Open Trainee Positions

Req #: 600658-00003
Job Title:  Postdoctoral Fellow       
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The postdoctoral fellow will perform hand-on experiments to measure ion channel activity, protein and gene expression, and the structural of protein complexes involved in pain and hypertension development. The fellow will also be involved in study design, data analysis and manuscript preparation by attending lab meetings, journal clubs, and research seminars.

Learning Objectives:
Gain mechanistic understanding of molecular mechanisms related to pain, opioid analgesia and hypertension development. Learn ion channel recording and biochemical analysis skills, animal models of pain and hypertension. Learn study design, data analysis and manuscript writing.

Eligibility Requirements:
Ph.D. degree in biochemistry, biotechnology and structural biology.

Dates or Training Schedule:
Research training will begin in August/September and will continue for 3-5 years, contingent on satisfactory progress of assigned projects and research funding.

Mentor Matching:
This position reports to Dr. Shao-Rui Chen and Dr. Jiusheng Yan in the department of Anesthesiology. 

Req #: 600567-00002
Job Title:  Postdoctoral Fellow       
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The Department of Biostatistics at  MD Anderson Cancer Center has one post-doc position open for biostatistics methodology research and application. The main focus is research and publication. The primary focus will be statistical and machine learning methods for large data sets. The post-doc will work under the supervision of Dr. Xuelin Huang and Dr. Peng Wei on challenging and important clinical and biological projects that involve complex statistical modeling and computation.

Learning Objectives:
The postdoctoral fellow will work under the supervision of Drs. Xuelin Huang and Peng Wei and may collaborate with other faculty in biostatistics, bioinformatics, basic science, or clinical departments at the MD Anderson Cancer Center. The primary research focus will be developing and applying novel statistical and machine learning methods for integrative analysis of multimodality clinical imaging data (including multiple sequences of MRI, PET-CT, ultrasound, mammogram, and/or pathology images) and genomics data (for example, mutation and gene expression profiling), as well as longitudinal clinical data, to predict treatment response and prognosis. The fellow will gain experience in cutting-edge analysis of “Big Data” and have the opportunity to publish in high-impact statistics, biostatistics, and health research journals.

Eligibility Requirements:
We seek a highly motivated individual with a Ph.D. in statistics/biostatistics/bioinformatics or a related quantitative field such as computer science, engineering, or quantitative computational biology. Applicants must have strong training in statistics and excellent programming skills, in particular R/Python and preferably one lower level computer language such as C/C++, and interest in the application of state- of-the-art statistical and machine learning methods to complex data. Interest or background in deep learning and image analysis is a plus.

Dates or Training Schedule:
Estimated start June 2020.

Mentor Matching:
This position reports to Xuelin Huang, Ph.D., and Peng Wei, Ph.D.

Req #: 600567-00003
Job Title:  Postdoctoral Fellow       
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The Department of Biostatistics at MD Anderson Cancer Center t1as one post-doc position open for biostatistics methodology research and clinical trial application. The main focus is research and publication. The primary focus will be develop novel methods for adaptive Bayesian clinical trial designs, derive related statistical theory, produce software for implementation, incorporate biomarkers i·n clinical trial design and analysis, and build statistical learning tools for large data sets. The post-doc will work under the supervision of Dr. J. Jack Lee and Dr. Ying Yuan on challenging and important clinical and biological projects that involve complex statistical modeling, data analysis and computation. 

Learning Objectives:
Learn statistical theory and application in can.cer clinical trials; Obtain expertise In Bayesian adaptive designs, hierarchical models, and biomarker based clinical trial design and analysis for precision medicine; Develop strong programming and computational skills; Gain interes.t in statistical methodology rese.arch; Acquire extensive experience in Rand R-Shiny.

Eligibility Requirements:
Applicants must have a recent PhD in biostatistics or statistics from a reputed University/Institute or within 0-1 years of graduation. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. A solid background in statistical theory, clinical tr-ial applications, and Bayesian methods and computation are requir.ed. Some experience with machine learning Is desirable.

Please send CV and information on three referees directly to slga.rcia@mdanderson.org .

Dates or Training Schedule:
May 2020-May 2022.

Mentor Matching:
This position reports to J. Jack Lee, Ph.D., and Ying Yuan, Ph.D.

Req #: 600567-00004
Job Title:  Postdoctoral Fellow       
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The DepartmeAt of Biostatistics at MD Anderson has one post-doc position open for biostatisUcs methodology research and clinical trial application. The main focus is research and publication. The primary focus will be develop novel methods for adaptive Bayesian clinical trial designs, derive related statistical theory, produce software for implementalion, incorporate biomarkers i·n clinical trial design and analysis, and build statistical learning tools for large data sets. The post-doc will work under the supervision of Dr. J. Jack Lee and Dr. Ying Yuan on challenging and important clinical and biological projects that involve complex statistical modeling, data analysis and computation.

Learning Objectives:
Learn statistical theory and application in can.cer clinical trials; Obtain expertise In Bayesian adaptive designs, hierarchical models, and biomarker based clinical trial design and analysis for precision medicine; Develop strong programming and computational skills; Gain interes.t in statistical methodology rese.arch; Acquire extensive experience in Rand R-Shiny.

Eligibility Requirements:
Applicants must have a recent PhD in biostatistics or statistics from a reputed University/Institute or within 0-1 years of graduation. At least one first author publication in a peer reviewed journal stemming from PhD studies is required. A solid background in statistical theory, clinical tr-ial applications, and Bayesian methods and computation are requir.ed. Some experience with machine learning Is desirable.

Please send CV and information on three referees directly to slga.rcia@mdanderson.org .

Dates or Training Schedule:
May 2020-May 2022.

Mentor Matching:
This position reports to J. Jack Lee, Ph.D., and Ying Yuan, Ph.D.

Req #: 600567-00005
Job Title:  Postdoctoral Fellow       
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The Department of Biostatistics at MD Anderson has one post-doc position open for biostatistics methodology research and application. The main focus is research and publication. The primary focus will be statistical and machine learning methods for large data sets. The post-doc will work under the supervision of Dr. Xuelin Huang and Dr. Peng Wei on challenging and important clinical and biological projects that involve complex statistical modeling and computation.

Learning Objectives:
The postdoctoral fellow will work under the supervision of Drs. Xuelin Huang and Peng Wei and may collaborate with other faculty in biostatistics, bioinformatics, basic science, or clinical departments at the MD Anderson Cancer Center. The primary research focus will be developing and applying novel statistical and machine learning methods for integrative analysis of multimodality clinical imaging data (including multiple sequences of MRI, PET-CT, ultrasound, mammogram, and/or pathology images) and genomics data (for example, mutation and gene expression profiling), as well as longitudinal clinical data, to predict treatment response and prognosis. The fellow will gain experience in cutting-edge analysis of “Big Data” and have the opportunity to publish in high-impact statistics, biostatistics, and health research journals.

Eligibility Requirements:
We seek a highly motivated individual with a Ph.D. in statistics/biostatistics/bioinformatics or a related quantitative field such as computer science, engineering, or quantitative computational biology. Applicants must have strong training in statistics and excellent programming skills, in particular R/Python and preferably one lower level computer language such as C/C++, and interest in the application of state- of-the-art statistical and machine learning methods to complex data. Interest or background in deep learning and image analysis is a plus.

Please send CV and information on three referees directly to slga.rcia@mdanderson.org .

Dates or Training Schedule:
Estimated start June 2020.

Mentor Matching:
This position reports to Xuelin Huang, Ph.D., and Peng Wei, Ph.D.

Req #: 198100-0003
Job Title:  Postdoctoral Fellow 
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Postdoctoral research fellow to carry out studies in translational breast cancer research.The laboratory focuses on identifying alterations with functional significance to the development and progression of breast cancer and translating results from basic, omic and preclinical studies into improved clinical interventions for cancer patients.

A major effort is directed towards elucidating the contribution made by heterogeneity (genomic, phenotypic, spatial and compositional) in both the tumor and its microenvironment to cancer progression and response to therapy. Technologies include
single cell RNA sequencing, ATAC-Seq, and imaging mass cytometry (IMC). Experimental models include human tumor tissue, PDX models of breast cancer and engineered mouse models.

Eligibility Requirements:
Applicants must have a recent Ph.D. (or equivalent) with experience in cancer genomics, cell biology, biochemistry, genetics or related fields. Applicants must have at least one first author publication in a high quality journal as well as a high level of written and oral communication skills in English. Experience working with mice is preferred.

Mentor Matching:
The position reports to Helen Piwnica-Worms, Ph.D.

Additional application information:
Interested applicants should submit a cover letter specifying past accomplishments, a curriculum vitae, and the contact information of three references to Helen Piwnica-Worms, Ph.D., at hpiwnica-worms@mdanderson.org.

