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Publications

Tahiri F, Li Y, Hawke D, Ganiko L, Almeida I, Levery S, Zhou D.  Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology.  J Carbohydr Chem. 2013 Jan 1;32(1):44-67. Epub 2013 Jan 11. PMID: 23378701

Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, Ellis LM.  Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1. Cancer Cell. 2013 Feb 11;23(2):171-85. doi: 10.1016/j.ccr.2012.12.021. Epub 2013 Jan 31. PMID: 23375636

Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, Hawke D, Kim SM, Lee JS, Goltsov AA, Park S, Ittmann MM, Troncoso P, Thompson TC.  Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2012 Dec 31. doi:pii: S1574-7891(12)00131-7. 10.1016/j.molonc.2012.12.005. [Epub ahead of print] PMID: 23333597

Angelo LS, Maxwell DS, Wu JY, Sun D, Hawke DH, McCutcheon IE, Slopis JM, Peng Z, Bornmann WG, Kurzrock R.  Binding partners for curcumin in human schwannoma cells: Biologic Implications.  Bioorg Med Chem. 2013 Feb 15;21(4):932-9. doi: 10.1016/j.bmc.2012.12.008. Epub 2012 Dec 13. PMID: 23294827

Nika H, Lee J, Willis IM, Angeletti RH, Hawke DH.  Phosphopeptide characterization by mass spectrometry using reversed-phase supports for solid-phase β-elimination/Michael addition.  J Biomol Tech. 2012 Jul;23(2):51-68. doi: 10.7171/jbt.2012-2302-002. PMID: 22951960. Free PMC Article

Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z.  PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell. 2012 Aug 17;150(4):685-96. doi: 10.1016/j.cell.2012.07.018. PMID: 22901803

Samanta S, Anderson K, Moran S, Hawke D, Gorenstein D, Fornage M.
Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.  PLoS One. 2012;7(8):e42417. doi: 10.1371/journal.pone.0042417. Epub 2012 Aug 7. PMID: 22879973

Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z.  AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.  EMBO Rep. 2012 Jun 1;13(6):554-60. doi: 10.1038/embor.2012.53. PMID: 22510990

Zheng Y, Yang W, Xia Y, Hawke D, Liu DX, Lu Z.  Ras-induced and ERK1/2 Phosphorylation-Dependent Isomerization of PTP-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST.  Mol Cell Biol. 2011 Aug 29. [Epub ahead of print] PMID: 21876001.

Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F.  PMLRAR{alpha} binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.  Blood. 2011 Jul 29. [Epub ahead of print]  PMID: 21803845.

Friedman DB, Andacht TM, Bunger MK, Chien AS, Hawke DH, Krijgsveld J, Lane WS, Lilley KS, Maccoss MJ, Moritz RL, Settlage RE, Sherman NE, Weintraub ST, Witkowska HE, Yates NA, Turck CW.  The ABRF Proteomics Research Group Studies: Educational exercises for qualitative and quantitative proteomic analyses.  Proteomics 11(8): 1371-81. 

Yokoi K, Hawke D, Oborn CJ, Jang JY, Nishioka Y, Fan D, Kim SW, Kim SJ, Fidler IJ. Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer.  Transl Oncol 4(2): 83-91. 

Mazouni C, Baggerly K, Hawke D, Tsavachidis S, Andre F, Buzdar AU, Martin PM, Kobayashi R, Pusztai L. Evaluation of changes in serum protein profiles during neoadjuvant chemotherapy in HER2-positive breast cancer using an LC-MALDI-TOF/MS procedure.  Proteomics 10(19): 3525-32. 

Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ.  Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.  Breast Cancer Res 12(6): R96.

Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W.  From combinatorial peptide selection to drug prototype (I): targeting the vascular endothelial growth factor receptor pathway.  Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5112-7. PMID: 20190181

Ji H, Wang, J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell 2009, 36(4): 547-59.

Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.Biochem Pharmacol. 2010 Mar 1;79(5):669-77. PMID: 19814999

Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 2009 Jul 10;35(1):11-25.

Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat-shock protein 90beta cleavage promotes ultraviolet B irradiation-induced cell apoptosis. Mol Cell Biol. 2009, 29(13): 3657-64.

Li Y, Thapa P, Hawke D, Kondo Y, Furukawa K, Furukawa K, Hsu FF, Adlercreutz D, Weadge J, Palcic M, Wang P, Levery S, Zhou D. Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J. Proteome Res. 2009, 8(6): 2740-51.

Clement, CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of Lung Innate Immunity Protects Against Lethal Pneumococcal Pneumonia in Mice. Am J Respir Crit Care Med. 2008.

Kim SW, Cheon K, Kim CH, Yoon JH, Hawke DH, Kobayashi R, Prudkin L, Wistuba II, Lotan R, Hong WK, Koo JS. Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method. Cancer Res. 2007; 67(14): 6565-6573.

Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007; 282(15): 11221-11229.

Ohshiro K, Rosenthal DI, Koomen JM, Streckfus CF, Chambers M, Kobayashi R, El-Naggar AK. Pre-analytic saliva processing affect proteomic results and biomarker screening of head and neck squamous carcinoma. Int J Oncol. 2007 Mar;30(3):743-9.

Coussot G, Hawke DH, Mularz A, Koomen JM, Kobayashi R. A method for the isolation of blocked N-terminal peptides. Anal Biochem. 2007; 361(2): 302-304.

