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Neurofibromatosis Q&A

CCH Newsletter - Summer 2011


Many people have heard of the genetic condition neurofibromatosis, but few can explain what this is.

It is common, yet baffling: occurring in about one in 2,500 live births, but with symptoms that vary from minimal to profound and debilitating. And it’s worthy of study, say cancer and genetic experts, because the DNA mutations that cause its three types may yield crucial information about how cancer develops — and new approaches to cancer treatment.

John Slopis, M.D., associate professor in the Department of Neuro-Oncology and medical director of the Neurofibromatosis Program at MD Anderson, explains the basics of the disease.

What is neurofibromatosis?

Neurofibromatosis is a name given to three different genetic conditions: neurofibromatosis 1, neurofibromatosis 2 and multiple schwannomatosis. These conditions are all called neurofibromatosis or NF because they all cause tumors to grow on nerves.

Neurofibromatosis 1 causes a variety of problems: tumors of the nerves from the spine to any extremity, including the skin; tumors of nerves in some organs and tumors of the optic nerves (from the eyes to the brain). NF 1 is also associated with other complications, including bone tumors, spinal scoliosis, high blood pressure, short stature (limited growth in children), brain tumors and learning disabilities.

The genetic mutation is found on chromosome 17 and is inherited from either mom or dad. In half of the cases, the person with NF 1 will be the first person in the family, but can then pass on the gene for NF 1 to his or her children. People with NF 1 have a great variety of different patterns of symptoms.

What about NF 2?

Neurofibromatosis type 2 is also genetic, passed down in the same pattern as NF 1, but the genetic mutation is on a different chromosome — chromosome 22. The disorder is quite different from NF 1.

In NF 2, tumors grow on any nerve from the spine or brainstem. The disorder is diagnosed clinically by loss of hearing or dizziness in the patient due to growth of tumors on the acoustic nerves (these are called 8th nerve schwannomas).

Tumors can grow on other structures in the spinal cord (these are called ependymomas) or on the bone of the skull (these are called meningiomas). Tumors of the spine can be very serious. Most people with NF 2 have very similar patterns of problems. NF 2 does not cause the other complications seen in NF 1.

And the third type of neurofibromatosis?

It’s called multiple schwannomatosis. It looks a lot like NF 2, but tumors of the nerves never occur in the brain or brain stem or anywhere above the neck. We know there is one gene mutation that causes it in about a third of cases — this gene mutation is called INI-1, and it was only recently discovered. The other two-thirds of cases must be caused by gene mutations, but these have not yet been identified. This condition is best known because it causes patients to experience a great deal of nerve-related pain.

What is the connection with cancer or cancer treatment?  

Most of the tumors of NF are benign tumors that grow slowly and do not become malignant. This means that these tumors are a lot like normal tissue, but when they grow in the wrong place, the mass of the tumor causes problems, like pressure on the nerves to the ear or eye, spinal cord, brain stem or brain. Sometimes the tumors cause pain. Only NF 1 tumors are known to transform into malignant cancers called malignant peripheral nerve sheath tumors. These are very serious cancers.

The connection with cancer is that many (if not most) cancers result from mutations of normal DNA. If we can work out the way a mutation changes the growth of a normal tissue into a tumor or cancer, we can find clues to help cure it.

What types of research are you conducting in the MD Anderson Neurofibromatosis Clinic?

We’re evaluating the use of positive emission tomography/computed tomography imaging, both of which provide three-dimensional images of functional processes in the body, to identify tumors in the early stages of malignant transformation.

There’s also clinical research, like our ongoing collaboration with oncologists at Johns Hopkins Hospital to determine how radical surgery must be to achieve optimal tumor control for malignant peripheral sheath tumors.

We’re working on whole-gene sequencing of the NF 1 gene to identify specific mutations that predict the development of malignancy in a given patient with NF.

And we’re attempting to characterize the tumor genetics and signaling mechanisms of NF 1 and NF 2 in hopes of discovering more targeted systemic therapies, which home in on the condition’s distinct biological pathways.


© 2014 The University of Texas MD Anderson Cancer Center