Req #: 198100-0004
Job Title:  Postdoctoral Fellow 
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The overarching goal of the Ma Lab is to understand the molecular mechanisms of tumor progression, metastasis, and cancer therapy resistance. Specifically, Dr. Ma's team is: (1) establishing new paradigms for RNA functions and mechanisms (non-coding RNAs, RNA epigenetics, and RNA-binding proteins) in tumor progression and metastasis; (2) screening for deubiquitinating enzymes that promote tumorigenesis, metastasis, and therapy resistance; (3) investigating novel regulators and regulations of tumor radioresistance and drug resistance; and (4) studying the role of specific developmental regulators in cancer, metabolism, and regeneration by using genetically engineered mouse models generated in Dr. Ma's lab.

Eligibility Requirements:
We consider highly motivated and creative candidates with a recently obtained Ph.D. degree and strong first-author publications. For those interested, please send a CV, three letters of recommendation, and a research statement (limalab2018@gmail.com). Duration of this posting: continuous until filled.

Mentor Matching:
The position reports to Li Ma, Ph.D.

Req #: 198100-0005
Job Title:  Postdoctoral Fellow 
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Postdoctoral positions are available immediately to work in the area of cancer biology, mouse genetics, and stem cells. The lab focuses on the roles of tumor suppressor genes and oncogenes in cell signaling pathways involved in tumor initiation, progression, tissue homeostasis, and tissue regeneration. The approaches we take range from mammalian cell culture, molecular biology, biochemistry, next-generation sequencing to mouse genetics. For more information, please visit our web site, www.JParkLab.org.

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full- time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
The position reports to Jae-Il Park, Ph.D.

Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 404400-00001
Job Title:  Postdoctoral Fellow 
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The laboratory of Dr. Gabriel Lopez in the Department of Experimental Therapeutics is seeking a post-doctoral fellow to study pharmacokinetics, apoptosis and atophagy as cellular death mechanism. Our laboratory explores the mechanisms of cancer cell survival, tumorigenesis and tumor progression and is focused on identifying signaling pathways regulating proliferation, invasion, drug resistance, apoptosis and autophagy. These studies provide a rational and basis for the development of therapeutic applications using RNA-inteference (siRNA and microRNA), oligonucleotides, (antisense), chemotherapeutic agents and small molecules in cancer and a wide variety of other diseases. Nanomedicine functions as a critical bridge that will connect basic science discoveries and clinical applications by enabling the development of highly effective targeted therapies utilizing nanoparticles that capable of delivering therapeutic payloads to disease sites and targeting identified molecular pathways.

Our long-term goal is to development clinically relevant, non-toxic, tumor-targeted nano-therapeutics agents that can be used translated into the clinic to improve the treatment options for the patients therapy and further enhance efficacy of current regimens.

Learning Objectives:
Under the supervision of the faculty mentor, will study pharmacokinetics, apoptosisand autophagy as cellular death mechanisms induced by novel compounds and siRNA and will have experience in laboratory techniques, including cell culture small interfered RNA (siRNA) and micro RNA-based gene silencing/regulation, pharmacokinetics, apoptosis and autophagy as cellular death mechanisms fluorescent microscopy, confocal imaging, and flow cytometry applications.

Eligibility Requirements:
An individual holding a recent PH.D. or equivalent doctorate who is seeking an appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in experimental therapeutics collaborations.

Dates or Training Schedule:
June 1, 2020 - May 31, 2021

Mentor Matching:
The position reports to Gabriel Lopez, MD.

Additional Application Information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 600658-0001
Job Title:  Postdoctoral Fellow       
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A joint postdoctoral position is immediately available in the Gastrointestinal Medical Oncology (GIMO) and Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform to conduct research in cancer biology of intestinal adenocarcinomas. This position is responsible for characterizing the preclinical biology of minimal residual disease (MRD) in colorectal cancer. Projects will include the development use and characterization of minimal residual disease mouse models that represent micrometastases, their evolution, and drug resistance. Clonal evolution and immune infiltration will be examined using CRISPR barcoding approaches, single cell RNAseq, FACS and multiplex immunofluorescence. These studies include modeling and connections to clinical efforts involving MRD identified by circulating tumor DNA (ctDNA).

Learning Objectives:
Learning objectives are to better understand colorectal cancer tumor heterogeneity and evolution in response to therapy. Plan and perform research project using molecular biology techniques, such as cloning, transfection, site-directed mutagenesis assay, allelic expression assay, CRISPR driven cell barcoding, flow cytometry single cell RNAseq and ctDNA analysis. Generate or learn to generate animal transgene expression and targeting constructs, including those using Cre/lox and CRISPR technologies Evaluate targeted drugs key molecular targets in minimal residual disease as part of a drug development program. Examine the molecular and cellular evolution in colorectal cancer development by single cell RNAseq.

Eligibility Requirements:
M.D. and/or Ph.D. degree in the following areas: Biochemistry, Cellular and/or Molecular Biology.

Mentor Matching:
This position interfaces between Scott Kopetz, M.D., Ph.D., and David Menter, Ph.D., in GIMO and Timothy Heffernan, Ph.D., in TRACTION to identify and characterize minimal residual disease biology along with subtype specific targets and agents.

Req #: 144300-00001 
Job Title:  Postdoctoral Fellow       
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The postdoctoral fellow will engage with the PI in understanding how neurons are shaped. This will require a deep interest and curiosity in cell biology and developmental biology, and depending on the project, in protein biochemistry (e.g. cytoskeleton) and signaling pathway biology. The PI will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation, but the fellow is expected at the same time to consistently undertake a highly active role in researching the literature and bringing new perspectives to the laboratory. Trainings that might be needed that are outside of the expertise of the PI will likely involve attending courses, engaging fully and smoothly with others possibly in collaborative ventures, and importantly, learning to be proficient in educating oneself, and thereby effectively advance one's own project(s) while strengthening the capabilities of the larger laboratory. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues - local as well as from participating in relevant scientific conferences or courses (etc.) - to all together enhance the impact of one's work in the laboratory, and equally critically, to help promote one's research program after leaving the laboratory.

Learning Objectives:
The postdoctoral fellow will engage with the Pl in understanding how neurons are shaped. This will require deep interest in cell biology and developmental biology, and depending on the project, on protein biochemistry and signaling pathway biology. The Pl will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar, and in critical thought, experimental design and interpretation, but the fellow is expected at the same time to consistently undertake an active role in researching the literature and bringing new perspectives to the laboratory. Trainings that may by needed that are outside of the expertise of the Pl will involve attending courses or engaging in collaborative ventures. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory, and, equally importantly, to promote one's research program after leaving the laboratory.

Eligibility Requirements:
Minimum requirement is to have recently been awarded (within three years) a Ph.D. Individual must have a beginning or ongoing interest in neuron cell & dev biology.

Mentor Matching:
This position reports to Pierre McCrea, Ph.D.

Req #: 144300-00001 
Job Title:  Postdoctoral Fellow       
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We are looking for candidates for postdoctoral fellowships to join the Department of Health Services Research at The University of Texas, MD Anderson Cancer Center. Under the mentorship of Dr. Maria E. Suarez-Almazor, this fellowship will provide individuals with the opportunity to work with a team of accomplished researchers in the field of medical decision-making.

As a member of the team, the fellow will gain experience in evidence-based approaches which include:

1. Cochrane Collaboration methods on systematic reviews of interventions.
2. Designing and implementing research protocols.
3. Collecting, preparing and analyzing research data; maintaining computer database of research data; tabulating and displaying data for presentation in research conferences and for manuscript.
4. Preparing manuscripts for publication at the direction of the Pl. Presenting research findings at professional meetings.

Applicants selected for this fellowship will have a one- to two-year, full-time research postdoctoral position with competitive salary and benefits.

Learning Objectives:
This fellowship focuses in: 1) developing clinical decision-analytic models based on existing literature to evaluate the benefits and risks of immunotherapy for patients with autoimmune diseases and cancer; 2) conducting interviews with target audience members to assess their knowledge and literacy levels; 3) developing decision support tools tailored to patients' individual characteristics to be used during the medical encounter in English and Spanish; and 4) pilot testing decision support tools in the clinical setting.

Eligibility Requirements:
Ideal candidates enjoy being part of a team and are self-motivated, organized, detail-oriented, and highly professional with strong interpersonal and communication skills and the ability to work effectively with a wide range of constituencies. Qualified candidates should have a doctorate in medicine, health services, public health, epidemiology, or biostatistics. Prior experience in rheumatology, health services, or decision making research is strongly preferred. Publications, statistical skills, and strong ability to deliver presentations are important. All candidates must be bilingual (English and Spanish), have evidence of strong writing skills and demonstrated experience in research study design and project implementation.

Mentor Matching:
This position reports to Maria Suarez-Almazor, M.D., Ph.D.

Req #: 600651-00001
Job Title:  Postdoctoral Fellow       
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Postdoctoral training that will consist of carrying out an independent research in the area of molecular photoacoustic imaging of ovarian and breast cancers using antibody-targeted liposom encapsulated J-aggregates of ICG dye molecules.

