PTEN Mutation Analysis
Indication
To detect and type mutations in the PTEN tumor suppressor gene for diagnosis of Cowden disease and Bannayan-Riley-Rucvalcaba syndrome and for prognosis and therapy selection in range of cancer types, particularly endometrial carcinoma, glioblastoma multiforme, melanoma, and prostatic carcinoma.
Methodology
This assay is part of the Next Gen Sequencing panel for solid tumors.
Test Parameters
Next generation sequencing-based analysis is performed to detect point mutations in mutational hotspots in the PTEN gene. The codons tested include, 6, 68, 173, 171, 214, 242, 248, 267, 290, 317, 318, 319, 321, 323, 335.
Turnaround Time
10 days
Sample Requirements
5ug purified DNA or 4-10 unstained tissue sections on glass slides along with 1 H&E-stained section.
81479