focus is PDXs in vivo studies.
• Plan and perform research projects under minimal supervision using experimental assays techniques such as DNA, RNA, protein extraction, western blotting, IHC, FACS, real time and qPCR.
• Conduct literature search and scientific papers reading related to the projects.
• Perform research data analysis and interpretation.
• Modifies and/or develops new techniques.
• Maintain accurate sample and data storage and record filling systems on all experiments performed.
• Assist lab manager with processing of clinical samples, including blood processing and implantation/ maintenance of patient-derived xenografts.
• Assists with preparation of grant and contract applications as requested by lab investigators.

Eligibility Requirements:
Education Required:  PhD, DVM or MD degree with strong background in biochemistry, molecular biology, and cell biology. 
Education Preferred:  PhD, DVM and/or MD with demonstrated experience in in vitro and in vivo pharmacology projects.

Experience Required:  Five years of experience in scientific or experimental research work

Mentor Matching:
This position interfaces between Scott Kopetz, M.D., Ph.D., Professor of GI Medical Oncology and David Menter, Ph.D., Assistant Professor of GI Medical Oncology.

Req #: 600656-00008
Job Title:  Postdoctoral Fellow       
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​Assists principal investigator with clinical, translational, and basic scientific research projects.  Functions in a separate and independent manner in the design and initiation of research experiments.  Designs, develops or adapts equipment used in experiments or research to obtain desired results.  Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems. 
Interfaces with the electronic medical record, and databases of tissue samples and tumor molecular data. Plans training and research work activity for assigned laboratory and research personnel.  Supervises the use of laboratory equipment and implements safety procedures. 
Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications.
Collaborates with both experimental and computational members of the lab.

Additionally,
a. Independently proposes innovative solutions to research projects and contributes to project goals through computational analysis; willing and able to learn and adapt existing bioinformatics tools for application to his/her research projects
b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.

Learning Objectives:

• ​Understanding of biology of colon and appendiceal cancers

• Ability to search and evaluate clinical and scientific literature

• Ability to form and then defend hypotheses based on prior clinical or experimental data

• Ability to effectively communicate findings in written and oral form

• Ability to write persuasive grant applications

• Ability to navigate scientific publication process
  

Eligibility Requirements:
​Graduate degree in medicine, science, or engineering field

Mentor Matching:
This position interfaces between John Paul Shen, M.D. View Dr. Shen's research profile.

Req #: 600656-00009
Job Title:  Postdoctoral Fellow       
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 A joint postdoctoral position is immediately available in the Gastrointestinal Medical Oncology that interfaces with our INTERCEPT program and the Immunotherapy Program to conduct research in cancer biology of intestinal adenocarcinomas. This position is responsible for characterizing the preclinical biology of minimal residual disease (MRD) in colorectal cancer.

Projects will include the development use and characterization of minimal residual disease mouse models that represent micrometastases, their evolution, and drug resistance. Immune infiltration will be examined using single cell RNAseq, FACS and multiplex immunofluorescence. These studies include modeling and connections to clinical efforts involving MRD identified by circulating tumor DNA (ctDNA).

Learning Objectives:

​To better understand colorectal cancer tumor heterogeneity and changes in the immune system in response to therapy. Plan and perform research project using Multiplex IF, flow cytometry, single cell RNAseq and ctDNA analysis. Evaluate targeted drugs key molecular targets in minimal residual disease as part of a drug development program. Examine the molecular and functional immune changes in colorectal cancer development through the use of leading-edge immune platform technologies.

Eligibility Requirements:
​M.D. and/or Ph.D. degree in the following areas: Biochemistry, Cellular and/or Molecular Biology.

Experience Required:  Five years of experience in scientific or experimental research work

Mentor Matching:
This position interfaces between Scott Kopetz, M.D., Ph.D., Professor of GI Medical Oncology and David Menter, Ph.D., Assistant Professor of GI Medical Oncology, and Timothy Heffernan, Ph.D., in TRACTION to identify and characterize minimal residual disease biology along with subtype specific targets and agents.

Req #: 144300-00004
Job Title:  Postdoctoral Fellow       
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Chronic pain is usually caused by disease or damage involving the somatosensory nervous system, adversely affecting millions of Americans. It is difficult to treat and remains a major clinical problem. Opioids, acting through opioid receptors, function as powerful analgesics. However, chronic opioid treatment causes hyperalgesia/analgesic tolerance and addiction, which have resulted in an opioid epidemic in the U.S. One position involves studying the mechanisms of chronic pain in mouse models and determining how these mechanisms could be utilized in therapeutic interventions of chronic pain.

Glioblastoma is a highly heterogeneous and lethal human brain tumor and is made up of multiple molecular subtypes, suggesting that therapy could be targeted to particular subtypes. Yet all newly diagnosed GBM patients are treated with a similar therapeutic regimen, which results in overall poor patient outcomes. The second project involves discovering mechanism-based therapeutic approaches for a molecularly-stratified glioblastoma tumor using mouse models and advanced drug-delivery systems.

Learning Objectives:
The postdoctoral fellow will engage with the Pl in understanding how REST regulates either chronic pain or glioblastoma in mouse models. This will require deep interest in pain research, cell biology and developmental biology, and depending on the project, on bioinformatic analyses. The Pl will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation, but the fellow is expected at the same time to consistently undertake an active role in researching the literature and bringing new perspectives to the laboratory. Trainings that may be needed that are outside of the expertise of the Pl will involve attending courses or engaging in collaborative ventures. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory, and, equally importantly, to promote one's research program after leaving the laboratory.

Eligibility Requirements:
We are looking for a committed Postdoctoral Fellow to join our group to work on the mechanisms by which the transcriptional repressor REST regulates chronic pain and glioblastoma regulation.

Excellent experience in epigenomic research is required. Excellent experience in Molecular Biology techniques such as ChIP, RT-PCR, Immunofluorescence microscopy, SDS-PAGE, Analytical chromatigraphy, and bioinformatic analysis is required.

Mentor Matching:
This position reports to Sadhan Majumder, Ph.D.

Additional Application Information:
Learn more about Dr. Majumder’s lab.

Req #: 144300-00003
Job Title:  Postdoctoral Fellow       
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Developmental birth defects, and failed pregnancies, are often linked directly to poor oocyte quality. For example, a poor-quality oocyte with wrong number of chromosomes results in severe aneuploidy in the fetus during early development leading to embryonic birth defects or death. However, several fetal abnormalities occur despite a normal oocyte chromosomal complement, suggesting that factors in addition to chromosomal numbers regulate oocyte quality. These factors remain unknown because the cell-intrinsic molecular cues, and the cellular and physiological parameters that determine oocyte quality remain mostly uncharacterized. The growth of the oocyte to its final size and accumulation of the cytoplasmic and maternal components - critical for early fetal development - occur during meiosis I of oogenesis. Mammalian meiosis I is largely completed in the fetal ovary. Thus, deciphering the molecular cues, and physiological states within the meiosis I oocyte in vivo remains a challenge.
Caenorhabditis elegans forms an excellent model system to understand the cellular and genetic mechanisms of oocyte quality at meiosis I; meiosis I of oogenesis occurs during adulthood in C. elegans. As in vertebrates, oocyte growth and development is controlled by the ERK signaling pathway in worms. We have shown that loss of ERK activity from oocytes, results in formation of giant oocytes, and conversely, excessive ERK activity results in multiple small oocytes (. Both large and small oocytes result in embryonic death or infertility. We have also shown that insulin like receptor (DAF-2) and maternal nutrition regulate the RAS-ERK signaling pathway to control oocyte growth and quality. Thus, a major goal in the lab is to investigate the role of ERK signaling that result in accurate regulation of germ cell development and oocyte quality.

Learning Objectives:
The postdoctoral fellow will engage with the PI is determining how ERK MAPK signaling functions during germ cell development. This will require deep interest in cell and developmental biology, including an interest in mathematical modeling of imaging data. The Pl will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation. Additional training will be provided by the mentor through courses and workshops offered by Cold Spring Harbor Labs, MBL among others. These will be determined by the trainee and the PI as the need arises. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory, and, equally importantly, to promote one's research program after leaving the laboratory.

Eligibility Requirements:
Ph.D. to be awarded, minimally, in the last 12 months.

Mentor Matching:
This position reports to Swathi Arur, Ph.D.

Additional Application Information:
Learn more about Dr. Arur's lab.

Req #: 144300-00005
Job Title:  Postdoctoral Fellow       
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​The Navin laboratory has an open position for a postdoctoral fellow in molecular biology and genomics. This individual will work on projects that use single cell DNA and RNA sequencing to study genomic evolution in breast cancer particularly in the context of metastasis and chromosome biology. The ideal candidate will have strong scientific writing skills, experience in genomics and extensive training in molecular biology and next-generation sequencing methods. Some familiarity with computational biology methods, including experience in Unix/Linux, scripting languages (Perl, Python) and statistical languages (R, Matlab) is also preferred

Learning Objectives:
​The individual will learn experimental methods related to performing single cell DNA and RNA sequencing experiments and will learn computational and statistical methods related to analyzing the resulting datasets. The postdoc will work closely with the PI to learn how to write and submit manuscript, write fellowship and grant applications. Towards the end of their postdoc training they will learn how to apply for faculty positions and will present their work at national and international conferences.

Eligibility Requirements:
​Ph.D. degree in molecular biology, genomics or cell biology

Mentor Matching:
This position reports to Nicholas Navin, Ph.D.

Additional Application Information:
Learn more about Dr. Navin's lab.

Req #: 144300-00006
Job Title:  Postdoctoral Fellow       
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​The Navin laboratory has an open position for a postdoctoral fellow in computational biology in the department of Genetics at the MD Anderson Cancer Center in Houston, TX. The individual will work on the development of statistical methods to analyze large-scale single cell DNA and RNA sequencing datasets to study human cancer progression. This person will lead individual projects related to cancer evolution, invasion, metastasis or therapy resistance. Strong programming skills are required in languages such as Perl, Python and Matlab. Strong statistical skills in R are also required, including knowledge of multivariate statistical methods, such as clustering, high-dimensional data reduction and phylogenetics. Good knowledge of Unix, Linux and Clusters is also necessary.

Learning Objectives:
The individual will learn cancer genomics and computational biology, particularly in relation to skills for analyzing large-scale single cell sequencing datasets.  They will learn how to analyze and interpret data related to genome evolution in breast cancer.   The postdoc will work closely with the PI to learn how to write and submit manuscript, write fellowship and grant applications and apply for faculty positions. ​

Eligibility Requirements:
​Ph.D. degree in computational biology, computer science, statistics or genomics

Mentor Matching:
This position reports to Nicholas Navin, Ph.D.

Additional Application Information:
Learn more about Dr. Navin's lab.

Req #: 144300-00007
Job Title:  Postdoctoral Fellow       
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​The Lozano laboratory has an open position for a postdoctoral fellow to study p53 genetic pathways in tumor progression.​

Learning Objectives:
​The individual will learn experimental methods related to the study of p53 genetic pathways in tumor progression using mice as a model system. They will work closely with the PI to learn how to write and submit manuscripts, write fellowship and grant applications, and present their work at national and international conferences. Towards the end of their postdoc training they will learn how to apply for faculty positions.​

Eligibility Requirements:
​Ph.D. or M.D./Ph.D. with a strong background in genetics, molecular biology or related fields​

Mentor Matching:
This position reports to Guillermina Lozano, Ph.D.

Additional Application Information:
For more information please visit these websites:

Genetics Department Website
Lozano Lab Website

Req #: 144300-00008
Job Title:  Postdoctoral Fellow       
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​Tumor cells must endure diverse intrinsic and extrinsic stressors that perturb proteome homeostasis. By serving as a protein-folding buffer within the cell, the chaperone protein HSP90 supports protein homeostasis and enables tumor cells to survive and rapidly evolve resistance to therapies. For this, HSP90 must bind to diverse proteins and stabilize them within the cytoplasm. However, the specific mechanisms through which HSP90 fosters cancer evolution remain obscure. We will examine these HSP90-dependent mechanisms using multiomic systems approaches and functional genomics methodologies and, subsequently, we will validate the mechanisms we identify in mice. This strategy will identify novel cancer therapies that limit the ability of tumors to evolve resistance.​​

Learning Objectives:
​The postdoctoral fellow will engage with the PI in understanding how the HSP90 chaperone is regulated in cancer and how it supports DNA repair in tumor cells. This will require deep interest in cell biology and signaling pathway biology. The PI will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar and in critical thought, experimental design and bringing new perspectives to the laboratory. Trainings that may be needed that are outside of the expertise of the PI will involved attending courses or engaging collaborative ventures. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one’s work in the laboratory, and to promote the trainee’s research program after leaving the laboratory.​​

Eligibility Requirements:
​We seek highly motivated postdocs interested in functional proteomics, quantitative genetics, biochemistry, cell biology, or cancer biology. We welcome applicants from diverse backgrounds who wish to apply their expertise to biological systems and to contribute to the advancement of precision medicine. Minimum requirement is to have recently been awarded (within two years) a Ph.D., and proficiency in spoken and written English. ​

Mentor Matching:
This position reports to Georgios Karras, Ph.D.

Additional Application Information:
For more information please visit these websites:

Genetics Department Website
Karras Lab Website

Req #: 144300-00009
Job Title:  Postdoctoral Fellow       
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​The research program focuses on vertebrate sexual development and reproduction, using genetic, cell, and developmental biology approaches. Candidate genes are mutated in animal systems to determine their roles in sexual development and reproduction. Genes with roles in sexual development and reproduction are then placed in gene regulatory networks for specific processes. Research results are communicated in peer-reviewed publications and at scientific conferences. Career mentoring is actively provided.

Learning Objectives:
​The postdoctoral fellow and/or the visiting postdoctoral fellow will collaborate with the PI to develop CRISPR/Cas genetic manipulation technologies in anole lizards to investigate reproduction and sexual development. The postdoctoral fellows will establish an anole lizard breeding colony to generate mutations and study mutant phenotypes in reproductive organs and fertility. The postdoctoral fellows will also pursue related projects in mice, using established genetic approaches. In addition to research the postdoctoral fellows will learn skills to advance their career objectives, including written and communication skills, presentation of research results at scientific conferences, and establishing professional networks.

Eligibility Requirements:
​Minimum requirement is to have recently been awarded (within three years) a Ph.D. The applicant must be an American citizen or US Permanent Resident. Individual must have an interested in the reproduction and developmental biology of reptiles.

Mentor Matching:
This position reports to Richard Behringer, Ph.D.

Additional Application Information:
For more information please visit these websites:

Genetics Department Website
Behringer Lab Website

Req #: 600138-00004
Job Title:  Postdoctoral Fellow       
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​We seek a talented and highly motivated Postdoctoral Fellow to work on lymphoma and CAR T single cell profiling projects. Our primary research focus areas are: to apply innovative bioinformatics approaches to better understand CAR T cell biology, resistance mechanisms to CAR T therapy, and the cellular & functional heterogeneity and evolutionary dynamics of cells within the tumor immune microenviroment (TME)​.

Learning Objectives:
​​The Postdoctoral Fellow will carry out integrative analysis of the multi-platform single cell sequencing (RNA/TCR/BCR/ATAC), cfDNA sequencing, and immunogenomic datasets generated on biopsies and therapeutic CAR T products from patients and patient-derived xenograft models, to comprehensively characterize the tumor ecosystem and identify predictive/prognostic signatures/biomarkers and potential targets that could be harnessed to design rational therapeutic interventions. The Postdoctoral Fellow will have great opportunities to collaborate with diverse groups of physician scientists, laboratory scientists and computational biologists at MD Anderson Cancer Center and will be co-mentored by Drs. Linghua Wang and Michael Green.​

Eligibility Requirements:
​Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills  are required.​

Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Linghua Wang, Ph.D. and is co-mentored by Michael Green, Ph.D., in Department of Lymphoma and Myeloma

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Wang (Lwang22@mdanderson.org)  and Dr. Green (MGreen5@mdanderson.org) with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.  

Req #: 600138-00006
Job Title:  Postdoctoral Fellow       
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​We seek a talented and highly motivated Postdoctoral Fellow to work on projects in the functional cancer epigenomics field utilizing CRISPR-based high-throughput screening approaches at bulk and single cell level. The primary research focus of the Rai lab is to determine epigenome reprogramming during cancer progression and resistance to immunotherapy, and to identify non-coding elements that can be targeted for therapeutics using novel modalities.  Dr. Rai and team have published a number of studies in this field in top journals including Cell, Cancer Discovery, Cancer Cell, Nature Communications and Cell Reports.​

Learning Objectives:
​Postdoctoral Fellow will develop and apply novel CRISPR based tools at bulk and single cell level for identification of functional non-coding elements in the immune cells for immunotherapies. They will learn to devise hypothesis, design experimental plans and execute the strategy in wet and dry lab settings to perform cutting-edge science. The lab presents opportunities to gain expertise in epigenomic methods, molecular biology techniques, animal modeling of cancer as well as computational biology. They will also gain experience in grant writing and training junior scientists/students.​

Eligibility Requirements:
​Individuals with a PhD degree in any discipline of biology.​

Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Kunal Rai, Ph.D. See Dr. Rai's research profile.

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Rai at Krai@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.    Consideration of applications will begin immediately and continue until the position is filled. 

Req #: 600138-00007
Job Title:  Postdoctoral Fellow       
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​We seek a talented and highly motivated Postdoctoral Fellow to work on projects in the computational epigenomics field. Project will involve developing computational approaches for cutting-edge single cell epigenomic, CRISPR screening and genomic methods. The primary research focus of the Rai lab is to determine epigenome reprogramming during cancer progression and resistance to immunotherapy, and to identify non-coding elements that can be targeted for therapeutics using novel modalities.  Dr. Rai and team have published a number of studies in this field in top journals including Cell, Cancer Discovery, Cancer Cell, Nature Communications and Cell Reports. ​

Learning Objectives:
​Postdoctoral Fellow will develop and apply computational tools to gain insights from bulk and single cell epigenomic and genomic data, as well as developing tools for single cell functional epigenomics tools. They will learn to devise hypothesis, design experimental plans and execute the strategy to perform cutting-edge science. They will also gain experience in grant writing and training junior scientists/students.​

Eligibility Requirements:
​Individuals with a PhD degree in any discipline of biology.​

Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Kunal Rai, Ph.D. See Dr. Rai's research profile.

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Rai at Krai@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.    Consideration of applications will begin immediately and continue until the position is filled. 

Req #: 600138-00008
Job Title:  Postdoctoral Fellow       
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​We seek a talented and highly motivated Postdoctoral Fellow to work on the cancer single cell profiling projects. The primary research focus is: to apply innovative bioinformatics approaches to dissect tumor ecosystem and better understand tumor-immune co-evolution and therapy response. In particular, to profile in-depth the cellular & functional heterogeneity, lineage plasticity and evolutionary dynamics of tumor cells, and cells of the tumor immune microenvironment (TIME). ​

Learning Objectives:
Gain mechanistic understanding of tumor cell heterogeneity and immune resistance. Learn skills for immunogenomics and single cell sequencing data analysis, and cancer-specific bioinformatics. Learn study design, data analysis, interpretation, presentation, and manuscript writing. ​​

Eligibility Requirements:
​Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required.​

Program Dates:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Linghua Wang, Ph.D.

Additional Application Information: 
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Linghua Wang at Lwang22@mdanderson.org with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.  Consideration of applications will begin immediately and continue until the position is filled. 

Req #: 600138-00009
Job Title:  Postdoctoral Fellow       
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​We seek a talented and highly motivated Postdoctoral Fellow to work in Genomic Medicine Department on metabolic heterogeneity in pancreatic cancer. The primary research will focus on determining the molecular mechanisms responsible for mitochondrial functional diversity at the subclonal level and how metabolic heterogeneity affects tumor response to therapy. ​

Learning Objectives:
Focusing on pancreatic cancer the study will involve the use of multiple cutting-edge technologies such as genomic and RNA sequencing, single-cell transcriptomics, ATAC-seq, molecular barcoding, metabolomics and high content-imaging. ​​

Eligibility Requirements:
​Highly motivated individuals with a recent PhD degree in biological fields or MD/PhD.  Experience preferred in metabolism, molecular biology and in vivo mouse work.​​

Program Dates:
The appointment is available effective April 1, 2021. 

Mentor Matching:
This position reports to Andrea Viale, M.D. See Dr. Viale's profile. 

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Andrea Viale at aviale@mdanderson.org  with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.  Consideration of applications will begin immediately and continue until the position is filled. 

Req #: 600138-00010
Job Title:  Postdoctoral Fellow       
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​We are seeking a talented and highly motivated Postdoctoral Fellow with computational and statistical background to work on immunogenomic profiling projects focusing on leukemias.  Our goal is to apply innovative immunogenomics and bioinformatics approaches to better understand leukemogenesis, resistance mechanisms to chemo and immunotherapy, and deep profiling of the cellular & functional heterogeneity of leukemic cells, and the diverse cell populations within the tumor immune microenvironment. We will primarily be utilizing patient samples from leukemia clinical trials allowing us to interrogate translational questions that have immediate patient impact.​

Learning Objectives:
Gain mechanistic understanding of tumor cell heterogeneity and immune resistance. Learn skills for immunogenomics and single cell sequencing data analysis, and cancer-specific bioinformatics. Learn study design, data analysis, interpretation, presentation, and manuscript writing. The Postdoctoral Fellow will carry out integrative analysis of the bulk and single cell sequencing (RNA/TCR/BCR/ATAC-seq), and immunogenomic datasets generated on clinical specimens from primarily patient samples on clinical trials, or animal models, to comprehensively characterize the tumor ecosystem and identify predictive/prognostic signatures/biomarkers and potential targets that could be harnessed to design rational therapeutic interventions. The Postdoctoral Fellow will have great opportunities to collaborate with diverse groups of physician scientists, laboratory scientists and computational biologists at MD Anderson Cancer Center and will be co-mentored by Dr. Hussein Abbas and Andy Futreal. Postdoc will have a primary appointment in Genomic Medicine Department with optional appointment in Department of Leukemia.​​

Eligibility Requirements:
​Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g. Python, Perl) and knowledge in biostatistics are required. Experience working with single cell sequencing data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. However, we will provide guidance through navigating different areas of translational research. Proven track record of publications, excellent spoken and written communication skills are required.​

Program Dates:
The appointment is immediately available.  Appointee is expected to work forty hours per week.  

Mentor Matching:
This position reports to Hussein Abbas, M.D., Ph.D., in Genomic Medicine and Leukemia Departments, and will be co-mentored by Andrew Futreal, Ph.D., Chair of Genomic Medicine. 

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. Hussein Abbas (habbas@mdanderson.org) with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name”.  

Req #: 600655-00001
Job Title:  Postdoctoral Fellow       
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Contribute to wrap up the PSOC project on metabolic perturbation of invading cancer. Transit to bone-related project work in preparation of a resubmission of an NIH-sponsored U-01 project on bone invasion. Interact with the team of Dr. Vivek Shenoy from UPENN to link cancer biology experiments to in silico modeling of cancer invasion and progression.