Learning Objectives:
Principles of photoacoustic imaging in vivo that will include instrumentation, fluence correction and spectral unmixing algorithms. In addition, there will be training in scientific writing through submission of peer reviewed manuscripts.

Eligibility Requirements:
Ph.D. in Bioengineering is preferred. Ph.D. in other natural science disciplines will be considered.

Dates or Training Schedule:
5/7/2020 to 5/6/2021

Mentor Matching:
This position reports to Konstantin V. Sokolov, Ph.D.

Req #: 206100 -0001
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. Our research is to understand the molecular basis of T cell mediated immune responses, and how abnormal immune regulation leads to immunodeficiency, autoimmunity and cancer. Autoimmunity and inflammation mouse models include experimental autoimmune encephalomyelitis (EAE), colitis, and lung airway inflammation; tumor immunity models include T cell-mediated immune responses against transplanted melanoma, chemical induced sarcoma, and lung cancer.

Learning Objectives:

The recruiting postdoctoral fellow will conduct research in the following projects: 1. The molecular mechanisms of T cell activation and tolerance; 2. The signaling and transcriptional mechanisms underlying T helper cell differentiation and function. Mentor’s main research goal is to understand the molecular and cellular mechanisms that control the development and progress of autoimmunity, inflammation and cancer, with particular emphasis on the signaling and transcriptional mechanisms underlying T helper cell development and T cell mediated immune responses.

Eligibility Requirements:
Candidates should have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Immunology, with preferred hand-on experience in flow cytometry, molecular techniques, and mouse models of autoimmunity and/or anti-tumor immunity.

Dates of Training Schedule:
Position is opened from January 1st 2020. Training schedule: 40 hours per week.

Mentor Matching:
This position reports to Roza Nurieva, Ph.D.

Req #: 206100-00004
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in Department of Immunology at MD Anderson Cancer Center, Houston, TX. The focus of the research project is understanding the basis of CD4+ T cell and CD8+ T cell recognition of tumor antigens in the context of a dynamic tumor microenvironment and development of improved personalized cancer treatments. This project will primarily utilize preclinical transplant and genetically engineered mouse models along with high dimensional analyses approaches such as mass cytometry by CyTOF and single-cell RNA sequencing.

Learning Objectives:
The successful applicant is expected to develop an in-depth understanding of cancer immunology mouse models, cancer vaccines, T cell responses to tumors, and high dimensional analyses approaches as well as display increasing research independence.

Eligibility Requirements:
Candidates should have a recent Ph.D. degree or be in the process of completing Ph.D. training and a solid background in Immunology, preferably with hands-on experience in mouse cancer models, flow cytometry and molecular immunology.

Dates of Training Schedule:
The position is available immediately.

Mentor Matching:
This position reports to Matthew Gubin, Ph.D.

Additional Application Information:
Successful candidates will join a collegial, dedicated group of researchers. The Department of Immunology, led by Nobel Laureate James Allison, conducts cutting-edge and diverse research using state-of-the-art tools in a highly interactive environment. Send curriculum vitae and names of three references to: Dr. Matthew Gubin, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston 77054. E-mail: mgubin@mdanderson.org.

Req #: 600140-0001
Job Title:  Postdoctoral Fellow       
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The postdoctoral fellow will be embedded within the Structural Chemistry group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform and analyze calculations, and attend and present results at project team meetings.

Learning Objectives:

The postdoctoral fellow will learn how to a) provide computational chemistry support to drug discovery project teams, b) design novel molecules using structure and ligand-based techniques, c) interface with structural biologists and medicinal chemists, d) communicate insights from molecular modeling to a diverse team of scientists, and e) perform independent computational research aimed at improving design of novel molecules.

Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, or a related discipline.

Dates of Training Schedule:
1 year, with extension to 3 years possible

Mentor Matching:
This position reports to Jason Cross, Ph.D.

Req #: 600140-0002
Job Title:  Postdoctoral Fellow
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The postdoctoral fellow will be embedded within the Structural Biology group in the Institute for Applied Cancer Science, part of the Therapeutics Discovery Division. The position is designed to provide the experience needed to operate as a key member of a drug discovery project team at the program's conclusion. The fellow will perform biophysical experiments (X-ray crystallography, cryo-EM), and attend and present results at project team meetings.

Learning Objectives:
The postdoctoral fellow will learn how to a) express and purify high quality protein for use in biophysical and structural biology experiments, b) collect crystallographic datasets at a national lab and fully analyze to produce structural models, c) generate grids, collect data, and solve structures using cryo-EM, d) interface with computational and medicinal chemists, and e) communicate structural biology insights to a diverse team of scientists.

Eligibility Requirements:
Ph.D. in Chemistry, Physics, Biophysics, Biology, or a related discipline.

Dates or Training Schedule:
1 year, with extension to 3 years possible

Mentor Matching:
The position reports to Dr. Paul Leonard.

Req #: 600411-0001
Job Title:  Postdoctoral Fellow                 

Postdoctoral Fellow will be responsible for characterization of breast cancer stem cell subpopulation through combinatorial studies of metabolomics, gene expression, and protein expression. Identifying novel susceptible metabolic pathways in drug-resistant breast cancer cells and stem-like cells. Collaborating with related investigators in an interdisciplinary research project that involves basic cell culture, flow cytometry/sorting, metabolic assays, mass cytometry, DNA/RNA sequencing/analysis, and the use of immuno-deficient mouse models. Presenting relevant scientific findings at project meetings, National and international conferences, and via publication in top-tier scientific publications.

Learning Objectives:
The potential candidate is expected to quickly learn various tissue culture techniques, stem cell functional assays, metabolic assays that we routinely use in our laboratory. Also, we have several animal models including patient-derived xenografts that need to be maintained and used for translational research. A thorough understanding of cancer metabolism and the biology of mitochondria is appreciated.

Eligibility Requirements:
Ph.D. degree in a life science (cellular or molecular biology). Research experience and an excellent knowledge-base in biochemical, metabolic, and signaling process as they relate to cancer. Experience in breast cancer, molecular cloning, the quantitative measurement of RNA expression, flow cytometry, metabolomics, big data analysis, and/or the use of animal models would be a plus. The applicant should enjoy providing a training role for students and other coworkers, and should be open to scientific collaboration within a large research group. The candidate should possess excellent written and spoken (English) communication skills.

Dates of Training Schedule:
December 2019 through November 2020

Mentor Matching:
Lokesh Venkata Battula, Ph.D.
Michael Andreeff, MD, Ph.D.
Naoto T. Ueno, M.D.

Additional Application Information:
Please submit curriculum vitae to Dr. Venkata Lokesh Battula at Vistula@mdanderson.org.

Req #: 600411-0001
Job Title: Postdoctoral Fellow
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The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells.

Learning Objectives:
1.) Develop skills in experimental design and conduct of biologic and molecular studies to characterize genomic alterations, epigenomic, transcriptional and protein expression studies (ATAC-Seq, ChIP-Seq, RNA-Seq, Confocal Microscopy, Flow Cytometry, Mass Cytometry and Western analysis) in bulk cell populations as well as at a single cell level.
2.) Cloning and transfer of genes into cancer cells.
3.) CRISPR-Cas9 techniques for gene-editing.
4.) Mouse xenograft models to determine biology of leukemia and lymphoma as well as to evaluate therapeutic efficacy of novel targeted agents.

Eligibility Requirements:
The qualified candidate must possess a Ph.D. in Biology, Biological Sciences, Life Sciences or related field; a keen interest and experience in cancer research; excellent English skills (both written and verbal); and current U.S. work authorization. The candidate should preferably have completed a 3 year Post-doctoral fellowship in an area relevant to the focus of research noted above. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection, analysis of gene expression through QPCR, microarrays, immunoblots and flow cytometry, as well as experience in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is preferred. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is preferred. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also preferred.

Dates of Training Schedule:
Monday - Friday, 8:00 - 6:00; Weekends when needed. Beginning April

Mentor Matching:
This position reports to Kapil Bhalla, M.D.

Req #: 600300-00001
Job Title:  Postdoctoral Fellow   
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The focus of our lab is dissecting the role of host factors on anti-tumor immunity and melanoma biology. Candidates will work with a multidisciplinary research team involving clinicians, biologists, epidemiologists, and bioinformaticians and under the direct supervision of Dr. Jennifer McQuade, Assistant Professor, Melanoma Medical Oncology.

This position will include focused studies on the role of diet, obesity, and gender on melanoma biology and anti-tumor immune response. Unique resources include one of the largest repositories of annotated melanoma biospecimens in the world, resources such as patient-derived tumor cell lines with matched autologous tumor infiltrating lymphocytes, and metabolic phenotyping systems.

Eligibility Requirements:
The ideal candidate will be proficient in flow cytometry and basic immunology and molecular biology techniques (cell culture, assessment of growth inhibition and apoptosis, western blotting, immunohistochemistry, DNA/RNA/protein isolation). Candidates should be enthusiastic about collaborative and interdisciplinary research, as well as self-motivated and independent. 

