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Micro-CT

Instrument

GE Micro CT

The Explore Locus RS pre-clinical in vivo scanner (GE Medical Systems, London Ontario) is a cone-beam volume CT system which permits the live imaging of rodents.

This systems uses a tungsten source X-ray tube operating at 80 kV and 450 microamperes. The X-ray source and CCD-based detector gantry is rotated around the subject in roughly 1.0-degree increments.

Typical scans generate 46, 92 or 138 µm isotropic voxels in live animals and require 10-40 minutes for data acquisition. The scanner is capable of respiratory and cardiac gating, permitting motion-suppressed scans of the inspired lung.

Applications

The RS CT is an optimal system for longitudinal studies of tumor progression in the lung of mice, and can clearly distinguish lesions that are smaller than a half-millimeter in diameter. The assessment of bone mineral density in live animals or specimens is also possible.

With the addition of exogeneous contrast agents, the RS CT can produce images of the vasculature or of many abdominal organs, such as the kidney, spleen and liver. Geometric models (.vtk, .stl, other) can be produced by the system for applications such as finite element modeling. This instrument is also often used to facilitate registration of data from multiple modalities.

Note: All images shown were produced with 92-μm voxel size reconstructions.

Contrast-Enhanced Imaging

↓ Planar image of mouse kidneys with renal cortex and medulla distinguished. Image courtesy Dr. Dianna Cody.

Contrast-Enhanced Imaging

Respiratory-Gated Lung Imaging

↓ Axial image of a mouse lung tumor model. Image courtesy of Lin Ji.

Axial image of a mouse lung tumor model

↓ Coronal image of a mouse lung tumor model, with vasculature enhancement (Fenestra contrast agent). Image courtesy of Dr. Jonathan Kurie.

Coronal image of a mouse lung tumor model

Evaluation of Disease Extent

↓ 3D rendering of lung with tumor from respiratory-gated acquisition. Image courtesy of Dr. Jonathan Kurie.

 Evaluation of Disease Extent

Contrast-Enhanced Imaging

↓ Mouse liver and vasculature, enhanced by Fenestra contrast agent. Image courtesy of Dr. Dianna Cody.

Contrast-Enhanced Imaging

High-Resolution Bone Imaging

↓ 3D rendering of an achondroplastic mouse skull. Image courtesy of Dr. Jackie Duke.

3D rendering of an achondroplastic mouse skull


© 2014 The University of Texas MD Anderson Cancer Center