Learning Objectives:
Intravital microscopy, intersection of in vivo cell biology, quantitative image analysis and mathematical modeling, RNA profiling of in vivo tissue samples.

Eligibility Requirements:
The candidate has a strong track record on cell migration and live-cell / 3D microscopy, and quantitative image analysis.

Dates or Training Schedule:
Learning objectives to be achieved within 2 years, and to be expanded towards a consolidated and diversified project line thereafter.

Mentor Matching:
This position reports to Peter Friedl, Ph.D.

Req #: 600655-00002
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellow position is available in Department of Genitourinary Medical Oncology at MD Anderson Cancer Center, Houston, TX. Our research is focused on understanding the molecular basis of primary and adaptive resistance mechanisms to immune checkpoint therapies in advanced prostate cancer. The laboratory focuses on addressing this issue using a wide range of tools from next-generation sequencing (WES, WGS, RNA-seq) and in vitro and in vivo immunologic assays (flow cytometry, mass cytometry, IHC). The candidate should be familiar with basic techniques in immunology, molecular biology, cell biology, and genomic profiling of tissues.

Learning Objectives:
​The postdoctoral fellow will work under the supervision of Drs. Sumit Subudhi and Theocharis Panaretakis. The successful applicant is expected to develop an in-depth understanding of cancer immunology mouse models, T cell responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.

Eligibility Requirements:
​Candidates should be highly motivated individuals who have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Immunology, with preferred hand-on experience in flow/mass cytometry, molecular techniques, and mouse models of autoimmunity and/or anti-tumor immunity. Only candidates who have published work from their pre- and/or post-doctoral studies will be considered.- Experience of laboratory techniques in the fields of molecular biology and immunology.

- Develop, analyze and validate data for assays using statistical methods.
- Previous experience with SOPs and animal protocols.
- Troubleshooting daily experiments. 
- Demonstrated ability for creative thinking and problem solving.
- Demonstrated ability to work in a multi-disciplinary team.

Dates or Training Schedule:
Anticipated start date is October 2020. 

Mentor Matching:
This position reports to Sumit Subudhi, M.D., Ph.D.

Req #: 600655-00003
Job Title:  Postdoctoral Fellow       
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Work within a research laboratory with focus on mechanistic and tissue based analysis of DNA repair defects and the interaction with immune response in kidney cancer.   Interact  with laboratory partners, bioinformatics team members and clinicians in a collaborative manner.   Develop laboratory, bioinformatics and translational knowledge pertinent to project. 

Learning Objectives:
​Successful candidate must be able to design novel projects, create hypothesis driven experiment, maintain excellent descriptions of experiments performed, standardize and validate new methods and be able to interpret results.  The candidate will develop skills that allow them to be responsible for coordinating procedures with collaborators, including bioinformatics, tissue and clinical partners.  They will learn to write and edit manuscripts and reports, as well as develop grant writing skills.

Specific technical skills that will be developed include DNA damage related procedures including fiber assays, RPA exhaustion assays, use and interpretation of multispectral imaging assays. Interest in developing an understanding of bioinformatics analyses is desirable..

Eligibility Requirements:
Candidates should be highly motivated individuals who have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in molecular biology and ideally immunology, with preferred hand-on experience in molecular techniques, and mouse cancer models . Only candidates who have published work from their pre- and/or post-doctoral studies will be considered.

- Experience of laboratory techniques in the fields of molecular biology and immunology.
- Develop, analyze and validate data for assays using statistical methods.
- Previous experience with SOPs and animal protocols.
- Troubleshooting daily experiments.
- Demonstrated ability for creative thinking and problem solving.
- Demonstrated ability to work in a multi-disciplinary team.

Dates or Training Schedule:
Anticipated start date is October 2020. 

Mentor Matching:
This position reports to Eric Jonasch, M.D.

Req #: 600655-00004
Job Title:  Postdoctoral Fellow       
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​The in vivo functional genomic laboratory of Dr. Giannicola Genovese at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for an exceptional postdoctoral fellow with a strong interest in understanding the mechanisms and dynamics of clonal evolution in the progression of aggressive solid tumors. The successful candidate will have significant experience in cancer genetics/genomics and immunology. Experience with molecular biology, histology and tissue preparation, cell biology are very helpful but not required.

Learning Objectives:
​The aim of our research is to dissect the mechanisms driving clonal diversification in malignant progression with a focus on functional determinants of metastatic dissemination and immune evasion. We address these fundamental questions in high-throughput in vivo models of cancer leveraging somatic mosaic genome editing methods and complex lineage/clonal tracing tools.   

- Training and expertise in genetics and functional genomics (in vivo somatic genetic/chromosomal engineering). 

- A stimulating environment with freedom to develop new research directions.

- The opportunity to work with the world leaders in cancer genomics. 

- Supportive mentorship for career development and opportunities tailored towards individual career goals and strengths.

- A fun, hard-working and supportive lab that practices team-based science.​

Eligibility Requirements:
Ideally someone who is less than one year out from completing their Ph.D.; however, each candidate with a strong interest in science and cancer medicine is encouraged to apply. We're looking people who are/have:

• An enthusiastic and ambitious individual with a strong curiosity and a desire to learn. 
• An independent thinker that works well in a team. 
• Strong verbal and written communication skills. 
• Willing to take advantage of career development opportunities. 
• Interest in working with junior lab members and summer undergraduates.

Dates or Training Schedule:
Anticipated start date is October 2020. 

Mentor Matching:
This position reports to Giannnicola Genovese, M.D., Ph.D. 

Req #: 600655-00005
Job Title:  Postdoctoral Fellow       
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​A postdoctoral fellow position is available in Department of Genitourinary Medical Oncology at MD Anderson Cancer Center, Houston, TX. Our research is focused on understanding the role of extracellular vesicles in the cross-talk between the cellular components of prostate cancer tumor microenvironment.  The laboratory employs both pre-clinical models and clinical samples for our studies on the molecular and functional properties of extracellular vesicles. In addition, the laboratory focuses on addressing this issue using a wide range of tools from next-generation sequencing (WES, WGS, RNA-seq) and in vitro and in vivo  assays (flow cytometry, mass cytometry, IHC). The ideal candidate will have experience with in vivo and/or in vitro models of exosome and cancer biology. The candidate should also be proficient in molecular and cellular biology techniques, particularly those that relate to the study of exosome biology.

Learning Objectives:
The postdoctoral fellow will work under the supervision of Drs. Theocharis Panaretakis and Christopher Logothetis. The successful applicant is expected to develop an in-depth understanding of prostate cancer biology at the primary site and metastatic sites, exosome biology, immune responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.​

Eligibility Requirements:
​Candidates should be highly motivated individuals who have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in cancer biology, with preferred hand-on experience in extracellular vesicles, molecular techniques, and mouse models of prostate cancer. Only candidates who have published work from their pre- and/or post-doctoral studies will be considered.

• Experience of laboratory techniques in the fields of extracellular vesicles and molecular biology.
• Develop, analyze and validate data for assays using statistical methods.
• Previous experience with SOPs and animal protocols.
• Troubleshooting daily experiments.
• Demonstrated ability for creative thinking and problem solving.
• Demonstrated ability to work in a multi-disciplinary team
  

Dates or Training Schedule:
Anticipated start date is June 2021. Learning objectives to be achieved within 2 years, and to be expanded toward a consolidated and diversified project line thereafter.

Mentor Matching:
This position reports to Theocharis Panaretakis, Ph.D. View Dr. Panaretakis' research profile.

Req #: 600655-0008
Job Title:  Postdoctoral Fellow       
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​​This postdoctoral position will require a PhD or MD degree in the field of biological science including immunology, molecular biology, genomics, or medicine. This position will provide research training in the field of immunotherapy in particular for genitourinary malignancies including bladder cancer, kidney cancer, and prostate cancer. Specifically, this position will involve identification of mechanisms of clinical response/resistance to immunotherapy.​

Learning Objectives:
The trainee is expected to to conduct high-quality and productive research for high impact publications. In addition, the trainee is expected to accumulate solid knowledge in the field of immunology and molecular biology. Furthermore, the trainee is expected to be proficient in conducting in vitro and in vivo studies in the field of immunology and molecular biology.​​

Eligibility Requirements:
​The minimum qualifications for this applicant will be a PhD degree or MD degree in the field of biological science of medicine. The applicant should have at least one high-quality publications to show basic skills for conducting bench research.​

Dates or Training Schedule:
Anticipated start date: September 1, 2021. Training schedule: daily research activities, attendance of lectures/seminars. Working hours: 40 hours per week.

Mentor Matching:
This position reports to Jianjun Gao, M.D., Ph.D. View Dr. Gao's research profile.

Req #: 600389-00001
Job Title:  Postdoctoral Fellow       
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​The postdoctoral fellow will work with a multidisciplinary team of clinical and laboratory-based faculty and administrators to support and implement a high-impact translational research program in uterine cancer research. Training experiences will focus primarily on research administration (grant proposal preparation, financial management) and scientific writing, with limited research studies. Mentorship and educational opportunities will be provided to support the transition from a research-focused background to research administration. ​

Learning Objectives:
At the conclusion of this postdoctoral fellowship, the postdoc will be able to develop and assemble a large-scale multi-disciplinary grant proposal in collaboration with principal investigators. The postdoc will develop basic skills to assist with financial management of the grant program. The postdoc will be able to present strategic-planning initiatives to support research efforts in a large multi-disciplinary program. ​​

Eligibility Requirements:
​PhD in biomedical sciences or related field​

Dates or Training Schedule:
4/1/2021 - 3/31/2022

Mentor Matching:
This position reports to Melinda Yates, Ph.D. See Dr. Yates' research profile.

Req #: 137100- 00002
Job Title:  Postdoctoral Fellow       
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The Amit Lab, in the Department of Head and Neck Surgery at he University of Texas M.D. Anderson Cancer Center, is seeking to recruit creative and driven postdoctoral fellows interested in working at the intersection of neuroscience and cancer biology.

A major goal of the lab is to advance the current understanding of the nervous system contribution to cancer. We established experimental models in neuroscience research to uncover novel mechanisms used by the nervous system to promote tumor initiation, progression, and metastasis.

Successful applicants will be expected to develop and/or apply these models to address basic or clinical research questions within our areas of focus, including tumor differentiation and development, the cellular composition of the tumor microenvironment, and cell lineage relationships in malignant and normal tissues. Key results are further explored experimentally, both in our lab and through collaboration, with the ultimate goal of translating promising findings into the clinic.

Learning Objectives:
Learn new skills
Learn laboratory operations and how laboratory functions
Form collaborations
Publish
Apply for funding
Transition to independence as a principal investigator

Eligibility Requirements:
Ph.D or MD and research experience in, Neuroscience, Immunology, Molecular Biology, or Cell Biology or related field.
All applicants should enjoy thinking deeply and working independently but also enjoy collaborating in a dynamic, exciting, and friendly team environment.
Qualified individuals will demonstrate the potential for research as evidenced by their training and first-author peer-reviewed publications in relevant journals and should become competitive for national research fellowships.
We are looking for candidates in two general areas to support these research goals including neuroscience and cell biology.
Wet lab candidates with a strong background in cellular and molecular techniques in cancer biology, stem cell biology, or tumor immunology are required. Familiarity with basic bioinformatics analysis is required.
Previous experience in common programming languages (i.e., R or Python) and image analysis is desired.

Dates or Training Schedule:
Postdoc Appointment Term: 3-5 years

Appointment Start Date: Immediate

Mentor Matching:
This position reports to Moran Amit, M.D., Ph.D.

Req #: 137100- 00003
Job Title:  Postdoctoral Fellow       
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​A postdoctoral position is available within the department of Head and Neck Surgery to conduct experiments in the research area of tumor immunology and immunotherapy. Candidates must have a background in immunology, cancer research, or related fields; must work well in a team environment; and must have strong communication skills. the candidate will conduct immunologic and cancer biology experiments in animal models (including syngeneic and immune-reconstituted mouse models), primary human cells, and additional model systems as needed. Familiarity with immunology laboratory techniques, and mouse model research is required. Candidates must have Ph.D. in a relevant scientific field, or M.D. degree.

Learning Objectives:
​1. Mastery of the scientific method - hypothesis generation, developing experimental design to test the hypothesis, interpretation of data, drawing conclusions from results. 
2. Understanding of human and murine immunology with an emphasis on host/cancer interactions, intrisic and acquired mechanisms of resistance to immunotherapy, and understanding the tumor immune microenvironment. 
3. Experience with techniques and approaches to modulate the immune microenvironment of cancers, and elicit effective anti-tumor responses. 

Eligibility Requirements:
​Candidates must have Ph.D. in a relevant scientific field, or M.D. degree.

Dates or Training Schedule:
40 hours per week. 

Mentor Matching:
Eligible candidates will have the opportunity to work with Dr. Andrew Sikora, a nationally recognized mentor with expertise in cancer immunology. 

Additional Application Information:
Responsibilities:
1. Conduct laboratory research on a semi-independent basis; design and execute laboratory experiments; prepare applications/submissions for external funding; interpret data; prepare and present findings in scholarly articles, conference presentations, etc.
2. Other responsibilities: may be responsible for operation and maintenance of specific equipment; may be assigned responsibility for certain tasks within the collaborative laboratory environment; to further the research and education missions of the institution, and comply with institutional expectations and requirements.

Req #: 600119-00002
Job Title:  Postdoctoral Fellow       
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Under the mentorship of Dr. Iakovos Toumazis, this postdoctoral fellowship will provide individuals with the opportunity to contribute to the design, implementation, analysis, and publication of studies focusing on health policy analytics and modeling. The position focuses on the development and application of computer simulation-based modeling to simulate the disease progression of specific cancers (e.g. lung cancer, ovarian cancer), assess the impact of alternative primary, secondary and tertiary prevention strategies on cancer incidence and mortality rates in the US population, and inform public health policy.

Job Responsibilities:
· Develop simulation models for decision analysis, cost-effectiveness analysis, and value of information analysis.
· Develop risk prediction models using advanced analytic methods.
· Work with the research team on development of decision aid tools.
· In coordination with the principal investigator, lead the research team in writing manuscripts and grant applications.​

Eligibility Requirements:
​Expertise in stochastic simulation modeling, Monte Carlo methods, model validation and calibration.

Experience in survival analysis, parameter estimation, data analytics, and applications of operations research to public health and medical decision making is highly desired.
Good understanding of mathematical modeling and hands-on experience of general-purpose programming languages such as R, Python, Julia, or MATLAB.
Strong writing and verbal communication skills are required.

Education:
Qualified candidates should have a Doctorate Degree in industrial engineering, operations research, computer science, health services research, epidemiology, health-outcomes research, biostatistics or a related quantitative field. ​

Mentor Matching:
This position reports to Iakovos Toumazis, Ph.D.

Additional Application Information:
This fellowship is a one-year, full-time commitment, renewable upon mutual consent with competitive salary and benefits. Opportunities for the fellow to write and submit his/her individual grant (e.g. NIH career development award) would be provided and strongly supported by the PI and the institution.

To apply, interested candidates should submit a brief cover letter personalizing one's interest in the position, with information about research experience and interests, and their CV with the names and contact information for references to Dr. Iakovos Toumazis, IToumazis@mdanderson.org with subject: ”Postdoctoral Fellowship Application.” Review of applications will begin immediately and continue until the position is filled.

Req #: 600119-00003
Job Title:  Postdoctoral Fellow       
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The Wehner Laboratory has an open, funded post-doctoral research fellow position in cancer epidemiology. The Wehner Laboratory is a based in the Department of Health Services Research at MD Anderson Cancer Center and focuses on patient-oriented skin cancer research. Our goal is to significantly decrease the burden of skin cancer in the United States. We strive to expand the understanding of skin cancer risk factors and prognostic markers, improve skin cancer care for vulnerable populations, as well as develop and test early detection and prevention interventions that directly impact patients. Our current research centers on skin cancer epidemiology and indoor tanning, utilizing large claims datasets as well as user-generated data. Please see https://www.mdanderson.org/research/departments-labs-institutes/labs/wehner-laboratory.html for more information.

The Wehner Laboratory aims to provides a productive, supportive and collaborative space for patient-oriented skin cancer research that includes trainees and research staff. We have ongoing projects available for a post-doctoral research fellow to take the lead on as well as ample opportunity and resources for the fellow to explore new avenues of independent research. While the Wehner Laboratory primarily focuses on skin cancer, we are supportive of research in other cancer types. The post-doctoral research fellow will have the support of a full-time MPH-level Program Coordinator and a full time Master's-level Biostatistical Analyst. Additionally, we support a rich learning environment with trainees of a variety of levels. The Department of Health Services Research has an active group of principal investigators and biostatistical analysts and access to multiple large claims and cancer registry datasets.

The ideal candidate has clear career goals that we can work together to achieve.

Learning Objectives:

• Advance skills in study design, data analysis, and interpretation, especially in large datasets
  
• Learn to develop independent lines of research
  
• Improve manuscript writing skills
  
• Present at national and international conferences
  
• Gain experience and skills to advance career to the desired next step, such as grant writing

Eligibility Requirements:
​Ph.D. (or equivalent) in public health, epidemiology, biostatistics, or a closely related field
Proficiency in spoken and written English
Experience in population-based or patient-oriented research
Proficiency with statistical programming (e.g. SAS, Stata, or R)
A track record of publications and competence in writing manuscripts

Program Dates:
This post-doctoral research fellowship is immediately available. It is a 1-2 year, full-time (40 hours per week) commitment, renewable upon mutual consent.

Mentor Matching:
This position reports to Mackenzie Wehner, M.D. with opportunity for co-mentoring from other faculty collaborators. 

Additional Application Information:
To apply, interested applicants should send 1) a cover letter specifying past research experience/skills/accomplishments, interests, and future goals, 2) a Curriculum Vitae, and 3) the contact information of three references to Candice Hinkston, Program Coordinator for Dr. Wehner, at clhinkston@mdanderson.org with the subject line entitled “Post-doctoral Research Fellow Application – Applicant’s Name."

Work may occur remotely or on-site, depending on COVID and institutional policies. Once hired, post-doctoral fellow must have a Houston address.

No positions in the Department of HematoPathology are currently available. Check back later for new opportunities.

Req #: 710597-00001
Job Title:  Postdoctoral Fellow 
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A Postdoctoral position is available in the Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.  This position reports to Dr. Deepa Sampath in the Department of Hematopoietic Biology and Malignancy.

Learning Objectives:
​We are seeking a talented and highly motivated Postdoctoral Fellow to perform hands-on experiments to generate novel cell culture model systems and perform basic and translational research to investigate the genetic and epigenetic mechaisms underlying the formation and growth of hematological malignancies. Research will also involve scientific projects utilizing genetic mouse models of cancer with the goal of translating findings to clinically meaningful advances. The Postdoctoral Fellow will conduct experiments to measure gene expression and chromatin conformation in cultured cells and primary tissue. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars. 

The Postdoctoral Fellow's primary research focus is to gain mechanistic understanding of genetic and epigenetic mechanisms that drive hematological malignancies; learn molecular biology and genomics analysis skills and train and learn study design, data analysis and manuscript writing.

Eligibility Requirements:
​Individuals with a PhD degree in cancer biology, molecular biology, genetics, immunology, or related fields with less than 2 years of postdoctoral experience.  Experience with rodent studies is required for this role.  Candidate should have strong organizational skills and the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.

Program Dates:
March 23, 2021 - March 22, 2022

Mentor Matching:
The position reports to Deepa Sampath, Ph.D.

Req #: 710597-00002
Job Title:  Postdoctoral Fellow 
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​A Postdoctoral position is available in the Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. This position reports to Dr. Jin Seon Im in the Department of Hematopoietic Biology and Malignancy.

Learning Objectives:
​​We are seeking a talented and highly motivated Postdoctoral Fellow to perform hands-on experiments to evaluate human invariant Natural Killer (iNK) T cells modified with chimeric antigen receptor targeting hematologic malignancies, and investigate mechanism of immune-regulation by modified iNK T cells with xenograft GVHD/GVL model. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars.

The Postdoctoral Fellow's primary research focus is to gain mechanistic understanding of immune-modulation by modified and unmodified iNK T cells in tumor immune-microenvironment, and train and learn study design, data analysis and manuscript writing.

Eligibility Requirements:
​Individuals with a PhD degree in immunology, or related fields with less than 1 year of postdoctoral experience.  Experience with rodent studies is required for this role.  Candidate should have strong organizational skills and the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.

Program Dates:
April 6, 2021 - April 5, 2021

Mentor Matching:
The position reports to Dr. Jin Seon Im.

Req #: 710597-00003
Job Title:  Postdoctoral Fellow 
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A Postdoctoral position is available in the Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. This position reports to Dr. Pavan Bachireddy in the Department of Hematopoietic Biology and Malignancy.

Learning Objectives:
We are seeking a talented and highly motivated Postdoctoral Fellow interested in understanding the co-evolutionary interactions between cancer and immune cells in the tumor microenvironment. Our lab uses unbiased, high-throughput technologies to decode the rules of interaction among diverse cell types in the tumor milieu that determine patient outcomes to cancer immunotherapy, primarily in hematologic malignancies. In vitro and in vivo functional genomic screens are critical approaches to validate and extend our findings.

Dr. Bachireddy is also deeply committed to the career growth and success for each member of the laboratory. Such mentorship should be intentional, planned and tailored to each member of the group – thus the laboratory operates with a primary goal of fostering career goals and development. To this end, a mentorship plan will be developed involving a senior faculty member with complementary expertise.

The fellow will lead work focused on 1) interrogation of factors reversing immune dysfunction and 2) identification of molecular and cellular determinants of successful graft-versus-leukemia outcomes, using multiple cutting-edge technologies as well as standard cell culture and immunologic approaches. Because Dr. Bachireddy is the Scientific Director of the ECLIPSE (Evolution of Cancer, Leukemia and Immunity Post Stem cEll transplant) platform, the fellow will have significant interaction and access to the vast immunogenomic and computational resources of the physically adjacent ECLIPSE platform.

We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position will require great planning and organizational skills. An ability to work well with others as part of a cohesive team, take initiative, and creatively problem solve are a must.

Eligibility Requirements:
Individuals with a PhD degree in cancer biology, molecular biology, genetics, immunology, or related fields. Experiences that are desirable (but not required) include: CRISPR, next-gen sequencing (bulk or single cell genomics), or animal modeling. Candidate should have a background in immunology and the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.

Program Dates:
Consideration of applications will begin immediately and continue until the position is filled.

Mentor Matching:
The position reports to Dr. Pravan Bachireddy.

Req #: 600651-00002
Job Title:  Postdoctoral Fellow       
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We are looking for several postdoctoral researchers in the areas of medical image analysis and translational cancer research to join a newly established research lab.

