Research Publications

Visit PubMed for links to full text versions of published pediatric research from faculty at the Children's Cancer Hospital at M. D. Anderson.

2008

Stromal cell-derived factor-1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor. Reddy K, Zhou Z, Jia SF, Lee TH, Morales-Arias J, Cao Y, Kleinerman ES. Int J Cancer. 2008 Aug 15;123(4):831-7.

Central neurocytoma responsive to topotecan, ifosfamide, carboplatin. Amini E, Roffidal T, Lee A, Fuller GN, Mahajan A, Ketonen L, Kobrinsky N, Cairo MS, Wells RJ, Wolff JE. Pediatr Blood Cancer. 2008 Jul;51(1):137-40.

All-trans-retinoic acid and arsenic trioxide as initial therapy for acute promyelocytic leukemia. Quezada G, Kopp L, Estey E, Wells RJ. Pediatr Blood Cancer. 2008 Jul;51(1):133-5.

Topotecan enhances immune clearance of gliomas. Wei J, Deangulo G, Sun W, Hussain SF, Vasquez H, Jordan J, Weinberg J, Wolff J, Koshkina N, Heimberger AB. Cancer Immunol Immunother. 2008 Jul 2.

A novel von Hippel-Lindau point mutation presents as apparently sporadic pheochromocytoma. Rich TA, Jonasch E, Matin S, Waguespack SG, Gombos DS, Santarpia L, Stolle C, Jimenez C. Cancer Invest. 2008 Jul;26(6):642-6.

Bone Marrow Subsets Differentiate into Endothelial Cells and Pericytes Contributing to Ewing's Tumor Vessels. Reddy K, Zhou Z, Schadler K, Jia SF, Kleinerman ES. Mol Cancer Res. 2008 Jun;6(6):929-36.

Primary renal sarcomas in the Intergroup Rhabdomyosarcoma Study Group (IRSG) experience, 1972-2005: A report from the Children's Oncology Group. Raney B, Anderson J, Arndt C, Crist W, Maurer H, Qualman S, Wharam M, Wiener E, Meyer W; For the Soft‐Tissue Sarcoma Committee of The Children's Oncology Group, Arcadia, CA. Pediatr Blood Cancer. 2008 Jun 3;51(3):339-343.

Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Gao S, Mobley A, Miller C, Boklan J, Chandra J. Leuk Res. 2008 May;32(5):771-80.

Critical role of notch signaling in osteosarcoma invasion and metastasis. Zhang P, Yang Y, Zweidler-McKay PA, Hughes DP.Clin Cancer Res. 2008 May 15;14(10):2962-9.

Quality of death in children: where is it higher--at home or in the hospital? Wolff J, Wolff B. Pediatr Blood Cancer. 2008 May;50(5):945-6.

Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients. Wolff JE, Berrak S, Koontz Webb SE, Zhang M. J Neurooncol. 2008 May;88(1):57-63.

Multimodality treatment of osteosarcoma: radiation in a high-risk cohort. Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P. Pediatr Blood Cancer. 2008 May;50(5):976-82.

Shrinkage of germinoma by dexamethasone only. Masoudi A, Amini E, Wolff JE, Fuller GN, Ketonen L, Mahajan A. Pediatr Blood Cancer. 2008 May;50(5):1079.

Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme. De Vleeschouwer S, Fieuws S, Rutkowski S, Van Calenbergh F, Van Loon J, Goffin J, Sciot R, Wilms G, Demaerel P, Warmuth-Metz M, Soerensen N, Wolff JE, Wagner S, Kaempgen E, Van Gool SW. Clin Cancer Res. 2008 May 15;14(10):3098-104.

Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Aplenc R, Alonzo TA, Gerbing RB, Lange BJ, Hurwitz CA, Wells RJ, Bernstein I, Buckley P, Krimmel K, Smith FO, Sievers EL, Arceci RJ; Children's Oncology Group. J Clin Oncol. 2008 May 10;26(14):2390-3295.

The impact of surgical excision in chest wall rhabdomyosarcoma: a report from the Children's Oncology Group. Hayes-Jordan A, Stoner JA, Anderson JR, Rodeberg D, Weiner G, Meyer WH, Hawkins DS, Arndt CA, Paidas C; Children's Oncology Group. J Pediatr Surg. 2008 May;43(5):831-6.

Results of treatment of patients with superficial facial rhabdomyosarcomas on protocols of the Intergroup Rhabdomyosarcoma Study Group (IRSG), 1984-1997. Raney RB, Chintagumpala M, Anderson J, Pappo A, Qualman S, Wharam M, Wiener E, Meyer W; Soft-Tissue Sarcoma Committee of the Children's Oncology Group, Arcadia, California. Pediatr Blood Cancer. 2008 May;50(5):958-64.

Subpopulations of malignant gliomas in pediatric patients: analysis of the HIT-GBM database. Wolff JE, Classen CF, Wagner S, Kortmann RD, Palla SL, Pietsch T, Kühl J, Gnekow A, Kramm CM. J Neurooncol. 2008 Apr;87(2):155-64.

Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Singh H, Manuri PR, Olivares S, Dara N, Dawson MJ, Huls H, Hackett PB, Kohn DB, Shpall EJ, Champlin RE, Cooper LJ. Cancer Res. 2008 Apr 15;68(8):2961-71.

Advances in hemophilia: experimental aspects and therapy. Rodriguez NI, Hoots WK. Pediatr Clin North Am. 2008 Apr;55(2):357-76, viii. Review.

VEGF(165) expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature. Reddy K, Cao Y, Zhou Z, Yu L, Jia SF, Kleinerman ES. Angiogenesis. 2008 Mar 16.

BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J. Blood. 2008 Mar 1;111(5):2904-8.

Outcomes of a two-drug chemotherapy regimen for intraocular retinoblastoma. Zage PE, Reitman AJ, Seshadri R, Weinstein JL, Mets MB, Zeid JL, Greenwald MJ, Strauss LC, Goldman S. Pediatr Blood Cancer. 2008 Mar;50(3):567-72.

Platelet-derived growth factor receptor expression and amplification in choroidplexus carcinomas. Nupponen NN, Paulsson J, Jeibmann A, Wrede B, Tanner M, Wolff JE, Paulus W,Ostman A, Hasselblatt M. Mod Pathol. 2008 Mar;21(3):265-70.

The ABCs of infant leukemia. Zweidler-McKay PA, Hilden JM. Curr Probl Pediatr Adolesc Health Care. 2008 Mar;38(3):78-94. Review.

Recent advances in thyroid cancer. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Curr Probl Surg. 2008 Mar;45(3):156-250.

EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH. Lee DA, Tatevian N, Herring RA, McClain KL. Pediatr Blood Cancer. 2008 Mar;50:728-730.

Music therapy in a comprehensive cancer center. Richardson MM, Babiak-Vazquez AE, Frenkel MA. J Soc Integr Oncol. 2008 Spring;6(2):76-81.

Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, Ferguson WS, Gebhardt MC, Goorin AM, Harris M, Kleinerman E, Link MP, Nadel H, Nieder M, Siegal GP, Weiner MA, Wells RJ, Womer RB, Grier HE; Children's Oncology Group. J Clin Oncol. 2008 Feb 1;26(4):633-8.

Intranasal granulocyte-macrophage colony-stimulating factor reduces the aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis. Quezada G, Koshkina NV, Zweidler-McKay P, Zhou Z, Kontoyiannis DP, Kleinerman ES. Antimicrob Agents Chemother. 2008 Feb;52(2):716-8.

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium. Beaudry P, Nilsson M, Rioth M, Prox D, Poon D, Xu L, Zweidler-Mckay P, Ryan A, Folkman J, Ryeom S, Heymach J. Mol Cancer Ther. 2008 Feb;7(2):418-24.

Secrecy and integrity in clinical trials. Wells RJ. J Clin Oncol. 2008 Feb 1;26(4):680-2.

Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies. De Angulo G, Yuen C, Palla SL, Anderson PM, Zweidler-McKay PA. Cancer. 2008 Jan 15;112(2):407-15.

The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells. Cao Y, Jia SF, Chakravarty G, de Crombrugghe B, Kleinerman ES. Mol Cancer Res. 2008 Jan;6(1):119-26.

Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases. Graat HC, van Beusechem VW, Schagen FH, Witlox MA, Kleinerman ES, Helder MN, Gerritsen WR, Kaspers GJ, Wuisman PI. Mol Cancer. 2008 Jan 23;7:9.

Targeting Notch signaling in autoimmune and lymphoproliferative disease. Teachey DT, Seif AE, Brown VI, Bruno M, Bunte RM, Chang YJ, Choi JK, Fish JD, Hall J, Reid GS, Ryan T, Sheen C, Zweidler-McKay P, Grupp SA. Blood. 2008 Jan 15;111(2):705-14.

Adoptive cellular immunotherapy for childhood malignancies. Cooper LJ.  Bone Marrow Transplant. 2008 Jan;41(2):183-92.

Outpatient chemotherapy plus radiotherapy in sarcomas: improving cancer control with radiosensitizing agents. Anderson P, Aguilera D, Pearson M, Woo S. Cancer Control. 2008 Jan;15(1):38-46. Review.

Failure to recognize multiple endocrine neoplasia 2B: more common than we think? Wray CJ, Rich TA, Waguespack SG, Lee JE, Perrier ND, Evans DB. Ann Surg Oncol. 2008 Jan;15(1):293-301.

Outpatient and home chemotherapy with novel local control strategies in desmoplastic small round cell tumor. Aguilera D, Hayes-Jordan A, Anderson P, Woo S, Pearson M, Green H. Sarcoma. 2008;2008:261589.

Cell therapies for traumatic brain injury. Harting MT, Baumgartner JE, Worth LL, Ewing-Cobbs L, Gee AP, Day MC, Cox CS Jr. Neurosurg Focus. 2008;24(3-4):E18. Review.

Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors. Wagner S, Peters O, Fels C, Janssen G, Liebeskind AK, Sauerbrey A, Suttorp M, Hau P, Wolff JE. J Neurooncol. 2008 Jan;86(2):175-81.

2007

Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. Koshkina NV, Kleinerman ES, Li G, Zhao CC, Wei Q, Sturgis EM. J Pediatr Hematol Oncol. 2007 Dec;29(12):815-21.

Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Komanduri KV, St John LS, de Lima M, McMannis J, Rosinski S, McNiece I, Bryan SG, Kaur I, Martin S, Wieder ED, Worth L, Cooper LJ, Petropoulos D, Molldrem JJ, Champlin RE, Shpall EJ. Blood. 2007 Dec 15;110(13):4543-51.

Low level of microsatellite instability in paediatric malignant astrocytomas. Vladimirova V, Denkhaus D, Soerensen N, Wagner S, Wolff JE, Pietsch T. Neuropathol Appl Neurobiol. 2007 Dec 5.

VEGF(165), but not VEGF(189),Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. Wrede B, Liu P, Wolff JE. J Neurooncol. 2007 Dec;85(3):345-51.

stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo. Zhou Z, Reddy K, Guan H, Kleinerman ES. Mol Cancer Res. 2007 Nov;5(11):1125-32.

Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcoma. Anderson P, Nuñez R.  Expert Rev Anticancer Ther. 2007 Nov;7(11):1517-27. Review.

Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. Das CM, Aguilera D, Vasquez H, Prasad P, Zhang M, Wolff JE, Gopalakrishnan V. J Neurooncol. 2007 Nov;85(2):159-70.

Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005. Safdar A, Rodriguez GH, De Lima MJ, Petropoulos D, Chemaly RF, Worth LL, Shpall EJ, Rolston KV, Raad II, Chan KW, Champlin RE. Medicine (Baltimore). 2007 Nov;86(6):324-33.

Chemotherapy for osteosarcoma with high-dose methotrexate is effective and outpatient therapy is now possible. Anderson P. Nat Clin Pract Oncol. 2007 Nov;4(11):624-5.

Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma. Koshkina NV, Khanna C, Mendoza A, Guan H, DeLauter L, Kleinerman ES. Mol Cancer Res. 2007 Oct;5(10):991-9.

Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: potential consequences of granulocyte-colony-stimulating factor administration. Morales-Arias J, Meyers PA, Bolontrade MF, Rodriguez N, Zhou Z, Reddy K, Chou AJ, Koshkina NV, Kleinerman ES. Cancer. 2007 Oct 1;110(7):1568-77.

C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL. Choi WT, Folsom MR, Azim MF, Meyer C, Kowarz E, Marschalek R, Timchenko NA, Naeem RC, Lee DA. Cancer Genet Cytogenet. 2007 Sep;177(2):108-14.

Malignant progression in choroid plexus papillomas. Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M. J Neurosurg. 2007 Sep;107(3 Suppl):199-202.

Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy. Zhou Z, Bolontrade MF, Reddy K, Duan X, Guan H, Yu L, Hicklin DJ, Kleinerman ES. Clin Cancer Res. 2007 Aug 15;13(16):4867-73.

Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine. Gordon N, Koshkina NV, Jia SF, Khanna C, Mendoza A, Worth LL, Kleinerman ES. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4503-10.

Continuous hyperthermic peritoneal perfusion for desmoplastic small round cell tumor. Hayes-Jordan A, Anderson P, Curley S, Herzog C, Lally KP, Green HL, Hunt K, Mansfield P. J Pediatr Surg. 2007 Aug;42(8):E29-32.

Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors. Hudson MM, Rai SN, Nunez C, Merchant TE, Marina NM, Zalamea N, Cox C, Phipps S, Pompeu R, Rosenthal D. J Clin Oncol. 2007 Aug 20;25(24):3635-43.

Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy. Zhou Z, Bolontrade MF, Reddy K, Duan X, Guan H, Yu L, Hicklin DJ, Kleinerman ES. Clin Cancer Res. 2007 Aug 15;13(16):4867-73.

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Miller CP, Ban K, Dujka ME, McConkey DJ, Munsell M, Palladino M, Chandra J. Blood. 2007 Jul 1;110(1):267-77.

Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. Huang G, Mills L, Worth LL. Mol Cancer Ther. 2007 May;6(5):1610-9.

Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Long J, Manchandia T, Ban K, Gao S, Miller C, Chandra J. Cancer Chemother Pharmacol. 2007 Mar;59(4):527-35.

Medical and non-medical barriers to outpatient treatment of fever and neutropenia in children with cancer. Quezada G, Sunderland T, Chan KW, Rolston K, Mullen CA. Pediatr Blood Cancer. 2007 Mar;48(3):273-7.

Quantifying health status outcomes in pediatric medulloblastoma patients. Wolff JE, Hüttermann U, Askins MA. Anticancer Res. 2007 Jan-Feb;27(1B):523-9.