Herling M, Patel KA, Khalili J, Schlette E, Kobayashi R, Medeiros LJ, Jones D. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia 2006; 20(2):280-285.

Pawlik TM, Hawke DH, Liu Y, Krishnamurthy S, Fritsche H, Hunt KK, Kuerer HM. Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein. BMC Cancer 2006; 6:68.

He G, Kuang J, Huang Z, Koomen J, Kobayashi R, Khokhar AR, Siddik ZH. Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer. 2006 Dec 4;95(11):1514-24. Epub 2006 Nov 7.

Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung, MC. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 2006; 8(12):1359-1368.

Koomen JM, Wilson CR, Guthrie P, Androlewicz MJ, Kobayashi R, Taegtmeyer H. Proteome Analysis of Isolated Perfused Organ Effluent as a Novel Model for Protein Biomarker Discovery. J. Proteome Res. 2006; 5:177-182.

Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res. 2005; 65:11118-11128.

Chu F, Koomen JM, Kobayashi R, O’Brian CA. Identification of an Inactivating Cysteine Switch in Protein Kinase Cε, a Rational Target for the Design of Protein Kinase Cε-Inhibitory Cancer Therapeutics. Cancer Res. 2005; 65:10478-10485.

Yokoi K, Shih LC, Kobayashi R, Koomen J, Hawke D, Li D, Hamilton SR, Abbruzzese JL, Coombes KR, Fidler IJ. Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer. Int J Oncol. 2005; 27:1361-1369.

Pan S, Wang R, Zhou X, He G, Koomen J, Kobayashi R, Sun L, Corvera J, Gallick GE, Kuang J. Involvement of the conserved adaptor protein Alix in actin cytoskeleton assembly. J Biol Chem. 2006 Nov 10;281(45):34640-50. Epub 2006 Sep 10.

Jia S, Kobayashi R, Grewal SI. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Nature Cell Biology 2005; 7:1007-1013.

Zhang K, Lin W, Latham JA, Riefler GM, Schumacher JM, Chan C, Tatchell K, Hawke DH, Kobayashi R, Dent SY. The Set1 methyltransferase opposes Ipl1 Aurora kinase functions in chromosome segregation. Cell 2005; 122:723-734.

Masumoto H, Hawke D, Kobayashi R, Verreault A. A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature 2005; 436:294-298.

Koomen JM, Li D, Xiao L, Liu TC, Coombes KR, Abbruzzese JL, Kobayashi R. Direct Tandem Mass Spectrometry Reveals Limitations in Protein Profiling Experiments for Plasma Biomarker Discovery. J. Proteome Res. 2005; 4:972-981.

Koomen JM, Zhao H, Li D, Nasser W, Hawke DH, Abbruzzese JL, Baggerly KA, Kobayashi R. Diagnostic Protein Discovery using Liquid Chromatography-Mass Spectrometry for Proteolytic Peptide Targeting. Rapid Commun. Mass Spectrom. 2005; 19:1624-1636.

Morris JS, Coombes KR, Koomen J, Baggerly KA, Kobayashi R. Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum. Bioinformatics 2005; 21:1764-1775.

He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 2005; 24:2929-2943.

Koomen JM, Shih LN, Coombes KR, Li D, Xiao LC, Fidler IJ, Abbruzzese JL, Kobayashi, R. Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. Clin.Cancer Res. 2005; 11:1110-1118.

Wang E, Ngalame Y, Panelli MC, Nguyen-Jackson H, Deavers M, Mueller P, Hu W, Savary CA, Kobayashi R, Freedman RS, Marincola FM. Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. Clin.Cancer Res. 2005; 11:113-122.

Lee S, Andrieu C, Saltel F, Destaing O, Auclair J, Pouchkine V, Michelon J, Salaun B, Kobayashi R, Jurdic P, Kieff ED, Sylla BS. IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Proc.Natl.Acad.Sci. U.S.A. 2004; 101: 17416-17421.

Koomen JM, Zhao H, Li D, Abbruzzese J, Baggerly K, Kobayashi R. Diagnostic protein discovery using proteolytic peptide targeting and identification. Rapid Commun. Mass Spectrom 2004; 18:2537-2548.

Bresalier RS, Byrd JC, Tessler D, Lebel J, Koomen J, Hawke D, Half E, Liu KF, Mazurek N; Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.. A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer. Gastroenterology 2004; 127(3):741-748.

Chattopadhyay C, Hawke D, Kobayashi R, Maity SN. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004; 32: 3632-3641.

Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117:225-237.

Gaertner TR, Kolodziej SJ, Wang D, Kobayashi R, Koomen JM, Stoops J.K. and Waxham, M.N. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. J.Biol.Chem. 2004; 279: 12484-12494.

Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol. Cell 2003; 12: 1151-1164.

Bogenhagen DF, Wang Y, Shen EL, Kobayashi R. Protein components of mitochondrial DNA nucleoids in higher eukaryotes. Mol.Cell.Proteomics 2003; 2:1205-1216.

Galfione M, Luo W, Kim J, Hawke D, Kobayashi R, Clapp C, Yu-Lee LY, Lin SH. Expression and purification of the angiogenesis inhibitor 16-kDa prolactin fragment from insect cells. Protein Expr.Purif. 2003; 28:252-258.

Nakayama J, Xiao G, Noma K, Malikzay A, Bjerling P, Ekwall K, Kobayashi R, Grewal SI. Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. EMBO J. 2003; 22:2776-2787.


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