Learning Objectives:
The research themes are center on 1) develop innovative quantitative imaging biomarkers to characterize cancer phenotypes; 2) integrate image with multi-omics data across multiple scales to decipher cancer mechanisms; 3) validate and translate imaging biomarkers to guide clinical practice.

Eligibility Requirements:
Candidates from a diverse background are encouraged to apply. The successful applicant must have a Ph.D. in the fields of Biomedical Engineering, Applied Mathematics,Computer Science, Electronic Engineering, Bioinformatics, or related fields.

Dates or Training Schedule:
8/15/2020-8/14/2021

Mentor Matching:
This position reports to Jia Wu, Ph.D.

Req #: 600651-00003
Job Title:  Postdoctoral Fellow       
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​​A postdoctoral fellowship position is available in the Department of Imaging Physics in the laboratory of Kristy Brock, Ph.D.  The Morfeus Lab at MD Anderson ( https://www.mdanderson.org/research/departments-labs-institutes/labs/morfeus-laboratory.html) is led by Dr. Kristy Brock. Our research is focused on development of deformable image registration, artificial intelligence (AI), biomechanical modeling, and image guided cancer therapy technologies for strategic research collaboration and deployment into the clinical setting. Our lab is a highly collaborative research training environment in a state-of-the-art imaging facility and world class resources. Ongoing projects seeking postdocs include: 
1) Image-guided liver surgery 
2) Image-guided head and neck surgery 
3) Cancer risk assessment and outcomes prediction using artificial intelligence 
4) Validating in vivo imaging signals using correlative pathology 
5) Image-guided focal liver ablation 
6) Dose accumulation for personalized adaptive radiation therapy​

Learning Objectives:
​​This postdoctoral fellow will engage in computational research projects in image guided cancer therapy including research, design, and implementation of deformable image registration, biomechanical modeling, and artificial intelligence technologies. The fellow will expand their knowledge and skills in imaging physics, data mining, predictive modeling, clustering, and classification and will develop, train, and apply deep learning in large data environments. The fellow will help to guide research and clinical collaborations and work with collaborators to integrate image guided cancer therapy models and technologies into the clinical workflow. They will collaborate and coordinate with research and clinical stakeholders, communicate findings via abstracts, poster and podium presentations, and publications. ​

Eligibility Requirements:
​Applicants should have earned a Ph.D. in one of the natural sciences, computer sciences, engineering, or related fields or a medical degree. Experience with machine learning and deep learning techniques, statistical modeling, biomechanical modeling, or image registration and analysis is preferred.​

Mentor Matching:
This position reports to Kristy Brock, Ph.D. 

Req #: 600651-00004
Job Title:  Postdoctoral Fellow       
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​Lung cancer is the leading cancer death for both men and women. PET/CT imaging, which provides both whole-body functional and anatomic information in one imaging session of 20-25 min, is the standard imaging tool for managing lung cancer patients for surgery, radiation therapy, chemotherapy, or a combination of these treatments. We are embarking on a new research and development to improve PET/CT imaging of the lung tumor in collaboration with an industry partner.

Learning Objectives:
​Learn the state-of-the-art clinical and research PET/CT technologies; participate in the development of a clinical solution to improve PET/CT imaging of lung cancer; evaluate clinical impacts of the proposed clinical solution; submit research papers to scientific journals; and give presentations in conferences.

Eligibility Requirements:
PhD in engineering or physics with the background or interest in medical imaging, and is proficient in scientific programing of Python.

Program Dates:
Period of 2 years once the position is filled.  Target date:  5/1/2020

Mentor Matching:
This position reports to Tinsu Pan, Ph.D.  See Dr. Pan's research profile.

Req #: 600651-00005
Job Title:  Postdoctoral Fellow       
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Postdoctoral training that will consist of carrying out an independent research in the area of molecular photoacoustic imaging of ovarian and breast cancers using antibody-targeted liposome encapsulated J-aggregates of ICG dye molecules.

Learning Objectives:
​Principles of photoacoustic imaging in vivo that will include instrumentation, fluence correction and spectral unmixing algorithms. In addition, there will be training in scientific writing through submission of peer reviewed manuscripts.

Eligibility Requirements:
​Ph.D. in Bioengineering is preferred. Ph.D. in other natural science disciplines will be considered.

Program Dates:
August 1, 2021 thru July 31, 2022

Mentor Matching:
This position reports to Konstanin Sokolov, Ph.D.  See Dr. Sokolov's research profile.

Req #: 206100 -0001
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. Our research is to understand the molecular basis of T cell mediated immune responses, and how abnormal immune regulation leads to immunodeficiency, autoimmunity and cancer. Autoimmunity and inflammation mouse models include experimental autoimmune encephalomyelitis (EAE), colitis, and lung airway inflammation; tumor immunity models include T cell-mediated immune responses against transplanted melanoma, chemical induced sarcoma, and lung cancer.

Learning Objectives:

The recruiting postdoctoral fellow will conduct research in the following projects: 1. The molecular mechanisms of T cell activation and tolerance; 2. The signaling and transcriptional mechanisms underlying T helper cell differentiation and function. Mentor’s main research goal is to understand the molecular and cellular mechanisms that control the development and progress of autoimmunity, inflammation and cancer, with particular emphasis on the signaling and transcriptional mechanisms underlying T helper cell development and T cell mediated immune responses.

Eligibility Requirements:
Candidates should have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Immunology, with preferred hand-on experience in flow cytometry, molecular techniques, and mouse models of autoimmunity and/or anti-tumor immunity.

Dates of Training Schedule:
Position is opened from January 1st 2020. Training schedule: 40 hours per week.

Mentor Matching:
This position reports to Roza Nurieva, Ph.D.

Req #: 206100-00004
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. The focus of the research project is understanding the basis of CD4+ T cell and CD8+ T cell recognition of tumor antigens in the context of a dynamic tumor microenvironment and development of improved personalized cancer treatments. This project will primarily utilize preclinical transplant and genetically engineered mouse models along with high dimensional analyses approaches such as mass cytometry by CyTOF and single-cell RNA sequencing.

Learning Objectives:
The successful applicant is expected to develop an in-depth understanding of cancer immunology mouse models, cancer vaccines, T cell responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.

Eligibility Requirements:
Candidates should have a recent Ph.D. degree or be in the process of completing Ph.D. training and a solid background in Immunology, preferably with hands-on experience in mouse cancer models, flow cytometry and molecular immunology.

Dates of Training Schedule:
The position is available immediately.

Mentor Matching:
This position reports to Matthew Gubin, Ph.D.

Additional Application Information:
Successful candidates will join a collegial, dedicated group of researchers. The Department of Immunology, led by Nobel Laureate James Allison, conducts cutting-edge and diverse research using state-of-the-art tools in a highly interactive environment. Send curriculum vitae and names of three references to: Dr. Matthew Gubin, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston 77054. E-mail: mgubin@mdanderson.org.

Req #: 206100-00005
Job Title:  Postdoctoral Fellow
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​Postdoctoral position at the nexus of immunology and neurology available in the lab of Dr. Michael A. Curran at the University of Texas MD Anderson Cancer Center. Dr. Curran was the first to study and report the combination of CTLA-4 and PD-1 blockade which remains the most effective clinical immunotherapy. The Curran lab studies mechanisms of immune resistance in "cold" cancers (prostate, pancreatic, glioblastoma), in particular focused on tumor hypoxia and oxygen metabolism, as well as on novel approaches to modulation of the tumor myeloid stroma. Application of this knowledge to addressing underlying causes of neurodegeneration in models of Alzheimer's disease has become a new focus within the lab. We have achieved success pursuing a novel immune therapy focused on removal of neurotoxic aggregates from the CNS. This work is funded by both a philanthropic award and grant, as well as by a dedicated NIH grant. Prior fellows hold tenured academic professorships, scientist positions in industry, and senior positions in patient-focused immune monitoring centers.

Learning Objectives:
​Successful candidates will lead a project to develop a myeloid-based adoptive cell therapy for the treatment of neurodegenerative disease.

Eligibility Requirements:
​Candidates must have a recent Ph.D. degree in a related field along with lead-author publications, excellent communication skills, and the ability to work independently within a research team. Candidates who pursue an independent career path are highly preferred. Expertise in immunology, neurology/neurodegeneration, and/or viral vector based cell engineering is also desirable.

Mentor Matching:
This position reports to Michael Curran, Ph.D. See Dr. Curran's research profile.

Req #: 206100-00006
Job Title:  Postdoctoral Fellow
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​Postdoctoral position in basic and translational immune checkpoint biology and immunotherapy available in the lab of Dr. Michael A. Curran at the University of Texas MD Anderson Cancer Center. Dr. Curran was the first to study and report the combination of CTLA-4 and PD-1 blockade which remains the most effective clinical immunotherapy. The Curran lab studies mechanisms of immune resistance in "cold" cancers (prostate, pancreatic, glioblastoma), in particular focused on tumor hypoxia and oxygen metabolism, as well as on novel approaches to modulation of the tumor myeloid stroma. Research in the lab spans basic T cell co-stimulatory biology, tumor microenvironment studies in murine models, and ongoing clinical trials and associated correlatives. The lab offers unique resources for research in mice and in man, as we have developed our own novel immune checkpoint antibodies and uniquely potent agonists of the Stimulator of Interferon Genes (STING) innate immune sensor. Prior fellows hold tenured academic professorships, scientist positions in industry, and senior positions in patient-focused immune monitoring centers.

Learning Objectives:
​Successful candidates will lead a project to integrate modulation of cold tumor metabolism and T cell / myeloid stroma to foster immune rejection of “cold” cancers.

Eligibility Requirements:
​Candidates must have a recent Ph.D. degree in a related field along with lead-author publications, excellent communication skills, and the ability to work independently within a research team. Candidates who pursue an independent career path are highly preferred. Expertise in cancer immunology, murine tumor modeling, and/or tumor/immune metabolism is also desirable. Specific interest in immunobiology of glioblastoma and its immune microenvironment is a plus.

Mentor Matching:
This position reports to Michael Curran, Ph.D. See Dr. Curran's research profile.

Req #: 206100-00007
Job Title:  Postdoctoral Fellow
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​The mission of our lab is to investigate the mechanisms that regulate T cell destabilization and infiltration in cancer. Specifically, we want to understand how antigen-presenting cells control Treg reprogramming and accumulation within the tumor microenvironment. Our final goal is to develop new strategies for patients that do not respond to current cancer immunotherapies.

Learning Objectives:
​By combining genetic mouse models and analyses of human cancer samples, the successful candidates are expected to identify which key signals are necessary for intratumoral Treg instability and expansion in order to finally provide new individualized immunotherapy approaches to patients.

Eligibility Requirements:
Ph.D. in life or physical sciences (examples: immunology, biology, bioinformatics, physics)

Record of successful first author publications

Expertise in flow-cytometry and/or analysis of high-dimensional biological datasets

Experience in mouse models, single cell genomics, molecular cloning and microscopy

Mentor Matching:
This position reports to Mauro Di Pilato, Ph.D.

Additional Application Information:
Two postdoctoral training positions are available in the laboratory of Mauro Di Pilato in the Department of Immunology at The University of Texas MD Anderson Cancer Center. 

Req #: 206100-00009
Job Title:  Postdoctoral Fellow
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​A postdoctoral fellow position is available in the laboratory of Dr. Shao-Cong Sun to study the molecular mechanisms that regulate anti-tumor immunity and autoimmune diseases. The focus of our research is on characterizing novel regulators of T cell activation, metabolic reprogramming, and effector functions in mouse models of anti-tumor immunity and autoimmune diseases. In addition, we are studying the signaling network in innate immune cells (dendritic cells and macrophages) that regulate inflammation, tumor microenvironment, and T cell functions. For more information, please check our recent publications in the website http://faculty.mdanderson.org/Shao-Cong_Sun/.

Learning Objectives:
​Successful candidates will join a collegial and highly interactive team and enjoy the stimulating environment of UT MD Anderson Cancer Center. The Department of Immunology, led by Nobel Laureate James Allison, conducts cutting-edge research in different areas of Immunology. Dr. Sun's laboratory has a long history of success in research and postdoctoral training.

Eligibility Requirements:
​Candidates should have a solid background in Immunology, with hand-on experience in flow cytometry, molecular techniques, and mouse models of anti-tumor immunity and/or autoimmune diseases.

Mentor Matching:
This position reports to Shao-Cong Sun, Ph.D. See Dr. Sun's research profile.

Req #: 206100-00010
Job Title:  Postdoctoral Fellow
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​The role of immunological and epigenetic pathways in resistance and response to immune checkpoint therapy.
 
General Laboratory duties or procedures:
 
1. To work with animal and human samples (Handling, Treatments, Inoculation and Processing of samples for long-term storage)
2. Perform single cell RNA sequencing, able to run the data in different packages and analyze the tumor immune microenvironment
3. Perform ATAC-sequencing, able to run the data in different packages and analyze chromatin accesibilites
4. CyTOF staining and analyses of the data
5. Flow cytometry staining and analyses
6.  Immunohistochemistry
7. Molecular biology techniques like PCR, RNA/DNA isolation, western blot and knock in/ out using CRISPR technology.

Learning Objectives:
​1. To understand immunological pathways involved in reponse and resistance to immune checkpoint therapy in single cell level. 
2. To understand the epigentic regulations of immune sub-populations. 
3. To analyze the single cell RNA sequencing and ATAC sequencing data.

Eligibility Requirements:
​PhD in Immunology or Bioinformatics

Mentor Matching:
This position reports to Sangeeta Goswami, M.D., Ph.D. See Dr. Goswami's research profile.

No positions in the Department of Infectious Diseases are currently available. Check back later for new opportunities.

Req #: 600140-0001
Job Title:  Postdoctoral Fellow       
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The postdoctoral fellow will be embedded within the Structural Chemistry group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform and analyze calculations, and attend and present results at project team meetings.

Learning Objectives:

The postdoctoral fellow will learn how to a) provide computational chemistry support to drug discovery project teams, b) design novel molecules using structure and ligand-based techniques, c) interface with structural biologists and medicinal chemists, d) communicate insights from molecular modeling to a diverse team of scientists, and e) perform independent computational research aimed at improving design of novel molecules.

Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, or a related discipline.

Dates of Training Schedule:
1 year, with extension to 3 years possible

Mentor Matching:
This position reports to Jason Cross, Ph.D.

Req #: 600140-0002
Job Title:  Postdoctoral Fellow
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The postdoctoral fellow will be embedded within the Structural Biology group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform biophysical experiments (X-ray crystallography, cryo-EM), and attend and present results at project team meetings.

Learning Objectives:
The postdoctoral fellow will learn how to a) express and purify high quality protein for use in biophysical and structural biology experiments, b) collect crystallographic datasets at a national lab and fully analyze to produce structural models, c) generate grids, collect data, and solve structures using cryo-EM, d) interface with computational and medicinal chemists, and e) communicate structural biology insights to a diverse team of scientists.

Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Biology, or a related discipline.

Dates or Training Schedule:
1 year, with extension to 3 years possible

Mentor Matching:
The position reports to Dr. Paul Leonard.

Req #: 600140-0003
Job Title:  Postdoctoral Fellow       
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​The post-doctoral fellow will be embedded within the Structural Chemistry group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will develop computational tools and models, perform and analyze calculations, and attend and present results at project team meetings.​

Learning Objectives:
​The post-doctoral fellow will learn how to a) provide cheminformatics support to drug discovery project teams, b) develop ligand and structure based models, and publish them for team use, c) interface with computational and medicinal chemists, d) communicate insights from cheminformatics analyses to a diverse team of scientists, and e) perform independent computational research aimed at improvinq desiqn of novel molecules.​

Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, Statistics, or a related discipline​

Dates of Training Schedule:
1 year, with extension to 3 years possible

Mentor Matching:
This position reports to Jason Cross, Ph.D.

No positions in the Department of Interventional Radiology are currently available. Check back later for new opportunities.

No positions in the Department of Investigational Cancer Therapeutics are currently available. Check back later for new opportunities.

Req #: 600411-0004
Job Title: Postdoctoral Fellow
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Dr. Michael Andreeff and Dr. Bing Carter, Section of Molecular Hematology & Therapy, Department of Leukemia at the University of Texas MD Anderson Cancer Center invite applications for a postdoctoral position. We are looking for a highly motivated and innovative individual with technical expertise in cell, molecular, or cancer biology to conduct a project for mechanism-based combinatorial targeting of drug-resistant leukemia stem cells.

Learning Objectives:
Applicant will conduct research into cell death and cell survival pathways, and mechanisms of drug resistance in myeloid leukemia stem cells through a combinatorial study of gene mutations, gene expression, protein expression, and responses to drug treatments in leukemia cells. The ultimate goal is to understand the functions of apoptotic regulators, cell signaling pathways, leukemia microenvironmental regulators, and their roles in drug resistance, and develop mechanism-based approach to overcome drug resistance. Researcher will collaborate with established and committed investigators in an interdisciplinary research project that involves cell culture, flow cytometry, mass cytometry, western blot analysis, immunohistochemistry, RT-PCR, DNA/RNA sequencing, and NSGS/NSG mouse models. Researcher will present scientific results in project meetings, national and international conferences, and in high impact scientific publications.

Eligibility Requirements:
​The ideal candidate is a recently graduated cell, molecular or cancer biologist PhD with practical experience and excellent knowledge-base in cell death pathways and cell signaling, and with experience in at least one of the following areas of discipline: cell culture, drug treatment, and cell death assay, molecular cloning, flow cytometry, and/or mouse work. Data analysis skill is highly desirable. The applicant enjoys providing practical and theoretical training for students and promotes scientific collaboration within the research group, and will have excellent written and spoken (English) communication skills. The candidate should have one or more publication as first author.

Mentor Matching:
This position reports to Michael Andreeff, M.D., Ph.D., and Bing Carter, Ph.D. 

Req #: 600411-0005
Job Title: Postdoctoral Fellow
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​The task:  Studying the novel immune checkpoint molecules expressed on leukemia stem cells and characterizing anti-leukemia efficacy of their targeting in immune-competent or immune-deficient humanized models of leukemia. The postdoctoral fellow will collaborate with related investigators in an interdisciplinary research project that involves immunological assays, basic cell culture, flow cytometry/sorting, metabolic assays, mass cytometry, DNA/RNA sequencing/analysis, and the use of mouse models. The postdoctoral fellow will present relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.

Learning Objectives:
Perfect and expand immunology skills; CyTOF mass cytometry; leukemia stem cell assays; in vivo work with leukemia xenograft models and novel agents that affect immune interactions​​

Eligibility Requirements:
​The applicant should be an innovative and motivated individual with technical expertise in immunology, cancer, biochemistry, and metabolism to conduct a highly ambitious project targeting immune defects of leukemia stem cells. The ideal candidate will possess a PhD degree in a life science, like immunology, cellular or molecular biology, with research experience and an excellent knowledge-base in immunology, biochemical, and signaling process as they relate to cancer. Experience in immunology, leukemia, molecular cloning, the quantitative measurement of RNA expression, flow cytometry, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills. 

Mentor Matching:
This position reports to Marina Konopleva, M.D, Ph.D. Dr. Konopleva is a Professor in a Department of Leukemia, physician-scientist with over 20 years laboratory experience in hematology.  See her research profile.

Additional Application Information:
Dr. Konopleva has sustained NIH funding and her research interests include leukemia stem cells, apoptosis, metabolism. She has mentored a number of postdoctoral fellows in clinical fellows over her career.

Req #: 600411-0006
Job Title: Postdoctoral Fellow
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​The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells.

Learning Objectives:
1.) Develop skills in experimental design and conduct of biologic and molecular studies to characterize genomic alterations, epigenomic, transcriptional and protein expression studies (ATAC-Seq, ChIP-Seq, RNA-Seq, Confocal Microscopy, Flow Cytometry, Mass Cytometry and Western analysis) in bulk cell populations as well as at a single cell level.

2.) Cloning and transfer of genes into cancer cells.

3.) CRISPR-Cas9 techniques for gene-editing. 

4.) Mouse xenograft models to determine biology of leukemia and lymphoma as well as to evaluate therapeutic efficacy of novel targeted agents.  ​

Eligibility Requirements:
​The qualified candidate must possess a Ph.D. in Biology, Biological Sciences, Life Sciences or related field; a keen interest and experience in cancer research; excellent English skills (both written and verbal); and current U.S. work authorization. The candidate should preferably have completed a 3 year Post-doctoral fellowship in an area relevant to the focus of research noted above. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection, analysis of gene expression through QPCR, microarrays, immunoblots and flow cytometry, as well as experience in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is preferred. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is preferred. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also preferred.

Mentor Matching:
This position reports to Kapil Bhalla, M.D. See Dr. Bhalla's research profile.

Additional Application Information:
Monday - Friday, 8:00 - 6:00; Weekends when needed. 

Req #: 600411-0007
Job Title: Postdoctoral Fellow
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​A postdoctoral research fellowship position is available to study breast cancer stem cells. The laboratory is studying the role of ganglioside GD2 and GD3 synthase in the regulation of cancer stem cell function in triple-negative breast cancer. In particular, we are interested in the development of novel small molecule inhibitors for targeting GD3 synthase in breast cancer cells as a part of DoD funded project. Postdoctoral fellows are responsible for the development of GD3 synthase inhibitors using several molecular and computational approaches and testing the compounds in vitro stem cell assays as well in vivo tumor growth studies. Candidates must have a doctoral degree with 0-2 years of postdoctoral experience. Preference will be given to candidates with previous experience with protein modeling, drug discovery/development, computational tools, mouse models, cancer stem cell biology, basic cell culture, and imaging skills. Candidates are expected to be self-motivated and have excellent writing and communication skills.

Learning Objectives:
​The potential candidate is expected to quickly learn various tissue culture techniques, stem cell functional assays, metabolic assays that we routinely use in our laboratory. Also, we have several animal models including patient-derived xenografts that need to be maintained and used for translational research. A thorough understanding of cancer biology, drug development, molecular modeling is appreciated.  

Eligibility Requirements:
​Ph.D. degree in a life science (cellular or molecular biology). Research experience and an excellent knowledge-base in biochemical, metabolic, and signaling process as they relate to cancer. Experience in breast cancer, molecular cloning, the quantitative measurement of RNA expression, flow cytometry, protein modeling, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within the institution as well as outside the institution. The candidate should possess excellent written and spoken (English) communication skills and should be able to present scientific data at international meetings.

Program Dates:
December 2021 through November 2022 - Consideration of applications will begin immediately and continue until the position is filled. 

Mentor Matching:
This position reports to Lokesh Venkata Battula, Ph.D., Michael Andreeff, M.D., Ph.D., Naoto T. Ueno, M.D., Ph.D.

