Research in the Krahe laboratory is targeted toward the identification and characterization of the human genes and their mutations that underlie several inherited Mendelian and multi-factorial diseases, using classic genetic and molecular genetic approaches. These include neuromuscular disorders (myotonic dystrophies) as well as inherited cancers (Li-Fraumeni syndrome and its variants). The molecular classification of cancers (head and neck cancer and gliomas) through functional genomics methodologies, to identify genetic changes underlying tumor initiation, progression and metastasis is another focus. A common underlying theme is the use of the tools developed by the human genome project.