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HPV-associated Cancers


Introductory video transcript:
English / Español

Course Overview

Human papillomavirus (HPV) is a common virus best known as the agent that causes benign warts. However, of the more than 100 types of HPV, about 13 types have been documented as “high risk”; that is they are associated with the development of human cancers.  HPV-related cancers include those of the cervix, vulva, and penis as well as cancers of the rectum, anus, and oropharynx.  Many of these diseases are preventable through HPV vaccination. In this course, a multidisciplinary faculty team discusses HPV biology, the specific cancers that are associated with HPV, the value of and recommendations for HPV vaccination for children, and coverage of conditions diagnosed via the “Breast and Cervical Cancer Early Detection Program”.

Lectures

 

Lois M. Ramondetta, M.D.Introduction to Human Papillomavirus-related Diseases   Top of Page
 
Presenter: Lois M. Ramondetta, M.D.
Professor, Gynecologic Oncology and Reproductive Medicine

 

 

Summary: “Almost all will be infected with at least one type of human papillomavirus at some point in their life,” says Dr. Lois Ramondetta, Professor of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center. In her lecture, “Introduction to Human Papillomavirus–Related Diseases,” Dr. Ramondetta discusses the prevalence of HPV infections across the United States and the early effects of HPV vaccination on this prevalence. She also describes the data that support the safety and efficacy of the HPV vaccine and introduces various HPV-associated cancers.

 

Karen A. Storthz, Ph.D.Biology of Human Papillomavirus   Top of Page
 
Presenter: Karen Storthz, Ph.D.
Professor Emerita, Diagnostic and Biomedical Sciences
The University of Texas Health Science Center at Houston School of Dentistry
 

Summary: Dr. Karen Storthz, Professor Emerita in the Department of Diagnostic and Biomedical Sciences at The University of Texas Dental Branch, has studied human papillomavirus (HPV) and its role in oropharyngeal and cervical cancer for more than 30 years. In her lecture, “Biology of Human Papillomavirus,” she discusses the diversity of HPV types and describes the benign and malignant diseases that HPV causes. Beginning with a brief history of the research advances that increased our understanding of HPV biology and led to the development of HPV vaccines, she explains HPV gene function and viral replication and the role of viral E6 and E7 proteins in deregulating the cell cycle, leading to malignant transformation. By showing clinical photos of common benign lesions and cancers caused by HPV, she contrasts low-risk and high-risk HPV types and explains the uncommon but devastating process of malignant transformation of some HPV types.

 

Kathleen Schmeler, M.D.Cervical Cancer   Top of Page

Presenter: Kathleen Schmeler, M.D.
Associate Professor, Gynecologic Oncology and Reproductive Medicine

 

Summary: “In the United States, there are an estimated 12,360 new cases and approximately 4000 deaths from cervical cancer per year. It’s the 14th most frequent cancer among women. However, in low- and middle-income countries, cervical cancer is the first or second leading cause of cancer death among women, with over 400,000 women dying per year,” says Dr. Kathleen Schmeler, Associate Professor of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center. In her presentation “Carcinoma of the Cervix,” she describes the epidemiology of cervical cancer, discusses cervical cancer screening and prevention, and explains the appropriate treatment for early-stage, locally advanced, metastatic, and recurrent disease.

Lois M. Ramondetta, M.D.       

Presenter: Lois M. Ramondetta, M.D.
Professor, Gynecologic Oncology and Reproductive Medicine

 

Summary: “Cervical cancer is a huge problem in the world today,” says Dr. Lois Ramondetta, Professor of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center. In the first lecture of her in-depth, two-part series “Management of Local-regionally Advanced and Recurrent Cervical Cancer,” Dr. Ramondetta discusses the usual presentation and survival rates of women with local-regionally advanced cervical cancer and explains standard treatment approaches for this disease. She also discusses the determinants of local-regional recurrence of cervical cancer. She expresses optimism that advanced cervical cancer can be prevented in the future thanks to three HPV vaccines approved by the US Food and Drug Administration. In the second lecture in the series, Dr. Ramondetta discusses the challenge of treating recurrent cervical cancer. She discusses appropriate use of surgery and radiation therapy in women with recurrent disease. She also describes chemotherapy and targeted therapy and response rates in women with recurrent and advanced cervical cancer. She concludes by discussing the important role of supportive care in the treatment of women with recurrent and advanced cervical cancer.

 

Anal Cancer   Top of Page
 
Presenter: Cathy Eng, M.D.
Associate Professor
Department of Gastrointestinal (GI) Medical Oncology
 

Summary: Coming soon!

 

Kristina R. Dahlstrom, Ph.D.Erich M. Sturgis, M.D., M.P.H.Oropharyngeal Cancer   Top of Page
 
Presenter: Kristina R. Dahlstrom, Ph.D.
Instructor, Head and Neck Surgery
 
Presenter: Erich M. Sturgis, M.D., M.P.H.
Professor, Head and Neck Surgery

 
Summary: “To date more than 150 types of HPV have been described. About 40 of these infect the genital tract and potentially the oral cavity and the oropharynx,” says Kristina R. Dahlstrom, Ph.D., an instructor in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center. In this lecture, “Oropharyngeal Cancer: Epidemiology,” Dr. Dahlstrom describes the role of HPV in oropharyngeal cancer, risk factors for the disease, why HPV-associated cancers are becoming an epidemic, and trends and incidence in survival. She also talks about methods for prevention of HPV-related oropharyngeal cancer, which includes a newly FDA approved HPV nonavalent vaccine.

When oropharyngeal cancer is HPV-related, there typically are no symptoms, but there may be a lump in the neck. In his lecture, “Oropharyngeal Cancer: Clinical Implications of the HPV Epidemic,” Erich M. Sturgis, M.D., Professor of Head and Neck Surgery and Epidemiology, describes the pathophysiology of HPV infection and malignant transformation, as well as the clinical differences between HPV-positive cancers and HPV-negative cancers. He also discusses current clinical trials.

 

Penile Cancer   Top of Page
 
Presenter: Curtis A. Pettaway, M.D.
Professor
Department of Urology
 

Summary: Coming soon!

 

Kathleen Schmeler, M.D.
Human Papillomavirus Vaccination   Top of Page
 
Presenter: Kathleen Schmeler, M.D.
Associate Professor, Gynecologic Oncology and Reproductive Medicine
 

Summary: In the United States, an estimated 14 million persons are newly infected annually with genital human papillomavirus (HPV), making this infection the nation’s most common sexually transmitted infection. In 2009, nearly 35,000 HPV-attributable cancers were reported in the United States. Of these, 39% occurred in males. The CDC Advisory Committee on Immunization Practices currently recommends routine HPV vaccination for all persons aged 11–12 years.  In her lecture, “Human Papillomavirus (HPV) Vaccination,” Kathleen Schmeler, MD, Associate Professor in the Department of Gynecologic Oncology and Reproductive Medicine, explains the epidemiology of cervical cancer and how to screen for and treat cervical cancer. Specific vaccine recommendations and the role of HPV vaccination in preventing cervical cancer are presented.

 

Medicaid for Breast and Cervical Cancer   Top of Page
 
Presenter: Maria E. Daheri, RN
Cervical Nurse Case Manager
Harris Health System
 

Summary: Coming soon!

 

 

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