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments.
A Curriculum Vitae and the contact information of three (3) Referees to Dr. Lokesh Battula with the subject line entitled
“Postdoctoral Fellow - Application – Applicant’s Name” to vbattula@mdanderson.org

Req #: 600664-00001
Job Title: Postdoctoral Fellow
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A new postdoctoral position is available to model aberrant RNA splicing in human diseases, in the laboratory of David Symer, MD, PhD, at the world-renowned, #1 ranked MD Anderson Cancer Center in Houston, Texas, United States.

Learning Objectives:
This postdoctoral fellowship will focus on developing and studying models of aberrant RNA splicing, caused by mutations in small nuclear RNA (snRNA) transcripts which result in several human developmental diseases. Somatic mutations in snRNA genes also have been identified recently in multiple human cancers. To identify and characterize the causes and consequences of these RNA splicing-mediated diseases, we will develop and use innovative new research methods involving in vivo disease models, functional genomics/CRISPR-Cas9 technology, molecular biology, human genetics and genomics methods, single-cell sequencing, and bioinformatics analysis. This fellowship is funded by an R01 grant awarded by the National Institutes of Health.

Eligibility Requirements:
Applicants must have a recent Ph.D. and/or M.D. degree with strong research abilities and interests. The successful candidate will have a track record of productivity in research, and have the talent, energy, passion, commitment and potential to take advantage of the impressive, deep resources available at the #1 ranked University of Texas MD Anderson Cancer Center. Excellent verbal and written communication skills, molecular genetics laboratory-based technical skills and strong reference letters are required, and strong interest in developing disease models is preferred.

Dates of Training Schedule:
The appointment is immediately available. Appointee is expected to work forty hours per week.

Mentor Matching:
This position reports to David Symer, M.D, Ph.D. 

Req #: 600664-00004
Job Title:  Postdoctoral Fellow       
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​The Green Laboratory at the University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated candidate for an open postdoctoral fellow position. The project is focused on exploring the role of unique genetic drivers of B-cell lymphoma and myeloma, and circulating cell-free DNA analysis. The project will employ advanced next generation sequencing technology and patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance.

The Green lab is part of the Department of Lymphoma & Myeloma and the Department of Genomic Medicine, which offer a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Green received his training at the Dana-Farber Cancer Institute/Harvard Medical School and Stanford Medical School, and places an emphasis on career development and trainee mentorship. 

Learning Objectives:
The laboratory of Dr. Michael Green is focused on understanding the molecular etiology of B-Cell lymphoma and aims to use this knowledge to identify novel therapeutics strategies. Our laboratory employs high-throughput genomics to interrogate primary tumor specimens and transgenic mouse models; including whole-genome/exome sequencing, RNA-seq, ChIP-seq, CUTRUN and ATAC-seq, as well as cutting-edge single cell approaches. This program will focus on the integration and analysis of multi-omic datasets from patient cohorts and controlled experiments to provide biological insight.

Eligibility Requirements:
​The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.

Applicants should have graduated with their PhD no earlier than 2019 and must have experience with molecular biology. Experience with animal models and/or next generation sequencing and/or bioinformatics is desirable. Interested applicants are invited to submit a C.V. and cover letter.

Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Michael Green, Ph.D.

Req #: 600664-00005
Job Title:  Postdoctoral Fellow       
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​The University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated postdoctoral fellow candidate in Dr. Michael Wang's lab. This is a full-time, hands on laboratory postdoctoral research position. We are seeking highly motivated colleagues, interested in applying his/her knowledge to in vivo tumor models, functional genomics/CRISPR-Cas9 technology, cancer biology, cell signaling, molecular biology, and pharmacology to ultimately solve therapeutic challenges in lymphoma. This position focuses on the integration and analysis of patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance. ​

Learning Objectives:
Dr. Michael Wang's lab is part of the Department of Lymphoma & Myeloma, which offers a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Wang currently has two R21s and two R01s funded by NIH/NCI and one CPRIT grant.

The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities. ​

Eligibility Requirements:​
Individuals with a PhD degree in bioinformatics, genomics, molecular biology, cancer biology or a related field are encouraged to apply. Must have experience with animal models. Experience with next generation sequencing and/or ChIP-seq, ATAC-seq, Hi-C, or other large-scale epigenomics data analysis is highly desirable. A good understanding of cancer biology, cell signaling pathways, or drug response mechanisms is also preferred. Interested applicants are invited to submit a C.V. and cover letter.

Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Luhua (Michael) Wang, M.D.

Req #: 600664-00006
Job Title:  Postdoctoral Fellow       
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​The University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated bioinformatics postdoctoral fellow candidate in Dr. Michael Wang's lab. This is a full-time, hands on laboratory postdoctoral research position. We are seeking highly motivated colleagues, interested in applying his/her knowledge to in vivo tumor models, functional genomics/CRISPR-Cas9 technology, cancer biology, cell signaling, molecular biology, and pharmacology to ultimately solve therapeutic challenges in lymphoma. This position focuses on the integration and analysis of patient-derived xenograft models to understand patterns of therapeutic response and genetic drivers of resistance.​

Learning Objectives:
Dr. ​Michael Wang's lab is part of the Department of Lymphoma & Myeloma, which offers a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia, and other funding mechanisms. Dr. Wang currently has two R21s and two R01s funded by NIH/NCI and one CPRIT grant.

The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.

Eligibility Requirements:​
​Individuals with a PhD degree in bioinformatics, genomics, molecular biology, cancer biology or a related field are encouraged to apply. Must have experience with animal models. Experience with next generation sequencing and/or ChIP-seq, ATAC-seq, Hi-C, or other large-scale epigenomics data analysis is highly desirable. A good understanding of cancer biology, cell signaling pathways, or drug response mechanisms is also preferred. Interested applicants are invited to submit a C.V. and cover letter

Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work 40 hours per week.

Mentor Matching:
This position reports to Luhua (Michael) Wang, M.D.

Req #: 600664-00007
Job Title:  Postdoctoral Fellow       
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​​​Researchers interested in postdoctoral fellowships are invited to apply for positions as part of the group led by Dr. Robert Orlowski, Florence Maude Thomas Cancer Research Professor and Director of the Myeloma Section in the Department of Lymphoma/Myeloma at The University of Texas MD Anderson Cancer Center. Our focus is on developing an expanded understanding of the molecular pathobiology of multiple myeloma and related disorders, validating novel targets and therapeutics that can be translated to the clinic, and understanding mechanisms of resistance that could serve as biomarkers and/or targets for chemosensitization. Current projects of interest focus on the activity of a novel, home-grown set of patented monoclonal antibodies that are showing immunomodulatory and direct cytotoxic activity against a variety of tumor models as naked antibodies, antibody-drug conjugates, and in chimeric antigen receptor guided T-cells.​

Learning Objectives:
The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. The postdoctoral fellow will work closely with an interactive team of wet lab scientists and computational biologists in the Green Laboratory, and will have great opportunities to collaborate with diverse groups of physicians, scientists and computational biologists at MDACC and the Texas Medical Center. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.​​​​

Eligibility Requirements:​
​Successful applicants would be part of an established, well funded, committed, and productive interdisciplinary research team of investigators. Ideal candidates would be molecular, cell, and immune biologists with PhD degrees in a closely related field. They should have experience in single cell RNA and TCR sequencing, immunophenotyping and immune assays, and in vivo tumor modeling. He/she should have excellent written and spoken (English) communication skills and promote scientific collaboration within the research group.​For those interested, please send a CV, contact information for three references (preferably three letters of recommendation), and a 2 page research statement describing past achievements, skills and research interests to Trish Waitschies at PMWaitschies@mdanderson.org.​

Dates or Training Schedule:
Consideration of applications will begin immediately and continue until the position is filled. 

Mentor Matching:
This position reports to Robert Orlowski, M.D, Ph.D. See Dr. Orlowski's research profile.

Req #: 600664-00008
Job Title:  Postdoctoral Fellow       
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​The laboratory of Dr. Michael Green at the University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated candidate for an open postdoctoral fellow position. The project is focused on exploring the role of the DTX1 E3 ubiquitin ligase and NOTCH1 in the etiology of diffuse large B-cell lymphoma. The project will employ advanced CRISPR gene editing and next generation sequencing technology, novel transgenic animal models, patient-derived xenograft models, and other primary patient material to understand the role of DTX1 mutations in lymphoma genesis and progression​.

Learning Objectives:
The Green lab is part of the Department of Lymphoma & Myeloma and the Department of Genomic Medicine, which offer a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia and other funding mechanisms, and is highly productive. Dr. Green places strong emphasis on trainee mentorship and career development. The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities. ​​

Eligibility Requirements:​
​Applicants should have graduated with their PhD no earlier than 2020 and must have experience with molecular biology. Experience with animal models and/or next generation sequencing and/or bioinformatics is desirable. Interested applicants are invited to submit a C.V. and cover letter.

The University of Texas MD Anderson Cancer Center is the nation’s #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. The postdoctoral fellow will work closely with a team of wet lab researchers in the Green Laboratory, and will have great opportunities to collaborate with diverse groups of physicians, scientists and computational biologists at MDACC and the Texas Medical Center. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities.

Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work forty hours per week.

Mentor Matching:
This position reports to Michael Green, Ph.D. See Dr. Green's research profile.

Req #: 600664-00009
Job Title:  Postdoctoral Fellow       
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​The laboratory of Dr. Michael Green at the University of Texas MD Anderson Cancer Center is seeking a highly qualified and motivated candidate for an open postdoctoral fellow position. The project is on the development of Nanopore-based long-read sequencing to understand the genetic and epigenetic etiology and B-cell lymphoma. The project will leverage and extensive tumor bank and cutting edge third generation sequencing technology to understand the effect of structural alterations on epigenetic regulation of gene expression in lymphoma B-cells. ​

Learning Objectives:
The Green lab is part of the Department of Lymphoma & Myeloma and the Department of Genomic Medicine, which offer a highly translational research environment. The lab is well funded through the NIH/NCI, research consortia and other funding mechanisms, and is highly productive. Dr. Green places strong emphasis on trainee mentorship and career development. The University of Texas MD Anderson Cancer Center is the nation's #1 ranked cancer center, located within the Texas Medical Center – home to 21 hospitals and 8 academic and research institutes. Houston is a large and vibrant city with an affordable cost of living, two major airports, professional sports teams, and cultural activities. ​​

Eligibility Requirements:​
​​Applicants should have graduated with their PhD no earlier than 2020 and must have experience with molecular biology. Experience with animal models and/or next generation sequencing and/or bioinformatics is desirable. Interested applicants are invited to submit a C.V. and cover letter.​

Dates or Training Schedule:
The appointment is immediately available. Appointee is expected to work forty hours per week.

Mentor Matching:
This position reports to Michael Green, Ph.D. See Dr. Green's research profile.

Req #: 600300-00003
Job Title:  Postdoctoral Fellow   
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A postdoctoral fellowship position is available immediately in the laboratory of Dr. Jennifer McQuade, a Physician-Scientist and Assistant Professor in the Department of Melanoma Medical Oncology at the University of Texas MD Anderson Cancer Center. The focus of our lab is dissecting the role of modifiable host factors (including diet, the microbiome, obesity, and stress) on melanoma biology and anti-tumor immunity. Our goal is to develop patient-relevant novel treatment strategies to improve outcomes with immune and targeted therapy.

​This position will include focused studies on the role of diet on melanoma biology, immune response, metabolism, and the microbiome. These preclinical studies (both in vivo and in vitro) will be in parallel to controlled feeding studies being conducted in humans by the McQuade lab with intensive translational components and the candidate will have opportunity to work on these correlative studies as well. Unique resources include metabolic phenotyping systems (metabolic mouse cage systems and Seahorse), one of the largest repositories of annotated melanoma biospecimens in the world, and resources such as patient-derived tumor cell lines with matched autologous tumor infiltrating lymphocytes.

Eligibility Requirements:
The candidate should have a doctorate degree and a strong background in one of more of the following: molecular biology, immunology, nutritional biochemistry, metabolism, cancer biology, and/or microbiome and experience with mouse models. Candidates should be enthusiastic about collaborative and interdisciplinary research, be eager to learn new skills and areas, self-motivated, independent, detail-oriented and a problem solver.

​The successful candidate will work under the supervision of Dr. Jennifer McQuade and have the opportunity for co-mentorship Drs. Jennifer Wargo/Carrie Daniel-MacDougall (microbiome), Dr. Michael Davies (Molecular Biology), and/or Dr. Cassian Yee (Immunology).

Mentor Matching:
This position reports to Jennifer McQuade, M.D.

Additional Application Information:
Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three (3) Referees to Dr. McQuade with the subject line entitled “Postdoctoral Fellow - Application – Applicant’s Name” to jmcquade@mdanderson.org.

Req #: 127800-0002
Job Title:  Postdoctoral Fellow
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Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. The laboratory is also investigating the functional importance of long noncoding RNAs in metabolic disorders and has been developed CRISPR/Cas9-mediated lncRNA editing/knockout/knockin mouse models, and transgenic mouse models. The newest projects will study lncRNAs' functional roles in the development of breast/pancreatic/lung cancer, and metabolic dis orders.

Eligibility Requirements:
1. PhD in Molecular Biology, Biochemistry or related field; 2. Outstanding publication record; 3. Strong previous experience in biochemistry; 4. Prior experience in RNA biology is preferred; 5. Prior experience in genetic mouse models is preferred; 6. Excellent communication with a focus on teamwork is required.

Mentor Matching:
The position reports to Dr. Chunru Lin. 

Additional application information:
Responsibilities: Use cutting-edge methods to seek novel therapy targets for human cancers and metabolic disorders; 2. Be responsible for the design and execution of experimental work, data analysis and their written records; 3. Attend and present at internal and international meetings; 4, Be expected to publish data in top scientific journals.

Req #: 127800-0003
Job Title:  Postdoctoral Fellow
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​The Program will define and integrate multi-scale structures and mechanisms controlling the DNA damage response to DNA double strand breaks (DSBs). DSBs are a highly cytotoxic and genotoxic form of DNA damage that can give rise to deletions, insertions, and chromosomal rearrangements, all of which are frequently observed in the genomes of cancer cells. Our NCI Program on the Structural Biology of DNA Repair strives to define abnormalities in DSB recognition and repair in cancer cells that can be targeted to enhance the efficacy of existing cancer therapies and the development of precision medicine approaches. We will determine how the core DSB repair complexes act together and the manner in which distinct DSB repair pathways are selected for lesion removal. Non-homologous end joining (NHEJ) (Aim 1), the main pathway for the repair of radiation-induced DSBs, is efficient but error-prone. The more accurate homologous recombination repair (HRR) pathway plays a lesser role in the elimination of radiation-induced DSBs but represents the primary mechanism for repairing DNA replication-associated DSBs (Aim 2). Emerging evidence points to functional interactions of HRR with NHEJ factors that challenges canonical concepts of distinct linear pathways. Furthermore, a highly error-prone, but mechanistically ill-defined minor DSB repair pathway, known as alternate end-joining (Alt-EJ), helps ensure the survival of cancer cells that are deficient in one of the major DSB pathways (Aim 3) and, as such, represents an attractive cancer cell-specific target for therapeutic development. Our integrated Aims will define the mechanistic underpinnings of the commitment step in the three DSB pathways and their crosstalk  that will integrate  data from atoms to cells.

Learning Objectives:
​Learn advanced methods to combine X-ray scattering with X-ray crystal and cryo-EM structures. Learn to integrate these combined methods with other biophysical measurements to enable design separation-of-function mutants, test and validate mechanisms and develop inhibitor tools for cancer biology. Learn to collect, analyze, and publish experimental structural and biochemical data and develop grant proposals for research support. One focus will on whether our newly discovered interaction between Artemis and the MRE11-RAD50-NBS1 (MRN) complex provides a functional link between NHEJ and HRR and test the hypothesis whether DNA-PK and ATM-mediated Artemis phosphorylation function as a key determining switch for this pathway crosstalk.

Eligibility Requirements:
​Required: PhD in structural biology and experience in the structural biology and biochemistry of DNA repair. Preferred: Two years of experience in scientific experimental research with DNA repair proteins as well as a general knowledge of DNA repair structural biology and biochemistry.

Mentor Matching:
The position reports to Dr. John Tainer. 

Req #: 127800-0004
Job Title:  Postdoctoral Fellow
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The research project focuses on understanding the roles of epigenetic modifiers in regulating cancer-epigenetic events and stem cell characteristics. In particular, the project seeks to identify novel functions of epigenetic modifiers (with an emphasis of histone methylation modifiers) and their new partner proteins in tumor suppression pathways, tumorigenesis and stem cell properties. 

Learning Objectives:
T​o learn epigenetic regulation of cancer and stem cells and become an independent scientist in the field. ​

Eligibility Requirements:
A Ph.D. in cancer biology or molecular biology is required. Experience and publications in the field of epigenetics are preferred. ​

Mentor Matching:
The position reports to Min Gyu Lee, Ph.D. 

Additional Application Information:
Please send CV and information for at least three references to:
Min Gyu Lee, Ph.D.
Associate professor
Dept. of Molecular & Cellular Oncology
The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Houston, TX 77030
Email: mglee@mdanderson.org

Req #: 600378-0001
Job Title:  Postdoctoral Fellow
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​​​​​​Daily responsibilities will include applying or developing novel bioinformatics algoriths to interpret cancer genomic and epigenomic datasets. These datasets include whole-genome sequencing from the Illumina or Oxford Nanopore platforms, chromatin accessibility (ATAC-Seq) and three-dimensional chromatin folding (Hi-C) datasets generated from human central nervous system (CNS) tumors.

• Good spoken and written communication skills in English is required.
• Write fellowship applications and submit abstracts to national, international scientific meetings.
• Develop manuscripts summarizing the research efforts for peer-reviewed publications.
• Plans, organizes, coordinates and participates in scientific research projects independently and meet one-on-one with the principal investigator regularly. 
• Collaborates with other research scientists to design experiments involving CNS tumor biology and analyze genomic datasets.
• Independently carries out computational analysis on existing or recently generated genomic datasets.
• Utilizes initiative and inventiveness in planning and executing the details of data analysis.
• Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to address problems.
• Under the direction of the principal investigator or his designee, develops new areas of investigation based upon prior experience.
• Keeps detailed, thorough notes of experiments in electronic record in English, and routinely discusses data with supervisor.
• Remains current on literature and techniques relating to the field of investigator.
• Attend and present data at weekly laboratory meetings within the department.
• Prepare and present a scientific analysis of the results, and assist in preparation of scientific publications.

Eligibility Requirements:
Required education: Graduate (Ph.D./M.D.)'s degree in one of the natural sciences, computer science or related field. 

Required experience: Previous coding and data analyses skills are required. At least one first/co-first author bioRxiv preprint or paper with submitted, accepted or published status in journals is required.

​Preferred experience: A background in cancer genomics and next-generation sequencing data handling is preferred.​

Mentor Matching:
The position reports to Kadir Akdemir, Ph.D. See Dr. Akdemir's research profile.

Req #: 710505-00001
Job Title:  Postdoctoral Fellow
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​The Department of Palliative, Rehabilitation, and Integrative Medicine at The University of Texas MD Anderson Cancer Center has a postdoctoral fellow position open for preclinical research in the laboratory of Dr. Peiying Yang. The Yang laboratory conducts research on identifying effective prevention and treatment modalities in oncology including botanical products, nutrition, and biofield therapies in various cancer models and dissecting the molecular and cellular mechanisms that are responsible for the relevant tumor modification properties of these modalities. The ultimate goal is to define novel effective strategies to prevent and treat cancer. The primary focus of the open position will be the study in the area of biofield therapies using both in vitro cells and in vivo mouse models. The postdoctoral fellow will work under the supervision of Dr. Peiying Yang on innovative and challenging biological projects that involve biofield therapy, stem cells, and epigenetic research. ​

Learning Objectives:
The primary research focus will be conducting biofield therapy research in both in vitro and in vivo experimental methods to better understand the therapeutic potential of biofield therapy in cancer. The fellow will gain extensive experience in biofield therapy research in the context of stem cells and epigenetics, and will have the opportunity to publish in high-impact research journals. ​

Eligibility Requirements:
​We seek a highly motivated individual with a Ph.D. in molecular biology/cancer biology with the experience of laboratory techniques in the fields of molecular biology, immunology, and drug development, and experience in antitumor efficacy study using animal study including transgenic mouse model and experience with SOPs and animal protocols. The candidate must have the ability to independently conduct research, troubleshoot daily experiments, be a creative thinker and problem solver, and excellent writing and presentation skills. Experience in mentoring graduate students and laboratory technicians is preferred.

Send CV and a statement of research interest to: Dr. Peiying Yang, Department of Palliative, Rehabilitation, and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030. E-mail: pyang@mdanderson.org

Dates of Training Schedule:
The position is immediately available.

Mentor Matching:
This position reports to Peiying Yang, Ph.D.

Req #: 600663-00003
Job Title:  Postdoctoral Fellow
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​The Department of Anatomic Pathology and Laboratory Medicine at The University of Texas MD Anderson Cancer Center in Houston offers a two-year postdoctoral research position in lung cancer research. We are seeking applicants with an interest in thoracic pathology, who are highly motivated and able to work independently. The successful candidate will receive faculty mentorship but is expected to carry out all aspects of an independent research project, including literature searches, data acquisition from electronic medical records, preview of histopathological samples for research purposes, data analysis and management, scientific publication, and participation and presentation in institutional meetings and scientific conferences. Furthermore, the successful candidate will be required to perform other duties as assigned by the supervising faculty. There will be additional opportunities to pursue translational research in personalized cancer care and involvement in institutional or national clinical trials. An outstanding salary and benefits package is included, with the salary level commensurate with experience. For full consideration, please send a cover letter containing information about your research interests and career plans, an updated CV, and names and contact information of three references to: Annikka Weissferdt, MD (aweissferdt@mdanderson.org).

Learning Objectives:
​1. To provide faculty support for clinical research activities.
2. To systemically review the literature, to collect and analyze research data and to write manuscripts.
3. Scientific communications and presentations at local and national meetings.

Eligibility Requirements:
​Applicants must have an MD or MD/PhD degree and have completed a residency in anatomic or anatomic/clinical pathology.

Program Dates:
This position is shceduled to start May 1.

Mentor Matching:
The position reports to Annikka Weissferdt, M.D.

Req #: 130100-00001 
Job Title:  Postdoctoral Fellow
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​A leading translational immune therapy research lab in the Division of Pediatrics at The University of Texas MD Anderson Cancer Center seeks a highly motivated postdoctoral fellow with a strong interest in TCR-antigen discovery or immune assay development.  ​

Eligibility Requirements:
​This lab focuses on the discovery of novel immune therapy for solid tumors.  Qualified postdoc candidates should have a doctoral degree, with strong experience in antigen discovery using newly revealed TCRs or T cell biology.​

Mentor Matching:
The position reports to Shulin Li, Ph.D. See Dr. Li's Research profile.