Mentor Matching:
This position reports to Jennifer McQuade, M.D.

Additional Application Information:
Requesting CV, Cover letter, 3 references and contact information.

Req #: 600300-00002
Job Title:  Postdoctoral Fellow   
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The ideal candidate will be proficient in flow cytometry and basic immunology and molecular biology techniques (cell culture, assessment of growth inhibition and apotosis, western blotting, immunohistochemistry, DNA/RNA/protein isolation). Independently design and conduct research experiments, including performing animal experiments, data analysis, present research results at meetings and engage in result publication, attend research seminars at Prinicpal Investigators request. Supervise students and staff if needed. Candidates should be enthusiastic about collaborative and interdisciplinary research, as well as self-motivated and independent.

Learning Objectives:
The postdoctoral Fellow will conduct research with a focus on metabolic pathways within tumor cells and their influence on the susceptibility of the cancer to immune-mediated destruction.

Eligibility Requirements:
Candidates should have a recent Ph.D. degree or in the process of completing Ph.D. training and a solid background in Melanoma with preferred hands-on experience in cell culture, flow cytometry, molecular techniques and mouse handling.

Mentor Matching:
This position reports to Patrick Hwu, M.D.

Req #: 127800-0001
Job Title:  Postdoctoral Fellow       
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Postdoctoral positions are immediately available in Dr. Laura Beretta's Laboratory, Department of Molecular and Cellular Oncology.  Since 1980, the incidence of liver cancer has tripled worldwide and is on the rise in the United States. The overall survival rate of liver cancer is poor as most patients are diagnosed late and limited therapeutic options are available. A successful candidate will be part of a major translational research effort integrating a diverse array of molecular profiles from genomics to metabolomics to identify novel targets for therapy, prevention and diagnosis, and their validation through preclinical models of liver cancer and patient cohorts. 

Eligibility Requirements:
A highly-motivated individual with Ph.D. in molecular and cell biology, biochemistry or bioinformatics to work on projects related to liver cancer treatment, diagnosis or prevention. The candidate should have demonstrated competence and experience through publications in internationally recognized journals. Candidates must be enthusiastic, self- motivated, dedicated to science and problem solving, with organizational skills and effective at working independently and leading projects, while also collaborating and assisting the team in its collective research goals.

Mentor Matching:
This position reports to Dr. Laura Beretta.

Additional application information:
Technical expertise in standard basic molecular and cellular techniques including DNA and RNA analysis, cell culture, and ability to analyze large datasets. Experience with cancer mouse models or in liver biology is preferred. Preference will be given for the candidates with prior experience in the field of Hepatology. Recent graduates are encouraged to apply.

Req #: 127800-0002
Job Title:  Postdoctoral Fellow
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Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. The laboratory is also investigating the functional importance of long noncoding RNAs in metabolic disorders and has been developed CRISPR/Cas9-mediated lncRNA editing/knockout/knockin mouse models, and transgenic mouse models. The newest projects will study lncRNAs' functional roles in the development of breast/pancreatic/lung cancer, and metabolic dis orders.

Eligibility Requirements:
1. PhD in Molecular Biology, Biochemistry or related field; 2. Outstanding publication record; 3. Strong previous experience in biochemistry; 4. Prior experience in RNA biology is preferred; 5. Prior experience in genetic mouse models is preferred; 6. Excellent communication with a focus on teamwork is required.

Mentor Matching:
The position reports to Dr. Chunru Lin. 

Additional application information:
Responsibilities: Use cutting-edge methods to seek novel therapy targets for human cancers and metabolic disorders; 2. Be responsible for the design and execution of experimental work, data analysis and their written records; 3. Attend and present at internal and international meetings; 4, Be expected to publish data in top scientific journals.

Req #: 600663-00001 
Job Title:  Postdoctoral Fellow
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A postdoctoral position is available immediately at the M.D. Anderson Cancer Center to conduct studies for the newly funded NIH ROI projects on pancreatic cancer. We are seeking applicants who are highly motivated, self-starters with strong bench skills, and can work independently. Candidates must have PhD or MD/PhD degree in biological sciences with a strong research background including designing and performing experiments involving transgenic animal models, siRNA gene silencing, IP-western, kinase assay, mammalian cell transfection techniques etc. Experience in transgenic animal models, cell cycle, receptor endocytosis, or ubiquitin pathway is a plus.

Eligibility Requirements:
Ph.D or M.D./Ph.D with 2 years minimum experience

Dates or Training. Schedule:
April 1, 2020

Mentor Matching:
The position reports to Huamin Wang, M.D., Ph.D.

Req #: 600469-00001 
Job Title:  Postdoctoral Fellow
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This position will study the role of the platelets in the progression of cancer and on the mechanisms of platelet extravasation into tumors.
1. To design and conducts in vitro experiments on the role of platelets in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of platelets on immune cells (neutrophils, T cells, B cells, and antigen-presenting cells)
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of platelets on the growth and metastasis of different cancers, and the therapeutic benefit of platelet inhibitors on blocking tumor growth.
4. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelet extravasation into the tumor microenvironment.
5. To design and conducts in vivo experiments using mouse models of cancers to investigate the mechanism of platelets on the immune profile of tumor microenvironment.
6. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
7. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
8. To conduct DNA, RNA, and protein extraction and purification.
9. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
10. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
11. To communicate freely and clearly, but also to be respectful to other lab members.
12. Records the experiments and results meticulously.
13. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:

• Learning to design and conduct experiments in vitro and in mouse models of cancer
• Learning to troubleshoot and analyze the generated data
• Learning important topic in platelet biology, imaging studies, immune profiling tumor microenvironment, mouse genetics

Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as ELISA, Western-blotting, flowcytomtery, RT-PCR, PCR, RNA, and DNA extraction
Familiarity with imaging studies including immunohistochemistry and immune fluorescence microscopy

Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.

Req #: 600469-00002
Job Title:  Postdoctoral Fellow
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This position will study the role of the complement system on the tumorigenesis and progression of cancer.
1. To design and conducts in vitro experiments on the role of complement proteins in cancer cell proliferation and morphological changes
2. To design and conducts in vitro experiments on the role of complement proteins in proliferation, differentiation, and polarization of T cells
3. To design and conducts in vivo experiments using mouse models of cancers to study the effect of the complement system in growth and metastasis of different cancers, and the therapeutic benefit of complement inhibitors on blocking tumor growth.
4. To conduct animal dissections and prepare tissue specimens from tumors for processing: fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, immunofluorescence microscopy, and in situ hybridization.
5. To perform imaging studies from tumor specimens: light microscope, immunofluorescence microscopy, and morphometric image analyses.
6. To conduct DNA, RNA, and protein extraction and purification.
7. To conduct DNA, RNA, and protein analysis by PCR, RT-PCR, Quantitative PCR, acrylamide gel electrophoresis, ELISA, and Western blotting.
8. To be up-to-date with the literature relevant to her project on complement biology and cancer immunology
9. To communicate freely and clearly, but also to be respectful to other lab members.
10. Records the experiments and results meticulously.
11. Analyze data, prepare graphs, figures, and help in writing and submitting the manuscript.

Learning Objectives:

• Learning to design and conduct experiments in vitro and in mouse models of cancer
• Learning to troubleshoot and analyze the generated data
• Learning important topic in complement biology, the immune response to the tumor, immune profiling tumor microenvironment, mouse genetics
  

Eligibility Requirements:
Ph.D. in biological sciences
Familiarity with murine studies
Familiarity with basic laboratory techniques, such as flow cytometry, ELISA, Western blotting, PCR, RT-PCR, RNA, and DNA extraction

Mentor Matching:
The position reports to Vahid Afshar-Kharghan, M.D.

Req #: 600469-00003
Job Title:  Postdoctoral Fellow
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Lung adenocarcinoma (LUAD), is still the leading cause of cancer mortality. Unfortunately, lung cancer patients harboring activating mutations of K-ras, which are heavily associated with tobacco exposure and poor prognosis, are resistant to most forms of systemic or targeted therapies. This fact clearly indicates that there is an urgent unmet need for alternative strategies targeting downstream effectors of K-ras and/or its cooperating pathways for treatment and prevention of K-ras mutant LUAD (KM-LUAD). Accordingly, our research program is focused on airway inflammation, intrinsic (e.g. oncogene driven) and extrinsic (e.g. smoke or infection induced), and its role in airway epithelial tumorigenesis. It is known that mutant epithelial cells begin to edit the microenvironment as soon as they transform but the exact mechanisms involved in this immuno-editing process from escaping the immunosurveillance to tumor progression and contribution of pro-tumor inflammatory signals in this process still not well understood.

