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Genetics & Cancer

Genetics & Cancer

Genes are microscopic structures that determine the hereditary characteristics of every living thing, from eye color to body type. About 5% to 10% of cancers are caused by variations or mutations in certain genes. Many of these genetic variations are inherited, meaning the increased risk for specific types of cancer is passed from parents to children. Cancer researchers have identified a number of inherited gene mutations that are known to cause cancer. For example, women with a specific mutation of the BRCA1 gene are much more likely to develop breast cancer than the general population, and their daughters and sisters may also face the same increased risk.

For people with a family history of cancer, genetic testing can help assess their individual risk. Counseling is an important part of the genetic testing process. A genetic counselor can evaluate your personal and family history to determine if it merits testing for hereditary cancers. The counselor can also discuss the risks, benefits and limitations of genetic testing, and help develop preventive strategies.

Patient Power: Genetics & Cancer (1:05:04)
Approximately 5-10% of cancers are hereditary. Learn about genetic counseling and testing, as well as the identified genetic connections to cancer. (October 2007)
D
ownload  /  Listen  /  Transcript (pdf)

Treatment at M. D. Anderson

Request an Appointment
To schedule a genetics consultation, call Clinical Cancer Genetics at 713-745-7391.

Clinical Trials
Learn about our open genetics clinical trials by searching our online database.

Hereditary Cancer Syndromes

There are many inherited genetic syndromes that significantly raise the risk of cancer in individuals and families who have them. M. D. Anderson provides genetic counseling, genetic testing and medical management for hereditary syndromes and the types of cancer associated with them:

Cowden Syndrome (pdf)

  • Thyroid cancer
  • Breast cancer
  • Uterine (endometrial) cancer

Familial Adenomatous Polyposis (Gardner's Syndrome) (pdf)

  • Colorectal cancer

Hereditary Breast & Ovarian Cancer (HBOC)

  • Breast cancer
  • Ovarian cancer

Li-Fraumeni Syndrome (pdf)

  • Brain tumors
  • Breast cancer
  • Soft tissue sarcomas
  • Osteosarcomas

Lynch Syndrome (Hereditary non-Polyposis Colorectal Cancer)

  • Colorectal cancer
  • Uterine (endometrial) cancer
  • Ovarian cancer

Multiple Endocrine Neoplasias

Neurofibromatosis

Von Hippel Lindau Disease

News & Articles

Gene-Environment Interactions

Gene Expression May Soon Guide Breast Cancer Treatment

Worldwide Study Looks at Inherited Brain Tumors

Cytogenetics: Major Insights from Microscopic Details

Diet, Genetics Linked to Bladder Cancer

Genetic Testing: To Test or Not to Test



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Links & Resources

NOTE: Pages will open in a new browser window. M. D. Anderson does not endorse external sites.

National Cancer Institute - general cancer genetics information.

GeneTests - a public resource funded by the National Institutes of Health.

Cancer Information Service
1-800-4-CANCER

Talk with a health information specialist to learn more about a particular type of cancer, treatment options and community resources.

   

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