Req #: 130100-00002
Job Title:  Postdoctoral Fellow
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​A leading research lab in the Division of Pediatrics at The University of Texas MD Anderson Cancer Center focused on basic and translational lab in brain tumor research seeks a highly motivated postdoctoral fellow with a strong interest in understanding the role of chromatin remodelers in the pathogenesis of pediatric brain tumors.​

Eligibility Requirements:
​This lab uses genetically engineered and xenograft mouse models as well as multi-omics approaches to study the role of chromatin remodelers in the control of neural lineage specification, the genesis of pediatric brain tumors and the development of targeted therapies. Qualified candidates should have a doctoral degree in one of the following disciplines: Biochemistry, Molecular Biology, Molecular Genetics, Cell Biology, or Pharmacology. Strong experience with mouse models and techniques related to the study of chromatin remodelers and epigenetic modifications is important. A background in brain tumors and or drug discovery will be beneficial, but not necessary.​

Mentor Matching:
The position reports to Vidya Gopalakrishnan, Ph.D. See Dr. Gopalakrishnan's Research profile.

Req #: 130100-00003
Job Title:  Postdoctoral Fellow
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​A leading translational research lab in the Division of Pediatrics at The University of Texas MD Anderson Cancer Center seeks a highly motivated postdoctoral fellow with a strong interest in cancer biology and a desire to work with projects relating to osteosarcoma with a focus of molecular biology, mechanisms of resistance, and tumorigenesis.  ​

Eligibility Requirements:
This lab, led by a Division Head, focuses on the discovery and mechanisms and pharmacology of novel targets in osteosarcoma.  Qualified postdoc candidates should have a doctoral degree, with strong experience in molecular biology and gene editing.   Prior experience in molecular pharmacology, mouse models, and dna barcoding are also very desirable. Experience with immunology and immunohistochemistry will allow for cross-over with other ongoing projects in the lab.  The postdoctoral fellow is expected to have impeccable work ethic, critical thinking abilities, and excellent organizational and communication skills. Expectations include abstracts/posters/talks at major national meetings, yearly publications, and capability to foster a vigorous scientific environment. Mentoring toward independent career goals and independent grant funding are also emphasized.​​

Mentor Matching:
The position reports to Richard Gorlick, M.D. See Dr. Gorlick's Research profile.

No positions in the Department of Plastic Surgery are currently available. Check back later for new opportunities.

Req #: 600469-00001 
Job Title:  Postdoctoral Fellow
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This position will study the role of the platelets in the progression of cancer and on the mechanisms of platelet extravasation into tumors.
1. To design and conducts in vitro experiments on the role of platelets in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of platelets on immune cells (neutrophils, T cells, B cells, and antigen-presenting cells)
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of platelets on the growth and metastasis of different cancers, and the therapeutic benefit of platelet inhibitors on blocking tumor growth.
4. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelet extravasation into the tumor microenvironment.
5. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelets on the immune profile of tumor microenvironment.
6. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
7. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
8. To conduct DNA, RNA, and protein extraction and purification.
9. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
10. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
11. To communicate freely and clearly, but also to be respectful to other lab members.
12. Records the experiments and results meticulously.
13. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:

• Learning to design and conduct experiments in vitro and in mouse models of cancer
• Learning to troubleshoot and analyze the generated data
• Learning important topic in platelet biology, imaging studies, immune profiling tumor microenvironment, mouse genetics

Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as ELISA, Western-blotting, flowcytomtery, RT-PCR, PCR, RNA, and DNA extraction
Familiarity with imaging studies including immunohistochemistry and immune fluorescence microscopy

Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.

Req #: 600469-00002
Job Title:  Postdoctoral Fellow
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This position will study the role of the complement system on the tumorigenesis and progression of cancer.
1. To design and conducts in vitro experiments on the role of complement proteins in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of complement proteins in proliferation, differentiation, and polarization of T cells
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of the complement system in growth and metastasis of different cancers, and the therapeutic benefit of complement inhibitors on blocking tumor growth.
4. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
5. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
6. To conduct DNA, RNA, and protein extraction and purification.
7. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
8. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
9. To communicate freely and clearly, but also to be respectful to other lab members.
10. Records the experiments and results meticulously.
11. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:

• Learning to design and conduct experiments in vitro and in mouse models of cancer
• Learning to troubleshoot and analyze the generated data
• Learning important topic in complement biology, the immune response to the tumor, immune profiling tumor microenvironment, mouse genetics
  

Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as flow cytometry, ELISA, Western blotting, PCR, RT-PCR, RNA, and DNA extraction

Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.

Req #: 600469-00004
Job Title:  Postdoctoral Fellow
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​Pneumonias are a leading cause of death in all populations, and exact a particularly severe toll on immunocompromised individuals, such as cancer patients receiving cytotoxic therapies or those who have received stem cell transplants. In an effort to protect vulnerable patients against lethal pneumonias, the Evans lab investigates means to manipulate the lungs’ intrinsic antimicrobial defenses to protect against the pathogens that people inhale or aspirate every day. Rather than rely on the canonical responses of leukocytes that are often deficient or dysfunctional in our cancer patient populations, the focus of our work is on manipulating microbicidal responses directly from lung epithelial cells, a long-lived cell population that is largely tolerant of cytotoxic therapies. Using this approach, the Evans lab has discovered epithelium-focused immunostimulatory therapies that are now in FDA-approved clinical trials in a variety of settings.

Our work now focuses on understanding how this manipulation can prevent both acute (lethal pneumonia) and chronic (asthma) complications of respiratory infections. Such understanding can allow development of next-generation therapies that exert even greater efficacy with even fewer off-target effects. Active projects in the laboratory include investigations into novel mechanisms to detect pathogens (and our pathogen-associated molecular pattern-based therapies), into mechanisms of intra- and inter-cellular signaling events that promote synergistic protective responses, into the inducible microbicidal effector mechanisms that reduce pathogen burdens, and into immunomodulatory effects of our epithelial treatments that exert their effects independent of pathogen burden.

Learning Objectives:

​1. To prepare and conduct in vivo studies of pneumonia and pneumonia protection in wildtype and genetically-manipulated mice.
2. To prepare and maintain cultures of immortalized and primary cells to investigate mechanisms of inducible protection.
3. To prepare and conduct ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and immunofluorescence staining.
4. To perform microscopic and morphometric image analyses of histological specimens.
5. To perform RNA and protein-based analysis of epithelial cells and leukocytes.
To perform cell sorting and flow cytometry to characterize immune responses.
7. To extract and record relevant information from published literature.
8. To learn data analysis and figure preparation for presentations.
9. To learn to write and submit manuscripts and grant proposals.
10. To present data and literature reviews at local, national, and international meetings.
11. To mentor undergraduate, graduate students, and other trainees.
12. To develop organizational and leadership skills in preparation for a career in science.
 

Eligibility Requirements:

EDUCATION:  Required: Ph.D. or M.D.
EXPERIENCE: Required: Basic molecular biology and immunology techniques are required. Work experience with small rodents is a plus.Mentor Matching:

Mentor Matching:
The position reports to Scott Evans, M.D.

Additional Application Informaiton:
SUMMARY:
Function: Carrying out studies of therapeutically-inducible lung antimicrobial responses to protect vulnerable subjects against pneumonia.
Scope: Enhance our understanding of the mechanisms of inducible antimicrobial responses from lung parenchymal cells, particularly epithelia, to protect against acute and chronic complications of lower respiratory tract infections.

ESSENTIAL JOB FUNCTIONS:
1. Prepares and conducts in vivo studies of inducible lung antimicrobial responses, including breeding mutant and wildtype mice, delivering various treatments to mice, delivering infectious challenges to mice, clinically assessing mice, harvesting mouse tissues, euthanizing some mice, and keeping excellent records of these processes.
2. Establishes and maintains in vitro/ex vivo cultures of primary and immortalized cells.
3. Prepares and conducts ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and in situ hybridization.
4. Performs microscopic and morphometric image analyses of histological specimens.
5. Constructs, assembles, and operates laboratory apparatus and equipment including thermocyclers, agarose gel electrophoresis units, nebulizers/gas compressors, and spectrophotometers.
6. Cultures and expands various microorganisms for both in vitro and in vivo infectious challenges.
7. Isolates, extracts, purifies, and analyzes mouse genomic DNA for genotyping purposes using PCR.
8. Isolates, extracts, purifies, and analyzes mouse RNA for purposes of gene expression analysis.
9. Performs cell sorting and flowcytometry.
10. Performs protein extraction and performing the protein based assays including ELISA and Western Blot
11. Reads literature relevant to lung infections, epithelial biology, immune cell functions and/or laboratory methods.
12. Communicates freely and clearly, and must confer with superiors regarding new procedures and modify them according to the needs of the project.
13. Records and evaluates data obtained in accordance with methods requested and confers with superiors regarding results obtained.
14. Analyzes data, prepares graphs and figures, and helps in writing and submitting manuscripts.

PERIODIC FUNCTIONS:
1. Presents data in formal departmental Laboratory Seminars.
2. Presents papers in departmental Journal Clubs.
3. Present data in weekly meetings of the Evans laboratory personnel.
4. Present papers in weekly Evans laboratory Journal Clubs.
5. Present data in national and international meetings in form of poster or podium talk.

SUPERVISION:
Received: Scientific Mentor and Technical supervisor.
Given: Laboratory Assistants, undergrad and grad students.

Req #: 600469-00005
Job Title:  Postdoctoral Fellow
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Postdoctoral fellowship positions are immediately available in the Laboratory of Scott Evans at the University of Texas MD Anderson Cancer Center. Pneumonias are a leading cause of death in all populations, and exact a particularly severe toll on immunocompromised individuals, such as cancer patients receiving cytotoxic therapies. In an effort to protect vulnerable patients against lethal pneumonias, the Evans lab investigates means to manipulate the lungs' intrinsic antimicrobial defenses to protect against the pathogens that people inhale or aspirate every day. Rather than rely on the canonical responses of leukocytes that are often deficient or dysfunctional in cancer patients, the focus of our work is on manipulating microbicidal responses directly from lung epithelial cells, a long-lived cell population that is largely tolerant of cytotoxic therapies. Using this approach, the Evans lab has discovered epithelium-focused immunostimulatory therapies that are now in FDA-approved clinical trials in a variety of settings. Our work now focuses on understanding how this manipulation can prevent both acute (lethal pneumonia) and chronic (asthma) complications of respiratory infections. Such understanding can allow development of next-generation therapies that exert even greater efficacy with even fewer off-target effects. Active projects in the laboratory include investigations into novel mechanisms to detect pathogens, into mechanisms of intra- and inter-cellular signaling events that promote synergistic protective responses, into the inducible microbicidal effector mechanisms that reduce pathogen burdens, and into immunomodulatory effects of our epithelial treatments that exert their effects independent of pathogen burden.

The Evans lab has "shovel ready" projects for postdoctoral fellows to lead on day one, but given the unconventional nature of the lab's programs, applicants' novel ideas for new projects are also encouraged. The Evans lab strives to be inclusive and supports a highly collaborative, team-oriented, learner-driven environment.

Successful applicants must have MD and/or PhD degrees with experience in immunology, microbiology, epithelial biology or other fields directly relevant to host-pathogen interactions. Postdoctoral fellows should be familiar with basic cell biology and immunology techniques. Strong written and spoken English communication skills are important to the positions, as successful applicants will participate in writing grants and papers, will present findings and novel research in various formats, and will provide supervision to more junior trainees. Experience with small rodents is a plus.

Learning Objectives:

• To prepare and conduct in vivo studies of pneumonia and pneumonia protection in wildtype and genetically-manipulated mice.
• To prepare and maintain cultures of immortalized and primary cells to investigate mechanisms of inducible protection.
• To prepare and conduct ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and immunofluorescence staining.
• To perform microscopic and morphometric image analyses of histological specimens.
• To perform RNA and protein-based analysis of epithelial cells and leukocytes.
• To perform cell sorting and flow cytometry to characterize immune responses.
• To extract and record relevant information from published literature.
• To learn data analysis and figure preparation for presentations.
• To learn to write and submit manuscripts and grant proposals.
• To present data and literature reviews at local, national, and international meetings.
• To mentor undergraduate, graduate students, and other trainees.
• To develop organizational and leadership skills in preparation for a career in science.
   

Eligibility Requirements:

EDUCATION:  Required: Ph.D. or M.D.
EXPERIENCE: Required: Basic molecular biology and immunology techniques are required. Work experience with small rodents is a plus.

Mentor Matching:
The position reports to Scott Evans, M.D.

Additional Application Informaiton:
SUMMARY:
Function: Carrying out studies of therapeutically-inducible lung antimicrobial responses to protect vulnerable subjects against pneumonia.
Scope: Enhance our understanding of the mechanisms of inducible antimicrobial responses from lung parenchymal cells, particularly epithelia, to protect against acute and chronic complications of lower respiratory tract infections.

ESSENTIAL JOB FUNCTIONS:
1. Prepares and conducts in vivo studies of inducible lung antimicrobial responses, including breeding mutant and wildtype mice, delivering various treatments to mice, delivering infectious challenges to mice, clinically assessing mice, harvesting mouse tissues, euthanizing some mice, and keeping excellent records of these processes.
2. Establishes and maintains in vitro/ex vivo cultures of primary and immortalized cells.
3. Prepares and conducts ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and in situ hybridization.
4. Performs microscopic and morphometric image analyses of histological specimens.
5. Constructs, assembles, and operates laboratory apparatus and equipment including thermocyclers, agarose gel electrophoresis units, nebulizers/gas compressors, and spectrophotometers.
6. Cultures and expands various microorganisms for both in vitro and in vivo infectious challenges.
7. Isolates, extracts, purifies, and analyzes mouse genomic DNA for genotyping purposes using PCR.
8. Isolates, extracts, purifies, and analyzes mouse RNA for purposes of gene expression analysis.
9. Performs cell sorting and flowcytometry.
10. Performs protein extraction and performing the protein based assays including ELISA and Western Blot
11. Reads literature relevant to lung infections, epithelial biology, immune cell functions and/or laboratory methods.
12. Communicates freely and clearly, and must confer with superiors regarding new procedures and modify them according to the needs of the project.
13. Records and evaluates data obtained in accordance with methods requested and confers with superiors regarding results obtained.
14. Analyzes data, prepares graphs and figures, and helps in writing and submitting manuscripts.

PERIODIC FUNCTIONS:
1. Presents data in formal departmental Laboratory Seminars.
2. Presents papers in departmental Journal Clubs.
3. Present data in weekly meetings of the Evans laboratory personnel.
4. Present papers in weekly Evans laboratory Journal Clubs.
5. Present data in national and international meetings in form of poster or podium talk.

SUPERVISION:
Received: Scientific Mentor and Technical supervisor.
Given: Laboratory Assistants, undergrad and grad students.

Req #: 600661-0003
Job Title:  Postdoctoral Fellow
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Postdoctoral positions are available immediately to work in the area of endoplasmic reticulum stress/unfolded protein response and cancer biology. Candidates should possess mastery of basic knowledge and techniques in molecular & cell biology, biochemistry, and mouse genetics. Knowledge and hands-on experience in immunology research is desirable. The candidate should also be highly motivated in learning new techniques and independent thinking. Compensation will adhere to institutional and NIH postdoc guidelines.

Learning Objectives:

• Use cutting-edge methods to delineate cancer-promoting cellular & molecular mechanisms and seek novel cancer therapy targets
• Be responsible for the design and execution of experimental work, data analysis and their written records
• Attend and present at internal and external meetings
• Publish data in top scientific journals
  

Eligibility Requirements:

• PhD in Cell and Molecular Biology, Biochemistry or related field obtained within three years.
• Outstanding publication record.
• Prior experience in in vitro & in vivo pharmacological studies is preferred.
• Prior experience in in vitro & in vivo immunological assays and flow cytometry analysis is a plus.
• Prior experience in genetic mouse models is a plus.
• Basic skills in data analysis using e.g. Excel and GraphPad Prism is required.
• Excellent communication with a focus on teamwork is required.

Mentor Matching:
This position reports to Albert Koong, M.D., Ph.D.

Additional application information:

The major focus of our laboratory is to investigate tumor microenvironment-regulated signaling pathways that contribute to tumor progression and resistance to anti-cancer therapy. Our laboratory has shown that the IRE1alpha-XBP1 pathway, a key component of the unfolded protein response (UPR), was activated by stress signals in the tumor microenvironment, such as hypoxia. Since identifying IRE1alpha-XBP1 as a potential therapeutic target in cancer, our laboratory has completed a high throughput small molecule screen of >120,000 compounds for inhibitors of this pathway and identified classes of compounds that selectively inhibit the endoribonuclease activity of IRE1alpha and demonstrate potent anti-cancer activity (Papandreou et al., Blood 2010; Jiang et al., Mol Cancer Ther 2016). To further accelerate the preclinical evaluation of other compounds targeting this pathway, we also developed an XBP1-luciferase transgenic mouse in which luciferase activity is detectable only when XBP1 is activated (Spiotto et al., Cancer Res 2009). In addition, the laboratory has completed a genome wide siRNA screen to identify other genes that are required for the activation of IRE1alpha (Yang et al., Mol Cancer Res 2017). Studies investigating the mechanisms of IRE1alpha activation will lead to the development of novel cancer therapeutics targeting this pathway. More recently, our laboratory has developed several computational biology methods of analyzing the drug screening data to improve the efficiency of drug discovery (Jiang et al. Jiang et al., Mol Cancer Ther 2016; Alagappan et al. Adv Exp Med Biol 2016), as well as novel application of artificial intelligence (AI) and deep learning approaches in drug discovery (Yuan et al. J Chem Inf Model 2017).

Our ongoing research projects include:

(1) Studying the role of IRE1alpha/XBP1 in tumor progression and chemo-/radio-resistance, using in vitro cell culture and organoid systems as well as in vivo xenograft and genetically modified mouse tumor models.
(2) Investigating the role of IRE1alpha/XBP1 in regulating proliferation and DNA damage response pathway.
(3) Developing biomarkers that may be used to guide therapeutic decisions in pancreatic cancer (Danai et al., Nature 2018; Qian et al., JAMA Oncol 2018).

Req #: 600661-0004
Job Title:  Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.

The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.

An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.

Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org).

Eligibility Requirements:
A recent Ph.D. or equivalent doctorate in microbiology (or similar, with experience in microbiology laboratory-based research and molecular biology) who is seeking a temporary appointment under the supervision of a faculty mentor involving full-time laboratory based research and scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
This position reports to Lauren Colbert, M.D.

Additional application information:

Required Background/ Skills:

• PhD in Microbiology or related field and relevant research experience
• Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development
  

Preferred Background/ Skills:

• Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
• Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
• Development and testing of model microbial systems in animals
• Experience with immune assays including flow cytometry and immunohistochemistry
• Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.

Req #: 600661-0006
Job Title:  Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a NIH/NCI-funded project that seeks to protect the intestine from radiation injury. This science has implications for oncology treatments (pancreatic and liver cancers) and nuclear countermeasures (medical response to a terrorist attack or nuclear accident). The successful candidate will have significant experience in intestinal stem cell biology or radiation biology/physics. Experience with molecular biology, histology and tissue preparation, cell biology, and mouse modeling are very
helpful but not required.

Learning Objectives:

• Training and expertise in radiation biology, intestinal stem cell biology
• A stimulating environment with freedom to develop new research directions, includingmechanistic approaches to understanding and translating EGLN inhibition to protect thesmall intestinal tract.
• Expectations to present and publish their data in a timely fashion
  

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary
appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an
independent investigator.

Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.

Dates or Training Schedule:

Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars

Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 600661-0007
Job Title:  Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.

The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.

An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.

Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org). 

Mentor Matching:
This position reports to Lauren Colbert, M.D.

Additional application information:

Required Background/ Skills:

• PhD in Microbiology or related field and relevant research experience
• Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development/ optimization
  

Preferred Background/ Skills:

• Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
• Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
• Development and testing of model microbial systems in animals
• Experience with immune assays including flow cytometry and immunohistochemistry
• Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.

Req #: 600661-0008
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in the department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. The program consists of a proposed plan for Health Economics Analysis of Proton Therapy vs. IMRT for Patients with Head and Neck Cancer. The program is designed to estimate the cost-effectiveness for all patients diagnosed nationally using US cancer statistics and to estimate economic burden of treating head and neck cancer in the US, considering lifetime treatment cost as well as the growing incidence of head and neck cancer in the future.

Learning Objectives:

• Lifetime cost per patient
• National annual cost of head and neck cancer management
• If there are cost differences, then national expenditure of treating patients using Proton therapy compared to IMRT
• Incremental cost-effectiveness ratio (ICERs) to identify valuable treatment
• ICERs specific to patient characteristics to evaluate whether the cost-effective strategy shifts
• Model will be validated through cross validation with by comparing with the model of the HPV-positive oropharyngeal cancer natural history and disease burden, and independent validation with empirical data sources.

Mentor Matching:
This position reports to Steven Frank, M.D. We will match the candidate with the appropriate co-mentoring team of faculty with the relevant expertise for the proposed post-doctor.

Dates or Training Schedule:
04/01/2020- 04/01/2021 

Req #: 600661-0009
Job Title:  Postdoctoral Fellow
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Postdoctoral position is available immediately in the area of cancer immunology and translational research. The laboratory seeks to identify novel agents and targets to enhance immune responses with cancer therapies and translate those findings to the clinic in ongoing clinical trials. We are interested in studying immunologic mechanisms that confer response through targeting dendritic cell and lymphocyte activation using various in vitro and in vivo tumor models.

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. The candidate should have proven scholarship in publications and presentations at major meetings in immunology, preferably cancer immunology.

Mentor Matching:
This position reports to Steven H. Lin. See Dr. Lin's research profile.

Dates or Training Schedule:
Available immediately, 3 years at the minimum

Additional Application Information:
We seek applicants who are self-motivated and career-oriented who ultimately would want to become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in immunology, cancer biology and translational collaborations.

Req #: 600661-0010
Job Title:  Postdoctoral Fellow
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The program is introducing a formal one-year educational and research program that will effectuate expertise sufficient to lead and accelerate the development of biomedical imaging application in radiation oncology. We aim to develop and effectuate a program that includes a mentored
education, training, and hands-on implementation of research activities related to biomedical imaging, clinical informatics, and clinical trial design and to enhance the recruitment of early career physician scientist from under-represented minorities or with disabilities or other social, cultural, economic, or educational disadvantages to enrich the diversity of our national workforce in biomedical imaging. Successful implementation of this program will directly augment novel research approaches towards the development of new biomedical imaging techniques and devices to fundamentally improve the detection, treatment, and prevention of disease; as well as enhancing existing imaging and clinical research and its implications.

Learning Objectives:
One of our direct objectives is to inculcate trainees with requisite research skills for integration of biomedical imaging and clinical imaging informatics in radiation oncology applications.