Our laboratory has developed and interrogated various human-relevant mouse models that closely emulate the molecular pathobiology of human airway inflammation, COPD, and lung cancer. We have previously shown that a network of immunomodulatory cytokines released during inflammation promotes lung tumorigenesis by providing a pro-tumor lung microenvironment in a genetic mouse model of lung cancer with K-ras mutation. We have further shown that targeting inflammatory pathways and modulating this cytokine network could be used as a preventive and therapeutic strategy for KM-LUAD. We are currently dissecting the cell-specific autocrine and paracrine mechanisms responsible for this phenomenon. We employ genetic and pharmacologic targeting interventions, immunophenotyping, histopathology, single-cell RNA sequencing, and other RNA- and protein-based approaches to study the effect of targeting these pathways on tumor cells and changes in immunomodulatory responses in vivo that could affect the pathogenesis of KM-LUAD.

These studies have the potential to detect and target important immunomodulatory pathways in the lung tumor cells and infiltrating immune cells, which could have major impacts on personalized prevention and treatment of lung cancer. They will also lay the groundwork to develop predictive and prognostic biomarkers to identify responders and non-responders.

Learning Objectives:

1. To prepare and conduct in vivo studies of lung inflammatory microenvironment and lung cancer using mouse models.
2. To prepare and conduct ex vivo/in situ histologic analyses using the following techniques: animal dissection, tissue fixation, paraffin embedding, cryofixation, tissue sectioning (paraffin and frozen), histochemistry, immunohistochemistry, and immunofluorescence staining.
3. To performs microscopic and morphometric image analyses of histological specimens.
4. To perform RNA and protein-based analysis of tumor and immune cells.
5. To perform cell sorting and flow cytometry of lung infiltrating immune cells.
6. To extract and record relevant information from published literature.
7. To learn data analysis, and graph/figure preparation for presentations (poster, and oral), manuscripts, reports, and grant proposals.
8. To learn writing and submitting manuscript as well as grant proposal.
9. To present at the local, national, and international meeting.
10. To co-mentor undergrad, graduate students, and other trainees.
 

Eligibility Requirements:

EDUCATION:  Required: PhD
EXPERIENCE:  Required: Basic molecular biology and immunology techniques are required. Work experience with small rodents is a plus.

Mentor Matching:

The position reports to Seyed Moghaddam, M.D.

Req #: 600661-0003
Job Title:  Postdoctoral Fellow
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Postdoctoral positions are available immediately to work in the area of endoplasmic reticulum stress/unfolded protein response and cancer biology. Candidates should possess mastery of basic knowledge and techniques in molecular & cell biology, biochemistry, and mouse genetics. Knowledge and hands-on experience in immunology research is desirable. The candidate should also be highly motivated in learning new techniques and independent thinking. Compensation will adhere to institutional and NIH postdoc guidelines.

Learning Objectives:

• Use cutting-edge methods to delineate cancer-promoting cellular & molecular mechanisms and seek novel cancer therapy targets
• Be responsible for the design and execution of experimental work, data analysis and their written records
• Attend and present at internal and external meetings
• Publish data in top scientific journals
  

Eligibility Requirements:

• PhD in Cell and Molecular Biology, Biochemistry or related field obtained within three years.
• Outstanding publication record.
• Prior experience in in vitro & in vivo pharmacological studies is preferred.
• Prior experience in in vitro & in vivo immunological assays and flow cytometry analysis is a plus.
• Prior experience in genetic mouse models is a plus.
• Basic skills in data analysis using e.g. Excel and GraphPad Prism is required.
• Excellent communication with a focus on teamwork is required.

Mentor Matching:
This position reports to Albert Koong, M.D., Ph.D.

Additional application information:

The major focus of our laboratory is to investigate tumor microenvironment-regulated signaling pathways that contribute to tumor progression and resistance to anti-cancer therapy. Our laboratory has shown that the IRE1alpha-XBP1 pathway, a key component of the unfolded protein response (UPR), was activated by stress signals in the tumor microenvironment, such as hypoxia. Since identifying IRE1alpha-XBP1 as a potential therapeutic target in cancer, our laboratory has completed a high throughput small molecule screen of >120,000 compounds for inhibitors of this pathway and identified classes of compounds that selectively inhibit the endoribonuclease activity of IRE1alpha and demonstrate potent anti-cancer activity (Papandreou et al., Blood 2010; Jiang et al., Mol Cancer Ther 2016). To further accelerate the preclinical evaluation of other compounds targeting this pathway, we also developed an XBP1-luciferase transgenic mouse in which luciferase activity is detectable only when XBP1 is activated (Spiotto et al., Cancer Res 2009). In addition, the laboratory has completed a genome wide siRNA screen to identify other genes that are required for the activation of IRE1alpha (Yang et al., Mol Cancer Res 2017). Studies investigating the mechanisms of IRE1alpha activation will lead to the development of novel cancer therapeutics targeting this pathway. More recently, our laboratory has developed several computational biology methods of analyzing the drug screening data to improve the efficiency of drug discovery (Jiang et al. Jiang et al., Mol Cancer Ther 2016; Alagappan et al. Adv Exp Med Biol 2016), as well as novel application of artificial intelligence (AI) and deep learning approaches in drug discovery (Yuan et al. J Chem Inf Model 2017).

Our ongoing research projects include:

(1) Studying the role of IRE1alpha/XBP1 in tumor progression and chemo-/radio-resistance, using in vitro cell culture and organoid systems as well as in vivo xenograft and genetically modified mouse tumor models.
(2) Investigating the role of IRE1alpha/XBP1 in regulating proliferation and DNA damage response pathway.
(3) Developing biomarkers that may be used to guide therapeutic decisions in pancreatic cancer (Danai et al., Nature 2018; Qian et al., JAMA Oncol 2018).

Req #: 600661-0004
Job Title:  Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.

The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.

An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.

Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org).

Eligibility Requirements:
A recent Ph.D. or equivalent doctorate in microbiology (or similar, with experience in microbiology laboratory-based research and molecular biology) who is seeking a temporary appointment under the supervision of a faculty mentor involving full-time laboratory based research and scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
This position reports to Lauren Colbert, M.D.

Additional application information:

Required Background/ Skills:

• PhD in Microbiology or related field and relevant research experience
• Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development
  

Preferred Background/ Skills:

• Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
• Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
• Development and testing of model microbial systems in animals
• Experience with immune assays including flow cytometry and immunohistochemistry
• Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.

Req #: 600661-0005
Job Title:  Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a funded project that will investigate how to exploit mitochondrial dynamics for therapy against pancreatic cancer. This project uses a combination of microscopy, metabolomics, cell biology, and mouse models and the successful candidate should have some experience in several of these core skill sets. Competency with SeaHorse is helpful, but expected.

Learning Objectives:

• Training and expertise in mitochondrial metabolism and mitochondrial biology
• Experimental approaches to model tumor-stroma interactions
• Expectations to present and publish their data in a timely fashion
  

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator.

Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.

Dates or Training Schedule:

Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars

Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 600661-0006
Job Title:  Postdoctoral Fellow
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The Radiation and Pancreatic Cancer Biology laboratory of Dr. Cullen Taniguchi at the University of Texas at MD Anderson Cancer Center in Houston, TX is looking for a postdoctoral fellow for a NIH/NCI-funded project that seeks to protect the intestine from radiation injury. This science has implications for oncology treatments (pancreatic and liver cancers) and nuclear countermeasures (medical response to a terrorist attack or nuclear accident). The successful candidate will have significant experience in intestinal stem cell biology or radiation biology/physics. Experience with molecular biology, histology and tissue preparation, cell biology, and mouse modeling are very
helpful but not required.

Learning Objectives:

• Training and expertise in radiation biology, intestinal stem cell biology
• A stimulating environment with freedom to develop new research directions, includingmechanistic approaches to understanding and translating EGLN inhibition to protect thesmall intestinal tract.
• Expectations to present and publish their data in a timely fashion
  

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary
appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an
independent investigator.

Mentor Matching:
This position reports to Cullen Taniguchi, M.D., Ph.D.

Dates or Training Schedule:

Starting ASAP
Weekly lab meeting
Monthly floor and departmental seminars

Additional application information:
We seek applicants who are self-motivated and career-oriented to join an exciting and highly interactive research team. We have track record of training the best and the brightest postdoctoral fellows who become independent group leaders in the United
States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in cancer biology and translational collaborations.

Req #: 600661-0007
Job Title:  Postdoctoral Fellow
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Post-doctoral researcher position available immediately for outstanding and self-motivated individual with strong laboratory skills in microbiology and molecular biology. Researcher will become a key member of a vibrant and collaborative patient-oriented translational research program studying the role of the human microbiome in HPV-related cancers. Our work is focused on the role of the tumor microbiome and gut microbiome in immune response to cancer therapy, including bacterial and tumor antigen recognition and response by the immune system during and after chemoradiation therapy. The candidate should have significant wet lab experience in microbiology and microbiology laboratory techniques, but previous computational experience in microbial ecology, including experience with R, Python and/or QIIME2 is preferred. Previous cancer biology experience is not required.

The researcher should be able to develop independent scientific goals and projects, devise and troubleshoot laboratory protocols, independently evaluate resulting research data and revise techniques or approaches to problems. The researcher must also work well in a team environment and take a leadership role in supervising the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures.

