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The Molecular Cytogenetics Core Facility provides the following services:

  • Study of genetic instability by chromosome analysis
  • Cell line identification: human, mouse, rat, dog, monkey or of any other mammalian origin
  • Giemsa (G), C, Q, R –banding, SCE (Sister Chromatid Exchange) and silver staining of metaphase chromosomes
  • Analysis of meiotic chromosomes of laboratory animals
  • Effects of pharmaceutical products on human and other mammalian chromosomes
  • Fluorescence in situ hybridization (FISH) on interphase and metaphase cells, paraffin sections, tissue microarray and frozen sections using whole chromosome paints, centromere probes, gene mapping with commercial and laboratory-generated DNA probes
  • Quantitative FISH (Q-FISH) analysis of telomeric sequences
  • Spectral karyotyping (SKY) of human, mouse and rat cells
  • Determination of the genetic suitability of mammalian stem cells to be used for cloning purposes

Services Form

High Impact Publications

Gallardo M, Lee HJ, Zhang X, Bueso-Ramos C, Pageon LR, McArthur M, Multani A, Nazha A, Manshouri T, Parker-Thornburg J, Rapado I, Qunitas-Cardama A, Kornblau SM, Martinez-Lopez J, Post SM. hnRNP K is a novel haploinsufficient tumor suppressor that regulates proliferation and differentiation programs in hematologic malignancies. Cancer Cell. pii: S1535-6108(15)00305-0. 9/2015 PMID: 26412324

Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 11;27(5):644-57, 5/2015 PMCID: PMC4596059

Wang Y, Waters J, Leung ML, Unruh A, Roh W, Shi X, Chen K, Scheet P, Vattathil S, Liang H, Multani A, Zhang H, Zhao R, Michor F, Meric-Bernstam F, Navin NE. Clonal evolution in breast cancer revealed by single nucleus genome sequence. Nature 512(7513):155-60, 8/2014. PMCID: PMC25079324.

Maiti SN, Huls H, Singh H, Dawson M, Figliola M, Olivares S, Rao P, Zhao YJ, Multani A, Yang G, Zhang L, Crossland D, Ang S, Torikai H, Rabinovich B, Lee DA, Kebriaei P, Hackett P, Champlin RE, Cooper LJ. Sleeping beauty system to redirect T-cell specificity for human applications. J Immunother 36(2):112-23, 2/2013. PMCID: PMC3568214.

© 2015 The University of Texas MD Anderson Cancer Center