Eligibility Requirements:
Domestic resident post-graduate physician trainees (PGY1-4).
-Accepted to the ACGME MD Anderson Clinical Radiation Oncology Program.
-Academically gifted physician trainees desiring a focal clinical research development term, and commitment to formal K01/K08/K12/K23 award application by R25 term completion.
-Commitment to academic radiation oncology career
-Evidence of clinical and scholastic performance (USMLE, undergraduate medical GPA, recommendation letters, etc.)
-History of publication or prior research is favorable
-Commitment to 1-year post-clinical residency clinical research fellowship (i.e. 1 year of R25-supported focal research effort).

Mentor Matching:
This position reports to Clifton David Fuller, M.D., Ph.D. and Kristy K. Brock, Ph.D.

Dates or Training Schedule:
August 2020 through February 2021

Req #: 600661-0011
Job Title:  Postdoctoral Fellow
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​A Postdoctoral Fellow position is avaialable in the department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. Dr. Chung's lab major research focus is to utilize advanced medical imaging tools to measure and predict response and toxicity to treatment with novel systemic agents and high precision radiotherapy. In addition, the lab is working on the standardization of collection and nomenclature of images to facilitate meaningful measurements and interpretation of imaging biomarkers across departments and institutions.

Learning Objectives:
​The Postdoctoral Fellow will develop quantitative imaging processing and analysis approaches in order to identify key imaging parameters that can be utilized as imaging biomarkers and to guide adaptice radiotherapy approaches. In addition, the Postdoctoral Fellow will also assist in leadership and mentoring of undergraduate and graduate students.​​

Eligibility Requirements:
​Successful applicants must have a PhD and/or MD degree with less that 2 years of postdoctoral experience, at least one first author publication, as well as a high level of written and oral communication skills in English.

Mentor Matching:
This position reports to Caroline Chung, M.D., a practicing central nervous system radiation oncologist with a translational research career focused on imaging biomarkers to guide personalized cancer therapy.

Dates or Training Schedule:
This position is open immediately.

Req #: 600662-0010
Job Title:  Postdoctoral Fellow
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​Development of evaluation metrics for radiation therapy treatment plans based on patient outcomes.  We will develop an evaluation methodology that quantifies the probability of a particular patient outcome based on the patient's radiation therapy treatment plan.  The resulting metric will then be used to develop a scoring system for patient plans.

Learning Objectives:​

​1. Learn how to correlate patient outcomes to radiation therapy treatment plans.
2. Learn how to create probability density functions that converts a planned radiation therapy dose into a probability for a particular patient outcome.
3. Learn about radiation oncology and medical physics in general.

Eligibility Requirements:
​The ideal candidates should have finished (or be about to finish) their Ph.D. degree in medical physics, computer science, physics, engineering or applied mathematics.  Programming skills in Python, R and/or C# is required.  The individual is
expected to work within a large group of motivated interdisciplinary professionals.

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Thomas Whitaker and Dr. Laurence Court.

Req #: 600662-0011
Job Title:  Postdoctoral Fellow
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​​The Lin/Schueler research lab in the Department of Radiation Oncology/Physics at UT MD Anderson Cancer Center is seeking a postdoctoral fellow. Our focus is on developing the foundation for a clinical translation of FLASH radiation therapy (RT). Current focus of interest is on hematological and gastrointestinal toxicity and how they relate to dose rate. A large focus is also on the immunological effects of FLASH and how combination treatments can further increase the therapeutic window of FLASH RT. More information on the position can be found at https://www.postdocjobs.com/posting/7071940  ​

Learning Objectives:​

​1. Gain insight into the biological effects of FLASH RT
2. Elucidate the dependence of the physical beam irradiation parameters on the FLASH effect on multiple organ systems
3. Developing irradiation setups for animal irradiations​

Eligibility Requirements:
​Ideal candidates should have experience in cancer biology and immunology. Excellent verbal and written communication skills are required. The individual is expected to work within a large group of motivated interdisciplinary researchers including clinicians, postdoctoral fellows and other research staff.​

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Emil Schueler.

Req #: 600661-0012
Job Title:  Postdoctoral Fellow
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The primary purpose of the Research Investigator is to assist the Principal Investigator and other Faculty members with scientific research projects. The primary activity of this position is academic research in association with a faculty member or team. An opening currently exists with a examining the role of microRNAs in head and neck cancer, animal models of tumorigenesis and immune responses against head and neck and metastasis in head and neck cancer.

Key Functions

​1. Perform technical laboratory duties, techniques, in vivo and in vitro experiments studying head and neck cancer biology and response to treatments including immunotherapy and/or radiotherapy.

2. Projects may include generation of novel transgenic animals; in vitro and in vivo miRNA assays; next generation approaches to miRNA and mRNA pathways; small animal image-guided radiotherapy; tissue harvesting and microscopy; in vivo and ex vivo immunological assays; in vitro radiosensitivity assays; implementation/development of novel protocols and procedures; execution of experiments; analysis of results.

3. Familiarity with histology, animal husbandry, in vivo surgical techniques, immune and miRNA assays is preferred. Ideal candidates would possess experience in molecular biology, cell culture, and animal models of human cancer.

4. Training and supervising other research personnel on techniques and equipment procedures

5. Maintenance of laboratory safety procedures and records and facilities

6. Collect, analyze, plot data using appropriate software applications, store and record data on computer and lab notebooks

7. Assist in writing of scientific papers for publication, grant applications and presentations at scientific meetings

8. Other duties as assigned

Eligibility Requirements:
​​An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.​

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Michael Spiotto, M.D., Ph.D.

Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations. 

Req #: 600661-0013
Job Title:  Postdoctoral Fellow
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​The primary purpose of the Postdoctoral Fellow is to assist the Principal Investigator and other Faculty members with scientific research projects. The primary activity of this position is academic research in association with a faculty member or team. A position is available immediately in the area of cancer immunology and translational research. The laboratory seeks to study therapy induced immune suppression and test drugs that can restore immunity and enhance immune responses with cancer therapies and translate those findings to the clinic in ongoing clinical trials. We are interested in studying immunologic mechanisms that confer response through various drugs that can act in tissue or bone marrow using various in vitro and in vivo tumor models.​

Learning Objectives:

• Perform technical laboratory duties, techniques, in vivo and in vitro experiments studying immune biology in the context of cytotoxic cancer therapies and response to treatments including immunotherapy and/or radiotherapy.
• Projects will include using mouse tumor models to assess immunologic effects of cancer therapy induced immune suppression on tumor biology and drugs or cytokines that could reverse this effect in tumor bearing animals; small animal image-guided radiotherapy; tissue harvesting and microscopy; in vivo and ex vivo immunological assays; single cell sequencing methods and/or single cell cytokine analysis; implementation/development of novel protocols and procedures; execution of experiments; analysis of results.
• Familiarity with histology, animal husbandry, in vivo surgical techniques, immune and proteomic or transcriptomic assays is preferred. Ideal candidates would possess experience in molecular biology, cell culture, and animal models of human cancer.
• Training and supervising other research personnel on techniques and equipment procedures
• Maintenance of laboratory safety procedures and records and facilities
• Collect, analyze, plot data using appropriate software applications, store and record data on computer and lab notebooks
• Assist in writing of scientific papers for publication, grant applications and presentations at scientific meetings
• Other duties as assigned​
  

Eligibility Requirements:
​Education Required:  Ph.D. or equivalent doctorate​

Experience Required:  At least 4 years of experience in scientific or experimental research work
Preferred:  With preferred degree, with at least four years of required experience and proven scholarship in peer-reviewed publications as a first author and presentations at major meetings. 

Mentor Matching:
This position reports to Steven H. Lin. See Dr. Lin's research profile.

Req #: 600661-00014
Job Title:  Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a funded project that will investigate how to exploit mitochondrial dynamics for therapy against pancreatic cancer. This project uses a combination of microscopy, metabolomics, cell biology, and mouse models and the successful candidate should have some experience in several of these core skill sets. Competency with SeaHorse is helpful, but expected.

Learning Objectives:

• Training and expertise in mitochondrial metabolism and mitochondrial biology
• Experimental approaches to model tumor-stroma interactions
• Expectations to present and publish their data in a timely fashion
  

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.

Dates or Training Schedule:
Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars

Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 600661-00015
Job Title:  Postdoctoral Fellow
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​The primary purpose of the Postdoctoral Fellow is to assist the Principal Investigator and other Faculty members with scientific research projects. The primary activity of this position is academic research. A position is available immediately in the area of cancer immunology and translational research. The laboratory seeks to study novel treatment strategies that can induce the anti-tumor immunity. We are interested in studying immunologic mechanisms that confer response through various drugs and bio-materials that can trigger the innate and adaptive immune response to inhibit the growth of tumor.​

Learning Objectives:

• Perform technical laboratory duties, techniques, in vivo and in vitro experiments studying immune biology in the context of cancer therapies and response to treatments including immunotherapy and/or radiotherapy.
• Projects will include using mouse tumor models to assess immunologic effects of cancer therapy induced immune response; small animal image-guided radiotherapy; tissue harvesting and microscopy; in vivo and ex vivo immunological assays; implementation/development of novel protocols and procedures; execution of experiments; analysis of results.
• Familiarity with histology, animal husbandry, in vivo surgical techniques, flow cytometry, immune and proteomic or transcriptomic assays is preferred. Ideal candidates would possess experience in molecular biology, cell culture, and animal models of human cancer.
• Training and supervising other research personnel on techniques and equipment procedures
• Maintenance of laboratory safety procedures and records and facilities.
• Collect, analyze, plot data using appropriate software applications, store and record data on computer and lab notebooks
• Assist in writing of scientific papers for publication, grant applications and presentations at scientific meetings
• Other duties as assigned
  

Eligibility Requirements:
EDUCATION Required:  Ph.D. or equivalent doctorate

EXPERIENCE Required:  At least 4 years of experience in scientific or experimental research work Preferred:  With preferred degree, with at least four years of required experience and proven scholarship in peer-reviewed publications as a first author and presentations at major meetings. 

Mentor Matching:
This position reports to Wen Jiang, M.D., Ph.D. 

Req #: 600661-0016
Job Title:  Postdoctoral Fellow
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​The primary purpose of the Postdoctoral Fellow is to assist the Principal Investigator and other Faculty members with scientific research projects. The primary activity of this position is academic research in association with a faculty member or team. A position is available immediately in the area of cancer immunology and translational research. The laboratory has identified a new immunotherapy target induced by radiation that appears to be expressed mutually exclusively with PD-L1 in tumors. While therapeutic antibody has already been developed against this novel target and we will soon start first-in-human clinical trials here at MD Anderson, the lab will conduct additional basic science and translational work on this target, focusing on unraveling the mechanisms of T-cell suppression, through a potential novel intracellular domain, and translating the potential of combining monoclonal antibody therapy and radiation in animal models. The research will be conducted in both syngeneic and humanized mouse tumor models and deep profiling of immunologic alterations within the tumor microenvironment. 

Learning Objectives:

• Perform technical laboratory duties, techniques, in vivo and in vitro experiments studying immune biology in the context of cytotoxic cancer therapies and response to treatments including immunotherapy and/or radiotherapy.
• Projects will include using mouse tumor models to assess immunologic effects of cancer therapy-induced immune suppression on tumor biology and drugs or cytokines that could reverse this effect in tumor-bearing animals; small animal image-guided radiotherapy; tissue harvesting and microscopy; in vivo and ex vivo immunological assays; mass cytometry/CyTOF and data analysis; implementation/development of novel protocols and procedures; execution of experiments; analysis of results.
• Familiarity with histology, animal husbandry, in vivo surgical techniques, immune and proteomic or transcriptomic assays is preferred. Ideal candidates would possess experience in molecular biology, cell culture, and animal models of human cancer.
• Training and supervising other research personnel on techniques and equipment procedures
• Maintenance of laboratory safety procedures and records and facilities
• Collect, analyze, plot data using appropriate software applications, store and record data on computer and lab notebooks
• Assist in writing of scientific papers for publication, grant applications and presentations at scientific meetings
• Other duties as assigned

Eligibility Requirements:
​​​​EDUCATION
Required: Ph.D. or equivalent doctorate

EXPERIENCE
Required: At least 4 years of experience in scientific or experimental research work
Preferred: With preferred degree, with at least four years of required experience and proven scholarship in peer-reviewed publications as a first author and presentations at major meetings.

Mentor Matching:
This position reports to Steven H. Lin. See Dr. Lin's research profile.

Req #: 600662-0003
Job Title:  Postdoctoral Fellow
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A postdoctoral position is immediately available in the Departments of Experimental Radiation Oncology and Radiation Physics to perform research in radiation induced immune activation. In particular, the postdoctoral fellow will be responsible for examining the use of different types of radiation, including photons and photons, in combination with DNA repair defects and immunotherapy to induce a systemic anti-tumor immune response.

Learning Objectives:
To understand how radiation in combination with DNA repair defects, DNA repair inhibiting drugs, and immunotherapy can activate a systemic anti-tumor immune response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.

Eligibility Requirements:
Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, immunology, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with immunology, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.

Dates of Training Schedule:
Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Mentor Matching:

The postdoctoral fellow will be mentored by Simona Shaitelman, M.D., and Gabriel Sawakuchi, Ph.D. to identify combination strategies to activate anti-tumor systemic responses.

Additional application information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.

Req #: 600662-0001
Job Title:  Postdoctoral Fellow       
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A postdoctoral position is immediately available in the Departments of Radiation Physics and Experimental Radiation Oncology to perform research in genomic biomarkers of radiation response. In particular, the postdoctoral fellow will be responsible for developing a bioinformatics pipeline to analyze cancer cell line and patient data from treatments with photon and proton therapies.

Learning Objectives:

To understand genomic biomarkers of radiation response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.

Eligibility Requirements:

Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, bioinformatics, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with bioinformatics, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.

Dates or Training Schedule:

Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Mentor Matching:
The postdoctoral fellow will be mentored by Gabriel Sawakuchi, Ph.D. and Simona Shaitelman, M.D., to identify genomic biomarkers of radiation response.

Dates or Training Schedule:

Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Additional Application Information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.

Req #: 600662-0002
Job Title:  Postdoctoral Fellow       
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in application of Case-Based Reasoning to Radiation Therapy Treatment planning.

Learning Objectives:
The learning objectives are to evaluate the efficacy and application of Case Based Reasoning approach to Radiation Therapy treatment planning and to explore its limitations and strength.

Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics and/or Computer Science

Mentor Matching:
This position reports to Mohammad R. Salehpour, Ph.D.

Additional Application Information:
Desired experiences: Radiation Treatment Planning, Python and C++, Artificial Intelligence and Fuzzy Logic programming

Req #: 600662-0004
Job Title:  Postdoctoral Fellow
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Learning Objectives:
The learning objectives are to develop and evaluate the performance of a novel automated treatment planning solution for a new treatment unit.

Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics or Nuclear Engineering

Mentor Matching:
The position reports to Laurence Court, Ph.D., and Carlos Cardenas, Ph.D.

Additional application information:
Desired experiences: Radiation Treatment Planning, Python, and Artificial Intelligence.

Req #: 600662-0005
Job Title:  Postdoctoral Fellow
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in Radiation transport and X-ray diffraction as applied to Radiation Therapy. The successful applicant will join a team of highly accomplished scientists to assist with computer simulation code development for the design and implementation of a novel radiation therapy delivery system.

Learning Objectives:
The learning objective of this fellowship is to evaluate the efficacy of focusing x-ray radiations using metallic crystals and further study its usability in treatment of cancerous tumors.

Eligibility Requirements:
The ideal candidate should have a PhD in physics and have experience in performing radiation transport calculations using Monte Carlo techniques. In addition he/she should have proven working knowledge of multiphysics simulation software and CAD systems, and be well versed in calculational methods of X-Ray diffractions.

Mentor Matching:
The postdoctoral position reports to Mohammad Salehpour, Ph.D.

Req #: 600662-0006
Job Title:  Postdoctoral Fellow
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Research into applications of deep learning and radiomics to understand patient outcomes. The fellow will help develop software tools for analyzing images and predicting outcomes. We will focus specifically on understanding how images can be used to support clinical decision making for patients with metastatic brain lesions.

Learning Objectives:​

​1. Learn how radiomics and deep learning can be applied to problems in radiation oncology
2. Learn how to investigate the impact of image quality on image analysis tasks
3. Learn about radiation oncology and medical physics in general, including how artificial intelligence can be applied to improve these fields and patient outcomes.

Eligibility Requirements:
​The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python and/or C++/C# is required. The individual is expected to work within a large group of motivated interdisciplinary professionals.

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Laurence Court, Ph.D.,  (primary), Carlos Cardenas, Ph.D., (deep learning), and Jinzhong Yang, Ph.D., (deformable image registration and auto-contouring).

Additional application information:
More information on our research group can be found at rpa.mdanderson.org.

Req #: 600662-0007
Job Title:  Postdoctoral Fellow
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​The fellow will develop deep-learning-based algorithms and tools for various applications in proton radiation therapy, such as fast dose prediction, plan robustness evaluation and optimization, auto segmentation and radiomics based on dual-energy CT, etc.

Learning Objectives:​

​1. Learn how deep learning can be used for problems in proton radiation therapy.
2. Learn how to apply mathematical knowledge and skills to medical problems.
3. Learn about radiation oncology and medical physics in general.

Eligibility Requirements:
​The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, computer science, physics, engineering or applied mathematics. Programming skills in Python and/or C++/C# is required.

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Ming Yang.

Req #: 600662-0008
Job Title:  Postdoctoral Fellow
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​Research into applications of FLASH RT. Fellow will develop and commission FLASH beam lines, develop detectors and dosimetry protocols, and be involved in developing shielding and irradiation setups for animal irradiations.

Learning Objectives:​

​1. Learn how to establish FLASH beam lines and the requirements of the dosimetry.
2. Develop detectors of FLASH RT
3. Developing irradiation setups for animal irradiations

Eligibility Requirements:
​The ideal candidates should have finished (or be about to finish) their Ph.D. degrees in medical physics, physics, engineering or similar. The individual is expected to work within a large group of motivated interdisciplinary professionals.

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Emil Schueler.

Req #: 600662-0009
Job Title:  Postdoctoral Fellow
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​Assists principal investigator with clinical, translational, and basic scientific 
Learning Objectives:​aims of our CRC Moon Shot and Astellas project. Mouse tumor, human tumor and PDX mouse model samples are to be analyzed for protein and molecular profiling to assess the impact of target metastatic site resident immune cells, immune infiltrates and mechanisms of CRC minimal residual disease (MRD).  Functions in a separate and independent manner in the design and initiation of research experiments.  Designs, develops or adapts equipment used in experiments or research to obtain desired results. Determines specific goals or objectives to be obtained, evaluates research data and develops and revises techniques or approaches to work problems.  Interfaces with the electronic medical record, and databases of tissue samples blood cytokines and protein biomarkers analysis and tumor molecular data.   
Compiles, writes and submits project results for publications. Writes grant applications independently and assists principal investigator with grant applications. 
Additionally, 
a. Applicant should have experience in methods of sensitive detection of proteins and also work on developing assays and CyTOF and multiplex panels that can distinguish determine the impact of resident immunity, immune infiltrates and mechanisms involved in CRC-MRD. 
b. Interpret, present and report research findings at internal meetings and potentially external scientific conferences.

​Learning Objectives:
​- understanding of biology of CRC-MRD and microenvironment interactions and predictors of outcome
- ability to search and evaluate clinical and scientific literature
- ability to form and then defend hypotheses based on prior clinical or experimental data
- ability to effectively communicate findings in written and oral form
- ability to write persuasive grant applications and scientific publications

Eligibility Requirements:
​​Graduate degree in verterinary medicine, science, or chemistry fields

Program Start Date:
Anticipated start date 12/14/2020, average 40 hours per week is needed to accomplish goals 

Mentor Matching:
David Menter, Ph.D., Assistant Professor of GI Medical Oncology; Scott Kopetz, MD, PhD. Professor of GI Medical Oncology; Natalie Fowlkes, DVM, Ph.D: Assistant Professor of Veterinary Medicine.

Req #: 600662-0010
Job Title:  Postdoctoral Fellow
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​Development of evaluation metrics for radiation therapy treatment plans based on patient outcomes.  We will develop an evaluation methodology that quantifies the probability of a particular patient outcome based on the patient's radiation therapy treatment plan.  The resulting metric will then be used to develop a scoring system for patient plans.

Learning Objectives:​

​1. Learn how to correlate patient outcomes to radiation therapy treatment plans.
2. Learn how to create probability density functions that converts a planned radiation therapy dose into a probability for a particular patient outcome.
3. Learn about radiation oncology and medical physics in general.

Eligibility Requirements:
​The ideal candidates should have finished (or be about to finish) their Ph.D. degree in medical physics, computer science, physics, engineering or applied mathematics.  Programming skills in Python, R and/or C# is required.  The individual is
expected to work within a large group of motivated interdisciplinary professionals.

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Thomas Whitaker and Dr. Laurence Court.

Req #: 600662-0011
Job Title:  Postdoctoral Fellow
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​​The Lin/Schueler research lab in the Department of Radiation Oncology/Physics at UT MD Anderson Cancer Center is seeking a postdoctoral fellow. Our focus is on developing the foundation for a clinical translation of FLASH radiation therapy (RT). Current focus of interest is on hematological and gastrointestinal toxicity and how they relate to dose rate. A large focus is also on the immunological effects of FLASH and how combination treatments can further increase the therapeutic window of FLASH RT. More information on the position can be found at https://www.postdocjobs.com/posting/7071940  ​

Learning Objectives:​

​1. Gain insight into the biological effects of FLASH RT
2. Elucidate the dependence of the physical beam irradiation parameters on the FLASH effect on multiple organ systems
3. Developing irradiation setups for animal irradiations​

Eligibility Requirements:
​Ideal candidates should have experience in cancer biology and immunology. Excellent verbal and written communication skills are required. The individual is expected to work within a large group of motivated interdisciplinary researchers including clinicians, postdoctoral fellows and other research staff.​

Program Start Date:
This position will start as soon as a suitable candidate is able to start.

Mentor Matching:
The position reports to Dr. Emil Schueler.

Req #: 600662-00012
Job Title:  Postdoctoral Fellow       
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 A postdoctoral fellow position is available in the Sawakuchi and Shaitelman lab at the University of Texas MD Anderson Cancer Center. The research projects involve investigations in the role of radiation and DNA repair defects on immune response activation and radiosensitization. Particularly, the postdoctoral fellow will contribute to the discovery and translation of biological pathways to: 1) predict tumor response to radiation using DNA repair defects; and 2) activate the immune system using radiation in combination with DNA repair defects.

Learning Objectives:
The postdoctoral fellow will learn the field of translational radiation oncology. Particularly, the trainee will learn how to apply principles and assays used in radiobiology, DNA repair and immunology to translate preclinical findings into clinical trials. The trainee will also have the opportunity to train in mentorship and leadership skills towards becoming an independent researcher.  