An outstanding research environment, new laboratory and core facilities are available in the Zayed building, Radiation Oncology/ Experimental Radiation Oncology and throughout the institution. We have an exceptional laboratory and administrative support team, including a very strong computational/ biostatistical team, and an exceptional dual PI mentoring team with a dedication to career development for all lab members.

Interested applicants should send a cover letter describing your past research experience and career goals, a curriculum vitae, and the contact information of three references to Dr. Lauren Colbert (lcolbert@mdanderson.org) and Dr. Ann Klopp (aklopp@mdanderson.org). 

Mentor Matching:
This position reports to Lauren Colbert, M.D.

Additional application information:

Required Background/ Skills:

• PhD in Microbiology or related field and relevant research experience
• Strong experimental skills in microbial and eukaryotic cell cultures and basic molecular microbiology, including sterile technique, bacterial growth assays, nucleic acid isolation, library prep and laboratory protocol development/ optimization
  

Preferred Background/ Skills:

• Experience with bacterial identification via traditional culture methods, RT-PCR, multiplex molecular sequencing, and/or via mass spectrometry techniques including PCR/ ESI-MS or MALDI-TOF MS.
• Experience with bacterial genome modification and editing techniques such as via CRISPR/ Cas9 plasmid construction
• Development and testing of model microbial systems in animals
• Experience with immune assays including flow cytometry and immunohistochemistry
• Experience with computational analysis of microbial and microbiome 16s and next generation sequencing data, such as use of QIIME amplicon analysis software, R software packages such as phyloseq, etc.

Req #: 600661-0008
Job Title:  Postdoctoral Fellow
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A postdoctoral fellow position is available in the department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. The program consists of a proposed plan for Health Economics Analysis of Proton Therapy vs. IMRT for Patients with Head and Neck Cancer. The program is designed to estimate the cost-effectiveness for all patients diagnosed nationally using US cancer statistics and to estimate economic burden of treating head and neck cancer in the US, considering lifetime treatment cost as well as the growing incidence of head and neck cancer in the future.

Learning Objectives:

• Lifetime cost per patient
• National annual cost of head and neck cancer management
• If there are cost differences, then national expenditure of treating patients using Proton therapy compared to IMRT
• Incremental cost-effectiveness ratio (ICERs) to identify valuable treatment
• ICERs specific to patient characteristics to evaluate whether the cost-effective strategy shifts
• Model will be validated through cross validation with by comparing with the model of the HPV-positive oropharyngeal cancer natural history and disease burden, and independent validation with empirical data sources.

Mentor Matching:
This position reports to Steven Frank, M.D. We will match the candidate with the appropriate co-mentoring team of faculty with the relevant expertise for the proposed post-doctor.

Dates or Training Schedule:
04/01/2020- 04/01/2021 

Req #: 600661-0009
Job Title:  Postdoctoral Fellow
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Postdoctoral position is available immediately in the area of cancer immunology and translational research. The laboratory seeks to identify novel agents and targets to enhance immune responses with cancer therapies and translate those findings to the clinic in ongoing clinical trials. We are interested in studying immunologic mechanisms that confer response through targeting dendritic cell and lymphocyte activation using various in vitro and in vivo tumor models.

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. The candidate should have proven scholarship in publications and presentations at major meetings in immunology, preferably cancer immunology.

Mentor Matching:
This position reports to Steven H. Lin

Dates or Training Schedule:
Available immediately, 3 years at the minimum

Additional Application Information:
We seek applicants who are self-motivated and career-oriented who ultimately would want to become independent group leaders in the United States and other countries. The research environment at MD Anderson is outstanding and nurturing, especially for applicants who are interested in immunology, cancer biology and translational collaborations.

Req #: 600662-0003
Job Title:  Postdoctoral Fellow
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A postdoctoral position is immediately available in the Departments of Experimental Radiation Oncology and Radiation Physics to perform research in radiation induced immune activation. In particular, the postdoctoral fellow will be responsible for examining the use of different types of radiation, including photons and photons, in combination with DNA repair defects and immunotherapy to induce a systemic anti-tumor immune response.

Learning Objectives:
To understand how radiation in combination with DNA repair defects, DNA repair inhibiting drugs, and immunotherapy can activate a systemic anti-tumor immune response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.

Eligibility Requirements:
Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, immunology, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with immunology, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.

Dates of Training Schedule:
Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Mentor Matching:

The postdoctoral fellow will be mentored by Simona Shaitelman, M.D., and Gabriel Sawakuchi, Ph.D. to identify combination strategies to activate anti-tumor systemic responses.

Additional application information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.

Req #: 600662-0001
Job Title:  Postdoctoral Fellow       
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A postdoctoral position is immediately available in the Departments of Radiation Physics and Experimental Radiation Oncology to perform research in genomic biomarkers of radiation response. In particular, the postdoctoral fellow will be responsible for developing a bioinformatics pipeline to analyze cancer cell line and patient data from treatments with photon and proton therapies.

Learning Objectives:

To understand genomic biomarkers of radiation response. The postdoctoral fellow will learn concepts of radiotherapy, genomic biomarkers of radiation response, DNA repair, bioinformatics techniques and wet lab techniques.

Eligibility Requirements:

Ideal candidates should have finished their Ph.D. and/or M.D. degrees in radiobiology, bioinformatics, biology, biochemistry, biomedical sciences, bioinformatics or similar research fields. Experience working with bioinformatics, radiobiology or small animal manipulation is important. Good verbal and written communication skills are also important. The individuals are expected to work within a large group of motivated interdisciplinary researchers.

Dates or Training Schedule:

Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Mentor Matching:
The postdoctoral fellow will be mentored by Gabriel Sawakuchi, Ph.D. and Simona Shaitelman, M.D., to identify genomic biomarkers of radiation response.

Dates or Training Schedule:

Positon is immediately available. MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Additional Application Information:
Visit Dr. Sawakuchi and Shaitelman's webpage for more information about their lab and research.

Req #: 600662-0002
Job Title:  Postdoctoral Fellow       
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in application of Case-Based Reasoning to Radiation Therapy Treatment planning.

Learning Objectives:
The learning objectives are to evaluate the efficacy and application of Case Based Reasoning approach to Radiation Therapy treatment planning and to explore its limitations and strength.

Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics and/or Computer Science

Mentor Matching:
This position reports to Mohammad R. Salehpour, Ph.D.

Additional Application Information:
Desired experiences: Radiation Treatment Planning, Python and C++, Artificial Intelligence and Fuzzy Logic programming

Req #: 600662-0004
Job Title:  Postdoctoral Fellow
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Learning Objectives:
The learning objectives are to develop and evaluate the performance of a novel automated treatment planning solution for a new treatment unit.

Eligibility Requirements:
Ph.D. degree in the following areas: Medical Physics or Nuclear Engineering

Mentor Matching:
The position reports to Laurence Court, Ph.D., and Carlos Cardenas, Ph.D.

Additional application information:
Desired experiences: Radiation Treatment Planning, Python, and Artificial Intelligence.

Req #: 600662-0005
Job Title:  Postdoctoral Fellow
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A postdoctoral fellowship position is immediately available in the department of Radiation Physics to conduct research in Radiation transport and X-ray diffraction as applied to Radiation Therapy. The successful applicant will join a team of highly accomplished scientists to assist with computer simulation code development for the design and implementation of a novel radiation therapy delivery system.

Learning Objectives:
The learning objective of this fellowship is to evaluate the efficacy of focusing x-ray radiations using metallic crystals and further study its usability in treatment of cancerous tumors.

Eligibility Requirements:
The ideal candidate should have a PhD in physics and have experience in performing radiation transport calculations using Monte Carlo techniques. In addition he/she should have proven working knowledge of multiphysics simulation software and CAD systems, and be well versed in calculational methods of X-Ray diffractions.

Mentor Matching:
The postdoctoral position reports to Mohammad Salehpour, Ph.D.

Req #: 600377-00001
Job Title:  Postdoctoral Fellow
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The Rezvani laboratory broadly focuses on the role of natural killer (NK) cells in mediating protection against hematologic malignancies and solid tumors and strategies to enhance killing function against various cancer.

Learning Objectives:

• Comprehensive analysis of NK cells and their receptors in cancer following hematopoietic stem cell transplantation using mass cytometry (CyTOF) and transcriptomic profiling.
• Engineering NK cells to express chimeric antigen receptor (CAR) and cytokine genes to enhance their effector function and persistence.
• Understanding mechanisms of NK immune evasion and using gene editing tools to target checkpoints to enhance NK effector function.
• Enhancing T cell function against viruses and cancer antigens using CARs and gene editing tools such as CRISPR.
  

Eligibility Requirements:
An individual holding a recent Ph.D. or equivalent doctorate who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research in preparation for independent research/academic career.

Dates or Training Schedule:
MD Anderson postdoctoral appointment policy limits an individual to no more than five years in the postdoctoral title at MD Anderson, or a total of six years in postdoctoral appointments at any combination of institutions.