Eligibility Requirements:
Ideal candidates should have finished their Ph.D., or M.D. degrees in radiobiology, immunology, bioinformatics, biology, biochemistry, biomedical sciences, or similar research fields. Experience with small animal handling, immunology and DNA damage assays is highly desired but not a requirement. Good verbal and written communication skills are also important. The individual is expected to work within a large group of motivated interdisciplinary researchers including clinicians, postdoctoral fellows and other research staff.

Dates or Training Schedule:
Anticipated start date June 14,2021.  This position will be for two years.

Mentor Matching:
The postdoctoral fellow will be mentored by Gabriel Sawakuchi, Ph.D. 

Additional Application Information:
Visit Dr. Sawakuchi's page for more information about their lab and research.

Req #: 600379-00003
Job Title:  Postdoctoral Fellow
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Postdoctoral research fellowship program is primary focusing on clinical training and conducting clinical researches in the field of stem cell transplantation and cellular therapy. The position is designed to provide the experience needed to perform hematopoietic cell transplant to treat patients with benign and malignant hematologic diseases as well as conduct and publish transplant-related prospective and retrospective researches. The fellow will work under supervision of Dr. Samer A. Srour and may collaborate with other faculties in the Department of Stem Cell Transplant and Cellular Therapy.

Learning Objectives:

1. Fellow will learn the processes of hematopoietic stem cell transplantation including pre-transplant patient evaluation, donor selection, mobilization and stem cell collection/apheresis, transplant procedure planning and performing, and spectrum and management of posttranspant complications.

2. Fellow will learn the processes of conducting researches in the field of hematopoietic cell transplant including data management, statistical analysis, manuscript writing and publishing research articles.

Eligibility Requirements:
​Appointee must have received a Ph.D. or M.D., completed hematology training and must have at least 1 year prior experience in clinical hematology patient cares.

Dates or Training Schedule:
October 2020 through October 2023

Mentor Matching:
This position reports to Samer A. Srour, M.B.

Req #: 117600-00002 
Job Title:  Postdoctoral Fellow
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​The Postdoctoral Fellowship Program is a one to five-year research fellowship dedicated to the advanced training of fellows focusing on research related to surgical oncology diseases.  The goal of the fellowship is to train, and education select fellows in advanced research of multidisciplinary treatment and surgery for challenging disorders and malignancies.

Learning Objectives:

The responsibilities include participating in the design, implementation and evaluation of collaborative research studies; analyzing and interpreting data; creating publication quality figures summarizing data; assisting with manuscript and grant preparation; maintaining a legible and self-explanatory scientific notebook and presenting results during lab meetings and at appropriate scientific conferences. Major duties will be to conduct bench research as deemed necessary and appropriate by PI and to assist and/or collaborate with other research staff on scientific pursuits of mutual interests.​

Eligibility Requirements:
​The candidate should have a Ph.D. and or M.D. Ph.D. degree in Biology Molecular Biology or related natural sciences field; excellent written and verbal communication; effective judgment and problem solving, ability to work independently and collaboratively, and a research background in immunology and cancer, and have an interest in translational research.  The candidate must have either a Ph.D. or M.D. with training in immunology and murine studies.  Prior experience in microbiome research is preferred.   Expertise in Excel, and other bioinformatics analysis software; strong attention to detail, multi- tasking; and a willingness to learn new technologies.

Dates or Training Schedule:

Mentor Matching:
This position reports to Jennifer Wargo, M.D.

Req #: 600659-00006
Job Title:  Postdoctoral Fellow
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The Laboratory of Neuroimmunology focuses on basic and translational research on exploring the mechanisms and treatment of the neurotoxic effects of cancer treatment.

Dr. Kavelaars is one of the founding scientists of the field of psychoneuroimmunology. Her research focuses on educational, behavioral, and medical interventions for pain, fatigue and cognitive impairment. Laboratory and neuroimaging studies are exploring the neurophysiological mechanisms of pain, fatigue, cognitive impairment and treatment-induced neuropathy.

Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in murine models of cancer and treatment-related neurotoxicities. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.

Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular damage to the brain as a result of cancer treatment and the neuroregenerative effects of cell therapy in the repair of structural and functional brain damage in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.

Applicants should have strong written and oral communication skills, ability to work with others in a highly collaborative manner and good problem-solving abilities.

Mentor Matching:
The position reports to Annemieke Kavelaars, Ph.D.

Req #: 600659-00007
Job Title:  Postdoctoral Fellow
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​The Laboratory of Neuroimmunology focuses her basic and translational research on exploring the mechanisms and treatment of the neurotoxic effects of cancer treatment.

Dr. Heijnen is one of the founding scientists of the field of psychoneuroimmunology. Her research focuses on educational, behavioral, and medical interventions for pain, fatigue and cognitive impairment. Laboratory and neuroimaging studies are exploring the neurophysiological mechanisms of pain, fatigue, cognitive impairment and treatment-induced neuropathy.​

Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in murine models of cancer and treatment-related neurotoxicities. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.​

Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular damage to the brain as a result of cancer treatment and the neuroregenerative effects of cell therapy in the repair of structural and functional brain damage in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research.

Applicants should have strong written and oral communication skills, ability to work with others in a highly collaborative manner and good problem-solving abilities.​

Mentor Matching:
The position reports to Jacoba (Cobi) J. Heijnen, Ph.D.

Req #: 600659-00010
Job Title:  Postdoctoral Fellow
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​​​The Grace lab is seeking an enthusiastic Postdoctoral Researcher to study how brain glia contribute to affective and cognitive disturbances that are co-morbid with high-impact chronic pain. This project involves complex behavioral measures of depression and motivation in models of neuropathic pain, stereotaxic surgeries, transgenic mouse strains, super-resolution microscopy, single-cell and next-generation RNA sequencing, and other biochemical techniques.

The applicant will join the Laboratories of Neuroimmunology, comprising the research teams of five collaborating Principal Investigators who aim at understanding chronic pain, cognitive deficits and fatigue in response to cancer and its treatment. The post-doctoral fellow will work under direct supervision of a Principal Investigator.

We highly value innovation, learning, hard work, creativity and an interactive, respectful and fun atmosphere. If you are interested in helping to understand the molecular and cellular mechanisms of pain and developing novel interventions to help improve the quality of life for people suffering from chronic pain in an internationally-renowned, well-funded group of scientists using a highly integrated and interdisciplinary approach in the number one cancer center in the USA, we are the perfect environment for you!

A PhD in neuroscience, immunology, or related disciplines is required. Experience in working with rodents and a background in pain or immunology is preferred.

ESSENTIAL FUNCTIONS

Research Activity
Nerve injury and stereotaxic surgeries in mice
Behavioral measures of pain, and affective and cognitive disturbances in mice
Immunohistochemistry and microscopy studies on cells and nervous system tissues
Single-cell and bulk RNA-seq
Western blotting and qPCR
Luciferase assays and immunoassays
Collect and process ex vivo biological samples including brain and spinal cord
Present results in departmental and national meetings
Prepare and write manuscripts for publication.
2. Interpersonal Skills, Communication, Learning Skills

Strong written and oral communication skills
Communication with faculty and staff within and outside the laboratory.
Ability to work with others in a highly collaborative manner.
Good problem-solving abilities.
​3. Other

Responsible for monitoring laboratory equipment and implementing safety procedures.
Strong interest in basic and translational research
Supervision of 1-2 research assistants

Learning Objectives:
​​Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing inmodels of neuropathic pain. They will become proficient with basic biochemical techniques employed in preclinicalneuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.​​

Eligibility Requirements:​​​A PhD in neuroscience, immunology, or related disciplines is required. Experience in working with rodents and a background in pain or immunology is preferred.

Mentor Matching:
The position reports to Peter Grace, Ph.D.

Req #: 600659-00011
Job Title:  Postdoctoral Fellow
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We are looking for a post-doctoral researcher with a strong background in neuroscience to join the Laboratories of Neuroimmunology at MD Anderson Cancer Center. Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project (funded by the US Department of Defense) will use immune system-targeted nanoparticles to track the effects of novel therapeutics on neuromuscular injury. Experience working with rodents and a background in neuroscience, pain research and/or immunology is preferred. The position is available April 1, 2020.

Research Activity:

• Immunohistochemistry and microscopy studies on nervous system, muscle and other tissues.
• Behavioral assays of physical activity and pain in mice.
• Work with genetically modified mice.
• Live-cell imaging of neuronal/immune cell physiology.
• Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues.
• Perform pharmacological manipulations in vivo.
• Prepare and write manuscripts for publication.

Interpersonal Skills, Communication, Learning Skills:

• Strong written and oral communication skills.
• Communication with faculty and staff within and outside the laboratory.
• Ability to work with others in a highly collaborative manner.
• Good problem-solving abilities.

Other Duties:

• Responsible for monitoring laboratory equipment and implementing safety procedures.
• Strong interest in basic and translational research.
• Supervision of research assistants.
  

Learning Objectives:
Applicants should have some experience with some of these techniques, but training will be provided in immunohistochemistry and microscopy studies on nervous system and other tissues, behavioral assays of physical activity and pain in mice and rats, live-cell imaging of neuronal/immune cell physiology, and preparing and writing manuscripts for publication.

Applicants will become proficient with biochemical techniques and develop advanced skills in the organization, presentation, and analysis of data.

Eligibility Requirements:​​​
​Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. Experience with rodent behavioral testing is preferred but not required. Successful applicants should be highly self-motivated, have outstanding experimental skills, and be able to think independently but also work well in a team.

Mentor Matching:
The position reports to Andrew Shepherd, Ph.D. See Dr. Shepherd's Research Profile.

Req #: 412100-00001 
Job Title:  Postdoctoral Fellow
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​The University of Texas MD Anderson Cancer Center invites applications for postdoctoral positions. The projects will be supported by a newly awarded and an incoming R01 grants from NIH. The projects are to develop novel and effective cancer immunotherapy based on DNA damage and stress response defects in cancers. ​

Learning Objectives:
Deepen the understanding of cancer development.
Advancing Cancer Research.
Translating scientific discoveries to therapeutic benefits for patients with cancer.​

Eligibility Requirements:​​​
Candidates should have rich experience in cancer biology and bioinformatics. In addition, expertise in cancer immunology is a big plus.   We are looking for outstanding entry-level candidates with high motivation, ability to work independently, and a strong commitment to working on these projects.    ​Candidates should have a PhD degree or equivalent.  ​

Program Dates:
Summer 2021 (Up to 5 years)

Mentor Matching:
The position reports to Shiaw-Yih (Phoebus) Lin, Ph.D. See Dr. Lin's Research Profile.

Req #: 600386-00001
Job Title:  Postdoctoral Fellow
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A postdoctoral position is available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Cardiovascular and Thoracic Surgery at The University of Texas MD Anderson Cancer Center with joint appointment in the Department of Genomic Medicine. Our lab focuses on understanding the role of chromatin biology in cancer development, identifying genetic vulnerabilities of cancers and development of novel cancer therapeutics (Lissanu Deribe et al Nature Medicine 2018, Lissanu Deribe et al PNAS 2016).
To this end, we utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens and epigenomic technologies such as high-throughput RNA- and ChIP-Seq and ATAC-Seq.

Learning Objectives:
We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and won several grants to further develop these molecules as therapies.
This position will provide deep exposure and training in cancer genetics, chromatin biology, functional genomics and cancer therapeutic development.
We seek a highly motivated individual with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry or genetics. Candidates with training in statistics or programming expertise, in particular R/Python and interest in the application of state-of-the-art computational/statistical methods to complex data are particularly encouraged to apply. Experience with hands on mice work is a big plus but not required.
The Lissanu laboratory is situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows.

Eligibility Requirements:
• PhD or equivalent in Molecular Biology, Biochemistry, Genetics or related field
• Good publication record
• Excellent communication skills is required.

Dates or Training Schedule:
MD Anderson Cancer Center allows up to 5 years of postdoctoral training.

Mentor Matching:
This position reports to Yonathan Lissanu Deribe, M.D ,Ph.D. See Dr. Lissanu Deribe's research profile.

Req #: 600386-00002
Job Title:  Postdoctoral Fellow
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​A postdoctoral position is available in the laboratory of Yonathan Lissanu Deribe, M.D, Ph.D., in the Department of Genomic Medicine and Department of Thoracic Surgery at The University of Texas MD Anderson Cancer Center. Our laboratory focuses on identification of cancer vulnerabilities, and discovery of novel therapeutics by leveraging our understanding of chromatin biology in cancer development (Lissanu Deribe et al Nature Medicine 2018, Lissanu Deribe et al PNAS 2016).

To this end, we utilize genetically engineered mouse (GEM) models of cancer, various functional genomic approaches including genome-wide CRISPR knockout screens, immunological and epigenomic technologies such as RNA- Seq, ChIP-Seq, and ATAC-Seq.

We plan to expand our efforts in identifying novel therapeutic targets in genetically defined tumors. Recently, we have discovered and patented novel proteolysis targeting chimeric molecules (PROTACs) that induce selective degradation of oncoproteins and received several grants to further develop these molecules as cancer therapeutics. (https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019200217). Excitingly, some of our chemical probes have synergistic anti-tumor efficacy in combination with immunotherapy.

The position will provide deep exposure and training in cancer functional genomics, chromatin biology, cancer immunology, and cancer drug discovery.

We seek highly motivated individuals with a Ph.D. or equivalent degree in all areas of molecular & cell biology, biochemistry, or genetics. Experience with hands on mice work, protein purification, or computational biology is a big plus but not required.

The Lissanu laboratory is a well-funded lab situated in a highly dynamic and stimulatory environment for learning. MD Anderson Cancer Center is rated number one hospital in cancer care in the United States. The institute offers active graduate and postdoctoral training programs and the unmatched scientific environment of the Texas Medical Center, the world's largest biomedical center. Competitive salary and benefits are provided to post-doctoral fellows. Houston is the fourth-largest city in the USA with a vibrant and booming economy. Houston has a mild winters and is sunny year-round.​

Learning Objectives:

• Use cutting-edge approaches to seek novel therapeutic targets for human cancers

• Be responsible for the design and execution of experimental work, data analysis and write up

• Attend and present at internal and international meetings

• Be expected to publish data in top scientific journals

Eligibility Requirements:

• PhD or equivalent in Molecular Biology, Biochemistry, Immunology, Genetics or related field

• Good publication record

• Excellent communication skills is required.

Please send a cover letter, curriculum vitae, names and contact information of three references, and a brief summary of past research accomplishments and future research plans to: Yonathan Lissanu Deribe, M.D, Ph.D.

Dates or Training Schedule:
MD Anderson Cancer Center allows up to 5 years of postdoctoral training.

Mentor Matching:
This position reports to Yonathan Lissanu Deribe, M.D ,Ph.D.  See Dr. Lissanu Deribe's research profile.

Req #: 600657 - 0001
Job Title:  Postdoctoral Fellow
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A postdoctoral position is available to study novel therapeutic targets and molecular mechanisms associated with therapeutic resistance in small cell lung cancer (SCLC) in the laboratory of Lauren Averett Byers, M.D. at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested using high-throughput proteomic screening to discover and validate potential drug targets and biomarkers of therapeutic resistance in SCLC. Qualified applicants are encouraged to apply and provide three professional references.

JOB KNOWLEDGE AND SKILLS: 

• Enthusiastic, highly self-motivated candidate, with the ability to function independently and as part of an interactive team
• A strong background in cell signaling, molecular biology, and immunology/immunotherapy.
• Experience in flow cytometry is preferred
• Dedication to basic research, a true “drive”, is important
• Prior experience with studies involving mice is preferred
• Command of written and spoken English language

Eligibility Requirements:
Applications are invited from qualified individuals, interested in working in a translational research lab, with a Ph.D. and/or M.D.. Preferred candidate should have less than 2 years of prior postdoctoral experience with background in cancer biology, biochemistry, cell biology, or molecular biology and be highly motivated to pursue a career in biomedical research.

Mentor Matching:
This position reports to Lauren A. Byers, M.D.

Req #: 600657-0002
Job Title:  Postdoctoral Fellow
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Learning Objectives:

• Planning and development of experimental studies testing novel immune-based therapies (T cell therapies and/or immune checkpoint inhibitors administered alone or in combination with other cancer therapies) in preclinical murine models of lung cancer.
• Analysis and interpretation of the results of in vivo and in vitro experimental studies using murine models of lung cancer and lung cancer cell lines, respectively.
• Integration of findings of experimental studies into multiple peer reviewed manuscripts as first and author and as co-author in collaboration with other trainees/collaborators.

Eligibility Requirements:
Qualified postdoctoral candidates should hold a doctorate degree and have strong background training in one or more of the following areas: biochemistry, molecular biology, cell biology, cancer biology, tumor immunology and cancer immunotherapy. Experience with murine models of cancer and an ability to analyze data derived from in vivo studies is strongly preferred. Expertise in performing flow cytometry on tissue-derived cell suspensions (human and murine tumor tissues), analyzing independently and interpreting data from flow cytometry studies is highly desired. Expertise in any of the following fields is advantageous: oncogenic signaling pathways, biomarkers of response and resistance to cancer therapies (targeted therapies, antiangiogenic therapies and immune-based therapies), cancer metabolism, and immuno-genomics. Highly motivated postdoctoral fellows who are self-starters and have critical thinking ability are encouraged to apply. Candidates should have good technical skills a strong work ethic and excellent organizational and communication skills.

Dates of Training Schedule:
Expected starting date: 1/2020
Expected training time: 3 to 5 years

Mentor Matching:
This position reports to Tina Cascone, M.D., Ph.D.

Req #: 600657-0004
Job Title:  Postdoctoral Fellow
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​My research program is focused on developing new and more effective treatments for HPV+ cancers using a combination of radiation and immunotherapy, and associated response biomarkers. In particular, to improve the responsiveness of HPV+ cancers to immunotherapy, it is necessary to understand 1) if HPV-antigens are effective targets for CD8+ T cells, and if not; 2) if other cancer antigens may be targeted, and whether the latter are unique to or shared between patients; 3) the features of T cells that recognize HPV+ cancer-associated Ag; and 4) how to unlock superior T cell functions in HPV+ cancer patients. 

To answer these questions, my lab employs a combination of multidisciplinary wet- and dry-lab based techniques. I strongly believe in team science, and I am building a lab in which scientists will be responsible for and learn from having one or several main projects, while also working together towards the lab's main goal.​

Learning Objectives:

​The position is designed to allow trainees to further develop their skills in immunological assays such as flow cytometry and sorting, functional T cell assays, and TCR engineering, as well as single cell sequencing (transcriptional, TCR, and cell surface stains), and bulk whole exome and RNA sequencing. The trainee will work in collaboration with other trainees and staff in the lab, as well as other labs and cores in the department and MD Anderson as a whole. 

The trainee will also work on developing his/her grantsmanship skills.​

Eligibility Requirements:
​​Individuals who have completed a Ph.D. and have training relevant to the position are eligible.​

Dates of Training Schedule:
The position is immediately available.

Mentor Matching:
This position reports to Nils-Petter Rudqvist, Ph.D.

Req #: 600657-0005
Job Title:  Postdoctoral Fellow
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​​​​​The Kurie Laboratory in the Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, seeks to fill multiple postdoctoral positions. Our research focuses on the molecular mechanisms by which lung cancer cells generate a pro-metastatic tumor microenvironment, with three complementary areas of investigation: (1) a tumor cell-derived collagen modifying enzyme called lysyl hydroxylase 2 (LH2) that functions as a nodal regulator of fibrosis and immunosuppression; (2) Golgi-directed secretory processes driven by oncogene-induced transcriptional programs; and (3) epithelial-to-mesenchymal transition as a driver of fibrosis and immunosuppression in the tumor microenvironment.​

Learning Objectives:

​​Postdoctoral fellows will benefit from training in model development and characterization, including 2- and 3-dimensional cell culture models and autochthonous and orthotopic mouse models that recapitulate features of the TME in human cancers, and translating those findings to clinically and molecularly annotated human tumor tissue banks. Fellows will have educational and mentoring opportunities (e.g., pilot funding, grant-writing courses, and teaching and mentoring experience in our summer undergraduate and graduate internship programs) and extensive opportunities to gain presentation skills at weekly Kurie lab meetings, monthly departmental joint lab meetings, monthly meetings for our programmatic research groups (NCI-funded SPORE, CPRIT-funded MIRA), and annual conferences (e.g., Keystone, Gordon, Cold Spring Harbor, AACR).​

Eligibility Requirements:
​​​​​Individuals who have completed a Ph.D and have training relevant to the position. Qualified individuals will demonstrate the potential for research as evidenced by their peer-reviewed publications and funding. Background in cancer biology and expertise in the design and execution of cell culture and in vivo experiments that incorporate a variety of molecular and cellular techniques is desirable.​

Dates of Training Schedule:
The position is immediately available.

Mentor Matching:
This position reports to Jonathan M. Kurie, M.D.

Req #: 149100-004
Job Title: Postdoctoral Fellow
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Despite recent advances in immunotherapy, lung adenocarcinoma remains the leading cause of death in smokers. A significant fraction of lung adenocarcinomas display somatic activating mutations in the KRAS oncogene. KRAS-mutant lung adenocarcinoma, compared to other solid tumors, displays very poor clinical outcomes. Despite the overwhelming public health burden of KRAS-mutant lung adenocarcinoma, there are very few, if any, strategies for early treatment of this disease -- largely due to a very poor understanding of molecular changes that drive its initiation and development. One of our laboratory's goals is to delineate early immune events in the transition of smoking-exposed normal airway to KRAS-mutant lung adenocarcinoma. Understanding these changes may pave for the development of new prevention (immune-based) strategies for KRAS-mutant lung cancer. Our laboratory is also actively investigating th role of the host microbiome in lung cancer development. We find that knockout of specific host defense and airway lineage genes perturb host microbiome homeostatis concomitant with lung tumor development. We are also eager to mechanistically understand novel cues between airway lineage factors and microbiome homeostasis as well as understand the role of the host gut (and possibly the lung) microbiome in the pathogenesis of KRAS-mutant lung cancer. Our laboratory is looking for a postdoctoral fellow to embark on different vignettes in the microbiome and mmune evolution of KRAS-mutant lung cancer including understanding the dynamic interplay between host defense (including immunomodulatory) responses, tumor-initiating inflammation and microbiome dysbiosis (local and systemic) in the development of the malignancy. There will be opportune elements for the candidate postdoctoral fellow at MD Anderson Cancer Center to collaborate with physician and physician-scientists to gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches these exciting and timely projects. The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry/cytochemistry, cell culture as well as basic molecular and cellular biology techniques. Experience in microbial (in vivo) research is a big plus. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork.

Learning Objectives:
-Learn uncharted cues and pathways in the inception and development of KRAS-mutant lung cancer (which will likely be applicable to other subtypes of lung cancer or other solid tumors).

-Learn individual roles of immune and epithelial cell subsets and functional states/phenotypes in the development of KRAS-mutant lung adenocarcinoma.