Mentor Matching:
This position reports to Katy Rezvani, M.D., Ph.D.

Req #: 600377-00001
Job Title:  Postdoctoral Fellow
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The University of Texas MD Anderson Cancer Center invites applications for a postdoctoral fellowship available in the laboratory of Drs. Lee Ellis and Rajat Bhattacharya at the University of Texas MD Anderson Cancer Center. This is a full hands-on laboratory postresearch position in the Department of Surgical Oncology. Applicants must have a recent Ph.D. and/or M.D. with focused research on the relevant subjects. The successful candidate will have a track record of productivity in research and have the training, talent and dedication to take advantage of the vast resources.

Learning Objectives:
We are seeking highly motivated and interactive colleagues with training in basic science/translational research and are interested in applying their knowledge and skill sets to cell signaling, genomic and proteomic analyses, high throughput drug screening technologies, and in vivo tumor modeling.

Eligibility Requirements:
Interested candidates should send a CV with 3 references and a one-page proposal of research interests, activities, and career goals.

Training Schedule:
March 3, 2020 - April 30, 2021

Mentor Matching:
The postdoctoral position reports to Rajat Bhattacharya, M.D.

Req #: 600659-0002
Job Title:  Postdoctoral Fellow
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We are searching for a post-doctoral researcher to join the MD Anderson Center for Integrated Systems for Patient-Reported Data in Cancer Care. The mission of the Center is to enhance cancer care and research by engineering, implementing, and evaluating computational tools to assess and report patient data. Concretely, the Center aims to solve two related problems. Firstly, that patient reported-outcomes are useful but are not routinely used in cancer care; and secondly, that the quality of patient-reported data could be dramatically improved by leveraging modern technologies, including psychometrics and machine learning.

The successful applicant will have the opportunities to use both their problem-solving skills to help enhance patient-reported outcomes in routine clinical care and their analytical skills to create new data-driven discoveries from patient data.

ESSENTIAL FUNCTIONS
Research Activity
Statistical programming using R (primarily}, Python, SAS, or STATA (occasionally}. Data preparation, cleaning, and manipulation with R (e.g., TidyVerse).
Self-directed learning of new programming or statistical techniques (e.g., using stackoverflow).
Expert knowledge and nascent history of publication in either psychometrics, computational social science, or machine
Developing proposals for grant-funded research. Developing research protocols and IRB submissions. Present results in departmental meetings.
Engage with collaborators at MD Anderson and around the world. Present work at international and national meetings.
Lead the preparation, submission, and revision of manuscripts for publication.
 

Learning Objectives:
Applicants will be supported to develop new skills in strategic areas relating to patient-reported data. They will develop technical skills in data science, statistics, and machine learning. Full support will be given to the candidate to develop a strong academic career.

Eligibility Requirements:
Doctoral degree in which they have gained demonstrable experience with techniques relevant to the INSPiRED Cancer Care mission which may include any combination of data science and machine learning, psychometrics, epidemiology, or computational linguistics.

Applicants will be comfortable working with R and RStudio and will be motivated to constantly develop their skills with self-directed training. Frequent one-to-one supervision will be available for technical aspects of work as well as early-career strategy and planning.

Mentor Matching:
The position reports to Christopher Gibbons, Ph.D.

Req #: 600659-0003
Job Title:  Postdoctoral Fellow
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The Laboratories of Neuroimmunology consist of the research teams of five collaborating Principal Investigators who aim at understanding chronic pain, cognitive deficits and fatigue in response to cancer treatment.

We are seeking an enthusiastic Postdoctoral Researcher to study how Fe gamma antibody receptors activate astrocytes and the consequences of this new activation pathway for neuropathic pain. Investigations will be performed using primary astrocytes in vitro and rat models of neuropathic pain. Experience in working with rodents and a background in pain or immunology is preferred. The position is funded by a Department of Defense grant and is available immediately. We highly value innovation, learning. hard work, creativity and an interactive, respectful and fun atmosphere. The post-doctoral fellow will work under direct supervision of the principal investigator on this Department of Defense-funded project.

If you are interested in helping to understand the molecular and cellular mechanisms of pain and developing novel interventions to help improve the quality of life for people suffering from chronic pain in an internationally-renowned, well-funded group of scientists using a highly integrated and interdisciplinary approach in the number one cancer center in the USA, we are the perfect environment for you! 

ESSENTIAL FUNCTIONS

Research Activity

• Primary astrocyte isolations and culture 
• Live cell imaging 
• Luciferase assays and immunoassays 
• CRISPR/Cas9 gene editing in vitro and in vivo 
• Nerve injury surgery 
• lntrathecal drug treatments in vivo 
• Behavioral assays of pain in rats 
• Collect and process ex vivo biological samples including brain and spinal cord lmmunohistochemistry and microscopy studies on cells and nervous system tissues
• Western blotting and qPCR 
• Present results in departmental and national meetings 
• Prepare and write manuscripts for publication.

.lnterpersonal Skills, Communication, Learning Skills

• Strong written and oral communication skills, Good problem-solving abilities 
• Communication with faculty and staff within and outside the laboratory, Ability to work with others in a highly collaborative manner.

Other

• Responsible for monitoring laboratory equipment and implementing safety procedures. 
• Strong interest in basic and translational research 
• Supervision of 1-2 research assistants

Learning Objectives:
Applicants will gain experience of preclinical research methods, with an emphasis on understanding behavioral testing in models of neuropathic pain. They will become proficient with basic biochemical techniques employed in preclinical neuroimmunology research and develop advanced skills in the organization, presentation, and analysis of data.

Eligibility Requirements:
We are looking for a post-doctoral researcher with a strong background in Molecular Neuroscience to study the molecular and cellular consequences of peripheral nerve injury in mouse models. Experience with (single cell) RNA sequencing, mass cytometry, molecular cloning techniques, biochemistry, cell culture, confocal microscopy, and rodent behavior would be of great value for the research. 

Mentor Matching:
The position reports to Peter Grace, Ph.D.

Req #: 600659-0004
Job Title:  Postdoctoral Fellow
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A position is open for a post-doctoral researcher with a strong background in neuroscience to join the Neuroimmunology lab at MD Anderson Cancer Center. Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project will study the ability of immune system-targeted nanotherapies to alleviate pain in rodent models of neuropathy. Experience working with rodents and a background in neuroscience, pain research and/or immunology is preferred. The position is available July 1, 2020.

Research Activity:

• lmmunohistochemistry and microscopy studies on nervous system and other tissues. Behavioral assays of physical activity and pain in mice.
• Work with genetically modified mice.
• Live-cell imaging of neuronal/immune cell physiology.
• Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues.
• Perform pharmacological manipulations in vivo. Prepare and write manuscripts for publication.
  
  

Learning Objectives:
Applicants should have some experience with some of these techniques, but training will be provided in immunohistochemistry and microscopy studies on nervous system and other tissues, behavioral assays of physical activity and pain in mice and rats, live-cell imaging of neuronal/immune cell physiology, and preparing and writing manuscripts for publication.

Applicants will become proficient with biochemical techniques and develop advanced skills in the organization, presentation, and analysis of data.

Eligibility Requirements:
Applicants should hold (or soon receive) a Ph.D. in Neuroscience or a related discipline. Experience with rodent behavioral testing is preferred but not required. Successful applicants should be highly self-motivated, have outstanding experimental skills, and be able to think independently but also work well in a team.

Mentor Matching:
The position reports to Dr. Andrew Shepherd.

Additional Application Information:
3 letters of Recommendation needed.

Req #: 600659-0005
Job Title:  Postdoctoral Fellow
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A position is open for a post-doctoral researcher with a strong background in behavioral neuroscience and neuroimmunology to join the Neuroimmunology lab at MD Anderson Cancer Center. Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project will study the role of inflammation and mitochondrial dysfunction in depression and fatigue using animal models of inflammation and cancer. Experience working with rodents and a background in neuroscience, behavior and neuroimmunology is preferred. The position is available May 1, 2020.

Research Activity:

• lmmunohistochemistry and microscopy studies on brain and other tissues.
• Behavioral assays of fatigue and motivated behavior.
• Work with genetically modified mice.
• Live-cell imaging of neuronal/immune cell physiology.
• Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues.
• Perform pharmacological manipulations in vivo.
• Prepare and write manuscripts for publication.

Learning Objectives:
Applicants should have some experience with neurobehavioral studies in mice, but training will be provided in immunohistochemistry and microscopy studies on nervous system and other tissues, live-cell imaging of neuronal/ immune cell physiology, and preparing and writing manuscripts for publication.

Applicants will become proficient with advanced molecular and cellular biology techniques and develop skills in the organization, presentation, and analysis of data.

Eligibility Requirements:
Applicants should hold (or soon receive) a Ph.D. in Behavioral Neuroscience or a related discipline. Experience with rodent behavioral testing is required. Successful applicants should be highly self-motivated, have outstanding experimental skills, and be able to think independently but also work well in a team.

Mentor Matching:
The position reports to Dr. Robert Dantzer.