-Develop a skill for collaboration and translation of laboratory-based findings (e.g., development of markers for outcome and response).

-Acquire skills for progression in academia including but not limited to delivering presentations, writing manuscripts and applying for grants/fellowships.

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Training Scheduled: 
January 2021 - December 2021, renewed annually

Mentor Matching:
This position reports to Dr. Humam Kadara. 

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-005
Job Title:  Postdoctoral Fellow       
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Looking for highly motivated and talented pathologist fellow who is interested in making a difference against breast cancer and the other tumors and improving the lives of patients. The long-term goal of our laboratory is to elucidate the molecular mechanism in the pathogenesis and progression of breast cancer and identifying molecular markers related with tumor development, progression, and metastasis in breast cancer and the other solid tumors. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of breast cancer by IHC, multiplex IF, RNAscope etc and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies in breast cancer. This lab in TMP is combined with Department of Investigation Cancer therapeutics providing biomarker assessment on longitudinal biopsy tissues for phase I clinical trials supported by strategic alliances and PI initiated studies. The broad areas of research in the Dr. Yang laboratory can be summarized as follows:

Identifying new molecular targets, validating biomarkers for targeted therapy and immunotherapy Molecular pathology research on tumor microenvironment Translational tissue biomarker study in Phase I/II clinic trials of multiple solid tumors.

Learning Objectives:
To learn aspects of breast cancer research undertaken in a hospital/research institute

To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.

To understand how studies done in laboratories can have an impact on patient care in the future

The trainee will To how to perform basic statistical analysis on path data

The trainee along with the mentor will present his data in lab meetings.

The trainee will participate in departmental education activities in particular those offered by ITERT

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Mentor Matching:
This position reports to Dr. Fei Yang.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-006
Job Title:  Postdoctoral Fellow       
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A postdoc will learn the techniques for assessing the role of an oncogene in cancer, specifically the gene encoding S6K1. An inhibitor for S6K1 or the upstream protein MEK will be tested in vitro, with or without knockout of the gene.

Learning Objectives:
This will entail CRISPR editing of cell lines, western blotting, and drug assays in vitro. Postdoc will also be expected to learn to write up the results for weekly meetings and to contribute writing to the eventual manuscript.

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Dates or Training Schedule:
December 2020- June 2021

Mentor Matching:
This position reports to Dr. Larry Kwong.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-007
Job Title:  Postdoctoral Fellow       
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​We are looking for a motived and passionate postdoctoral fellow to join our laboratory focused on brain tumor research. We focus on glioblastoma (GBM), one of the most recalcitrant cancers with a median survival of only 12-15 months. Unlike other cancers, targeted therapies or "personalized medicine" approaches as well as immunotherapies have failed to improve outcome in GBM and therefore novel strategies are urgently needed to combat this disease. Our laboratory takes multipronged approaches to address these areas of unmet need for brain tumors. The current position will focus on single cell genomic studies on brain tumor immune cells and spatial statistics to elucidate pro-/anti-tumoral innate immune cell states using multiplexed imaging analyses on clinical specimens.

Learning Objectives:​

• To understand the biology of brain tumors at the cellular and molecular level
• To elucidate mechanisms underlying tumor progression in brain cancer with a a focus on immune biology
• To be able to apply computational and statistical approaches to understand immune landscape of brain tumors
• To be able to present findings in institutional and national meetings
• To document data and write manuscripts for publication
• To utilize educational and training opportunities within the department and the Institution to enrich career path
  

Eligibility Requirements:
​An individual with a Ph.D. in bioinformatics and/or computational biology from a reputed University/Institute within one year of graduation is eligible. At least one first author publication in a peer reviewed journal stemming from Ph.D. studies is required. The candidate must have independent thinking and passionate about a career in academic science.

Mentor Matching:
This position reports to Dr. Krishna Bhat.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-008
Job Title:  Postdoctoral Fellow       
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​The Computational Pathology Program (CPP) in the Department of Translational Molecular Pathology is a focused initiative aimed at research and discovery to enable the emerging concepts of precision pathology and medicine using data science and computational algorithms. A major goal of this program is to apply statistical and computational principles to develop novel biomarkers as well as performing image-based data analytics for elucidating biological and clinical variables that underlie cancer mechanisms. CPP strives to identify critical molecular markers, signatures, and mechanisms through appropriate statistical analysis and data integration schemes, including clinical and omics data.

We invite a highly motivated post-doctoral fellow to perform cutting-edge research on the Immune Topographical Atlas of Brain Tumors. The primary focus is on developing a robust spatial statistics portfolio through the application of stochastic processes and analysis of brain tumor images using R/Python, leading to good quality publication(s). The person will need to be able to work as part of a multidisciplinary team involving immunology, pathology, and neurosurgery at MD Anderson Cancer Center while working towards enhancing his/her research portfolio.

Learning Objectives:​
​The position will require learning and applying stochastic processes and algorithms to multiplex brain tumor images to understand and decipher the immune landscape. He/she will be offering creative solutions and are expected to develop good data science skills and solutions in elucidating mechanisms underlying tumor progression in brain cancer with a focus on immune biology.

The postdoc will also be expected to learn to write up the results for weekly meetings, contribute writing to manuscripts, and present findings in institutional and national meetings.

Eligibility Requirements:
​The position will require learning and applying stochastic processes and algorithms to multiplex brain tumor images to understand and decipher the immune landscape. He/she will be offering creative solutions and are expected to develop good data science skills and solutions in elucidating mechanisms underlying tumor progression in brain cancer with a focus on immune biology.The postdoc will also be expected to learn to write up the results for weekly meetings, contribute writing to manuscripts, and present findings in institutional and national meetings.

Mentor Matching:
This position reports to Dr. Kasthuri Kannan.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-009
Job Title:  Postdoctoral Fellow       
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The Genomics Test Development Laboratory (GTDL) in the Department of Translational Molecular Pathology, develops new techniques for cancer genotyping in liquid biopsies, hematological malignancies and solid tumors; partners with the Molecular Diagnostic Laboratory (MDL) at MD Anderson to assess, optimize and validate novel molecular diagnostic tests to facilitate the cost-effective transfer of discovery markers and related assays into the CLIA environment.

The GTDL is interested in having a Post-doctoral fellow with a strong molecular biology background and a familiarity with Bioinformatics pipelines for Next Generation Sequencing (NGS) who will work to accomplish the goals of the laboratory. The primary purpose of the Post-doc is to design, optimize and perform new molecular assays geared for use in both the research and clinical space. This person would also help to facilitate the transition of translational research projects into the clinical lab and work closely with collaborators in different departments.

Key functions:

• Design, optimize, and validate new or existing genomic assays, including NGS, ddPCR, and gene expression by PCR, HTG, and NanoString for translational research or transfer into the CLIA environment.
• Works with internal and external collaborators (clinicians, vendors, faculty, staff, industry partners) to develop new molecular assays for the laboratory
• Assists in project planning and adheres to realistic timelines for implementation of assays in development.
• Works closely with Bioinformatics in the analysis and interpretation of NGS data and provides written reports to collaborators.
• Assists in the development of lab policies and procedures including assay Standard Operating Procedures (SOPs), assay transfer documentation and quality control procedures.
• Evaluates instruments, reagents and supplies for new and existing molecular assays
• Presents work at National conferences and for publication in peer-reviewed scientific journals
  

Desired skills:

• Hands on experience with NGS library preparation and sequencing platforms.
• Hands on experience in running different molecular assays including qPCR, ddPCR,
• NanoString and HTG.
• Experience with manual and automated nucleic acid extraction methodologies.
• Familiarity with Bioinformatics analysis for NGS and laboratory automation software.
  

Learning Objectives:

• ​To understand the process of diagnostic test development.
• To apply the scientific method in the design and optimization of new molecular assays.
• To analyze data, write manuscripts for publication, present data/results at National and International conferences.
• To participate in the teaching/training of Research Assistants, graduate students and visiting fellows.
• To utilize the education and training opportunities within the department and the institution for career growth.
  

Eligibility Requirements:
​ An individual with a PhD in bioinformatics and/or computational biology from a reputed University/Institute with zero to one year of experience post-graduation is eligible. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. The candidate must have independent thinking and be passionate about a career in academic science. 

Program Dates:
Appointment will be for one year from date of hire.

Mentor Matching:
This position reports to Rajyalakshmi Luthra, Ph.D.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-009
Job Title:  Postdoctoral Fellow       
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Seeking a to incorporate to our Research Lab a highly motivated and talented pathologist fellow who is interested in making a difference against cancer and improve patient's outcomes. The long-term goal of our laboratory is to elucidate the molecular mechanism in cancer pathogenesis and progression, identifying molecular markers related with tumor development, progression, and metastasis in breast cancer and the other solid tumors. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of breast cancer by IHC, multiplex IF, RNAscope etc and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies in breast cancer. This lab in TMP is combined with Department of Investigation Cancer therapeutics providing biomarker assessment on longitudinal biopsy tissues for phase I clinical trials supported by strategic alliances and PI initiated studies. The broad areas of research in this laboratory can be summarized as follows:

Identifying new molecular targets, validating biomarkers for targeted therapy and immunotherapy Molecular pathology research on tumor microenvironment Translational tissue biomarker study in Phase I/II clinic trials of multiple solid tumors. 

Learning Objectives:

• To learn aspects of breast cancer research undertaken in a hospital/research institute
• To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
• To understand how studies done in laboratories can have an impact on patient care in the future
• The trainee will learn how to perform basic statistical analysis on path data
• The trainee along with the mentor will present his/her data in lab meetings.
• The trainee will participate in departmental education activities in particular those offered by ITERT
  

Eligibility Requirements:
​An individual holding an M.D. or equivalent doctorate (e.g., Sc.D., Ph.D., D.V.M.) in an appropriate field , with postgraduate training in surgical or anatomical pathology or equivalent and who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity. 

Program Dates:
November 2020 to November 2021

Mentor Matching:
This position reports to Gabriela Raso, M.D.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00011
Job Title:  Postdoctoral Fellow       
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​Looking for highly motivated and talented individual who is interested in making a difference against pancreatic cancer, and improving the lives of patients stricken with this disease. The most important criteria will be your creativity and zeal to make a difference.
The long-term goal of our laboratory is to improve the dismal survival rates for patients with pancreatic cancer, which is now the 3rd most common cause of cancer-related deaths in the United States. Our laboratory has been an integral part of the team that sequenced the genomes of pancreatic ductal adenocarcinoma (PDAC) and other variant tumors, including pancreatic cystic neoplasms and neuroendocrine tumors of the pancreas. The research performed in our laboratory is entirely translational in that we always keep a line of sight to the clinic as one of the overarching objectives. The broad areas of research in the Maitra laboratory can be summarized as follows:

· Functional annotation of epigenetic drivers in pancreatic cancer
· Mouse models of pancreatic cystic neoplasia
· Liquid Biopsies for Therapeutic Stratification and Disease Monitoring 

Learning Objectives:

• ​To learn aspects of pancreatic cancer research undertaken in a hospital/research institute
• To learn how laboratory operations are conducted and how data is interpreted, and analyzed in research laboratory
• To understand how studies done in laboratories can have an impact on patient care in the future
• The trainee will learn cell culture techniques of pancreatic cancer.
• The trainee along with the mentor will present his data in lab meetings. 
• The trainee will participate in departmental education activities in particular those offered by ITERT.
  

Eligibility Requirements:
​An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity. 

Program Dates:
March 1, 2021 - February 28, 2022

Mentor Matching:
This position reports to Anirban Maitra, M.D.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00012
Job Title:  Postdoctoral Fellow       
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​Seeking to incorporate to our Translational Molecular Pathology Immnunoprofiling  Research Laboratory (TMP-IL ) a highly motivated and talented pathologist fellow who is interested in making a difference against cancer and improve patient's outcomes. The Translational Molecular Pathology –Immunoprofiling lab (TMP-IL) translates immunopofiling data into research that is clinically applicable and can aid in the treatment and outcome of future cancer patients. The long-term goal of our laboratory is to elucidate the molecular mechanism in cancer pathogenesis and progression, identifying molecular markers related with tumor development, progression, and metastasis in solid tumors and hematological malignancies. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of  cancer by IHC, multiplex IF, RNAscope and highplex technologies and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies.

Learning Objectives:

• To learn aspects of cancer research undertaken in a hospital/research institute
• To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
• To develop research projects using novel multiplex based techniques (CODEX, GeoMxDSP, IMC, MIBI) utilizing FFPE surgical specimens, core needle biopsies and smears from different tumor types for biomarkers analysis of complex research projects of TMP-IL.
• To understand how studies done in laboratories can have an impact on patient care in the future
• The trainee will learn how to perform basic statistical analysis on path data
• The trainee along with the mentor will present his/her data in lab meetings.
• The trainee will participate in departmental education activities in particular those offered by ITERT
  

Eligibility Requirements:
​An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Program Dates:
One year from the date of hire; may be renewed.

Mentor Matching:
This position reports to Ignacio Wistuba, M.D. See Dr. Wistuba's research profile.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00012
Job Title:  Postdoctoral Fellow       
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​Our program is focused on identifying context-specific druggable vulnerabilities required for oncogenic signaling and function, with a specific interest in surface proteins. We aim to gain deep molecular insights into the complicated array of oncogene-dependent and -independent events driving tumor progression to discover novel therapeutic approaches that target mechanism essential for cancer cell survival. We are currently using proteomic, genetic, molecular biological as well as biochemical technologies to identify context-specific druggable vulnerabilities required for oncogenic function in preclinic model system, such as genetically engineered mouse model and patient derived xenograft model. We have been focusing on gaining deep molecular insights into the complicated array of oncogenic Kras-dependent (published in Nature, 2019) and –independent (published in Cell, 2014) events driving tumor progression to discover novel therapeutic approaches that target mechanism essential for cancer cell survival.

Learning Objectives:

• Learn under the supervision of the faculty mentor who will provide mentoring in topics and basic/advanced techniques and the opportunity for collaborative and independent research.
• To better understand pancreatic cancer tumor heterogeneity and evolution.
• To gain ability to search and evaluate scientific literature, to propose and verify hypotheses based on preliminary data, to plan and perform research project, to effectively disseminate research findings in form of publication and presentation, and to write persuasive grant application.
• To participate in all relevant activities related to an independent research career.

Program Dates:
April 1, 2021 

Mentor Matching:
This position reports to Dr. Wantong Yao.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00014
Job Title:  Postdoctoral Fellow       
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​Our Lung Cancer laboratory, in the Department of Translational Molecular Pathology, is seeking to incorporate to our Lung Cancer Program a highly motivated and talented postdoctoral fellow with a strong research background who is interested in making a difference against cancer and improve patient's outcomes. The long-term goal of our lung cancer laboratory is to elucidate the molecular mechanism in cancer pathogenesis and progression, identifying molecular markers related with tumor development, progression, immune infiltration, and metastasis in lung cancer tumors. Our group is focused on understanding molecular and immune-centric mechanisms that underlie lung cancer development and progression and that can inform of new therapeutic strategies for this disease. There will be opportune elements for the candidate postdoctoral fellow to collaborate with physician and physician-scientists and gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches this exciting area of research. The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology, and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry, cytochemistry, cell culture, as well as basic molecular and cellular biology techniques. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork. The program's areas of interest include but are not limited to identifying new targets for lung cancer therapy, validating biomarkers for targeted therapy and immunotherapy, understanding the role of the tumor immune microenvironment in lung cancer development and progression and delineating the roles of specific cellular populations in lung oncogenesis.

Learning Objectives: 

• Mechanistically dissect mechanisms of lung cancer pathogenesis and immunity utilizing both animal models and human specimens.
• Understand the roles of immune-centric mechanisms in lung cancer progression and treatment.
• The trainee will learn how to perform basic statistical analysis on path data.
• The trainee, along with the mentor, will present his/her data in lab meetings.
• Develop a skill for collaboration and translation of laboratory-based findings (e.g., development of markers for outcome and response).
• Acquire skills for progression in academia including but not limited to delivering presentations, writing manuscripts, and applying for grants/fellowships.
• The trainee will participate in departmental education activities.
  

Eligibility Requirements:
​An individual holding a Ph.D,  M.D. or equivalent doctoral degree (e.g., Sc.D., D.V.M.) in an appropriate field, with a strong research background, with experience leading their own projects, who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity. 

Program Dates:
March 2021-March 2022 (may be renewed) 

Mentor Matching:
This position reports to Ignacio Wistuba, M.D. See Dr. Wistuba's research profile.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00015
Job Title:  Postdoctoral Fellow       
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The Genomics Test Development Laboratory (GTDL) in the Department of Translational Molecular Pathology, develops new techniques for cancer genotyping in liquid biopsies, hematological malignancies and solid tumors; partners with the Molecular Diagnostic Laboratory (MDL) at MD Anderson to assess, optimize and validate novel molecular diagnostic tests to facilitate the cost-effective transfer of discovery markers and related assays into the CLIA environment.

The GTDL is interested in having a Post-doctoral fellow with a strong molecular biology background and a familiarity with Bioinformatics pipelines for Next Generation Sequencing (NGS) who will work to accomplish the goals of the laboratory. The primary purpose of the Post-doc is to design, optimize and perform new molecular assays geared for use in both the research and clinical space. This person would also help to facilitate the transition of translational research projects into the clinical lab and work closely with collaborators in different departments.

Key functions:

• Design, optimize, and validate new or existing genomic assays, including NGS, ddPCR, and gene expression by PCR, HTG, and NanoString for translational research or transfer into the CLIA environment.
• Works with internal and external collaborators (clinicians, vendors, faculty, staff, industry partners) to develop new molecular assays for the laboratory
• Assists in project planning and adheres to realistic timelines for implementation of assays in development.
• Works closely with Bioinformatics in the analysis and interpretation of NGS data and provides written reports to collaborators.
• Assists in the development of lab policies and procedures including assay Standard Operating Procedures (SOPs), assay transfer documentation and quality control procedures.
• Evaluates instruments, reagents and supplies for new and existing molecular assays
• Presents work at National conferences and for publication in peer-reviewed scientific journals
  

Desired skills:

• Hands on experience with NGS library preparation and sequencing platforms.
• Hands on experience in running different molecular assays including qPCR, ddPCR, NanoString and HTG.
• Experience with manual and automated nucleic acid extraction methodologies.
• Familiarity with Bioinformatics analysis for NGS and laboratory automation software. 

Learning Objectives:

• To understand the process of diagnostic test development.
• To apply the scientific method in the design and optimization of new molecular assays.
• To analyze data, write manuscripts for publication, present data/results at National and International conferences.
• To participate in the teaching/training of Research Assistants, graduate students and visiting fellows.
• To utilize the education and training opportunities within the department and the institution for career growth. ​
  

Eligibility Requirements:
​ An individual with a PhD or equivalent doctorate (e.g. Sc.D, M.D., D.V.M) in an appropriate field from a reputed University/Institute with zero to one year of experience post-graduation is eligible. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. The candidate must have independent thinking and be passionate about a career in academic science.  This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.​

Mentor Matching:
This position reports to Rajyalakshmi Luthra, Ph.D.

Additional application information:
Please submit resume and cover letter to Dr. Raja Luthra via email: rluthra@mdanderson.org. Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00016
Job Title: Postdoctoral Fellow
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​Despite recent advances in immunotherapy, lung adenocarcinoma remains the leading cause of death in smokers. Despite the overwhelming public health burden of lung adenocarcinoma, there are very few, if any, strategies for early treatment of this disease -- largely due to a very poor understanding of molecular changes that drive its initiation and development. One of our laboratory's goals is to delineate early immune events in the transition of smoking-exposed normal airway to lung adenocarcinoma. Understanding these changes may pave for the development of new prevention (immune-based) strategies for lung cancer.

Our lung cancer program is also actively investigating the role of the host microbiome in lung oncogenesis. We find that knockout of specific host defense and airway lineage genes perturb host microbiome homeostasis concomitant with lung tumor development. We are also eager to mechanistically understand novel cues between airway lineage factors, alveolar reprogramming, and microbiome homeostasis as well as understand the role of the host gut (and possibly the lung) microbiome in the pathogenesis of lung cancer. Our lung cancer research program at the Department of Translational Molecular Pathology is looking for a postdoctoral fellow to embark on different vignettes in the microbiome and immune evolution of lung cancer including understanding the dynamic interplay between host defense (including immunomodulatory) responses, tumor-initiating inflammation and microbiome dysbiosis (local and systemic) in the development of the malignancy.

The postdoctoral fellow will also work on understanding the role of lung epithelial reprogramming, in the context of inflammation, in early lung adenocarcinoma development. There will be opportune elements for the candidate postdoctoral fellow at MD Anderson Cancer Center to collaborate with physician and physician-scientists to gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches these exciting and timely projects.

The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology, and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry/cytochemistry, cell culture as well as basic molecular and cellular biology techniques. Experience in microbial (in vivo) research is a big plus. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork and collaborations with different members of the lung cancer research program.​ 

Learning Objectives:
-Learn uncharted cues and pathways in the inception and development of lung adenocarcinoma (which will likely be applicable to other subtypes of lung cancer or other solid tumors).

-Learn individual roles of immune and epithelial cell subsets and functional states/phenotypes in the development of lung adenocarcinoma.

-Develop a skill for collaboration and translation of laboratory-based findings (e.g., development of markers for outcome and response).

-Acquire skills for progression in academia including but not limited to delivering presentations, writing manuscripts and applying for grants/fellowships.​

Eligibility Requirements:
​ An individual with a Ph.D. or equivalent doctorate (e.g. Sc.D, M.D., D.V.M) in an appropriate field from a reputed University/Institute with zero to one year of experience post-graduation is eligible. At least one first author publication in a peer reviewed journal stemming from Ph.D. studies is required. The candidate must have independent thinking and be passionate about a career in academic science. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.​

Mentor Matching:
This position reports to Dr. Humam Kadara. 

Additional application information:
Please submit cover letter and resume to Dr. Humam Kadara.

Visit the Translational Molecular Pathology page for more information.

Req #: 149100-00017
Job Title: Postdoctoral Fellow
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​To participate in the development and conduct of a research project to study the roles of non-coding RNAs and non-coding DNAs in tumor development in vitro and in vivo models and in human samples

Learning Objectives:

• To understand the complex concepts of non-codingRNAs roles in biology and medicine
• To learn the advanced techniques of cloning, functional studies and in vivo work for noncodingRNAs and non-coding DNA and their structural and functional characterization
  
• To learn the bioinformatics methods used currently in the non-coding field
• To write fluently in English and to develop in writing complex and innovative concepts necessary for
  manuscripts, fellowships and grants​

Eligibility Requirements:
​An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Mentor Matching:
This position reports to George Calin, M.D., Ph.D. 

Additional application information:
Please submit resume and cover letter to Dr. George Calin : gcalin@mdanderson.org.

Visit the Translational Molecular Pathology page for more information.