Req #: 600657 - 0001
Job Title:  Postdoctoral Fellow
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A postdoctoral position is available to study novel therapeutic targets and molecular mechanisms associated with therapeutic resistance in small cell lung cancer (SCLC) in the laboratory of Lauren Averett Byers, M.D. at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested using high-throughput proteomic screening to discover and validate potential drug targets and biomarkers of therapeutic resistance in SCLC. Qualified applicants are encouraged to apply and provide three professional references.

JOB KNOWLEDGE AND SKILLS: 

• Enthusiastic, highly self-motivated candidate, with the ability to function independently and as part of an interactive team
• A strong background in cell signaling, molecular biology, and immunology/immunotherapy.
• Experience in flow cytometry is preferred
• Dedication to basic research, a true “drive”, is important
• Prior experience with studies involving mice is preferred
• Command of written and spoken English language

Eligibility Requirements:
Applications are invited from qualified individuals, interested in working in a translational research lab, with a Ph.D. and/or M.D.. Preferred candidate should have less than 2 years of prior postdoctoral experience with background in cancer biology, biochemistry, cell biology, or molecular biology and be highly motivated to pursue a career in biomedical research.

Mentor Matching:
This position reports to Lauren A. Byers, M.D.

Req #: 600657-0002
Job Title:  Postdoctoral Fellow
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Learning Objectives:

• Planning and development of experimental studies testing novel immune-based therapies (T cell therapies and/or immune checkpoint inhibitors administered alone or in combination with other cancer therapies) in preclinical murine models of lung cancer.
• Analysis and interpretation of the results of in vivo and in vitro experimental studies using murine models of lung cancer and lung cancer cell lines, respectively.
• Integration of findings of experimental studies into multiple peer reviewed manuscripts as first and author and as co-author in collaboration with other trainees/collaborators.

Eligibility Requirements:
Qualified postdoctoral candidates should hold a doctorate degree and have strong background training in one or more of the following areas: biochemistry, molecular biology, cell biology, cancer biology, tumor immunology and cancer immunotherapy. Experience with murine models of cancer and an ability to analyze data derived from in vivo studies is strongly preferred. Expertise in performing flow cytometry on tissue-derived cell suspensions (human and murine tumor tissues), analyzing independently and interpreting data from flow cytometry studies is highly desired. Expertise in any of the following fields is advantageous: oncogenic signaling pathways, biomarkers of response and resistance to cancer therapies (targeted therapies, antiangiogenic therapies and immune-based therapies), cancer metabolism, and immuno-genomics. Highly motivated postdoctoral fellows who are self-starters and have critical thinking ability are encouraged to apply. Candidates should have good technical skills a strong work ethic and excellent organizational and communication skills.

Dates of Training Schedule:
Expected starting date: 1/2020
Expected training time: 3 to 5 years

Mentor Matching:
This position reports to Tina Cascone, M.D., Ph.D.

Req #: 600657 - 0003
Job Title:  Postdoctoral Fellow
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A postdoctoral position is available in Dr. Jonathan Kurie's laboratory, which studies mechanisms of lung cancer metastasis. The focus is on how genetic and biochemical changes alter the proliferative and invasive behaviors of lung cancer cells and how lung cancer cells alter the behaviors of other cell types that facilitate lung cancer progression.

Learning Objectives:
The position is designed to teach trainees the methods of characterizing the genetic, biochemical and biological properties of lung cancer cells and of modifying lung cancer cells to test the roles of specific genes in the metastatic process. In addition, training is provided to characterize cells in thetumor microenvironment.

Eligibility Requirements:
Individuals who have completed a Ph.D. and have training relevant to the position are eligible.

Dates or Training Schedule:
The position is immediately available. Trainee will be expected to work at least 40 hours per week.

Mentor Matching:
This position reports to Jonathan Kurie, M.D.

Req #: 149100-004
Job Title:  Postdoctoral Fellow       
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Despite recent advances in immunotherapy, lung adenocarcinoma remains the leading cause of death in smokers. A significant fraction of lung adenocarcinomas display somatic activating mutations in the KRAS oncogene. KRAS-mutant lung adenocarcinoma, compared to other solid tumors, displays very poor clinical outcomes. Despite the overwhelming public health burden of KRAS-mutant lung adenocarcinoma, there are very few, if any, strategies for early treatment of this disease -- largely due to a very poor understanding of molecular changes that drive its initiation and development. One of our laboratory's goals is to delineate early immune events in the transition of smoking-exposed normal airway to KRAS-mutant lung adenocarcinoma. Understanding these changes may pave for the development of new prevention (immune-based) strategies for KRAS-mutant lung cancer. Our laboratory is looking for a postdoctoral fellow to embark on different vignettes in the immune evolution of KRAS-mutant lung cancer including understanding the dynamic interplay between host defense (including immunomodulatory) responses, tumor-initiating inflammation and microbiome dysbiosis (local and systemic) in the development of the malignancy. There will be opportune elements for the candidate postdoctoral fellow at MD Anderson Cancer Center to collaborate with physician and physician-scientists to gain translational insights from laboratory-based findings. We are seeking a postdoctoral fellow whose motivation and ambition matches these exciting and timely projects. The postdoctoral fellow must have abundant experience in immunology, oncoimmunology, cancer biology and molecular biology. Technically, the candidate postdoctoral fellow must have abundant/adequate experience in animal modeling and work, flow cytometry, immunohistochemistry/cytochemistry, cell culture as well as basic molecular and cellular biology techniques. Experience in microbial (in vivo) research and genomics is a plus. The candidate postdoctoral fellow is also required to display good to excellent communication skills in English (written and oral) as well as showcase a spirit for teamwork.

Learning Objectives:

-Learn uncharted cues and pathways in the inception and development of KRAS-mutant lung cancer (which will likely be applicable to other subtypes of lung cancer or other solid tumors).
-Learn individual roles of immune and epithelial cell subsets and functional states/phenotypes in the development of KRAS-mutant lung adenocarcinoma.
-Develop a skill for collaboration and translation of laboratory-based findings (e.g., development of markers for outcome and response).
-Acquire skills for progression in academia including but not limited to delivering presentations, writing manuscripts and applying for grants/fellowships.

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) 

Training Scheduled: 
July 2020 - July 2021, renewed annually

Mentor Matching:
This position reports to Dr. Humam Kadara.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-005
Job Title:  Postdoctoral Fellow       
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Looking for highly motivated and talented pathologist fellow who is interested in making a difference against breast cancer and the other tumors and improving the lives of patients. The long-term goal of our laboratory is to elucidate the molecular mechanism in the pathogenesis and progression of breast cancer and identifying molecular markers related with tumor development, progression, and metastasis in breast cancer and the other solid tumors. Our laboratory has focused on molecular immune-profiling research on the tumor microenvironment of breast cancer by IHC, multiplex IF, RNAscope etc and pursuing prognostic and predictive molecular biomarkers for chemo and target and immune therapies in breast cancer. This lab in TMP is combined with Department of Investigation Cancer therapeutics providing biomarker assessment on longitudinal biopsy tissues for phase I clinical trials supported by strategic alliances and PI initiated studies. The broad areas of research in the Dr. Yang laboratory can be summarized as follows:

• Identifying new molecular targets, validating biomarkers for targeted therapy and immunotherapy
• Molecular pathology research on tumor microenvironment
• Translational tissue biomarker study in Phase I/II clinic trials of multiple solid tumors
  
  

Learning Objectives:

To learn aspects of breast cancer research undertaken in a hospital/research institute
To learn how to perform digital pathology analysis on IHC, multiplex IF, and RNAScope etc.
To understand how studies done in laboratories can have an impact on patient care in the future
The trainee will To how to perform basic statistical analysis on path data
The trainee along with the mentor will present his data in lab meetings.
The trainee will participate in departmental education activities in particular those offered by ITERT

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Mentor Matching:
This position reports to Dr. Fei Yang.

Additional application information:
Visit the Translational Molecular Pathology page for more information.

Req #: 149100-006
Job Title:  Postdoctoral Fellow       
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A postdoc will learn the techniques for assessing the role of an oncogene in cancer, specifically the gene encoding S6K1. An inhibitor for S6K1 or the upstream protein MEK will be tested in vitro, with or without knockout of the gene.

Learning Objectives:

This will entail CRISPR editing of cell lines, western blotting, and drug assays in vitro. Postdoc will also be expected to learn to write up the results for weekly meetings and to contribute writing to the eventual manuscript.

Eligibility Requirements:
An individual holding a recent (within three years) Ph.D. or equivalent doctorate (e.g., Sc.D., M.D., D.V.M.) in an appropriate field who is seeking a temporary appointment, under the supervision of a faculty mentor, involving full-time laboratory-based research or scholarship in preparation for an academic or research career as an independent investigator. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

Dates or Training Schedule:
December 2020 - June 2021

Mentor Matching:
This position reports to Dr. Larry Kwong

Additional application information:
Visit the Translational Molecular Pathology page for more information.